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Mixing and fluid bed granulation

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Feed ingredients

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Essential oils are known as the liquid gems of nature. The sweet-smelling essences impact not just our senses but also our biochemical and cellular make-up. Besides aromatherapy, the products of an essential oil extraction system found applications in pharmaceuticals and foods.

Essential oil

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Aquaculture feed is used when rearing marine livestock such as fish, shellfish, and algae. Quality nutrition is needed for healthy growth and reproduction and feed usually consists of fats, carbohydrates, protein, vitamins, and minerals. Extruded aquaculture feed floats on the water surface and pressure-pelleted feed will sink to the bottom.

Aquafeed

Organic fertilizer production has ancient roots, tracing its origins to ancient farmers who used natural materials like animal manure, compost, and crop residues to improve soil fertility. This sustainable tradition of repurposing organic waste for agricultural benefits has endured through the ages, handed down from one generation of farmers to the next. Producing organic fertilizer industrially involves a series of steps such as extraction, granulation, drying, and employs a combination of organic fertilizer production equipment.

Organic fertilizer

Fluid bed dryers use a stream of hot air to reduce the moisture content of powders and granules. This principle is often used for the production of high-quality pharmaceutical powders as well as the production of animal feed, minerals, sand, and dairy products.

Continuous

In various industries, precise and reliable film coating processes are essential for achieving uniform coverage and protection of materials. Production settings that require consistent quality often face challenges related to scalability and integration with existing systems.
<h2>Achieve precise mid-capacity film coating</h2>
The IRCD HR600 with RFBD600 offered by Hoopman Equipment is a versatile film coating line tailored for mid-capacity production. This system can be configured from basic setups to fully automated solutions including Smart Liquid Supply Systems (SLSS) and advanced air conditioning systems. This turn-key solution is designed to provide optimal coating performance through integration of rotary coaters and fluid bed dryers, offering consistent and efficient results for a variety of materials. Particularly useful in industries needing an automated and scalable coating process, the IRCD HR600 with RFBD600 also features user-friendly controls and easy maintenance to minimize downtime.

Mid-capacity film coating solution

To coat your consumer products with color or taste-enhancing substances, specialized technologies are available that ensure all the contents are individually and evenly covered. The process starts with loading your goods onto rotating drums, exposing the products to spray nozzles that treat them with your prescribed coating formula.

Coating

solid

In the seed coating industry, maintaining high output while ensuring efficient drying is essential. Traditional large static dryers and high-cost vibratory dryers often come up short, leading to operational inefficiencies and higher costs.
<h2>Optimize drying with a continuous fluid bed system</h2>
The RFBD Rotary Fluid Bed Dryers from Hoopman Equipment combine the speed and efficiency of a fluidized bed system with the simplicity of a continuous rotary drum. This non-vibrating system ensures continuous fluid-bed drying and is self-cleaning. It can keep up with various coating capacities such as HR350, HR600, and HR800, making it adaptable for different production scales. The straightforward design minimizes maintenance requirements while maximizing drying performance. Available models include RFBD300-8, RFBD600-12, and RFBD600-19, among others, tailored for short conditioning and high capacities.

Continuous fluid bed drying system for seed coating

In a Fluid Bed, a product or solid is made fluid by an upward moving flow of gas. The mechanical movement of the Fluid Bed strengthens this effect. Thus, the gas and product are intensively mixed so that high heat transfer and an optimum physical reaction speed are achieved.


<h2>Continuous fluid bed dryer for an energy-efficient drying</h2>
Ventilex Continuous fluid bed dryers apply world-leading fluid bed technology to high-throughput bulk processes. By choosing a good combination of gas speed and mechanical movement, you will be able to process granular products with a wide range of grain sizes while forming a minimum amount of dust.

A whole range of products can be processed in the fluid bed for long residence times, up to two hours per machine are possible. Ventilex Fluid bed dryer can function at temperatures from–15ºC to +600ºC. The gas speed can vary from 0.2 to 3m/sec.

Continuous fluid bed dryer

Batch

In pharmaceutical R&D labs, precise granulation and coating of small batches are critical for formulation and scale-up studies. Challenges include accurate processing, efficient use of materials, and maintaining consistent quality throughout various stages of production.
<h2>Achieves uniform granulation and coating efficiently</h2>
The MYLAB by IMA is a compact and modular fluid bed and coating system designed for small batch processing. It features a Main Technical Unit (MTU) with an integrated air-handling unit, spray system, and control panel for seamless operation. The fluid bed module allows both top and bottom spray processes, accommodating batch sizes from 3 to 6 liters. Additionally, a high shear mixer is available for dry mixing and wet granulation tasks. The coating pan module offers interchangeable drums, including fully perforated, solid wall, and Wedge wire screen options, suitable for batches from 0.5 to 10 liters. The MYLAB ensures precise control and scalability, making it ideal for pharmaceutical development and formulation studies. Compliant with stringent GMP standards, it simplifies product changes and enhances productivity.

