archive tax-process theme-making woocommerce-js customize-support

operation type

product format

Privacy Policy

User Agreement

Terms of Service

Default Confirmation

If too long

This form auto replies from Zendesk on submission
on Trigger ID: tbc
https://vekamafsupport.zendesk.com/agent/admin/triggers

Admin Notification

New submission from {form_title}

Messages backup

Notify Teammedia of submission

Submission from Making.com Ad Campaign

Maker - Product Challenge

Products

Technologies

About us

Changemakers

Granulation Technologies

A granulator is a high-speed knife mill designed to cut down large components of feedstock and reduce them to smaller particle sizes. Selecting the right scissor geometry and configuration allows granulators to process plastic bottles, organic fibers, films, wires, cables, and other difficult materials. Agglomeration granulators combine fine particles into larger granules by creating bonds between them. Bonds are formed by compressing fine particles or through the use of a binding agent.

Granulators

granulation-process

Granulation-process

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Detergents are cleaning agents that help remove dirt and grease from porous and non-porous surfaces. Industrial production of detergents began after World War I. Still, it was after the 1950s and 1960s that the detergent industry grew exponentially due in part to the development of new detergent manufacturing equipment.

Detergents

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Organic fertilizer production has ancient roots, tracing its origins to ancient farmers who used natural materials like animal manure, compost, and crop residues to improve soil fertility. This sustainable tradition of repurposing organic waste for agricultural benefits has endured through the ages, handed down from one generation of farmers to the next. Producing organic fertilizer industrially involves a series of steps such as extraction, granulation, drying, and employs a combination of organic fertilizer production equipment.

Organic fertilizer

Granules

Continuous

Industrial

In pharmaceutical production, the need for efficient and contained granulation processes is critical. Traditional multi-step methods can expose operators to hazardous materials and increase contamination risks, resulting in compromised product quality and longer processing times.
<h2>Achieve seamless in-containment granulation</h2>
The ROTO CUBE from IMA is a single-pot processor that revolutionizes granulation by integrating multiple processing steps within a sealed bowl. This system handles everything from the loading of raw powders to the discharge of dry milled granules without the need for product transfers. Featuring accurate detection of the wet granulation end-point and a tilting bowl design for optimal heat exchange, the ROTO CUBE improves drying efficiency and prevents product sticking. The GA.ST. system enhances vacuum drying through inert gas injection, ensuring a dust-free process and safe solvent use. Suitable for high-potency active ingredients (HAPI), the ROTO CUBE maximizes product yield and simplifies cleaning operations.

Single-pot granulation processor for pharmaceutical applications

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Granulation

A loading system feeds your continuous or batch processing machine with the specified material or item in line with the flow of production. Loaders transfer the articles from one stage of preparation to the next with uniformity and accuracy.

Loading

solid

Batch

In pharmaceutical manufacturing, achieving optimal drying, granulation, and pellet coating can be challenging due to the need for precise control and high containment. Ensuring product consistency and safety while maintaining efficiency is crucial.
<h2>Efficiently dry, granulate, and coat with high containment</h2>
The GHIBLI fluid bed processor by IMA Active is designed to address challenges in pharmaceutical manufacturing by providing efficient drying, granulation, and pellet coating processes. Its rotating expansion chamber allows full accessibility to product filters for easy inspection and maintenance. The GHIBLI can work in high containment environments and is compatible with various filter types, including bag filters, star-pleated, or stainless steel cartridges. It is ATEX compliant, ensuring safe use with solvents, and features powder dedusting, absolute filtration, and 12-bar Pressure Shock Resistance. The processor also offers product discharge by gravity through the floor as an optional feature. Custom double fluid nozzles enhance accuracy in spraying during granulation or coating, with continuous control of liquid flow, volume, and pressure. Available in different models, the GHIBLI caters to batch sizes ranging from 66 to 1,400 liters.

Fluid bed processor for pharmaceutical granulation and drying

To coat your consumer products with color or taste-enhancing substances, specialized technologies are available that ensure all the contents are individually and evenly covered. The process starts with loading your goods onto rotating drums, exposing the products to spray nozzles that treat them with your prescribed coating formula.

Coating

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

In the pharmaceutical, chemical, and food processing industries, achieving high-quality granulation and homogenization of bulk materials is essential. Conventional methods often struggle with handling soft to medium-hard materials efficiently and cleanly, particularly when precision and consistency are crucial.
<h2>Granulate and homogenize bulk materials effectively</h2>
The Bexmill ABM from Hosokawa Alpine is a versatile and efficient solution for granulating and homogenizing bulk materials. This equipment is designed to handle soft to medium-hard materials in a single step, ensuring quick tool changes and minimal cleaning times. With a conical grinding chamber, it provides high throughput rates and fine particle size distribution. The adjustable rotor allows for optimal crushing without opening the chamber, making it suitable for various applications such as crushing flakes, homogenizing mixtures, and disintegrating agglomerates. Available in multiple sizes, the Bexmill ABM can process from laboratory-scale to industrial-scale operations, with capacities ranging from 10 kg/h to 10 t/h. It supports industries like pharmaceuticals, chemicals, and food processing, offering options for dust-tight, gas-tight, and stainless steel designs compliant with FDA standards.

Granulation and homogenization with bexmill Abm

Crushing is the process of applying an amplified force to a material to break it down into smaller pieces. A crusher is a machine designed to crush large chunks of material into smaller bits or a powder. They are used to reduce mineral rocks to smaller rocks, gravel, or dust. They are also used to reduce the size of waste materials for easier disposal/recycling or to reduce the size of a solid mix of raw materials. Crusher equipment selection depends on the physical properties of the material to be processed, the in-feed size, and the desired output particle size.

Crushing

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

In industries such as pharmaceuticals, chemicals, and food production, achieving consistent granulation, drying, and coating of free-flowing bulk materials can be a major challenge. Optimizing heat and mass transfer processes while maintaining product quality and minimizing downtime is crucial.
<h2>Achieve precise granulation and coating</h2>
The Glatt Fluid Bed and Spouted Bed Systems are designed for efficient granulation, drying, and coating of free-flowing bulk materials. These systems excel in handling particles that are challenging to fluidize, using patented apparatus geometry for optimal energy input. Fluid bed systems offer flexibility to process product quantities from a few grams in the lab to several tons in production. The spouted bed technology features adjustable energy input, ensuring higher heat and mass transfer rates. Glatt's systems cater to pharmaceuticals, chemicals, food, ceramics, and cosmetics industries, among others. With capabilities for batch or continuous operation, these systems provide customized control and maintain high standards of safety and hygiene. Additionally, Glatt guarantees process parameters such as capacity, particle size, and bulk density, ensuring cost-effective and high-quality production.

Fluid bed and spouted bed systems for granulation and coating

In specialized production environments, maintaining the stability and consistency of temperature-sensitive materials during granulation can be challenging. This is particularly true when dealing with highly viscous solutions or precise mixing requirements in continuous operations.
<h2>Streamline granulation and drying processes</h2>
The Glatt fluid bed plants type AGT® are designed for continuous spray granulation, providing an optimal solution for the food, feed, and fine chemical industries. These plants feature a circular single-chamber design, which allows for the simultaneous drying of liquid raw materials and granulate formation in an ideally mixed fluidized bed. The system combines high process flexibility and adaptability with interchangeable process chambers, allowing for operations like spray granulation of liquids, powder agglomeration, and coating. The AGT® series supports both continuous and batch-controlled operations, making it versatile for various applications. Its controlled environment ensures consistent particle size and effective mixing, while options such as different nozzle systems, flexible solids feeders, and adaptable filters enhance its utility.

