Flexstream fluid bed processor for pharmaceutical applications

Addressing the limitations of traditional fluid bed processing, this advanced unit consolidates drying, granulation, and coating processes, ensuring superior product homogeneity and streamlined production with efficient scale-up and containment features.

Combines Granulation, Drying, and Coating Processes

The FlexStream Fluid Bed Processor from GEA revolutionizes pharmaceutical solid dosage manufacturing by seamlessly integrating granulation, drying, and coating into one compact system. Utilizing GEA’s proven fluid bed technology, this processor addresses traditional challenges like scale-up and material handling with linear scalability and fully contained loading and unloading. Designed for producing tablet coatings, APIs, and controlled-release tablets, it operates efficiently in both batch and continuous modes, with high-speed capabilities. Its single product container minimizes footprint while ensuring superior product homogeneity. Featuring PLC-controlled automation, the FlexStream supports in-line particle growth measurement for precise process control, reducing energy consumption through optimized airflow management. Constructed with GMP-compliant materials, it is equipped with WIP and CIP systems, ensuring easy and effective cleaning. This processor integrates seamlessly into pharmaceutical and chemical production lines, offering robust customization options to meet specific scale and process requirements.

Benefits

  • Enhances process efficiency with seamless transition between granulating, drying, and coating.
  • Reduces scale-up complexity, ensuring consistent product quality across production volumes.
  • Optimizes energy usage through advanced airflow management, reducing operational costs.
  • Ensures clean, contamination-free operations with integrated CIP and WIP systems.
  • Configurable design accommodates custom operational needs, improving versatility in production lines.

General


Applications
Granules,Coating materials,Tablets,Solid dosage forms,Pharmaceuticals
End products
Effervescent granules,Active pharmaceutical ingredients (apis),Tablet coatings,Film-coated tablets,Multi-layer tablets,Granulated excipients,Controlled-release tablets
Steps before
High Shear Mixing,Granulation,Blending,Liquid Preparation
Steps after
Tablet Compression,Packaging,Sterilization
Input ingredients
dry powders,aqueous granulations,solvent granulations,raw materials for solid dosage forms,organic solvents
Output ingredients
dried granules,coated pellets,tablets,blended powders
Market info
GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.

Technical Specifications


Capacity
Single module processing
Automation
PLC-controlled
Cleaning method
CIP / WIP
Loading/Unloading
Fully contained
Particle growth measurement
PAT-compatible in-line
Spraying systems
Nozzles,pumps,and liquid preparation units
Airflow management
Gill Plate airflow
Installation type
Through-the-wall
Solvent emission control
Open- and closed-cycle systems
Scale-up
Linear scale-up

Operating Characteristics


Working mechanism
Fluid bed granulation,drying,and coating
Integrated steps
Granulation,drying,coating in a single module
CIP/SIP
WIP and CIP
Batch vs. continuous operation
Batch / Inline Continuous
Automation level
Automation with PLC
Changeover time
Minimal due to no mechanical adjustment needed
Cleaning method
CIP

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Container size and shape
Customizable

Physical Characteristics


Compact footprint
Reduced build envelope
Discharge method
Lean phase conveying system
Control panel type
PAT-compatible in-line measurement
Mechanical adjustment
Not necessary for switching operations

Custom Options


Control panel type
PLC / HMI / SCADA
Integration possibilities
PAT-compatible / In-line particle growth measurement
Installation type
Through-the-wall installation
Cleaning system
WIP / CIP