Fluid bed and coating system for small batch processing

Blending

Granulation

Industrial

In various industries, achieving uniform particle sizes and enhancing physical properties of powders such as solubility, flowability, and bulk density is a common challenge. Traditional batch processes often fall short in providing consistent results and may require significant manual intervention.
<h2>Automate continuous mixing and agglomeration of powders.</h2>
The Flexomix powder agglomeration system by Hosokawa Micron is a compact, continuous solution that excels in mixing and agglomerating powders with liquids. Its unique design combines the Flexomix continuous mixer/agglomerator with the Schugi fluid bed dryer and cooler. This integration allows for effective process control and the production of porous agglomerates with sizes ranging from 100 to 1,500 microns. The system supports capacities from 100 to 40,000 kg/h, making it adaptable to diverse industrial requirements. Its ability to manage accurate powder and liquid ratios ensures consistent product quality. Ideal for industries such as food, chemical, and pharmaceuticals, this system produces instantly soluble agglomerates with excellent physical properties.

Continuous powder agglomeration system

Agglomeration

Industrial cooling equipment varies according to the consistency and temperature conversion demands the material you are handling, but the process typically involves heat exchange treatment as your products are conveyed through a cooling chamber equipped with extraction fans or circulating water. Temperature control is a crucial aspect of your commercial production and cooling systems are applied to a range of industries.

Cooling

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Powder

In seed processing facilities, drying small seed lots efficiently and flexibly is often a challenge. Traditional stationary dryers can be limiting, especially when small seed lots need to be processed in different areas of the facility.
<h2>Facilitates flexible and controlled seed drying</h2>
The FBM Fluid Bed Mobile Dryer from Hoopman Equipment & Engineering is designed to dry small seed lots almost anywhere within your facility. Its mobility, enabled by four swivel wheels, ensures that you can place it wherever needed, requiring only a power connection to operate. The unit includes an internal heating system regulated by a PI-controlled thermostat to maintain optimal drying temperatures, preventing overheating of the seeds. A simple operating panel allows you to set drying times or choose continuous operation. The adjustable airflow valve ensures you can create an optimal fluidized bed for various seeds. An aluminum hopper with a 110-liter gross capacity can dry between 40-60 liters of seeds per batch, depending on the seed species. Additional options include an RH upgrade with PLC control and logging, and a 3-box adapter for enhanced functionality.

Mobile fluid bed dryer for small seed lots

In seed coating and pelleting laboratories, the necessity to dry small seed lots efficiently and without excessive noise is a common challenge. Precise temperature control is essential to ensure the quality and viability of the seeds during drying.
<h2>Dry small seed lots with precision and low noise</h2>
The FBL Fluid Bed Lab Dryer by Hoopman Equipment is designed for drying small seed lots using the fluid bed principle. This dryer can handle capacities ranging from 0.2 to 8 liters, depending on the product. It features an integrated electrical heating system that maintains precise temperature control throughout the drying process. The material cylinder is easily replaceable—simply pull it out, empty it, and insert the next sample. For smaller needs, an optional cylinder can accommodate 200 grams to 2 liters. The low-noise design, achieved through a frequency-controlled fan and isolated air outlet, makes it ideal for laboratory environments. The unit is also equipped with swivel wheels for easy maneuverability.

Fluid bed lab dryer for small seed lots

In seed processing plants, ensuring uniform drying of primed or pelleted seeds is crucial. Variations in drying conditions can lead to suboptimal product quality. This situation requires a reliable drying method to maintain the integrity and viability of the seeds, especially when dealing with intermediate batch sizes.
<h2>Improves drying precision with fluid bed technology</h2>
The FB Fluid Bed Cabinet Dryer by Hoopman Equipment is designed for customers needing an efficient and straightforward method to dry pellets or naked seeds. This system is modular and can be upgraded for full conditioned and weather-independent operation. Using the same material container as the FB Mini Dryer, the cabinet version can be coupled with a dust extraction system and equipped with a conditioning setup. Standard features include fluidization through negative pressure, an aluminum holding bucket (100 liters), and a control box with a PLC system and a 10-inch HMI control interface. The FB Cabinet Dryer allows for local logging of temperatures and processes, with a USB export function for easy data management. Equipped with a frequency-controlled main fan (4kW) and external hot water circuit connection, the system ensures precise drying conditions.

Fluid bed drying system for seed pellets

Manual

Ensuring optimal conditions for seed treatment processes such as hot water treatment and rinsing requires precise, configurable solutions to maintain seed integrity and treatment efficacy.
<h2>Treat seeds with configurable rinsing and drying</h2>
The BioRinse 100L from Hoopman Equipment is designed for various liquid treatment protocols including hot water treatment, rinsing, and drum priming. The system starts with a modular 200L drum where seeds remain during the entire process. This drum moves through different modules: the Rinsing module and an optional Centrifuge module with an extra Rinse/Cool-Down option. After rinsing and centifuging, the drum transitions to the Drying module, equipped with weigh cells for precise drying to the original seed weight based on user-defined protocols. This system offers configurations from manual to fully automatic, allowing flexibility for different treatment needs.