Fluid bed granulation system for food and chemical industries

Agglomeration

liquid

Manual

In pharmaceutical and industrial applications, forming medium to high-density granules from powders is often challenging. Precise control and uniform mixing are essential to ensure high product quality and efficiency.
<h2>Facilitates homogeneous wet granulation</h2>
The GMX GRANUMEIST® is a high shear granulator and mixer designed by Freund for the efficient and homogeneous wet granulation of powders. Its top-drive design enhances user safety and enables faster processing times. The removable bowl and mixing blade with a fixed bowl lid allow for superior cleaning and maintenance. The vertical shaft chopper improves granulation, while the user-defined mixer and chopper speeds offer processing flexibility for both aqueous and solvent materials. Optional features include vacuum drying for one-pot processing and a jacketed bowl for product temperature control. The system is equipped with a color touch screen control for validatable process control, configuring both automatic and manual modes. It also supports 21 CFR Part 11 compliant data and recipe handling. The GMX GRANUMEIST® series comes in various models, offering bowl capacities from 150 to 1200 liters.

High shear wet granulation line

Blending

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

In pharmaceutical manufacturing and other powder processing industries, achieving uniform granule density and size is crucial. Traditional mixing methods often struggle with consistency and efficiency, leading to variations in the final product quality.
<h2>Rapid and uniform granulation</h2>
The GMX-LAB Mini GRANUMEIST® from Freund is a high shear wet granulation system designed to provide consistent and efficient granulation of powders. Its top-drive design facilitates easy cleaning and maintenance, ensuring faster processing times and enhanced safety. This granulator features interchangeable 4L and 8L bowls, user-defined mixer and chopper blade speeds, and an integrated peristaltic pump for precise solution addition. The system can handle both aqueous and solvent processing with optional jacketed bowls for temperature control. Its quick-change design requires no tools and is mounted on casters for easy maneuverability, making it an ideal solution for flexible and scalable production needs.

Mini High shear granulator for wet granulation

Achieving consistent and homogenous granulation of powders is crucial in pharmaceutical and chemical manufacturing. Traditional methods often struggle with inefficiencies, extended processing times, and intricate maintenance, making innovation in wet granulation technology necessary.
<h2>Ensures consistent and homogenous wet granulation</h2>
The GMX-LAB Micro GRANUMEIST®, from Freund, is a state-of-the-art high shear granulation system designed to streamline the wet granulation process for powders. Its top-drive design facilitates easy cleaning and maintenance, while ensuring faster processing times and enhanced user safety. With interchangeable 1L and 4L bowls, it offers processing flexibility and accommodates varying batch sizes. User-defined settings for mixer and chopper blade speeds, along with an integrated peristaltic pump, provide precision in solution addition. An optional jacketed bowl allows for precise product temperature control. The Smart-Safe™ containment option adds an extra layer of security, and the color touchscreen control system supports validatable process control with various end-point detection parameters. This system is well-suited for industries requiring medium to high density granules, including pharmaceuticals and chemicals.

High shear lab granulation system for powder processing

Dispersing systems are used to produce emulsions of two immiscible liquids or dispersions of solid particles in a liquid medium. The mixers generally operate on the rotor/stator principle and apply a high shear force on the suspended particles to break them down. The choice of a dispersion mixer depends on the physical state of the material being dispersed, the continuous or batch nature of the process, desired particle size, and the viscosity of the mixture. Dispersion mixers are widely used in the food industry for the dispersion of solid ingredients in oil or water and in the coatings industry for the dispersion of pigments.

Dispersing

Pilot

When producing pharmaceuticals or food products, achieving a homogeneous wet granulation of powders is crucial for consistent product quality and process efficiency. Processing powders into medium to high-density granules requires a granulation system that ensures rapid mixing and uniform consistency.
<h2>Enhanced wet granulation with flexible bowl capacities.</h2>
The GMXB-Pilot GRANUMEIST® by Freund is a high shear granulator designed for efficient and homogeneous wet granulation of powders. It features a bottom-drive system that enhances user safety and simplifies maintenance. The modular design allows for interchangeable product bowls in capacities of 10L, 25L, and 65L, catering to various batch sizes. An integrated peristaltic pump and user-defined settings for mixer and chopper blade speeds provide operational flexibility. Optional features include a jacketed bowl for temperature control and vacuum drying for one-pot processing. The system is equipped with a color touchscreen control system with both automatic (recipe driven) and manual modes, ensuring process control. Data can be collected via a USB port, and the system supports 21 CFR Part 11 compliance for data and recipe handling. The GMXB-Pilot GRANUMEIST® is suitable for pharmaceutical, nutraceutical, and food industries, offering scalable granulation solutions from lab to production scale.

Pilot High shear granulator for wet granulation

In the pharmaceutical and chemical industries, achieving a consistent particle size and density during wet granulation is crucial. Traditional granulation methods can present challenges such as long processing times and difficult maintenance, affecting production efficiency and output quality.
<h2>Enhance wet granulation efficiency and uniformity</h2>
The GMXB-LAB Mini GRANUMEIST® by Freund is a bottom-drive high shear granulator and mixer designed for efficient and homogenous wet granulation of powders. This system features interchangeable product bowls with capacities of 4L, 6L, and 10L, allowing for flexibility in processing different batch sizes. Its bottom-drive design simplifies cleaning and maintenance, resulting in faster processing times and improved user safety. The system includes user-defined settings for mixer and chopper blade speeds, an integrated peristaltic pump, and optional features such as a jacketed bowl for product temperature control and vacuum drying for one-pot processing. The GMXB-LAB Mini GRANUMEIST® allows for both aqueous and solvent processing, supporting a wide range of granulation requirements. Furthermore, the system features a color touchscreen control system with validatable process control and multiple endpoint detection parameters, ensuring consistent and reliable results.

High shear granulator for wet granulation of powders

In pharmaceutical or chemical manufacturing, obtaining uniform granules with specific density and size is critical. Traditional granulation methods can lead to uneven granules, prolonging production times and complicating downstream processes.
<h2>Create uniform granules with precise control</h2>
The GMXB GRANUMEIST® from Freund is a high shear granulator and mixer designed for efficient and homogenous wet granulation of powders. It features a bottom drive mechanism and is built using GMP-compliant 316 stainless steel, ensuring robust, clean processing suitable for pharmaceutical and chemical applications. The granulator supports flexible processing with user-defined settings for mixer and chopper blade speeds, allowing for aqueous and solvent processing. An optional jacketed bowl enables precise product temperature control, and the system can also be equipped for vacuum drying for all-in-one processing. Built with ease of access in mind, it allows for straightforward maintenance, calibration, and inspection. Engineered scalability allows for processing volumes ranging from 30 liters to 1800 liters, accommodating various production needs. The Smart-Safe™ containment and EcoClean™ technology enhance safety and simplify cleaning, making it a versatile solution for granulation suites.

High shear granulation mixing system

Lyophilization

Vacuum

In manufacturing sectors involving pharmaceuticals, food processing, and chemicals, achieving uniform powder densification and granulation is crucial to enhance product stability and handling. Traditional methods often fail to ensure consistent particle size and density, leading to inefficiencies and waste.
<h2>Produce consistent compacted sheets</h2>
The GRANUFORCE™ Roller Compaction system by Freund is engineered to efficiently compact powdered materials into uniform sheets with increased density and hardness. Utilizing a cantilevered roll design — unique in its vertical tapered feed screw system — this system ensures consistent material feeding and compacting. It's equipped with standard serrated rolls and alternative roll options, catering to various material properties. The system offers a wide production capacity of up to 700 kg/hr and features precision controls including laser roll gap measurement and roll force adjustment. The system also includes a contained compaction zone that reduces the amount of fines, enhancing overall production yield and quality. Optional features like inline PAT monitoring and vacuum de-aeration further enhance its versatility. Designed for easy cleaning and maintenance, it supports quick changeovers and includes a scalable roll and screw design adaptable from developmental models to large-scale production.

