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Multi-layer tablets making equipment

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Which multi-layer tablets technology do you need?

Pharmaceutical tablet coating machine

Pharmaceutical tablet coating machine

Tablet coating requires spraying, mixing, and drying procedures that must be carried o…

Single-use containment valves

Single-use containment valves

From GMP and HSE perspective material transfer is critical for chemical and pharmaceutical form…

High containment split butterfly valve

High containment split butterfly valve

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. F…

Agitator bead mill for API

Agitator bead mill for API

To achieve precisely defined API properties and safe and reproducible production, rigorous impleme…

Continuous wet granulator and dryer for R&D

Continuous wet granulator and dryer for R&D

Pharmaceutical laboratories need compact equipment to handle and produce small …

Dry granulator for pharmaceutical powders

Dry granulator for pharmaceutical powders

In pharmaceutical industries, where large-volume production is the norm, compacto…

Energy-efficient film coating machine for pharmaceutical tablets

Energy-efficient film coating machine for pharmaceutical tablets

Tablet coating involves applying a thin layer of coating…

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Entry-level X-ray inspection system

Entry-level X-ray inspection system

Without compromising on performance, if you need an entry level x-ray inspection system …

Serialization and aggregation inspection system

Serialization and aggregation inspection system

Including serialization and aggregation inspection systems to packaging lin…

Serialization and aggregation system

Serialization and aggregation system

Manufacturers from the pharmaceutical industry require a variety of cartons, cases and …

Contained Visual Inspection System

Contained Visual Inspection System

In the medicine industry, it is important to ensure there are no defects in tablets or ca…

High speed bottle filler with inspection

High speed bottle filler with inspection

Medicines in tablet, capsule, or soft gel forms undergo various processes before re…

High Speed Visual Inspection System for Tablets

High Speed Visual Inspection System for Tablets

In order to ensure quality and standard specifications of tablets, capsules…

Lifter and De-duster for Tablets

Lifter and De-duster for Tablets

The use of several different tools for lifting, de-dusting, and polishing in the pharmaceuti…

Industrial scale tablet coater

Industrial scale tablet coater

During the coating process, tablets pass many stages that can make them wet and sticky or crac…

Tablet counting machine

Tablet counting machine

Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and co…

Laboratory Tablet Press

Laboratory Tablet Press

Pharmaceutical research and development projects may require small samples of high quality tablets for…

Dust-tight metal detector for tablets

Dust-tight metal detector for tablets

For FDA-compliant production of tablets, the elimination of airborne dust containing a…

High Speed Double-Sided Tablet Press

High Speed Double-Sided Tablet Press

To achieve as much as double the output of single-sided tablet press, the upper and low…

Semi-automatic case packer

Semi-automatic case packer

Pharmaceutical products require complete traceability throughout the production cycle. For smaller…

Benchtop tablet press

Benchtop tablet press

For lab work or small-scale production, a purpose-designed tablet press that meets your exact requiremen…

Stand-alone aggregation station

Stand-alone aggregation station

The aggregation of pharmaceutical products for tracking purposes is already compulsory in man…

Serialization coding and labeling equipment

Serialization coding and labeling equipment

In the pharmaceutical industry, product serialization is the cornerstone of all…

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Tablet auto coater for lab scale

Tablet auto coater for lab scale

Many pharmaceutical doses in tablet form require a coating before they are ready for use. Th…

Automatic tablet coater for lab scale

Automatic tablet coater for lab scale

The ability to coat tablets in an even and controlled way is an important stage in the…

Single and double layer tablet press

Single and double layer tablet press

High performance tablet presses that are capable of producing both single and double-la…

Rotary tablet press

Rotary tablet press

For pharmaceutical tablet producers looking to reduce waste, costs and  increase production volume, a high…

Granulation line of mixer and fluid bed dryer

Granulation line of mixer and fluid bed dryer

A complete granulation line allows for the mixing and granulation of pharmace…

Fluid bed dryer for production scale

Fluid bed dryer for production scale

Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for dryin…

Entry-level high-shear mixer for drug formulation

Entry-level high-shear mixer for drug formulation

For pilot and lab-scale pharmaceutical formulations, a high-shear granul…

Small feeder with flexible wall hopper

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powde…

Customizable dehumidifier

Customizable dehumidifier

Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fix…

Large scale desiccant dehumidifier

Large scale desiccant dehumidifier

Moisture sensitive processing and storage facilities need low humidity environments to sa…

Industrial desiccant dehumidifier

Industrial desiccant dehumidifier

Dehumidification of medium sized manufacturing and processing facilities can be a daunting…

Heat recycling sorption dehumidifier

Heat recycling sorption dehumidifier

Facilities that handle large amounts of water can become very humid. High humidity may …

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Use accurate weight-dosing systems and excipients to avoid delamination


Tablet sequencing is vital to achieving the correct lamination in the inner layer of the capping. Multi-layer technology relies on the accuracy of weight-dosing systems to counter delamination.


An inadequate ratio of the layer sizes presents an additional challenge to layering.  The target ratio is 1:1, but API incompatibility and separate formulation mixtures impact the sizing of layers. Compressibility, flowability, and particle size distribution are crucial to controlling the weight and size of different layers.


Reduce cross-contamination with gluing pills technology to ensure adhesion between layers

Gluing pills technology (GPT) uses a binding agent to attach both layers after they’ve been individually compacted. The binding process safeguards against cross-contamination and ensures both tablet layers do not interact with one another.

Cross-contamination is a significant risk in formulation design when active pharmaceutical ingredients are exposed to other materials.

Superdisintegrants facilitate repeat-action of multilayer tablets

A tablet-within-tablet design makes multilayer formulations a good solution for repeat-action products. But their pharmacological effectiveness depends on the correct disintegration ability of the outer tablet.

Traditionally, starches and clays have been used as disintegrants by attracting water into the tablet. However, these may occupy up to a fifth of the weight of the final tablet. Specially developed disintegrants like Crospividone, Croscarmellose Sodium and Sodium Starch Glycote offer higher effectiveness at a lower concentration. These three make up the main categories of superdisintegrants.

Multilayer tablet technology is ideal for polypharmacy in single dose form


Polypharmacy is a growing area of interest in medication. It finds an effective solution in multilayer tablets by administering a minimum of 5 medicines at regular intervals.


Formulas designed for this purpose may include high-potency active pharmaceutical ingredients (HPAPI) with smaller but more powerful concentrations of materials. Multilayer tablet technology combines these complex formulations to manufacture more efficacious pharmaceutical products.


Processing steps involved in multi-layer-tablets making

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