Liquid treatment system for seed processing

Industrial centrifuges are widely used for mechanical solid-liquid separation of components in the pharmaceutical and chemical industries. This is achieved by rapidly rotating the contents within a container to separate fluid of different densities or to remove liquids from solids.

Centrifuging

Industrial cleaning equipment is used to wash or disinfect machinery and the production/warehouse area. It may also be used to sterilize the product, equipment, tools, floor or work surfaces and to purify or clean the product by removing impurities. Choosing a suitable cleaning system depends on the type of product or equipment to be cleaned, the sensitivity of the product to heat, pressure, and chemicals, and the level of sterility desired.

Cleaning

Rinsing

In the seed processing industry, maintaining seed quality during coating and drying is crucial. Traditional methods often lead to mechanical stress and uneven drying, causing potential harm to the seeds. A refined process ensures better quality control and efficiency.
<h2>Combine coating and drying with minimal seed stress</h2>
The ICD Integrated Coater/Dryer from Hoopman Equipment & Engineering is designed to enhance the seed coating and drying process while minimizing mechanical stress on the seeds. Utilizing a fluidized bed system, it ensures efficient drying and homogeneous liquid spray supply. The integrated system allows for precise control over seed temperature during the drying process. It's user-friendly, featuring an HMI (Human-Machine Interface) for easy operation and comprehensive process overview. Additionally, the ICD Integrated Coater/Dryer is easy to clean, ensuring minimal maintenance downtime. This equipment is highly suitable for industries focused on seed treatment, providing both higher loading and gentle handling of seeds during processing.

Integrated coater/dryer for seed treatment

liquid

In industries such as pharmaceuticals, chemicals, and food production, achieving consistent granulation, drying, and coating of free-flowing bulk materials can be a major challenge. Optimizing heat and mass transfer processes while maintaining product quality and minimizing downtime is crucial.
<h2>Achieve precise granulation and coating</h2>
The Glatt Fluid Bed and Spouted Bed Systems are designed for efficient granulation, drying, and coating of free-flowing bulk materials. These systems excel in handling particles that are challenging to fluidize, using patented apparatus geometry for optimal energy input. Fluid bed systems offer flexibility to process product quantities from a few grams in the lab to several tons in production. The spouted bed technology features adjustable energy input, ensuring higher heat and mass transfer rates. Glatt's systems cater to pharmaceuticals, chemicals, food, ceramics, and cosmetics industries, among others. With capabilities for batch or continuous operation, these systems provide customized control and maintain high standards of safety and hygiene. Additionally, Glatt guarantees process parameters such as capacity, particle size, and bulk density, ensuring cost-effective and high-quality production.

Fluid bed and spouted bed systems for granulation and coating

In food processing, feed production, and fine chemical manufacturing, achieving uniform particle size distribution and stable product quality is critical. Complexity arises when trying to combine multiple processing steps like granulation, drying, and cooling in a single continuous operation.
<h2>Achieve uniform granulation and high flexibility</h2>
The Glatt GF Series fluid bed granulators offer a solution tailored for continuous granulation, drying, and coating processes. These granulators feature an elongated, rectangular fluidized bed, allowing for targeted material movement through various zones. Each zone can have different process conditions, such as flow rates and temperatures, enabling seamless transitions between granulation, drying, and cooling. The design's flexibility includes multiple nozzle arrangements, internal filters, and modular assemblies, making it adaptable to specific production needs. The equipment is suitable for industries like food, feed, and fine chemicals, and it comes with options like high supply air temperatures for chemicals or hygienic designs for food applications.

Fluid bed granulator for food and chemical industries

In specialized production environments, maintaining the stability and consistency of temperature-sensitive materials during granulation can be challenging. This is particularly true when dealing with highly viscous solutions or precise mixing requirements in continuous operations.
<h2>Streamline granulation and drying processes</h2>
The Glatt fluid bed plants type AGT® are designed for continuous spray granulation, providing an optimal solution for the food, feed, and fine chemical industries. These plants feature a circular single-chamber design, which allows for the simultaneous drying of liquid raw materials and granulate formation in an ideally mixed fluidized bed. The system combines high process flexibility and adaptability with interchangeable process chambers, allowing for operations like spray granulation of liquids, powder agglomeration, and coating. The AGT® series supports both continuous and batch-controlled operations, making it versatile for various applications. Its controlled environment ensures consistent particle size and effective mixing, while options such as different nozzle systems, flexible solids feeders, and adaptable filters enhance its utility.

