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Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients.

Which multi-layer tablets equipment do you need?

Single-use containment valves

From GMP and HSE perspective material transfer is critical for chemical and pharmaceutical for...

High containment split butterfly valve

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. ...

Premium vacuum conveyor

When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...

R&D electronic counter for capsules and tablets

This machine has been designed to offer an ever-precise and reliable count...

Checkweigher

A check weigher that is equipped with high speed/high accuracy force balance load cell. It meets stringent accura...

Single rotary tablet press

Creating batches of consistent high quality pharmaceutical grade tablets from your powdered ingre...

Sorption dehumidifier with air-chilled condenser

It is not always possible to duct out the wet air from a dehumidifier ser...

Small portable dehumidifier

Water damaged areas require dehumidification to limit the damage and prepare the area for restor...

Sorption dehumidifier for large temperature differences

Small, humid areas can be difficult to dehumidify in humid ambien...

Sorption dehumidifier for deep drying

Humid ambient conditions such as those in tropical climates make dehumidification mor...

Dehumidifier for difficult wet airflows

Sealed rooms can be challenging to dehumidify with ordinary dehumidifiers. The wet ...

Sorption dehumidifier for overpressured rooms

Small humid spaces, used for processing or storage, often need a simple dehu...

Heat recycling sorption dehumidifier

Facilities that handle large amounts of water can become very humid. High humidity may...

Industrial desiccant dehumidifier

Dehumidification of medium sized manufacturing and processing facilities can be a dauntin...

Large scale desiccant dehumidifier

Moisture sensitive processing and storage facilities need low humidity environments to s...

Customizable dehumidifier

Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fi...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Entry-level high-shear mixer for drug formulation

For pilot and lab-scale pharmaceutical ...

Fluid bed dryer for production scale

Fluidized bed drying (FBD) is a common process in the ...

Granulation line of mixer and fluid bed dryer

A complete granulation line allows for the m...

Rotary tablet press

For pharmaceutical tablet producers looking to reduce waste, costs and  i...

Single and double layer tablet press

High performance tablet presses that are capable of pr...

Automatic tablet coater for lab scale

The ability to coat tablets in an even and controlled...

Tablet auto coater for lab scale

Many pharmaceutical doses in tablet form require a coating ...

Serialization coding and labeling equipment

In the pharmaceutical industry, product serial...

Stand-alone aggregation station

The aggregation of pharmaceutical products for tracking purp...

Benchtop tablet press

For lab work or small-scale production, a purpose-designed tablet press that meets your exact requireme...

Semi-automatic case packer

Pharmaceutical products require complete traceability throughout the production cycle. For smalle...

High Speed Double-Sided Tablet Press

To achieve as much as double the output of single-sided tablet press, the upper and lo...

Dust-tight metal detector for tablets

For FDA-compliant production of tablets, the elimination of airborne dust containing ...

Laboratory Tablet Press

Pharmaceutical research and development projects may require small samples of high quality tablets fo...

Tablet counting machine

Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and c...

Industrial scale tablet coater

During the coating process, tablets pass many stages that can make them wet and sticky or cra...

Lifter and De-duster for Tablets

The use of several different tools for lifting, de-dusting, and polishing in the pharmaceut...

High Speed Visual Inspection System for Tablets

In order to ensure quality and standard specifications of tablets, capsule...

High speed bottle filler with inspection

Medicines in tablet, capsule, or soft gel forms undergo various processes before r...

Contained Visual Inspection System

In the medicine industry, it is important to ensure there are no defects in tablets or c...

Serialization and aggregation system

Manufacturers from the pharmaceutical industry require a variety of cartons, cases and...

Serialization and aggregation inspection system

Including serialization and aggregation inspection systems to packaging li...

Entry-level X-ray inspection system

Without compromising on performance, if you need an entry level x-ray inspection system...
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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Use accurate weight-dosing systems to avoid delamination

Tablet sequencing is vital to achieving the correct lamination in the inner layer of the capping. Multi-layer technology relies on the accuracy of weight-dosing systems to counter delamination.

An inadequate ratio of the layer sizes presents an additional challenge to layering.  The target ratio is 1:1, but API incompatibility and separate formulation mixtures impact the sizing of layers. Compressibility, flowability, and particle size distribution are crucial to controlling the weight and size of different layers.

Reduce cross-contamination with gluing pills technology

Gluing pills technology (GPT) uses a binding agent to attach both layers after they’ve been individually compacted. The binding process safeguards against cross-contamination and ensures both tablet layers do not interact with one another.

Cross-contamination is a significant risk in formulation design when active pharmaceutical ingredients are exposed to other materials.

Superdisintegrants facilitate repeat-action of multilayer tablets

A tablet-within-tablet design makes multilayer formulations a good solution for repeat-action products. But their pharmacological effectiveness depends on the correct disintegration ability of the outer tablet.

Traditionally, starches and clays have been used as disintegrants by attracting water into the tablet. However, these may occupy up to a fifth of the weight of the final tablet. Specially developed disintegrants offer higher effectivity at a lower concentration. The main categories of these superdisintegrants are crospovidone, croscarmellose sodium, and sodium starch glycolate

Multilayer tablet technology is ideal for polypharmacy

Polypharmacy is a growing area of interest in medication. It finds an effective solution in multilayer tablets by administering a minimum of 5 medicines at regular intervals.

Formulas designed for this purpose may include high-potency active pharmaceutical ingredients (HPAPI) with smaller but more powerful concentrations of materials. Multilayer tablet technology combines these complex formulations to manufacture more efficacious pharmaceutical products.

Processing steps involved in multi-layer-tablets making

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