Tell us about your production challenge

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients.

What multi-layer tablets equipment do you need?

Granulation line for pharmaceutical solid dosage forms

Granulation is a common technique in production of pharmaceutical ...

Industrial scale tablet coater

During the coating process, tablets pass many stages that can make them wet and sticky or cra...

Fluid bed dryer for pharmaceutical solid dosage form

Fluid bed drying is a pharmaceutical process carried out to reduce t...

Industrial high shear mixer granulator for drug formation

It is rather difficult to successfully produce a pharmaceutica...

Tablet coater for laboratory scale

Tablet coating can be applied for adding colours or glosses, or based around sugar in or...

Tablet counting machine

Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and c...

High Speed Double-Sided Tablet Press

To achieve as much as double the output of single-sided tablet press, the upper and lo...

Laboratory Tablet Press

Pharmaceutical research and development projects may require small samples of high quality tablets fo...

High-speed strip packaging machine

Pack your solid pharmaceutical products in four-side sealed foil packs at very high spee...

Automatic filling line for solid doses

For medium-scale production of solid doses such as tablets, capsules, and softgels t...

Benchtop tablet press

For lab work or small-scale production, a purpose-designed tablet press that meets your exact requireme...

Single rotary tablet press

Creating batches of consistent high quality pharmaceutical grade tablets from your powdered ingre...

Feeder with flexible wall hopper

The varying properties of dry powder products mean that specialized feeders are required fo...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Conical mill for drug formulation

The efficient size reduction of granular powders is a key step in many pharmaceutical pro...

Automatic tablet coater for lab scale

The ability to coat tablets in an even and controlled way is an important stage in th...

Tablet auto coater for lab scale

Many pharmaceutical doses in tablet form require a coating before they are ready for use. T...

Single and double layer tablet press

High performance tablet presses that are capable of producing both single and double-l...

Granulation line of mixer and fluid bed dryer

A complete granulation line allows for the mixing and granulation of pharmac...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

Rotary tablet press

For pharmaceutical tablet producers looking to reduce waste, costs and  increase production volume, a hig...

Fluid bed dryer for production scale

Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for dryi...

Fluid bed dryer for lab scale

Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compo...

Fluid bed dryer and mixer for lab scale

Designed for pharmaceutical R&D, a lab-scale fluid bed dryer and mixer/granulat...

High-shear mixer

For the efficient mixing of larger batches of pharmaceutical compounds and high-shear mixer provides the opti...

Entry-level high-shear mixer for drug formulation

For pilot and lab-scale pharmaceutical formulations, a high-shear granu...

Premium vacuum conveyor

When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...

Sorption dehumidifier with air-chilled condenser

It is not always possible to duct out the wet air from a dehumidifier ser...

Small portable dehumidifier

Water damaged areas require dehumidification to limit the damage and prepare the area for restor...

Sorption dehumidifier for large temperature differences

Small, humid areas can be difficult to dehumidify in humid ambien...

Sorption dehumidifier for deep drying

Humid ambient conditions such as those in tropical climates make dehumidification mor...

Dehumidifier for difficult wet airflows

Sealed rooms can be challenging to dehumidify with ordinary dehumidifiers. The wet ...

Sorption dehumidifier for overpressured rooms

Small humid spaces, used for processing or storage, often need a simple dehu...

Heat recycling sorption dehumidifier

Facilities that handle large amounts of water can become very humid. High humidity may...

Industrial desiccant dehumidifier

Dehumidification of medium sized manufacturing and processing facilities can be a dauntin...

Large scale desiccant dehumidifier

Moisture sensitive processing and storage facilities need low humidity environments to s...

Customizable dehumidifier

Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fi...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Pick and place transfer for strips into cartoner

Transfer your strip packs products directly to the cartoner.

Versatile strip packaging machine

Pack diverse products such as diagnostics, pharmaceutical liquids or flat, stable product...

Entry-level blister machine

A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...

Compact blister machine

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Show more equipment
Contact us

Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
Contact us

Use accurate weight-dosing systems to avoid delamination

Tablet sequencing is vital to achieving the correct lamination in the inner layer of the capping. Multi-layer technology relies on the accuracy of weight-dosing systems to counter delamination.

An inadequate ratio of the layer sizes presents an additional challenge to layering.  The target ratio is 1:1, but API incompatibility and separate formulation mixtures impact the sizing of layers. Compressibility, flowability, and particle size distribution are crucial to controlling the weight and size of different layers.

Reduce cross-contamination with gluing pills technology

Gluing pills technology (GPT) uses a binding agent to attach both layers after they’ve been individually compacted. The binding process safeguards against cross-contamination and ensures both tablet layers do not interact with one another.

Cross-contamination is a significant risk in formulation design when active ingredients are exposed to other materials.

Superdisintegrants facilitate repeat-action of multilayer tablets

A tablet-within-tablet design makes multilayer formulations a good solution for repeat-action products. But their pharmacological effectiveness depends on the correct disintegration ability of the outer tablet.

Traditionally, starches and clays have been used as disintegrants by attracting water into the tablet. However, these may occupy up to a fifth of the weight of the final tablet. Specially developed disintegrants offer higher effectivity at a lower concentration. The main categories of these superdisintegrants are crospovidone, croscarmellose sodium, and sodium starch glycolate

Multilayer tablet technology is ideal for polypharmacy

Polypharmacy is a growing area of interest in medication. It finds an effective solution in multilayer tablets by administering a minimum of 5 medicines at regular intervals.

Formulas designed for this purpose may include high-potency active pharmaceutical ingredients (HPAPI) with smaller but more powerful concentrations of materials. Multilayer tablet technology combines these complex formulations to manufacture more efficacious pharmaceutical products.

Let's talk about your project!

Try us and get in touch. Send us a message and we will try to reply within 24 hours or give us a call at +31 10 206 8000
Contact us
All your data is kept confidential