Fluid bed granulation system for food and chemical industries

When working with fine powders or small pellets in industries such as pharmaceuticals or food processing, achieving uniform, high-quality coatings can be challenging. Problems like agglomeration and inefficient coating times may arise, requiring an advanced solution to optimize the coating process.
<h2>Enhance coating quality and minimize agglomeration</h2>
The Wurster Accelerator from Freund is a sophisticated coating system designed for the efficient coating of fine powders (~10 microns) to small pellets (2-3 mm). This system utilizes a patented processing insert that fits into a fluid bed processor. The key feature of this system is the use of compressed air to divert the product away from the spray nozzle tip, optimizing product movement through the spray zone. This minimizes agglomeration and improves both coating quality and coating times. The increased atomization volume from the accelerator spray gun enables faster solution application rates while ensuring proper atomization. Freund's specially designed perforated plate further enhances particle movement through the spray zone, leading to consistent and efficient coatings.

Wurster coating system for fine powders and pellets

Pilot

In pharmaceutical and nutraceutical industries, achieving uniform granulation and coating is essential for product consistency and quality. Traditional batch processes can be time-consuming and variable, requiring advancements in technology for better efficiency.
<h2>Combine granulation and coating in one process</h2>
The FC-MX FLO-COATER® from Freund is a versatile fluid bed system designed for both granulation and coating applications. It features a unique 3-piece construction for flexibility in processing capacities ranging from 20L to 1900L. Equipped with Freund's patented Wurster Accelerator System, the device ensures reduced process times and increased airflow, leading to effective material processing. Its EcoClean™ technology offers high-pressure, low-volume systems for self-cleaning and efficient maintenance. The intuitive color touchscreen control system supports both automatic and manual operation modes, ensuring ease of use. The system is validated for compliance with 21 CFR Part 11, meeting stringent regulatory requirements.

Fluid bed system for granulation and coating

In industrial manufacturing processes, achieving uniform granulation can be challenging due to varying particle sizes and moisture content. Consistent granulation is critical for efficient downstream processing and product quality.
<h2>Facilitates uniform and controlled granulation</h2>
The FC-M FLO-COATER® by Freund is a multipurpose fluid bed system designed for both pilot and production-scale granulation. The system offers flexible configurations with capacities ranging from 20L to 1900L, making it suitable for various production volumes. It utilizes top spray granulation and bottom spray for both solution and powder coatings. The patented Wurster Accelerator System significantly reduces process times, while the GRANUREX® rotor technology enhances solution/suspension coating, spherical granulation, and polymer/powder layering. Additionally, the system includes EcoClean™ technology, which features high-pressure, low-volume cleaning systems and removable cartridge filters with single-point cleaning connections. Optional inline PAT monitoring provides real-time moisture and drying analysis to ensure optimal processing conditions. The FC-M FLO-COATER® is designed to meet the rigorous requirements of industries such as pharmaceuticals, food processing, and chemicals.

Fluid bed granulator for industrial granulation

Analysis

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

In laboratory-scale applications, achieving efficient drying, granulation, and coating processes while conforming to solvent processing regulations is critical. Limited space, need for flexibility, and stringent safety standards pose additional challenges in these environments.
<h2>Perform drying, granulation, and coating processes</h2>
The FC-LAB Mini FLO-COATER® from Freund is a self-contained development fluid bed system designed for laboratory-scale applications that require solvent processing. The system includes a unique combination product container and Wurster processing insert, eliminating the need for additional costly components. With a capacity range of 0.8L to 2.5L, it offers flexibility in processing activities and comes equipped with a product sampling port and HEPA filters for both inlet and exhaust. For ease of use, it features an integrated peristaltic pump and a color touchscreen control system for automatic (recipe driven) and manual modes. The FC-LAB Mini is compliant with UL, CE, NFPA, and CSA design standards, and meets Class 1, Division 2 and ATEX Zone 2 safety standards.

Laboratory fluid bed system for solvent processing

Entry level

In pharmaceutical or chemical development, scaling up or testing new formulations requires precise and adaptable processing systems. Addressing small batch requirements with high flexibility can be challenging.
<h2>Perform granulation, coating, and drying processes</h2>
The FC-LAB Micro FLO-COATER® from Freund is a multi-purpose benchtop fluid bed system tailored for feasibility studies. This self-contained unit can handle batches from as small as 20 grams to as large as 600 grams, offering flexibility with its capacity. The system supports top spray granulation, bottom spray coating, and drying processes without the need for inserts. Key features include an integrated peristaltic pump, a removable spray gun, and product screens, which facilitate quick changeover and cleaning without tools. It also includes a color touchscreen control system for validatable process control, making it user-friendly. With optional components like a nano container for volumes down to 5 grams and the Smart-Safe™ Containment for enhanced safety, the FC-LAB Micro is versatile. It complies with UL, CE, NFPA, and CSA design standards, and meets Class 1, Division 2, and ATEX Zone 2 safety standards.

