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Multi-layer tablets drying Equipment

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

It is not always possible to duct out the wet air from a dehumidifier servicing an enclosed facility. In such cases, the water is condensed out from the wet air flow and disposed off through a floor drain or a pump.


<h2>Dehumidify at sub-zero dew points with an air-chilled condensation dehumidifier</h2>
AQUASORB dehumidifiers from Seibu Giken function as a Consorb but condense the wet air flow in an air-chilled condensor instead of being lead out. These dehumidifiers have a high dry airflow, which improves the drying effect. It incorporates a next generation, washable, D-MAX silica gel dessicant rotor.

The chassis is made of stainless steel which is especially important in condensing units to prevent corrosion. Aquasorb can operate at dew points below 0°C. The fan for dry air and cool air helps accumulate the energy in the dry air.

Capacity
AQUASORB A-30B/BP: 0.5kg/h*, dry air flow rate: 400m3/h
* at 20°C and 60%RH

Sorption dehumidifier with air-chilled condenser

Water damaged areas require dehumidification to limit the damage and prepare the area for restoration. A handy, portable dehumidifier that is easy to setup and works silently is ideal for such applications. Dehumidifying can be particularly problematic in tropical conditions with high ambient humidity.


<h2>A small portable dehumidifier fit for climates with high humidity</h2>
The CONSORB CS series dehumidifiers from Seibu Giken use the Consorb principle. They are ideal for facilities with surplus heat or when dehumidifying very damp air. They are also useful when there is a large difference in moisture content between process and regeneration air inlets. Consorb CS dehumidifiers are fitted with a self regulating heater and a high quality, washable, D-MAX silica gel rotor.

The CONSORB CS has been designed as a very silent, compact and handy dehumidifier that can be easily placed indoors and in smaller areas. The corrosion resistant chassis is made of stainless steel. CS units deliver high performance in all climates.

Capacity
CS-5/-5L: 0.35 - 0.4kg/h*, dry air flow rate: 65 - 90m3/h
* at 20°C and 60%RH

Small portable dehumidifier

Small, humid areas can be difficult to dehumidify in humid ambient conditions such as those in tropical climates. A large difference in moisture content between process and regeneration air can be problematic during dehumidification. Processing and storage facilities that require deep drying can be especially difficult to dehumidify in these conditions.


<h2>Dehumidify areas with a large difference between incoming and required moisture content</h2>
The CONSORB DC series dehumidifiers from Seibu Giken use the Consorb principle. They are ideal for facilities with surplus heat or when dehumidifying very damp air. They are also useful when there is a large difference in moisture content between process and regeneration air inlets. DC dehumidifiers incorporate the new generation of high quality, washable, silica gel desiccant D-MAX rotor

DC series units are small, portable and light-weight with the smallest units weighing as little as 15Kgs. They have a maintenance-friendly, rust free, stainless steel chassis. The DC range offers a self-regulating heater and a protected control panel.

Capacity
DC-10: 0.6kg/h*, dry air flow rate 190m3/h
DC-20/30 T10, T16: 1.1 – 1.5kg/h*, dry air flow rate 310 - 400m3/h
* at 20°C and 60%RH

Sorption dehumidifier for large temperature differences

Humid ambient conditions such as those in tropical climates make dehumidification more challenging as there is a large difference in moisture content between process and regeneration air. Processing and storage facilities that require deep drying can be especially difficult to dehumidify in these conditions.


<h2>Dehumidify very damp air in tropical climates with deep drying</h2>
The CONSORB CZ series dehumidifiers from Seibu Giken use the Consorb principle. They are ideal for facilities with surplus heat or when dehumidifying very damp air. They are also useful when there is a large difference in moisture content between process and regeneration air inlets. CZ dehumidifiers incorporate the new generation of high quality, washable, silica gel desiccant D-MAX rotor

CZ series units can work with hot water for regeneration or with water in combination with an electric heater. In addition, electricity, steam and gas can also be used for regeneration. The CZ dehumidifiers are made with aluzinc and have an excellent deep drying ability. An ICE-version with higher process airflow, ideal for re-circulating installations, is also available.

Capacity: 22 – 69kg/h*,dry air flow rate 3,200 – 8,000m3/h
* at 20°C and 60%RH

Sorption dehumidifier for deep drying

Sealed rooms can be challenging to dehumidify with ordinary dehumidifiers. The wet air needs to be recycled and water removal must be by way of condensation. Condensing units can have high energy requirements if heat is not properly recycled.