Dry granulation system for powder compaction

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

In pharmaceutical and chemical manufacturing, producing uniform, high-density compacted granules from powdered materials poses challenges. This process is crucial for achieving consistent tablet formulation and optimizing bulk material handling. Issues often arise in maintaining consistent hardness and density, impacting final product quality.
<h2>Ensures uniform compacted sheets with consistent hardness</h2>
The GFC-520 GRANUFORCE™ by Freund is a dry granulation system designed for pilot and production-scale applications. It utilizes a cantilevered roll design with a vertical tapered feed screw system and standard serrated rolls. This technology produces uniform, dense compacted sheets by compacting powdered materials between two uniquely designed rolls. It offers a wide production capacity ranging from 5 to 130 kg per hour. The system features parallel roll movement and a unique compaction seal design to reduce fines, enhancing production yields. Optional inline PAT monitoring and de-aeration ensures product quality and consistency. The smart containment design achieves containment levels of 5µg/m3 without an isolator. This system is easy to clean and operate, with a color touchscreen control system for efficient workflow management. The GFC-520 is suitable for industries such as pharmaceuticals and chemicals.

Roller compaction system for dry granulation

In pharmaceutical and powder-processing industries, achieving uniform compaction and density of powdered materials is critical. Traditional methods often struggle with consistent output and optimal processing efficiencies, which leads to operational challenges and quality control issues.
<h2>Produces uniform compacted sheets with increased density</h2>
The GFC-220 GRANUFORCE™ by Freund is a pilot roll compactor system designed to facilitate dry granulation and densification of powdered materials. Employing a cantilevered roll design, the GFC-220 achieves consistent hardness and density by compacting materials between specially designed serrated rolls. This system supports capacities ranging from 1 to 30 kg/hr and includes a vertical tapered feed screw for enhanced processing flexibility. Additional features like the unique compaction seal design minimize fines and ensure a contained compaction zone. Optional inline PAT monitoring and de-aeration designs further enhance product quality while maintaining efficient operation. Ideal for pharmaceutics and powder processing industries, this system is easy to clean, economical, and engineered for scalability.

Roll compactor system for dry granulation

In pharmaceutical and nutraceutical industries, achieving uniform granulation and coating is essential for product consistency and quality. Traditional batch processes can be time-consuming and variable, requiring advancements in technology for better efficiency.
<h2>Combine granulation and coating in one process</h2>
The FC-MX FLO-COATER® from Freund is a versatile fluid bed system designed for both granulation and coating applications. It features a unique 3-piece construction for flexibility in processing capacities ranging from 20L to 1900L. Equipped with Freund's patented Wurster Accelerator System, the device ensures reduced process times and increased airflow, leading to effective material processing. Its EcoClean™ technology offers high-pressure, low-volume systems for self-cleaning and efficient maintenance. The intuitive color touchscreen control system supports both automatic and manual operation modes, ensuring ease of use. The system is validated for compliance with 21 CFR Part 11, meeting stringent regulatory requirements.

Fluid bed system for granulation and coating

In industrial manufacturing processes, achieving uniform granulation can be challenging due to varying particle sizes and moisture content. Consistent granulation is critical for efficient downstream processing and product quality.
<h2>Facilitates uniform and controlled granulation</h2>
The FC-M FLO-COATER® by Freund is a multipurpose fluid bed system designed for both pilot and production-scale granulation. The system offers flexible configurations with capacities ranging from 20L to 1900L, making it suitable for various production volumes. It utilizes top spray granulation and bottom spray for both solution and powder coatings. The patented Wurster Accelerator System significantly reduces process times, while the GRANUREX® rotor technology enhances solution/suspension coating, spherical granulation, and polymer/powder layering. Additionally, the system includes EcoClean™ technology, which features high-pressure, low-volume cleaning systems and removable cartridge filters with single-point cleaning connections. Optional inline PAT monitoring provides real-time moisture and drying analysis to ensure optimal processing conditions. The FC-M FLO-COATER® is designed to meet the rigorous requirements of industries such as pharmaceuticals, food processing, and chemicals.

Fluid bed granulator for industrial granulation

Analysis

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

In pharmaceutical and chemical research, developing processes for granulation and coating requires precise control and flexibility. Researchers need equipment that can handle multiple processes while ensuring easy cleaning and quick changeover to maximize efficiency during development stages.
<h2>Supports granulation, coating, and drying processes</h2>
The FC-LAB 1 FLO-COATER® by Freund is a laboratory scale fluid bed system designed for versatile process development. It supports drying, top spray, and bottom spray capabilities, with an optional GRANUREX® rotor insert for enhanced granulation and coating functions. The system features a combination product container and Wurster processing insert with an integrated solution pump, eliminating the need for additional costly add-ons. The portable and self-contained design ensures easy integration and removal with simple electrical and compressed air connections. An intuitive color touchscreen control system facilitates both automatic and manual operation, with validatable process controls such as inlet airflow and temperature control. With a quick-changeover design, no tools are required for process changeover, making it highly efficient for research environments. The unit conforms to CE, ATEX, UL, NFPA, and CSA standards, ensuring it meets various international safety and performance criteria.

Laboratory scale fluid bed system for granulation and coating

In pharmaceutical manufacturing, achieving uniform particle size and consistent mixture quality is essential. Traditional mixing processes often struggle with issues like uneven granule size and excessive heat generation, which can compromise the product’s quality.
<h2>Ensures uniform mixing and granulation</h2>
The High Shear Mixer Granulator by Fabtech is designed to address these challenges with its ergonomic and compact design. It facilitates both dry mixing and wet granulation processes, ensuring homogeneous mixing and even binder distribution. The four-blade impeller design provides efficient dry mixing, while the rapidly moving chopper blades break down oversized agglomerates and distribute the binder uniformly. Constructed in SS 316, the mixer includes features such as a wet co-mill at discharge for uniform drying, a binder addition port with sprinkle nozzle, and a pneumatically operated top lid and discharge port. The system is GMP and 21 CFR Part 11 compliant, making it suitable for various scales of pharmaceutical production, from lab to commercial models.

High shear mixer granulator for efficient wet granulation

In the pharmaceutical and chemical industries, efficient granulation and coating processes are essential for producing high-quality products. Challenges often include long process times and complex material handling requirements that demand precise control and flexibility.
<h2>Granulate and coat in a single vessel</h2>
The Fluid Bed Processor by Fabtech is designed to handle multiple processes like granulation and coating within a single vessel. This combined approach reduces material handling and process times compared to other wet granulation processes. The top spray method in the fluid bed system produces granules with a porous structure that enhances wettability. This system is cGMP and 21 CFR Part 11 compliant and constructed with SS 316/SS316L for lab, pilot, and commercial production models. The contact parts feature a mirror finish, while the non-contact parts have a matt finish. Additional features include a pneumatically controlled damper for accurate air monitoring, a 3-stage filtration system, and a spray gun for precise control. It also supports high containment isolation systems to ensure operator safety.

Fluid bed processor for granulation and coating

When experimenting with formulations in pilot plants, achieving consistent and high-quality granulates poses a significant challenge. Combining multiple processes like mixing, granulating, and drying in a compact setup is often crucial.
<h2>Mix, granulate, and dry in one processor</h2>
The single-pot processor P/VAC 10-60 by Diosna is designed specifically for pilot plants requiring multi-functionality in a compact form. This processor allows for full-scale production of dry blends, wet granulates, and vacuum-dried granulates. It has an integrated peristaltic pump to ensure precise liquid addition and features PC control systems compliant with 21 CFR part 11 for thorough batch data logging and audit trails. The P/VAC 10-60 includes replaceable containers and seals, making it versatile for various production needs, and is equipped with CIP-capable air gap shaft seals for easy cleaning. Bowl sizes range from 10 to 60 liters, accommodating a variety of batch sizes. This processor is applicable in industries like pharmaceuticals, cosmetics, and fine chemicals.