Development fluid bed system for feasibility studies

In many R&D labs, there's a need for versatile systems that can handle various granulation and coating processes efficiently. However, traditional systems can be cumbersome to maintain and switch between different processes, leading to increased downtime and associated costs.
<h2>Flexible granulation and efficient coating</h2>
The FC-LAB 3XL FLO-COATER® by Freund is a laboratory-scale fluid bed system designed to address the diverse needs of process development. This system stands out due to its combination product container/Wurster processing insert and integrated solution pump, eliminating the need for additional costly components. It supports drying, top spray, and bottom spray capabilities, as well as optional GRANUREX® rotor insertion. The design allows for quick changeovers and easy cleaning, enhancing operational efficiency. Featuring a patented Wurster Accelerator System, it reduces process time significantly. With portable and self-contained design, the FC-LAB 3XL FLO-COATER® offers flexibility for aqueous and solvent processing. Optional features include inline PAT monitoring for real-time moisture and drying analysis, and a Smart-Safe™ containment system to maintain safety standards. It complies with CE, ATEX, UL, NFPA, and CSA standards, making it viable for various lab applications.

Laboratory fluid bed granulator and coater

In pharmaceutical and chemical research, developing processes for granulation and coating requires precise control and flexibility. Researchers need equipment that can handle multiple processes while ensuring easy cleaning and quick changeover to maximize efficiency during development stages.
<h2>Supports granulation, coating, and drying processes</h2>
The FC-LAB 1 FLO-COATER® by Freund is a laboratory scale fluid bed system designed for versatile process development. It supports drying, top spray, and bottom spray capabilities, with an optional GRANUREX® rotor insert for enhanced granulation and coating functions. The system features a combination product container and Wurster processing insert with an integrated solution pump, eliminating the need for additional costly add-ons. The portable and self-contained design ensures easy integration and removal with simple electrical and compressed air connections. An intuitive color touchscreen control system facilitates both automatic and manual operation, with validatable process controls such as inlet airflow and temperature control. With a quick-changeover design, no tools are required for process changeover, making it highly efficient for research environments. The unit conforms to CE, ATEX, UL, NFPA, and CSA standards, ensuring it meets various international safety and performance criteria.

Laboratory scale fluid bed system for granulation and coating

In the pharmaceutical and chemical industries, efficient granulation and coating processes are essential for producing high-quality products. Challenges often include long process times and complex material handling requirements that demand precise control and flexibility.
<h2>Granulate and coat in a single vessel</h2>
The Fluid Bed Processor by Fabtech is designed to handle multiple processes like granulation and coating within a single vessel. This combined approach reduces material handling and process times compared to other wet granulation processes. The top spray method in the fluid bed system produces granules with a porous structure that enhances wettability. This system is cGMP and 21 CFR Part 11 compliant and constructed with SS 316/SS316L for lab, pilot, and commercial production models. The contact parts feature a mirror finish, while the non-contact parts have a matt finish. Additional features include a pneumatically controlled damper for accurate air monitoring, a 3-stage filtration system, and a spray gun for precise control. It also supports high containment isolation systems to ensure operator safety.

Fluid bed processor for granulation and coating

In pharmaceutical manufacturing, ensuring consistent product quality and compliance with stringent regulations is crucial. Achieving optimal granulation can be challenging, especially when transitioning from clinical samples to full-scale production batches and meeting regulatory standards like 21 CFR Part 11.
<h2>Handles mixing, granulation, and drying processes</h2>
The CCS granulation line by Diosna integrates a mixer-granulator with a fluid bed processor to streamline wet granulation and subsequent drying. The system features quick change of material containers without tools, allowing efficient batch processing. Its through-the-wall setup ensures strict separation between production and technical areas, enhancing contamination control. Automated processes backed by 21 CFR Part 11 compliant PC control and remote maintenance bolster operational efficiency. Pressure-shock resistant up to 12 bar, the fluidized bed unit meets regulatory and safety requirements, including ATEX standards. With user-friendly terminals and customizable container sizes, the CCS line is suitable for adapting to diverse production needs in the pharmaceutical industry.

Granulation line for pharmaceutical manufacturing

In the pharmaceutical and chemical industries, developing reliable, scalable processes at the laboratory level is crucial. This can often be challenging and time-consuming due to the need for high flexibility and precise control over various parameters.
<h2>Combines fluid-bed drying and coating</h2>
The Midilab RC from Diosna is a versatile laboratory unit designed to accelerate your product and process development. It integrates both a fluid-bed module and a drum coating module, allowing for comprehensive testing and development in one compact system. The fluid-bed module supports processes such as drying, top and tangential spray, and Wurster coating in four different material containers ranging from 7 to 20 liters. The drum coating module is suitable for film and sugar coating, and can handle batch sizes from 2 to 16 kilograms. The unit’s tool-free, quick-change modules and integrated systems for air preparation, heating, and fan functions make it a practical choice for many laboratory settings. Operation is made easy via a swiveling and tilting touch screen with a stainless steel housing. The system is 21 CFR Part 11 compliant and features a semi-automatic cleaning mode for ease of maintenance.