<h2>Dehumidify sealed rooms and wet airflows efficiently</h2>
FRIGOSORB dehumidifiers from DST Seibu Giken are built on the patented Frigosorb sorption technology. These dehumidifiers are very energy efficient due to their heat pump function and use approximately one-third of the total energy consumption of regular sorption dehumidifiers. They incorporate the new generation of high quality, washable, silica gel desiccant D-MAX rotor

The F-31 unit works well at low temperatures. The chassis is made of stainless steel which prevents corrosion in condensing units. It is especially suited for sealed rooms as it condenses out the water. Applications include sealed pharmaceutical and health facilities, food processing and storage of sensitive goods.

Capacity:
F31: 1.1kg/h*, dry air flow rate 850– 400m3/h
* at 20°C and 60%RH

Dehumidifier for difficult wet airflows

Small humid spaces, used for processing or storage, often need a simple dehumidification solution. A single-phase powered dehumidifier with a compact, maintenance friendly design is ideally suited to these situations. Energy efficiency and low noise level operation are also important when working in small spaces.


<h2>Dehumidify small rooms with light weight &amp; efficient heat recycling technology</h2>
RECUSORB DR series dehumidifiers are built on the DR sorption technology from DST Seibu Giken. They incorporate the new generation of high quality, silica gel desiccant D-MAX rotor, a self regulating heater and integrated heat recycling technology. Heat is recycled, to pre-heat and partly dehumidify the incoming air. It uses a fan for both the dry airflow and the wet airflow making installation simpler in rooms with over pressure. They are also suitable for achieving very low dew points.

DR series dehumidifiers are suitable for small storage areas, archives, museums and other small spaces. The single-phase, compact DR-units have a stainless steel construction and offer a long life of robust performance.

They are available in the following capacities:
DR-31 T10: 1.6kg/h*, dry air flow rate 310m3/h
DR-40 T10/T16: 1.6-2.8kg/h*, dry air flow rate 550– 600m3/h
DR-010B: 0.5kg/h*, dry air flow rate 190m3/h
* at 20°C and 60%RH

Sorption dehumidifier for overpressured rooms

Facilities that handle large amounts of water can become very humid. High humidity may lead to corrosion in installed machinery and control systems. A dehumidifier is necessary to protect the installed machinery in these cases. The dehumidifier itself must have a robust construction to withstand these harsh conditions.


<h2>Dehumidify medium sized spaces with robust heat recycling technology</h2>
RECUSORB R series dehumidifiers are built on the Recusorb R sorption technology from DST Seibu Giken. They incorporate a washable, silica gel desiccant rotor and integrated heat recycling technology. Heat absorbed during rotor regeneration is recycled to pre-heat and partly dehumidify the incoming air.

The compact R-units have a stainless steel construction and offer a long life of robust performance in both indoor and outdoor settings. They are suitable for small to medium sized storage and processing facilities as well as museums, power plants and pumping stations.

The R series dehumidifiers are available in the following capacities:
R-060BR: 4.6kg/h*, dry air flow rate 1,000m3/h
R-51/61R: 7.3-10kg/h*, dry air flow rate 1,250– 1,450m3/h
* at 20°C and 60%RH

Heat recycling sorption dehumidifier

Dehumidification of medium sized manufacturing and processing facilities can be a daunting task considering the setup and maintenance effort associated with ordinary dehumidifiers. A compact dehumidifier, that's energy efficient and easy to setup and maintain, can greatly simplify the dehumidification process while lowering costs.


<h2>Dehumidify medium sized facilities with compact, service friendly, energy efficient technology</h2>
RECUSORB RL industrial dehumidifiers are built on the Recusorb R sorption technology from DST Seibu Giken. They incorporate the new generation of high quality, silica gel desiccant D-MAX rotor and integrated heat recycling technology. Heat absorbed during rotor regeneration is recycled to pre-heat and partly dehumidify the incoming air.

The compact RL-units are easy to service with easy access to filters, rotor and seals. Optional features include linear capacity control and frequency inverter to control airflows. They are suitable for extending life of stored products in small to medium sized warehouses, preventing condensation in cold stores &amp; ice rinks and ensuring desired ambient humidity in manufacturing facilities.