Pilot single-pot processor for granulation and drying

Entry level

In pharmaceutical and fine chemical research, achieving consistent granulation and mixing in small batches is a critical challenge, requiring precise control over shear forces and homogeneity. Without efficient tools, R&D operations face setbacks, increasing both time and costs.
<h2>Intuitive high-shear mixing for lab-scale batches</h2>
The P1-6 laboratory mixer from Diosna is designed for high-quality mixing, granulating, and pelletizing in a compact form. This equipment features cylindrical-conical mixer geometry and an integrated chopper tool. These innovations ensure perfect homogeneity and optimal Active Pharmaceutical Ingredient (API) distribution in granulations. The mixer is capable of handling batches from 0.04 to 2.7 kg and operates with a range of chopper speeds from 220 to 2,200 min-1. Its intuitive plug-and-play system and tool-free scale-up make it particularly user-friendly. Additionally, the optional spheronizer attachment allows for efficient pellet production, catering to diverse laboratory needs. The P1-6 occupies minimal lab space (950x550x550 mm) while delivering reliable and reproducible results.

Compact laboratory mixer for high-shear granulation

Pelleting equipment transforms powdered, mashed, or grounded material into a denser cylindrical shape. Pellet processing compresses the fine material against a perforated die, where it will be shaped and cut. Although granulating and extrusion also produce pellet-like products, manufacturing pellets is a distinct process.

Pelleting

In the pharmaceutical and fine chemicals industries, wet granulation followed by effective drying is crucial when handling adhesive and temperature-sensitive materials. Traditional methods often struggle with uniform drying and deposition issues, leading to inefficiencies and potential product quality concerns.
<h2>Produces and dries granules efficiently</h2>
The VAC 150-1200 Single-Pot processor by Diosna is designed to mix, granulate, and dry components in a single system. What sets this processor apart is its cylindrical mixing bowl with two heating zones and a double jacket. During the drying process, compressed air or nitrogen is introduced to ensure uniform drying, even for adhesive products. The system's scraper-equipped mixing tool runs close to the wall to prevent deposits, making it efficient for drying sticky granules. The unit also features an industrial PC compliant with 21 CFR Part 11 for full automation and remote maintenance, ensuring that all processes are meticulously monitored and controlled. The inclusion of a sight glass allows real-time observation and adjustments, while the CIP/WIP cleaning process ensures high levels of cleanliness and downtime reduction.

Single-pot processor for wet granulation and vacuum drying

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

In pharmaceutical manufacturing, ensuring high product yield while maintaining stringent safety standards is critical. Managing the granulation process efficiently can prevent product loss and optimize overall production performance.
<h2>Optimize granulation with minimal product loss</h2>
The CGS compact granulation system from Diosna is designed to enhance your production processes with precision. Featuring geometrically optimized lines between the mixer and dryer, this system reduces product-contacting surfaces, thereby maximizing yield. It ensures safe operation with integrated explosion protection per ATEX standards, accommodating solvent applications. Additionally, the system is designed for easy maintenance, with all components accessible via an operating platform. The CGS system supports batch production ranging from 25 to 600 kg and offers 21 CFR Part 11-compliant software for data recording and documentation, controlled through two operator terminals. The granulation line adheres to GAMP 5 standards and integrates PAT concepts to meet quality control requirements.

Pharmaceutical granulation line

In pharmaceutical manufacturing, ensuring consistent product quality and compliance with stringent regulations is crucial. Achieving optimal granulation can be challenging, especially when transitioning from clinical samples to full-scale production batches and meeting regulatory standards like 21 CFR Part 11.
<h2>Handles mixing, granulation, and drying processes</h2>
The CCS granulation line by Diosna integrates a mixer-granulator with a fluid bed processor to streamline wet granulation and subsequent drying. The system features quick change of material containers without tools, allowing efficient batch processing. Its through-the-wall setup ensures strict separation between production and technical areas, enhancing contamination control. Automated processes backed by 21 CFR Part 11 compliant PC control and remote maintenance bolster operational efficiency. Pressure-shock resistant up to 12 bar, the fluidized bed unit meets regulatory and safety requirements, including ATEX standards. With user-friendly terminals and customizable container sizes, the CCS line is suitable for adapting to diverse production needs in the pharmaceutical industry.

Granulation line for pharmaceutical manufacturing

In pharmaceutical R&D and quality control, achieving uniform wet mixing and granulation for small batch sizes is crucial. Traditional methods may fall short in terms of precision and control, leading to inconsistent particle sizes and suboptimal end products.
<h2>Mix, granulate, and dry small batches efficiently</h2>
The laboratory high shear mixer by Cos.Mec is designed for the precise wet mixing, granulation, and drying of small quantities of pharmaceutical products. Equipped with an array of advanced features, this unit offers both manual and automatic management of processing cycles via a PLC touchscreen. A key highlight is its granulating chamber, available in various volumes, complete with a transparent lid and an exhaust filter for safe operation. The mixer includes a funnel and manual valve for precise addition of granulation liquids, and a pad valve with pneumatic control. Constructed with high-quality materials, all parts in contact with the product are made from mirror-polished AISI 316 L, achieving a roughness average (RA) of ≤ 0.4 μm, while other parts are made from AISI 304 with an RA of ≤ 0.8 μm. Optional features include a product temperature probe and a heating jacket with a vacuum system for enhanced drying capabilities. Connectivity is ensured through USB and RJ45 terminals, allowing for efficient recipe management and data collection.

Laboratory high shear mixer for wet mixing and granulation

When developing small batches of pharmaceutical products, precise control over granulation and drying is crucial. Ensuring that the powders and granules are processed effectively can pose a significant challenge without the right technology.
<h2>Granulate and dry small quantities with precision</h2>
The laboratory fluid bed dryer by Cos.Mec is designed specifically for the granulation and drying of small quantities of pharmaceutical products. It offers advanced features such as high-retention polyester filter cartridges, which ensure efficient drying and granulation processes. The dryer allows for repeated cartridge filter cleaning using compressed air counterblows while the processes continue uninterrupted. This model also includes a rupture disc, sample thief, and inspection windows for easy monitoring and operation. The system operates with automatic management via a PLC and touch screen operator panel. Notable accessories include options for gravimetric or vacuum loading, internal washing (WIP), and air dehumidification for the Air Treatment Unit. Parts in contact with the product are crafted from AISI 316 L stainless steel with a mirror glass polished finish for optimal hygiene and performance, while parts not in contact are made from AISI 304 stainless steel. Cos.Mec equipment complies with CFR 21 part 11 standards for automated systems.

Laboratory fluid bed dryer for pharmaceutical granulation

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

Developing formulations with variable batch sizes is often challenging, particularly when scaling from small laboratory samples to larger production batches. Managing different batch sizes efficiently while maintaining product consistency is crucial.
<h2>Achieve precise wet granulation with batch flexibility</h2>
The Multi Bowl Spheronization Kit by Caleva is a versatile solution for wet granulation pellets, designed for laboratory bench-tops. The kit includes the Caleva bench-top screen Extruder 20, which comes with both full height and reduced height screens to handle varying batch sizes from 50g to 1kg. Additionally, the system features interchangeable spheronizer bowls of sizes 60 mm, 85 mm, 120 mm, and 250 mm diameter, allowing users to start with one bowl and add more as needed. This flexibility facilitates effective product development and easy scale-up to larger production without the need for extensive reconfiguration. The equipment is fully compliant with GLP/GMP requirements, making it suitable for pharmaceutical, nutraceutical, and food industries.