Midilab for efficient laboratory-scale product development

When you're transitioning from laboratory to large-scale production, optimizing processes like granulating, drying, and coating is crucial. Space limitations in pilot plants or production halls often complicate this scale-up, requiring solutions that offer flexibility and efficient use of available space.
<h2>Granulates, dries, and coats with scalable flexibility</h2>
The CAP 10-80 RC by Diosna is a comprehensive fluidised bed processor designed for pilot-scale operations, ideal for producing granulates, powders, and coated tablets. This versatile system supports top, bottom, or tangential spray technologies, enabling fluid bed granulation, drying, and Wurster coating to be performed efficiently. Its low installation height and swiveling centre section ensure easy integration into spaces with low ceilings. The system features the Rapid Change principle, allowing for quick and flexible changes of product bowls, covering diverse batch sizes from 5 to 36 kg. Additionally, its design includes pressure shock resistance and inflatable seals for safety. The apparatus streamlines automated processes and recipe storage, enhancing process optimization. Crucially, the filter housing is located at body height and can be swiveled for convenient access to filter elements, ensuring minimal maintenance disruptions. Diosna’s CAP 10-80 RC is fully qualified for production-scale use, adhering to GMP standards with CIP and WIP cleaning concepts, making it an excellent choice for industries such as pharma solids and fine chemicals.

Fluid bed processor for granulating, drying, and coating in pilot scale

In pharmaceutical and chemical laboratories, rapid and efficient product and process development is crucial. You need a versatile solution that offers both fluid-bed drying and tablet coating capabilities without compromising on flexibility or ease of operation.
<h2>Combine fluid-bed drying and tablet coating</h2>
The Midilab RC by Diosna is a laboratory unit integrating both a fluid-bed module and a drum coating module, facilitating efficient product and process development. This unit supports various batch sizes, ranging from 0.6 to 16 kg, depending on the module and process. The Midilab RC is equipped with a swivelling and tilting touch screen for easy operation. Its modules can be changed without tools, simplifying transition between processes. The unit can handle drying, top and tangential spray, and Wurster coating with fluid-bed containers of 7, 12, 16, and 20 liters. Similarly, the drum coating module is capable of film and sugar coating with drum sizes of 7, 12, and 20 liters. The unit includes integrated air preparation, heater, and fan, ensuring plug & play operation. It is 21 CFR Part 11 compliant, making it suitable for regulatory environments.

Laboratory fluid-bed dryer and tablet coater

Drying various industrial materials, such as fibers, fish meals, clays, metallic powders, and grains, often requires precise, efficient, and controlled drying processes to prevent product degradation and ensure uniform quality.
<h2>Efficient drying with controlled residence time</h2>
The Vertical Flash Dryer from Crown Iron Works is designed for the efficient drying of a wide range of fine and coarse materials. It utilizes a combination of hot air and static classification to evenly disperse the material into the drying column. The dryer features adjustable residence times, allowing for efficient moisture removal without particle breakage. This flexibility makes it suitable for drying temperature-sensitive materials. The vertical construction minimizes floor space requirements, while custom-engineered systems enhance energy efficiency. The dryer supports both direct and indirect heating systems, using various heat sources. Crown Iron Works offers this solution primarily for sectors like oilseed processing, specialty chemicals, and plant-based proteins.

Vertical flash dryer for industrial drying applications

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

When developing small batches of pharmaceutical products, precise control over granulation and drying is crucial. Ensuring that the powders and granules are processed effectively can pose a significant challenge without the right technology.
<h2>Granulate and dry small quantities with precision</h2>
The laboratory fluid bed dryer by Cos.Mec is designed specifically for the granulation and drying of small quantities of pharmaceutical products. It offers advanced features such as high-retention polyester filter cartridges, which ensure efficient drying and granulation processes. The dryer allows for repeated cartridge filter cleaning using compressed air counterblows while the processes continue uninterrupted. This model also includes a rupture disc, sample thief, and inspection windows for easy monitoring and operation. The system operates with automatic management via a PLC and touch screen operator panel. Notable accessories include options for gravimetric or vacuum loading, internal washing (WIP), and air dehumidification for the Air Treatment Unit. Parts in contact with the product are crafted from AISI 316 L stainless steel with a mirror glass polished finish for optimal hygiene and performance, while parts not in contact are made from AISI 304 stainless steel. Cos.Mec equipment complies with CFR 21 part 11 standards for automated systems.

Laboratory fluid bed dryer for pharmaceutical granulation

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

A loading system feeds your continuous or batch processing machine with the specified material or item in line with the flow of production. Loaders transfer the articles from one stage of preparation to the next with uniformity and accuracy.