The RL series dehumidifiers are available in the following capacities:
RL-60R/LR : 4-5kg/h*, dry air flow rate 850– 1,000m3/h
RL-71R/ ICE/ LR: 13-17kg/h*, dry air flow rate 2,500– 3,200m3/h
* at 20°C and 60%RH

Industrial desiccant dehumidifier

Moisture sensitive processing and storage facilities need low humidity environments to safequard the quality of products. Large spaces require specialized dehumidifiers that have the necessary capacity and good energy efficiency to keep costs at a minimum. An industrial, automated humidity control system is best suited for these applications.


<h2>Dehumidify large facilities with high efficiency heat recycling technology</h2>
RECUSORB RZ industrial dehumidifiers are built on the Recusorb R sorption technology from DST Seibu Giken. They incorporate a silica gel desiccant rotor and integrated heat recycling technology. Heat absorbed during rotor regeneration is recycled to pre-heat and partly dehumidify the incoming air. They are available with electric, steam or gas reactivation.

RZ dehumidifiers have an aluzinc construction and offer multiple PLC control options. They are available in the capacity range 19 - 65kg/h (at 20°C / 60%RH) and dry air flow rate 2,800 – 10,500 m3/h. Some applications include preventing clumping of dried foods during processing, protecting hygroscopic materials in pharma manufacturing, excluding moisture during packaging, extending life of warehoused products and preventing condensation in cold stores and ice rinks. They are also available in an ICE-version with higher process airflow, ideal for re-circulating installations.

Large scale desiccant dehumidifier

Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fixed configuration therefore do not always fit your needs. A flexible dehumidification system that can be tailored to meet your requirements from basic desiccant dehumidification to a complete climate control system becomes useful in this situation.


<h2>Dehumidify with a customized solution that fits your processing needs</h2>
FLEXISORB from DST Seibu Giken is a versatile industrial dehumidifying system that can be configured to meet your particular needs. Flexisorb dehumidifiers use the Recusorb R sorption technology which incorporates a silica gel desiccant rotor and integrated heat recycling. Heat is absorbed during rotor regeneration and recycled in the “purge zone” where incoming air is pre-heated and partly dehumidified.

Flexisorb systems are available in the capacity range 19 - 300kg/h (at 20°C / 60%RH) and dry air flow rate of 900 – 61,100 m3/h. Options include pre-cooling, post-cooling and post-heating. Flexisorb has an anodized aluminum frame with a smooth interior design and external locks. Some applications include preventing clumping of dried or powdered foods during processing, protecting hygroscopic materials in pharma manufacturing, excluding moisture during packaging and extending life of warehoused products.

Customizable dehumidifier

<span style="font-weight: 400;">Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for drying compounds to achieve the required moisture content, as well as applying coatings or binders before further processing prior to the tablet formulation. For production-scale processes, a fluid bed dryer needs to be robust, easy to operate and flexible enough to handle continuous operation.</span>
<h2>Dry pharmaceutical compounds with increased control and reduced maintenance time</h2>
<span style="font-weight: 400;">The Sejong D Series is a production scale fluid bed dryer for use in the pharmaceutical industry, or in any scenario where powder fluid processes are required.</span>

<span style="font-weight: 400;">The D Series has been designed to offer a robust production unit with the highest levels of safety and operator ease of use. All valves, seals, flanges and weld points have been designed to be 12 bar pressure resistant. The ergonomic user interface uses graphical representations to allow a single operator to manage all aspects of the machine setup, running and discharge. Recipe systems allows full automation of the whole drying process, without user intervention.</span>

<span style="font-weight: 400;">The D Series filter system uses pulse blowback air to clear dust from the filters. This allows for a highly consistent fluid flow and can reduce the production time. For ease of maintenance, the in-built winch is computer-controlled to allow for quick and accurate filter maintenance.</span>

<span style="font-weight: 400;">For cleaning, the D series adopts a Clean in Place system using 3 low-flow rotary nozzles which are placed directly inside the body of the machine and powered by a high-pressure pump. This allows maximum cleaning performance with low water flow and minimal downtime.</span>

Fluid bed dryer for production scale

<span style="font-weight: 400;">A complete granulation line allows for the mixing and granulation of pharmaceutical compounds for the production of tablets. By linking fully compatible milling, mixing and fluid bed machinery with vacuum conveying it provides a turnkey solution for preparation of powder doses ready for pressing into tablets.</span>
<h2>Complete solution for preparation of granular pharmaceutical compounds for tablets</h2>
<span style="font-weight: 400;">Sejong Pharmatech’s Granulation Line is the most cost-effective way to achieve a turn-key granulation solution for the manufacture of pharmaceutical compounds for tablet preparation.</span>

