Single-pot granulation processor for pharmaceutical applications

For manufacturers needing precise granulation and drying in a single, sealed environment, this solution ensures efficient production of high-quality granules while minimizing contamination risks and enhancing process containment.

Processes and Dries Pharmaceutical Powders and Granules

The ROTO CUBE from IMA Group is a versatile single-pot processor for pharmaceutical and biotech industries, designed for efficient granulation, vacuum drying, and milling within one sealed unit. This processor excels in handling HAPI with its high containment capabilities, minimizing contamination and ensuring safety. It operates with a tilting bowl to enhance heat exchange, reducing drying times and preventing product sticking. The GA.ST. system introduces inert gas during vacuum drying, optimizing the drying process. With bowl capacities ranging from 12 to over 1,500 liters, the ROTO CUBE accommodates various batch sizes, making it suitable for both laboratory-scale R&D and full-scale production. Its in-line dry milling feature ensures granules are ready for further processing into tablets or capsules, adapting seamlessly into existing production lines. Constructed with stainless steel and meeting GMP standards, it supports clean-in-place (CIP) systems for efficient maintenance, and offers customization in sizes and configurations to meet specific production needs.

Benefits

  • Enhances product purity and safety with high containment for HAPI processing.
  • Shortens production cycles with effective heat exchange and reduced drying time.
  • Minimizes contamination risks with a fully sealed single-pot design.
  • Facilitates seamless integration with in-line dry milling for ready-to-use granules.
  • Simplifies maintenance and cleaning with CIP system compatibility.

General


Applications
Pharmaceutical tablets,Nutraceuticals,Pharmaceutical powder,Granules,Hapi (highly active pharmaceutical ingredients)
End products
Antidepressant granules,Antibiotic granules,Sustained-release tablets,Oncology drug formulations,Pain relief granules,Film-coated tablets,Antiviral active ingredients,Protein powder supplements,Effervescent tablets,Herbal powder preparations
Steps before
Raw Powder Loading
Steps after
Dry Milling,Sachet Filling,Tablet Pressing,Capsule Filling
Input ingredients
raw powders
Output ingredients
dry milled granules,sachets,tablets,capsules
Market info
IMA is known for its expertise in manufacturing automated packaging machines and solutions, particularly for the pharmaceutical, cosmetics, food, tea, and coffee industries, offering innovative, high-quality equipment and comprehensive customer service.

Technical Specifications


Bowl capacity
12–1,500 L
Product quantity
4–1,000 L
Impeller speed
20–597 rpm
Chopper speed
700–1,500 rpm
Bowl tilting
Yes,increases heat exchange surface
Gas stripping system (GA.ST.)
Inert gas injection for vacuum drying
In-line dry milling
Yes,ready for sachets,tablets,capsules
Drying time
Shortened due to tilting bowl
Process containment
High,single sealed bowl

Operating Characteristics


Working Mechanism
Single-pot granulation
Integrated Steps
Loading,granulation,vacuum drying
CIP Principles
Facilitates cleaning operations
Batch vs. Continuous Operation
Batch processing
Automation Level
PLC control
Safety Features
Dust-free process,gas stripping system
Energy Efficiency
Efficient heat exchange
Product Containment
High containment capability
Product Yield
Maximized
Drying Time
Shortened due to tilting bowl

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Physical Characteristics


Bowl shape
Single,completely sealed bowl
Bowl capacity
12 - 1,500 liters
Bowl tilting
Yes
Discharge method
Milled granules discharge

Custom Options


Tilting Bowl
Increases surface for heat exchange
Gas Stripping (GA.ST.)
Inert gas injection for vacuum drying
In-line Dry Milling
Ready granules for sachets or tablets