Loading

In cereal production, maintaining the precise color, texture, and taste of flaked or puffed products is crucial. Traditional methods may not offer the necessary control, leading to inconsistencies in product quality.
<h2>Ensure uniform quality with fluid-bed technology.</h2>
The AeroToast Fluid-bed toaster from Bühler offers precise control over color, texture, and taste for cereal processing, thanks to its high-velocity impingement technology. This innovative toaster utilizes individually controllable process zones to optimize product characteristics. Its high-velocity air and re-circulated heated airflow enable rapid heat transfer, reducing operating costs. The fluidized air during the conveying process ensures uniform product quality by generating a high thermal transfer rate. Additionally, the AeroToast’s fully-welded frame and quality construction materials facilitate superior sanitation, minimizing cleaning downtime. Optional features such as an airflow cooler prepare the product for downstream processes, ensuring that it meets specific requirements for subsequent packaging or processing stages.

Fluid-bed toaster for cereal processing

<span style="font-weight: 400">The heating process is a step of raising the temperature of food, pharma, cosmetics, and many other types of products. You may employ different heating solutions for this process, depending on the type of product you intend to manufacture. Selecting the appropriate heater machine for your product is quite important since various products require different ranges of temperatures and different ways of heat transfer using exchangers. Industrial heating equipment varies in two ways - the type of material it can process and the reaction you want to achieve.</span>

Heating

In pharmaceutical manufacturing, achieving consistent granule size and composition is crucial for the production of solid dosage forms like tablets. Traditional batch granulation methods can be time-consuming and labor-intensive, requiring advanced solutions for continuous operation and precise control.
<h2>Provides consistent granule size for pharmaceuticals</h2>
The continuous wet granulation equipment by Austar, developed in partnership with NEUHAUS NEOTEC, offers a comprehensive solution for the pharmaceutical industry. The system integrates auto loss-in-weight feeding, mixing, granulating, drying, tableting, and tablet coating, ensuring seamless operation. It supports top-spray granulating and bottom-spray pellet coating using a horizontal fluid bed processor. Capable of handling scales from pilot (20 kg/h) to commercial production (>2000 kg/h), it features an automatic control system compliant with data integrity requirements from EMA and FDA. The production line holds ATEX explosion-proof certification from the EU, incorporating PAT technology for real-time process monitoring and feedback.

Continuous wet granulation equipment

In the biomass industry, various drying methods struggle to efficiently handle large particles like wood chips and green waste. This often results in uneven drying and high energy consumption, prompting the need for more effective and economical solutions.
<h2>Provides efficient drying for all biomass types</h2>
The Rolling Bed Dryer WB-T by Allgaier Process Technology is designed to effectively dry all types of biomass using a low temperature level and long residence time. This equipment combines the benefits of both Drum Dryers and Fluidized Bed Dryers. The product layer is positioned on a perforated plate, with drying air circulating from below, ensuring consistent and gentle drying. An agitator stirs the product for excellent mixing and transport, preventing the formation of moist zones and ensuring uniform drying. It is highly suitable for waste/recycling, biofuel industries, and agriculture, efficiently handling large wood chips, green waste, bioresidues, and digestate. The low operating costs are a result of utilizing residual energy.

Biomass drying solution

In industries such as chemicals, fodder, and foodstuffs, managing bulk materials with low feed moisture and uniform grain size can be challenging. Effective drying and cooling processes are crucial to maintaining product integrity and efficiency, especially with materials like salt, soda, and potato granules.
<h2>Optimize bulk material drying and cooling</h2>
The Allgaier Fluidized Bed Dryer/Cooler with Heat Exchangers WS-HF-T/K is designed for efficiently drying and cooling bulk materials. The equipment uses tube bundle heat exchangers in a fluidized solid bed to ensure a constant heat supply or removal. This allows for high water evaporation and cooling capacities at low air volumes and temperatures, significantly reducing thermal and electrical energy consumption. It's particularly suitable for processing materials with low feed moisture and low lump-forming tendencies. The compact design minimizes the size of the dryer and associated air equipment components, making it easy to integrate into various systems. Common heating media like saturated steam, hot water, or thermal oil can be used, offering flexibility in different operational environments.

Fluidized bed dryers/coolers for bulk material processing

Drying bulk materials such as granulates, powders, or other granular materials requires efficient and uniform heat distribution. Traditional drying methods can struggle with large particles and high moisture content, often resulting in uneven drying and higher energy consumption.
<h2>Ensures efficient drying with vibration support</h2>
The fluidized bed dryer from Allgaier Process Technology is designed for drying and cooling a wide variety of bulk materials effectively. Utilizing a fluidized bed system, the dryer maintains particles in suspension using hot gas streams (air or inert gas), allowing for consistent heat distribution. Vibration support ensures optimal drying even for materials with poor flowability or higher moisture content. The system can be configured in static or vibratory modes and includes options like cantilever or two-mass oscillator drives. Heating mechanisms can range from direct gas/oil burners to electric coils, or through heat recovery systems, making it energy-efficient and adaptable. Ideal for the food, pharmaceutical, and chemical industries, the fluidized bed dryer offers compact design options and high performance across multiple applications.