Flexible spheronization kit for wet granulation pellets

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

In pharmaceutical production, achieving uniform granule size is essential for consistent product quality and enhancing bioavailability. Traditional batch granulation methods often result in variability and inefficiency, making it challenging to maintain high standards in large-scale operations.
<h2>Ensures uniform granule size in continuous production</h2>
The Continuous Wet Granulation Equipment by Austar provides a reliable solution for producing uniform granules in a consistent, efficient manner. This equipment is specifically designed for the pharmaceutical industry, offering a seamless integration into existing production lines. Utilizing advanced granulation techniques, the system ensures that each granule meets stringent quality standards, significantly reducing production variability. The continuous process also enhances efficiency, allowing for higher throughput and reducing downtime associated with batch processing. Ideal for large-scale manufacturing, it supports the production of tablets and similar oral dosage forms by delivering precise, repeatable results. Additionally, the system is designed for easy cleaning and maintenance, ensuring compliance with stringent regulatory requirements.

Continuous wet granulation equipment

In pharmaceutical manufacturing, achieving consistent granule size and composition is crucial for the production of solid dosage forms like tablets. Traditional batch granulation methods can be time-consuming and labor-intensive, requiring advanced solutions for continuous operation and precise control.
<h2>Provides consistent granule size for pharmaceuticals</h2>
The continuous wet granulation equipment by Austar, developed in partnership with NEUHAUS NEOTEC, offers a comprehensive solution for the pharmaceutical industry. The system integrates auto loss-in-weight feeding, mixing, granulating, drying, tableting, and tablet coating, ensuring seamless operation. It supports top-spray granulating and bottom-spray pellet coating using a horizontal fluid bed processor. Capable of handling scales from pilot (20 kg/h) to commercial production (>2000 kg/h), it features an automatic control system compliant with data integrity requirements from EMA and FDA. The production line holds ATEX explosion-proof certification from the EU, incorporating PAT technology for real-time process monitoring and feedback.

In pharmaceutical manufacturing, achieving consistent granule size and quality is crucial for product effectiveness. Variations in granulation can lead to issues in tablet formulation and drug release, making precise control over the compaction process imperative.
<h2>Ensure uniform feed and compaction control</h2>
The WP200 Pharmaceutical Roller Compactor from Alexanderwerk addresses strict pharmaceutical industry standards for producing consistent and high-quality granules. This compactor features patented vertical roller arrangements for improved feed flow control and reduced material loss. The Combi-Vent-Feeder® technology allows air to escape during compaction, ensuring even material distribution. Additionally, the Diagonal-Design® two-stage granulator improves screen effectiveness, increasing capacity by up to 100% for medium to hard products. With a modern interface for precise adjustments, this roller compactor enables stable and controlled processing, making it ideal for pharmaceutical, food, and chemical applications. Specifications include a throughput range of 10 to 500 kg/h and a maximum press force of 20 kN/cm.

Pharmaceutical roller compactor for precise granulation

Pharmaceutical production often demands highly controlled granulation processes to ensure product consistency and quality. Traditional methods may not meet stringent industry standards for efficiency and containment, leading to potential issues in product uniformity and safety.
<h2>Compacts and granulates pharmaceutical products efficiently</h2>
The WP 150 Pharmaceutical Roller Compactor by Alexanderwerk is designed to meet the highest standards of the pharmaceutical industry. It features a vertical roller arrangement that enhances feed flow control, reducing fine material in the final product. The patented Combi-Vent-Feeder® system ensures uniform feeding by allowing air to escape, which avoids feed disturbances. The Diagonal-Design® single-stage granulator increases throughput by up to 100% and improves screen efficiency. The WP 150 is capable of producing up to 250 kg/h of granulated product, making it suitable for high-volume production environments. With an advanced interface for comprehensive control over roller gap and compaction pressure, it offers precise control options, ensuring consistent quality. Key specifications include a roller width of 50 mm, diameter of 150 mm, and maximal pressure force of 20 kN/cm. The equipment also has built-in features for pre-crushing and individualized compaction, optimizing the process further.

Pharmaceutical roller compactor for granulation

Industrial feeding systems allows you to control the flow of solid bulk materials throughout the manufacturing line. After loading your material onto the vibrating hopper, a screw at the base drives it out in uniform doses to the next stage of processing. New feeding technologies are designed to deal with challenges of powders clumping together in the hopper (bridging and ratholing) that interrupt the outflow. Common feeder systems include centrifugal feeders, vibratory feeders as well as elevator, linear and pneumatic feeders.

Feeding

In pharmaceutical and chemical manufacturing, certain raw materials cannot be processed in a dry state. These materials require a reliable method to form granules with uniform size and high solubility, mitigating dust and cross-contamination issues during processing.
<h2>Ensuring homogeneous and rapidly soluble granules</h2>
The MG Series from Alexanderwerk is a moist granulation system designed to process moist and pasty materials using counter-rotating cylinders. This system excels at producing granules with diameters ranging from 1.0 mm to 10.0 mm. Moist granulation involves adding a liquid to dry materials, forcing the mixture into a granulating extrusion cylinder, compressing it, and cutting it into granules. The MG Series is known for its quick disassembly, facilitating easy cleaning and maintenance. Models like the GA 65, G 1/100, G 1/168, and G 1/244 cater to different throughput needs, from 100 kg/hr to 2000 kg/hr. The process is essential in industries such as pharmaceuticals, chemicals, food, and nutraceuticals to ensure product uniformity and stability. Alexanderwerk's moist granulators are ideal for situations where air entrapment must be minimized and active ingredients evenly distributed.

Moist granulation system for pharmaceutical and chemical industries

Compression

Cutting

In pharmaceutical, chemical, and food industries, the need for improved powder processing methods is crucial. Traditional wet granulation often results in challenges like poor flow, inconsistent compressibility, and product integrity issues due to added moisture.
<h2>Enhance powder properties without added moisture</h2>
The dry granulation process by Alexanderwerk uses roller compaction to form granules from dry powders without liquid binders. This two-step process compresses powders between counter-rotating rollers to produce densified flakes, which are then milled into granules of uniform size and density. Alexanderwerk's design features vertically aligned rollers and a special control logic to maintain consistent flake thickness and density, ensuring high-quality granules. This method offers versatility for both batch and continuous operations, making it ideal for applications in the pharmaceutical, chemical, and food industries. Typical uses range from tablet and capsule production to processing chemicals like silica and carbon black. Alexanderwerk's roller compactors like the WP Pharma Series, with capacities ranging from 8 kg/h to 400 kg/h, provide tailored solutions for various industrial needs.

Dry granulation technology

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

In pharmaceutical manufacturing, achieving consistent particle size and uniform density in powders is critical. When faced with dry granulation challenges, particularly for active pharmaceutical ingredients or excipients, precise control and efficient processing are crucial to maintain product quality.
<h2>Compact and granulate pharmaceutical powders efficiently.</h2>
The BT 120 pharmaceutical roller compactor from Alexanderwerk is designed for small-scale production and pilot plants. This roller compactor works through a three-step process: feeding, compacting, and granulating. The integrated LCD touchscreen offers simple control over the compaction process. With a hopper for raw materials and a screw feeder unit, it ensures consistent feeding into the compacting zone. The two counter-rotating rollers, with a diameter of 120mm and width of 25mm, compress powders into flakes at a maximum press force of 20 kN/cm. These flakes are then granulated using flake-crushers and a size-reduction zone to achieve the desired particle size. This compactor operates continuously with a throughput of up to 8 kg/h. It also features a maximum roller speed of 15 rpm and a roller gap of 4mm, making it suitable for a range of pharmaceutical applications. The compact size and up to 8 kg/hr throughput make it ideal for advancing into galenics.

