Let's make multi layer tablets
Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.
Which multi-layer tablets equipment do you need?
Pharmaceutical tablet coating machine
Single-use containment valves
High containment split butterfly valve
Premium vacuum conveyor
R&D electronic counter for capsules and tablets
Single rotary tablet press
Sorption dehumidifier with air-chilled condenser
Small portable dehumidifier
Sorption dehumidifier for large temperature differences
Sorption dehumidifier for deep drying
Dehumidifier for difficult wet airflows
Sorption dehumidifier for overpressured rooms
Heat recycling sorption dehumidifier
Industrial desiccant dehumidifier
Large scale desiccant dehumidifier
Small feeder with flexible wall hopper
Entry-level high-shear mixer for drug formulation
Fluid bed dryer for production scale
Granulation line of mixer and fluid bed dryer
Rotary tablet press
Single and double layer tablet press
Automatic tablet coater for lab scale
Tablet auto coater for lab scale
Serialization coding and labeling equipment
Stand-alone aggregation station
Benchtop tablet press
Semi-automatic case packer
High Speed Double-Sided Tablet Press
Dust-tight metal detector for tablets
Laboratory Tablet Press
Tablet counting machine
Industrial scale tablet coater
Lifter and De-duster for Tablets
High Speed Visual Inspection System for Tablets
High speed bottle filler with inspection
Contained Visual Inspection System
Serialization and aggregation system
Serialization and aggregation inspection system
Entry-level X-ray inspection system
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Select your multi-layer tablets process
Tell us about your production challenge
Use accurate weight-dosing systems and excipients to avoid delamination
Tablet sequencing is vital to achieving the correct lamination in the inner layer of the capping. Multi-layer technology relies on the accuracy of weight-dosing systems to counter delamination.
An inadequate ratio of the layer sizes presents an additional challenge to layering. The target ratio is 1:1, but API incompatibility and separate formulation mixtures impact the sizing of layers. Compressibility, flowability, and particle size distribution are crucial to controlling the weight and size of different layers.
Reduce cross-contamination with gluing pills technology to ensure adhesion between layers
Gluing pills technology (GPT) uses a binding agent to attach both layers after they’ve been individually compacted. The binding process safeguards against cross-contamination and ensures both tablet layers do not interact with one another.
Cross-contamination is a significant risk in formulation design when active pharmaceutical ingredients are exposed to other materials.
Superdisintegrants facilitate repeat-action of multilayer tablets
A tablet-within-tablet design makes multilayer formulations a good solution for repeat-action products. But their pharmacological effectiveness depends on the correct disintegration ability of the outer tablet.
Traditionally, starches and clays have been used as disintegrants by attracting water into the tablet. However, these may occupy up to a fifth of the weight of the final tablet. Specially developed disintegrants like Crospividone, Croscarmellose Sodium and Sodium Starch Glycote offer higher effectiveness at a lower concentration. These three make up the main categories of superdisintegrants.
Multilayer tablet technology is ideal for polypharmacy in single dose form
Polypharmacy is a growing area of interest in medication. It finds an effective solution in multilayer tablets by administering a minimum of 5 medicines at regular intervals.
Formulas designed for this purpose may include high-potency active pharmaceutical ingredients (HPAPI) with smaller but more powerful concentrations of materials. Multilayer tablet technology combines these complex formulations to manufacture more efficacious pharmaceutical products.