Single-pot granulation processor for pharmaceutical applications
For manufacturers needing precise granulation and drying in a single, sealed environment, this solution ensures efficient production of high-quality granules while minimizing contamination risks and enhancing process containment.

Processes and Dries Pharmaceutical Powders and Granules
The ROTO CUBE from IMA Group is a versatile single-pot processor for pharmaceutical and biotech industries, designed for efficient granulation, vacuum drying, and milling within one sealed unit. This processor excels in handling HAPI with its high containment capabilities, minimizing contamination and ensuring safety. It operates with a tilting bowl to enhance heat exchange, reducing drying times and preventing product sticking. The GA.ST. system introduces inert gas during vacuum drying, optimizing the drying process. With bowl capacities ranging from 12 to over 1,500 liters, the ROTO CUBE accommodates various batch sizes, making it suitable for both laboratory-scale R&D and full-scale production. Its in-line dry milling feature ensures granules are ready for further processing into tablets or capsules, adapting seamlessly into existing production lines. Constructed with stainless steel and meeting GMP standards, it supports clean-in-place (CIP) systems for efficient maintenance, and offers customization in sizes and configurations to meet specific production needs.
Benefits
- Enhances product purity and safety with high containment for HAPI processing.
- Shortens production cycles with effective heat exchange and reduced drying time.
- Minimizes contamination risks with a fully sealed single-pot design.
- Facilitates seamless integration with in-line dry milling for ready-to-use granules.
- Simplifies maintenance and cleaning with CIP system compatibility.
- Applications
- Pharmaceutical tablets,Nutraceuticals,Pharmaceutical powder,Granules,Hapi (highly active pharmaceutical ingredients)
- End products
- Antidepressant granules,Antibiotic granules,Sustained-release tablets,Oncology drug formulations,Pain relief granules,Film-coated tablets,Antiviral active ingredients,Protein powder supplements,Effervescent tablets,Herbal powder preparations
- Steps before
- Raw Powder Loading
- Steps after
- Dry Milling,Sachet Filling,Tablet Pressing,Capsule Filling
- Input ingredients
- raw powders
- Output ingredients
- dry milled granules,sachets,tablets,capsules
- Market info
- IMA is known for its expertise in manufacturing automated packaging machines and solutions, particularly for the pharmaceutical, cosmetics, food, tea, and coffee industries, offering innovative, high-quality equipment and comprehensive customer service.
- Bowl capacity
- 12–1,500 L
- Product quantity
- 4–1,000 L
- Impeller speed
- 20–597 rpm
- Chopper speed
- 700–1,500 rpm
- Bowl tilting
- Yes,increases heat exchange surface
- Gas stripping system (GA.ST.)
- Inert gas injection for vacuum drying
- In-line dry milling
- Yes,ready for sachets,tablets,capsules
- Drying time
- Shortened due to tilting bowl
- Process containment
- High,single sealed bowl
- Working Mechanism
- Single-pot granulation
- Integrated Steps
- Loading,granulation,vacuum drying
- CIP Principles
- Facilitates cleaning operations
- Batch vs. Continuous Operation
- Batch processing
- Automation Level
- PLC control
- Safety Features
- Dust-free process,gas stripping system
- Energy Efficiency
- Efficient heat exchange
- Product Containment
- High containment capability
- Product Yield
- Maximized
- Drying Time
- Shortened due to tilting bowl
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Bowl shape
- Single,completely sealed bowl
- Bowl capacity
- 12 - 1,500 liters
- Bowl tilting
- Yes
- Discharge method
- Milled granules discharge
- Tilting Bowl
- Increases surface for heat exchange
- Gas Stripping (GA.ST.)
- Inert gas injection for vacuum drying
- In-line Dry Milling
- Ready granules for sachets or tablets