Pharmaceutical roller compactor for dry granulation

When producing pharmaceuticals or nutraceuticals, achieving content uniformity and narrow particle-size distribution during wet granulation is crucial. Common challenges include ensuring consistent material processing and maintaining operator safety in high-pressure environments.
<h2>Ensures uniform granulation with enhanced safety</h2>
The QUEST HSM II by ACG World is an advanced high-shear granulator designed for precise wet granulation. Equipped with ACG X•ONE command process control, it ensures faster processing and uniform granule size. The system features the unique MOST™ (Maximum Operator Safety Technology) concept, making it highly safe and compliant with cGMP standards. It offers interchangeable bowls of 2, 5, and 10 liters, facilitating flexible batch sizes. The granulator's Z-shaped impeller blades and laser-cut multi-blade chopper ensure optimal material flow and uniform binder distribution, minimizing lumps and 'dead zones' during processing. This system is mobile and plug-and-play, allowing easy use in various lab settings.

High-shear granulator for wet granulation

In pharmaceutical production, achieving uniform granulation and mixing is crucial for maintaining product quality. However, conventional methods often fall short, especially for smaller production batches where precision and consistency are key.
<h2>Achieve high-quality granulation and mixing</h2>
The HSM 150 by ACG World is a high-shear mixer designed for small production batches, ideal for wet granulation and mixing applications. This mixer features an ergonomic design for easy access and compliance with Good Manufacturing Practices (GMP). It is equipped with both a Z-shaped impeller and a multi-blade chopper, which ensure uniform binder distribution and optimal particle-size distribution. The system's multiple charging and discharging options facilitate quick, dust-free transfer of raw materials. Integrated cleaning nozzles simplify cleaning, enhancing operational efficiency. With a working volume ranging from 45 to 120 liters depending on bulk density, the HSM 150 can be used either as a standalone unit or integrated into a granulation train. This versatility makes it an excellent choice for pharmaceutical companies focused on achieving high-quality end products.

High-shear mixer for small batch granulation

In pharmaceutical manufacturing, achieving efficient and dust-free granulation processes is essential for producing high-quality products. Traditional approaches often fall short in terms of efficiency, safety, and space utilization, posing significant challenges for manufacturers.
<h2>Combines high-shear mixing and fluid-bed systems</h2>
The GT series from ACG World is an integrated granulation system designed to optimize manufacturing efficiency while ensuring safe, single-handed operation. The system combines an advanced high-shear mixer (HSM) and fluid-bed (FBE/FBC) system, which are designed in Germany. It achieves a highly efficient, dust-free wet granulation process within a cost-effective, closed-loop design. The contained product handling is supported by a vacuum charging system that ensures closed-loop transfer for smooth material flow and minimum product leftover. The compact design reduces floorspace requirements by around 50%, and the through-the-wall construction allows clear separation between processing and technical areas, ensuring easier maintenance, cleaning, operation, and GMP compliance. Additionally, multiple systems for charging, discharging, and WIP (wash-in-place) minimize dust generation and product exposure, making GMP compliance easier. The equipment can be customized to a wide range of product and process requirements.

Integrated granulation train for pharmaceutical processes

Industrial cooling equipment varies according to the consistency and temperature conversion demands the material you are handling, but the process typically involves heat exchange treatment as your products are conveyed through a cooling chamber equipped with extraction fans or circulating water. Temperature control is a crucial aspect of your commercial production and cooling systems are applied to a range of industries.

Cooling

Industrial washing systems are used to clean and disinfect a variety of items in research and manufacturing facilities. Industrial washers use solvents and cleaning agents with mechanical action to remove deposits and residues from stainless steel machinery components, empty containers, and other soiled surfaces. The selection of an industrial or commercial washer depends on the type of items and surfaces to be cleaned, the type of deposits/residue that is typically present, whether drying is required after rinsing and the level of sterilization necessary. Manufacturers will have cleaning specifications and as a result, require washers to be engineered to meet these specs.

Washing

In pharmaceutical and nutraceutical production, processing large batches often demands efficient drying and granulation techniques to ensure product quality and consistency. Limitations in traditional methods can lead to prolonged processing times and incomplete granulation, requiring advanced solutions tailored specifically for these industries.
<h2>Dry and granulate batches up to 1,300 liters</h2>
The FBE 1300 is a high-performing fluid-bed system from ACG World, designed for both drying and top-spray granulation. It is ideal for pharmaceutical and nutraceutical production, accommodating batches up to 1,300 liters. The system ensures operator and product safety with a precisely calculated and tested vent for handling pressure shocks. A state-of-the-art filter bag shaking system maximizes filtration area while minimizing compressed air consumption, making it more efficient and easier to maintain. Additionally, the 21 CFR part 11-compliant PC control system provides a regulatory-compliant, audit-friendly environment. The equipment is flexible, available in customized charging, discharging, and wash-in-place (WIP) systems, suitable for standalone or granulation-train configurations. The working volume ranges from 335 to 1,288 liters, depending on the bulk density of the material.

Fluid-bed drying and granulation system

Achieving consistent granulation and drying in the pharmaceutical industry requires equipment that ensures precise control and efficiency. Ensuring that granules have the right moisture content and consistency is essential to producing high-quality pharmaceutical and nutraceutical products.
<h2>Streamlines fluid bed drying and granulation</h2>
The FBE 125 from ACG World is an advanced fluid bed solution designed for pharmaceutical and nutraceutical applications, offering top-spray granulation and wet-mass drying. Capable of handling batches up to 125 liters, it is ideal for efficient processing. The system features a precisely calculated and practically tested vent that ensures operator and system safety during pressure shocks. Additionally, its state-of-the-art filter bag shaking system maximizes filtration area and reduces the use of compressed air, making it both easier to handle and more effective in cleaning. The FBE 125 includes customizable charging, discharging, and WIP (wash-in-place) systems, which can be configured as standalone units or integrated into granulation trains. The 21 CFR part 11-compliant PC control system ensures regulatory compliance and is audit-friendly. This system is suitable for top-spray granulation, wet-mass drying, and hot-melt granulation, providing a comprehensive solution for fluid-bed processing needs.

Advanced fluid bed for pharmaceutical granulation

In pharmaceutical and nutraceutical manufacturing, achieving consistent drying and granulation while ensuring operator safety is a primary challenge. This is particularly true when scaling up processes and conducting design of experiments (DoE) studies, which require versatile and reliable equipment.
<h2>Supports drying, granulation, and coating processes</h2>
The QUEST FB III X•ONE by ACG World is a versatile fluid bed system designed for intermediate-scale applications. It is equipped to handle multiple processes including drying, wet granulation, Wurster coating, top-spray, tangential-spray, and rotor granulation. The system incorporates advanced safety features such as a 12-bar pressure shock-resistant design and unique C-flanged inflatable seals that resist deformation even at low pressures. The twin-filter bag-shaking system effectively removes sticky materials, enhancing filter performance and yield. The integrated X•ONE command process control system complies with ATEX, GAMP 5, and 21 CFR Part 11, offering secure and intuitive control. This equipment is well-suited for both commercial-scale and developmental applications, thanks to its robust design and scalability.

Intermediate-scale fluid bed system for drying and granulation

In laboratory-scale pharmaceutical and nutraceutical production, the need for flexible operation and precise control is paramount. Challenges include managing multiple processes such as granulation and coating with minimal equipment adjustments.
<h2>Combines granulation and coating efficiently</h2>
The ACG World QUEST FB is a compact, portable fluid-bed unit designed for R&D applications. This system features both top-spray and Wurster coating technologies within a single container, making it highly adaptable for various operations. Its configurability allows seamless transition between granulation and coating processes with minor adjustments. The integrated weighing scale connected to a PLC (programmable logic controller) ensures precise spray-rate measurement, while the touchscreen HMI (human-machine interface) provides user-friendly control. The unit is equipped with multiple air distribution plates, enabling customization based on specific product requirements. Ideal for tasks such as top-spray granulation, wet-mass drying, and hot-melt granulation, the QUEST FB enhances process efficiency and flexibility in lab environments.