<span style="font-weight: 400;">The granulation line consists of the Sejong CM series production scale conical mill, the Sejong M series production-scale speed mixer, the Sejong D series production scale fluid bed dryer and an optional vacuum conveyor system for the creation of a completely closed line environment.</span>

<span style="font-weight: 400;">Designed for total compatibility, these devices work together seamlessly to provide the perfect input for tablet pressing machines. When buying as a line package, significant cost savings can be made compared to sourcing individual machines.</span>

<span style="font-weight: 400;">The optional vacuum conveyor removes the need for manual handling between processes, and ensure a clean and safe transfer of powders between process stages.</span>

<span style="font-weight: 400;">All the Sejong machinery is manufactured with ergonomics and ease of use in mind, and the touch screen HMI’s are fully 21CFR part 11 compliant.</span>

Granulation line of mixer and fluid bed dryer

Pharmaceutical laboratories need compact equipment to handle and produce small amounts of granules from a mixture of wet and dry elements for R&amp;D applications. Furthermore, the granulation process requires short residence times in drying the products to easily identify and remove the defects without discarding the entire batch.


<h2>Automatic feeding, granulating, and quick drying of pharmaceutical  products</h2>
The QbCon 1 from L.B. Bohle is a continuous wet granulating and drying system for pharmaceutical laboratory scale applications. The system performs three processes: feeding, granulating, and drying. It features a twin screw granulator with a hinged barrel for easy access to its parts. The unit comes with a multi-position feeder and interchangeable ports, ensuring accurate gravimetric feeding of dry powder and using a pulsation-free pressurized feeder for granulation liquid.

The wet granules are gently dried by a moving fluid bed that provides short residence times and consistent product output. Its narrow residence time distribution allows easy traceability from the initial product to the final tablet or vice versa. The drying process parameters, such as airflow, temperature, and conveying speed, can be controlled and adjusted according to product requirements. The system allows for sampling wet and dry granulations without interrupting the ongoing processes. The system also has an innovative filter cleaning system to prevent clogging for longer hours of operation. The unit also features a complete WIP (Wash-in-Place) cleaning.

Continuous wet granulator and dryer for R&D

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Making.com is a new online platform that helps makers find production technology quicker by grouping it around the products they make.

What's new in pharmaceutical packaging?



During <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we met Chantal Younes, Key Account Manager at <a href="https://www.csptechnologies.com/" target="_blank" rel="noopener">Aptar CSP Technology</a>, who introduced us to the world of active packaging.

The pharmaceutical industry is subject to strict regulations, so that's why manufacturers are very meticulous when formulating their products but especially about their packaging, which must keep their products safe. Due to the formulation or active ingredient, pharmaceutical products can present significant stability issues if they come in contact with moisture or oxygen.

This is where Aptar CSP Technology comes in. Aptar CSP Technology has developed several active packaging solutions to protect pharmaceutical products and ensure extended shelf life.

The company has developed a new class of highly engineered polymer compounds that protect drug products, probiotics, and drug delivery systems from impurities, oxygen, and moisture. The polymer can be extruded into a film, injection molded, or blow molded.

#Changemaker: Ready to protect your pharmaceutical products from moisture?

Pharmaceutical

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

Did I take my medicine this morning or not?

Let's be honest. How often have we asked ourselves this question and failed to find an answer simply because… our memory sometimes doesn’t serve us right!

&nbsp;

Coming to the rescue of patients who need to keep track of their chronic medication and adhere to their daily treatment plan is FebriSol, a scratch-card calendar developed by Studio Fundi.

At <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we had the pleasure of meeting Ricky Stoch, the founder of <a href="https://studiofundi.com/" target="_blank" rel="noopener">Studio Fundi</a>, who showed us how simple it is to use FebriSol.

All the patient has to do is scratch off the day’s metallic coating that will reveal the check mark after taking the pill.

Current solutions for daily tracking are inconvenient and expensive.  FebriSol is a low-cost alternative that can help you keep track of your medicine every day.

#Changemaker: Keep track of your medicine every day with FabriSol sticker

Find production technology for Multi-layer tablets drying, and connect directly with leading machine manufacturers worldwide