High shear granulator for pharmaceutical applications

Efficiently transform powders into uniform granules for consistent tablet and capsule production while ensuring fast processing and optimal product quality through advanced high shear mixing and granulation techniques.

Performs Mixing, Granulation, and Pelletization

The Gral High Shear Granulator from GEA Pharma stands out for its top-driven design that ensures efficient mixing, granulation, and pelletization for pharmaceutical manufacturing. Utilizing a unique vessel and mixer configuration, it promotes optimum product flow and precise granule formation. Designed for producing tablets, capsules, and other pharmaceutical forms, this granulator supports dry powders, aqueous solutions, and solvent granulations. With a capacity range from 10 to 1200 liters, it accommodates scales from clinical trials to full production. Equipped with PLC controls, it integrates smoothly into automated production lines, offering energy efficiency through variable-speed motors. Constructed from robust, corrosion-resistant materials, it is compliant with GMP and FDA standards. The system includes CIP and WIP features for efficient cleaning, minimizing downtime and ensuring contamination-free operations. Customization options and engineering support are available to meet specific processing needs.

Benefits

  • Enhances production efficiency by minimizing manual intervention through automated PLC controls.
  • Supports scalability from initial formulation to full-scale production with versatile capacity options.
  • Promotes product safety and quality with GMP and FDA-compliant design.
  • Reduces energy costs through optimized motor speeds and efficient mixing processes.
  • Ensures quick cleaning transitions to minimize downtime using CIP and WIP systems.

General


Applications
Apis (active pharmaceutical ingredients),Dry powders,Melt pelletization,Effervescent products,Solvent granulations,Aqueous granulations,Pharmaceuticals
End products
Tablets,Wet granules for oral suspension,Api granules,Pharmaceutically active granules,Pelletized medications,Controlled-release pills,Water-soluble powder formulations,Effervescent tablets,Capsules,Sustained-release capsules
Steps before
Powder Blending,Powder Loading,Binder Solution Preparation
Steps after
Granule Calibration,Drying,Mill Integration,Fluid Bed Drying
Input ingredients
dry powders,aqueous granulations,solvent granulations,effervescent products,melt pelletization,binder liquid
Output ingredients
granules,wet granules,calibrated granules
Market info
GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.

Technical Specifications


Batch size
10–1200 liters
Capacity
10–1200 liters
Automation
PLC-controlled
Loading method
Gravity / Vacuum
Binder distribution
Spray system
Cleaning system
CIP / WIP options
Discharge method
Proportionally regulated outlet valve
Cooling option
Yes
Torque Measurement
Yes
Explosion proof design
Yes
Variable speed
Chopper and impeller
Product containment
Yes
Integration with Fluid Bed Dryer
Yes
Pressure shock resistance
Yes
Movable Head
Yes (for UltimaGral)

Operating Characteristics


Automation level
PLC / Manual / Auto
Batch vs. continuous operation
Batch
CIP/SIP
CIP with optional recipe control
Changeover time
Low
Energy efficiency
High
Cleaning method
CIP / WIP
Integrated steps
Mixing,Granulation,Discharge
Working mechanism
Top-drive high shear mixing
Cleaning cycles
Automated
Control panel type
Touchscreen PLC

Material Compatibility


Corrosive resistance (e.g. acids)
Yes
Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Powder type
Dry / Aqueous / Solvent
Granulation
Wet / Melt Pelletization
Discharge method
Gravity / Vacuum

Physical Characteristics


Machine footprint
Free standing or through-the-wall design
Bowl shape and volume
Ranging from 10 to 1200 liters
Discharge method
Full opening discharge
Control panel type
PLC/operating panel
Movable head
Yes

Custom Options


Control panel type
PLC / HMI
Integration possibilities
Closed link to wet screening unit and fluid bed
Customization Design
Through-the-wall configuration
Automation Options
Recipe control
Movable Head
Yes
Explosion Proof Design
ATEX compliant
Liquid Addition System
Peristaltic pump / pressure vessel
Discharge method
Full opening / swing away outlet valve