Versatile fluid bed combo for granulation and coating

Weighing

In academic and research settings, handling small batches for granulation, drying, and coating processes requires precise and versatile equipment. The challenge lies in achieving efficient granulation and coating without scaling up to industrial-level machinery.
<h2>Enables versatile granulation and coating operations</h2>
The MINIQUEST F by ACG World is a compact, tabletop system designed for handling batch sizes as small as 50g. It utilizes top-spray granulation and Wurster coating technology in a single unit. The system features a Düsen-Schlick nozzle from Germany, facilitating drying, granulation, and coating processes efficiently. Its integrated peristaltic pump minimizes the system footprint, making it ideal for academic use. An innovative tower assembly allows for easy operation, inspection, and cleaning. The venturi-based fluidisation system eliminates the need for an electrically powered blower, simplifying installation and reducing costs. A 5μ sock filter ensures a cleaner working environment by preventing dust escape. Ideal for research settings, this system supports multiple granulation techniques including top-spray, tangential spray, and hot-melt granulation.

Tabletop granulation system for small batches

In pharmaceutical and nutraceutical manufacturing, achieving efficient granulation and coating of particles can be challenging without the right technology. Various processes such as drying, particle coating, and spray agglomeration require precise control to ensure high-quality output.
<h2>Dry, granulate, and coat with precision</h2>
The GPCG 1.1 by ACG World is a versatile fluid bed combo designed for a wide range of granulation and coating applications. This equipment supports drying, granulation, particle/pellet coating, dry-powder layering, spray agglomeration, and hot-melt coating. It features both top-spray and Wurster coating technologies. Its mobile plug-and-play design with an optional integrated air-handling unit makes it highly portable and user-friendly for quick application switches. The inclusion of multiple interchangeable air-distribution plates allows users to select and install the most suitable plate for their product. Filter bags with a shaking mechanism ensure faster and more effective cleaning. The hinged filter-housing design reduces height and enhances mobility. Suitable for feasibility and scale-up studies, the GPCG 1.1 has a working volume range from 0.5 liters up to 4 liters.

Fluid bed combo for granulation and coating

In pharmaceuticals and nutraceuticals manufacturing, achieving multiple processing steps such as drying, granulation, and coating in a single operation is essential to enhance process efficiency and reduce downtime. Handling large batch sizes efficiently while ensuring safety and cleanable degrees of freedom pose significant challenges.
<h2>Handle multiple processes in one system</h2>
The FBE 250C from ACG World is a versatile fluid bed combo, designed to significantly enhance your process efficiency with its multi-functional capabilities. Featuring top-spray granulation and Wurster coating technology within a single system, this equipment can carry out drying, top-spray granulation, hot-melt granulation, tangential spray granulation, rotor-based drug layering, and tangential spray processes. Its precisely calculated and tested vent ensures operator and equipment safety by managing pressure shocks. The state-of-the-art twin-chamber filter bag shaking system optimizes fluidization and cleaning while consuming less compressed air. The product container, equipped with multiple air-distribution plates, allows customization based on product requirements. Available in standalone and granulation-train configurations, the system also offers customized charging, discharging, and wash-in-place (WIP) systems for efficient formulation processing and easy maintenance.

Fluid bed combo for top-spray granulation and wurster coating

In the pharmaceutical industry, dealing with varied processes such as drying, granulation, and coating often requires multiple machines, adding complexity and inefficiency to production lines. This creates a need for versatile, robust equipment that can handle multiple processes within a single system.
<h2>Integrated drying, granulation, and coating</h2>
The FBC 1800 X•ONE by ACG World is a versatile fluid bed combo designed to handle drying, top-spray granulation, and Wurster coating for batches up to 1800 liters. The 12-bar pressure shock-resistant system incorporates the MOST™ concept, ensuring supreme operator safety and compliance with ATEX (Directive 2014/34/EU). Unique features such as C-flanges prevent explosion pressure transfer, while QASV ensures containment of explosions within 20 milliseconds. The system also offers customizable charging, discharging, and WIP (wash-in-place) configurations to enhance efficiency and safety during granulation and pellet processing. The exclusive X•ONE command process control system allows intuitive and secure monitoring, compliant with GAMP 5 and 21 CFR Part 11. With components developed in collaboration with Düsen-Schlick GmbH, this solution ensures enhanced productivity and simplified operation and cleaning.

In pharmaceutical manufacturing, achieving precise granulation and coating of powders while ensuring operator safety is critical. Challenges include controlling dust, preventing cross-contamination, and ensuring uniform coating of particles.
<h2>Combines drying, granulation, and coating processes</h2>
The FBC 125 X•ONE by ACG World is a versatile fluid bed combo designed for diverse applications such as drying, top-spray granulation, and Wurster coating, capable of handling batches up to 125 liters. This system is equipped with the MOST™ (Maximum Operator Safety Technology) concept, approved by the FSA and compliant with ATEX Directive 2014/34/EU, ensuring supreme safety. The innovative C-flanges prevent explosion pressure transfer beyond the system, while the X•ONE inflatable seals provide safety even at low pressures. The system includes Quick Action Stop Valves (QASV) that contain explosions within 20 milliseconds. Furthermore, the exclusive X•ONE command process control system allows intuitive, secure monitoring and control, complying with GAMP 5 and 21 CFR Part 11 standards. Additionally, the machine features patented nozzles developed in collaboration with Düsen-Schlick GmbH, enhancing productivity and simplifying operation and cleaning.

Fluid bed dryer with granulation and coating

Pharmaceutical industries employ several processes including drying, coating and granulation to create high-quality granules. Manufacturers can benefit from a single system that can complete all of these tasks simultaneously, increasing production yield without sacrificing the quality of the final product.


<h3>Coating, granulation, and drying granules by tangential fluid bed method</h3>
The Fluidized Bed System BFS from Bohle, is a system that can perform multiple processes such as coating, granulation, and drying to turn fine solids and dry powders into granules. The cone is equipped with a specially slotted air distributor plate which allows complete fluidization of particles while the tangential motion helps in achieving a uniform coating without the particles adhering to one another. Due to a relatively low fluidization height, the system does not require a high-volume expansion saving costs and production floor space.

The system can also be equipped with an online moisture measurement system using NIR technology to precisely identify moisture levels during the granulation and drying. The BFS has at least 6 filter elements that can be cleaned separately and ensure good uninterrupted airflow. To make it simple to use, the entire system is PLC controlled.

Fluidized bed system for the granulation and drying of pharmaceuticals

When making tablets, pharmaceutical manufacturers need to use a mechanical process, like a rolling press for compaction, to produce granules from powders susceptible to moisture and temperature. This method also applies to large-volume products where the compaction of powders requires consistent and precise control of the force applied to achieve uniform density.


<h3>Transforming dry particles into uniformly dense granules</h3>
The Dry Granulation BRC from Bohle, is a compacting system for fine solids and dry powders to form granules in pharmaceutical industries. The system is equipped with screw feeders that push the powders toward two rollers. The rollers apply precise compaction force to produce uniformly dense, ribbon-shaped products before crushing them down to the desired granule size through a cone-shaped rotary sieve mill. The granule size can be quickly adjusted using a different rotary sieve with a suitable profile. The system has a production range of less than 1kg/h up to 400 kg/h and has a hygienic design using integrated washer nozzles for an effective WIP process.

