High shear granulator for pharmaceutical applications
Efficiently transform powders into uniform granules for consistent tablet and capsule production while ensuring fast processing and optimal product quality through advanced high shear mixing and granulation techniques.

Performs Mixing, Granulation, and Pelletization
The Gral High Shear Granulator from GEA Pharma stands out for its top-driven design that ensures efficient mixing, granulation, and pelletization for pharmaceutical manufacturing. Utilizing a unique vessel and mixer configuration, it promotes optimum product flow and precise granule formation. Designed for producing tablets, capsules, and other pharmaceutical forms, this granulator supports dry powders, aqueous solutions, and solvent granulations. With a capacity range from 10 to 1200 liters, it accommodates scales from clinical trials to full production. Equipped with PLC controls, it integrates smoothly into automated production lines, offering energy efficiency through variable-speed motors. Constructed from robust, corrosion-resistant materials, it is compliant with GMP and FDA standards. The system includes CIP and WIP features for efficient cleaning, minimizing downtime and ensuring contamination-free operations. Customization options and engineering support are available to meet specific processing needs.
Benefits
- Enhances production efficiency by minimizing manual intervention through automated PLC controls.
- Supports scalability from initial formulation to full-scale production with versatile capacity options.
- Promotes product safety and quality with GMP and FDA-compliant design.
- Reduces energy costs through optimized motor speeds and efficient mixing processes.
- Ensures quick cleaning transitions to minimize downtime using CIP and WIP systems.
- Applications
- Apis (active pharmaceutical ingredients),Dry powders,Melt pelletization,Effervescent products,Solvent granulations,Aqueous granulations,Pharmaceuticals
- End products
- Tablets,Wet granules for oral suspension,Api granules,Pharmaceutically active granules,Pelletized medications,Controlled-release pills,Water-soluble powder formulations,Effervescent tablets,Capsules,Sustained-release capsules
- Steps before
- Powder Blending,Powder Loading,Binder Solution Preparation
- Steps after
- Granule Calibration,Drying,Mill Integration,Fluid Bed Drying
- Input ingredients
- dry powders,aqueous granulations,solvent granulations,effervescent products,melt pelletization,binder liquid
- Output ingredients
- granules,wet granules,calibrated granules
- Market info
- GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.
- Batch size
- 10–1200 liters
- Capacity
- 10–1200 liters
- Automation
- PLC-controlled
- Loading method
- Gravity / Vacuum
- Binder distribution
- Spray system
- Cleaning system
- CIP / WIP options
- Discharge method
- Proportionally regulated outlet valve
- Cooling option
- Yes
- Torque Measurement
- Yes
- Explosion proof design
- Yes
- Variable speed
- Chopper and impeller
- Product containment
- Yes
- Integration with Fluid Bed Dryer
- Yes
- Pressure shock resistance
- Yes
- Movable Head
- Yes (for UltimaGral)
- Automation level
- PLC / Manual / Auto
- Batch vs. continuous operation
- Batch
- CIP/SIP
- CIP with optional recipe control
- Changeover time
- Low
- Energy efficiency
- High
- Cleaning method
- CIP / WIP
- Integrated steps
- Mixing,Granulation,Discharge
- Working mechanism
- Top-drive high shear mixing
- Cleaning cycles
- Automated
- Control panel type
- Touchscreen PLC
- Corrosive resistance (e.g. acids)
- Yes
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Powder type
- Dry / Aqueous / Solvent
- Granulation
- Wet / Melt Pelletization
- Discharge method
- Gravity / Vacuum
- Machine footprint
- Free standing or through-the-wall design
- Bowl shape and volume
- Ranging from 10 to 1200 liters
- Discharge method
- Full opening discharge
- Control panel type
- PLC/operating panel
- Movable head
- Yes
- Control panel type
- PLC / HMI
- Integration possibilities
- Closed link to wet screening unit and fluid bed
- Customization Design
- Through-the-wall configuration
- Automation Options
- Recipe control
- Movable Head
- Yes
- Explosion Proof Design
- ATEX compliant
- Liquid Addition System
- Peristaltic pump / pressure vessel
- Discharge method
- Full opening / swing away outlet valve