Continuous roller compactor for dry granulation of pharmaceuticals

Granulation is a common technique in production of pharmaceutical solid dosage forms. Due to high quality requirements of the formed granules in terms of content uniformity and its physicochemical properties, it is important to choose the right process. The wet granulations process will ensure that a fine-powder heterogeneous mixture will turn into a uniform granulation, with increased particle size and higher density.
<h2>Complete turnkey solution for granulation of tablets</h2>
The Granulation Line from Romaco Tecpharm is a single frame solution which carries out all options for wet granulation process. It integrates the High Shear Granulator for mixing and granulation, the Fluidized Bed Dryer for drying, granulation and coating, and the Conical and Cylindrical Calibrators for calibration. It thus helps in reducing the space required in the clean-room and minimizing the risks of cross-contamination while giving maximum flexibility to process development and scalability studies.

The Granulation Line for pharmaceutical solid dosage forms is available in capacities ranging from 25 L to 1.400 L and can carry out two different processes. The first being, wet granulation where an agglutinative solution is added to form granules. The equipment combines one or more dust particles and forms a granule within the required limits.

The second being, the drying process by fluidization which is widely used in the pharmaceutical industry to reduce the moisture content of powder and granules. Hot air is passed at a given pressure and flow rate through a perforated bed of moist solid particles. The wet solids are lifted from the bottom and suspended in a stream of air. Heat is transferred by direct contact between the wet solid and hot gases. The vaporized liquid is then carried away by the drying gasses.

Granulation line for pharmaceutical solid dosage forms

<span style="font-weight: 400;">A complete granulation line allows for the mixing and granulation of pharmaceutical compounds for the production of tablets. By linking fully compatible milling, mixing and fluid bed machinery with vacuum conveying it provides a turnkey solution for preparation of powder doses ready for pressing into tablets.</span>
<h2>Complete solution for preparation of granular pharmaceutical compounds for tablets</h2>
<span style="font-weight: 400;">Sejong Pharmatech’s Granulation Line is the most cost-effective way to achieve a turn-key granulation solution for the manufacture of pharmaceutical compounds for tablet preparation.</span>

<span style="font-weight: 400;">The granulation line consists of the Sejong CM series production scale conical mill, the Sejong M series production-scale speed mixer, the Sejong D series production scale fluid bed dryer and an optional vacuum conveyor system for the creation of a completely closed line environment.</span>

<span style="font-weight: 400;">Designed for total compatibility, these devices work together seamlessly to provide the perfect input for tablet pressing machines. When buying as a line package, significant cost savings can be made compared to sourcing individual machines.</span>

<span style="font-weight: 400;">The optional vacuum conveyor removes the need for manual handling between processes, and ensure a clean and safe transfer of powders between process stages.</span>

<span style="font-weight: 400;">All the Sejong machinery is manufactured with ergonomics and ease of use in mind, and the touch screen HMI’s are fully 21CFR part 11 compliant.</span>

Granulation line of mixer and fluid bed dryer

In pharmaceutical production, achieving precise mixing and granulation of powder ingredients is crucial to ensure product quality and consistency. Traditional methods often struggle to prevent powder sticking and contamination, leading to inefficiencies and potential product losses.
<h2>Optimal shear for consistent granulation</h2>
The ROTO MIX by IMA is a latest-generation high shear mixer granulator specifically designed for the dry mixing of powders and wet granulation in the pharmaceutical industry. Inspired by the proven Roto technology, it ensures the optimum shear for granulation at all speeds. The mixer uses a unique impeller and chopper combination along with a liquid binder distributor to achieve efficient mixing and agglomeration. Its design minimizes powder sticking, thereby maximizing product yield. The through-the-wall installation optimizes room layout and integrates seamlessly with other granulation equipment. Additionally, the in-line dry milling enables wet granule sizing and direct transfer to a fluid bed dryer. Equipped with strategically positioned washing nozzles, the system also offers Wash In Place (WIP) capabilities, ensuring thorough cleaning even in hard-to-reach areas.

High shear mixer granulator for pharmaceutical applications

In pharmaceutical R&D labs, precise granulation and coating of small batches are critical for formulation and scale-up studies. Challenges include accurate processing, efficient use of materials, and maintaining consistent quality throughout various stages of production.
<h2>Achieves uniform granulation and coating efficiently</h2>
The MYLAB by IMA is a compact and modular fluid bed and coating system designed for small batch processing. It features a Main Technical Unit (MTU) with an integrated air-handling unit, spray system, and control panel for seamless operation. The fluid bed module allows both top and bottom spray processes, accommodating batch sizes from 3 to 6 liters. Additionally, a high shear mixer is available for dry mixing and wet granulation tasks. The coating pan module offers interchangeable drums, including fully perforated, solid wall, and Wedge wire screen options, suitable for batches from 0.5 to 10 liters. The MYLAB ensures precise control and scalability, making it ideal for pharmaceutical development and formulation studies. Compliant with stringent GMP standards, it simplifies product changes and enhances productivity.

Fluid bed and coating system for small batch processing

For industries dealing with fine powdery products, transitioning to a more manageable form is critical. Problems like poor flow properties, dust generation, and inconsistent dosing can hinder efficient processing.
<h2>Transform powders into free-flowing granules</h2>
The compaction and granulation technologies from Hosokawa Alpine are designed for transforming powdery chemical, pharmaceutical, mineral, and metal products into compacted shapes. Utilizing methods such as compaction, dry granulation, high-pressure roller grinding, briquetting, or pelletizing, these technologies improve product characteristics like bulk density, flowability, and dosing accuracy. This results in dust-free granules that streamline subsequent processing steps. Suitable for multiple industries, these technologies reduce common issues associated with fine powders, enhancing overall operational efficiency.

Compactors and granulators for powdery products

Before final granulation, coarse crushing of materials is necessary, especially when dealing with continuous flakes or clumped materials. Effective preliminary crushing can ensure smooth granulation and prevent downstream equipment blockages.
<h2>Efficiently crushes large flakes and materials</h2>
The Pre-Crusher APC from Hosokawa Alpine is engineered for effective coarse crushing. This unit features counter-rotating grinding rollers that efficiently crush flakes and other materials into smaller pieces. The rollers can be outfitted with either bars or discs, offering flexibility based on specific requirements. With roller diameters of 300 mm and working widths ranging from 200 to 800 mm, the pre-crusher caters to a variety of processing needs. It offers a throughput capacity ranging from 1 to 120 t/h, driven by robust units of 2 x 1.5 kW to 2 x 15 kW. The system is designed for dust-free operation and can produce particles smaller than 30 mm, making it suitable for a broad range of industrial applications, including chemical, food, and recycling industries.

Industrial pre-crusher for coarse crushing

In chemical, food, and pharmaceutical industries, ensuring optimal powder properties is essential. Challenges include dust pollution, inconsistent particle sizes, and poor flow properties, which can affect the quality and efficiency of production processes.
<h2>Optimize powder compaction with advanced roller design</h2>
The Hosokawa Alpine APC L, APC C, and ARC K series offer robust solutions for powder compaction across various industries, including chemicals and pharmaceuticals. These compactors feature high pressing force, stainless steel construction, and design options for ease of cleaning and maintenance. The APC L series excels in smaller throughputs and rapid roller changes due to its swing concept, achieving up to 150 kg/h. The ARC K series supports higher throughputs up to 1000 kg/h with adjustable roller gaps and cooling, enhancing flexibility. The APC C series, designed for the pharmaceutical sector, includes special features like gap and screw control for precise granulation, supporting cleaning-in-place systems. These models address specific needs for improved flow properties, dust reduction, and customized particle size, making them suitable for diverse applications such as catalysts, nutritional supplements, and tableting granulation.