Fluidized bed dryer for industrial materials

Managing high-moisture bulk materials in industrial processes, such as powdered chemicals or food products, often requires an efficient drying solution to avoid lengthy processing times and additional costs. A solution ensuring rapid, thorough drying without the need for product recirculation is essential.
<h2>Dry bulk materials efficiently in seconds</h2>
The Allgaier Flash Dryer is a high-performance drying unit designed specifically for handling bulk materials with high moisture content. Utilizing a fluidized bed dryer design, the Flash Dryer enables drying in seconds without product recirculation. The drying gas enters through a nozzle below the perforated air distribution plate, ascending in a spiral motion. The moist product is introduced through a feed pipe and dispersed by a rapidly rotating centrifugal wheel, optimizing heat and mass transfer. This method allows for efficient drying compared to conventional stream dryers. Industries such as food, chemicals, pharmaceuticals, and recycling benefit from its compact design, wide range of applications, and ability to handle moist, lumpy materials. Allgaier Process Technology, the supplier, ensures effective and flexible drying solutions with various heating options including natural gas, steam, hot water, electric heat, or thermal oil.

Flash dryer for high-moisture bulk materials

In pharmaceutical manufacturing, achieving efficient and dust-free granulation processes is essential for producing high-quality products. Traditional approaches often fall short in terms of efficiency, safety, and space utilization, posing significant challenges for manufacturers.
<h2>Combines high-shear mixing and fluid-bed systems</h2>
The GT series from ACG World is an integrated granulation system designed to optimize manufacturing efficiency while ensuring safe, single-handed operation. The system combines an advanced high-shear mixer (HSM) and fluid-bed (FBE/FBC) system, which are designed in Germany. It achieves a highly efficient, dust-free wet granulation process within a cost-effective, closed-loop design. The contained product handling is supported by a vacuum charging system that ensures closed-loop transfer for smooth material flow and minimum product leftover. The compact design reduces floorspace requirements by around 50%, and the through-the-wall construction allows clear separation between processing and technical areas, ensuring easier maintenance, cleaning, operation, and GMP compliance. Additionally, multiple systems for charging, discharging, and WIP (wash-in-place) minimize dust generation and product exposure, making GMP compliance easier. The equipment can be customized to a wide range of product and process requirements.

Integrated granulation train for pharmaceutical processes

Industrial washing systems are used to clean and disinfect a variety of items in research and manufacturing facilities. Industrial washers use solvents and cleaning agents with mechanical action to remove deposits and residues from stainless steel machinery components, empty containers, and other soiled surfaces. The selection of an industrial or commercial washer depends on the type of items and surfaces to be cleaned, the type of deposits/residue that is typically present, whether drying is required after rinsing and the level of sterilization necessary. Manufacturers will have cleaning specifications and as a result, require washers to be engineered to meet these specs.

Washing

When developing and scaling pharmaceutical formulations, finding an efficient and safe method for granulation and drying is crucial. Top-spray granulation and wet-mass drying processes require equipment that ensures consistent results while maintaining operational safety standards.
<h2>Enhance granulation and drying safety</h2>
The FBE 1800 X•ONE from ACG World is designed to provide advanced fluid bed granulation and drying for batches up to 1,800 liters. Manufactured in their Design Centre in Mülheim, Germany, it offers exceptional performance and operational safety. It features a 12-bar pressure-shock-resistant system, equipped with the MOST™ concept, approved by FSA from Germany, ensuring no mechanical deformation occurs during pressure shocks. The system supports applications such as top-spray granulation, wet-mass drying, and hot-melt granulation. With ATEX (Directive 2014/34/EU) compliance, the FBE 1800 X•ONE integrates unique C-flanges to prevent the external release of explosion pressure, X•ONE inflatable seals for low-pressure safety, and QASV (Quick Action Stop Valves) that contain explosions within 20 milliseconds. Additionally, the exclusive X•ONE command process control system facilitates secure and intuitive monitoring, adhering to GAMP 5 and 21 CFR Part 11 standards. The fluid bed granulator is customizable with charging, discharging, and WIP (wash-in-place) systems, available in standalone or granulation-train configurations suitable for the pharmaceutical industry.

Fluid bed granulator for pharmaceutical applications

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

In pharmaceutical and nutraceutical production, processing large batches often demands efficient drying and granulation techniques to ensure product quality and consistency. Limitations in traditional methods can lead to prolonged processing times and incomplete granulation, requiring advanced solutions tailored specifically for these industries.
<h2>Dry and granulate batches up to 1,300 liters</h2>
The FBE 1300 is a high-performing fluid-bed system from ACG World, designed for both drying and top-spray granulation. It is ideal for pharmaceutical and nutraceutical production, accommodating batches up to 1,300 liters. The system ensures operator and product safety with a precisely calculated and tested vent for handling pressure shocks. A state-of-the-art filter bag shaking system maximizes filtration area while minimizing compressed air consumption, making it more efficient and easier to maintain. Additionally, the 21 CFR part 11-compliant PC control system provides a regulatory-compliant, audit-friendly environment. The equipment is flexible, available in customized charging, discharging, and wash-in-place (WIP) systems, suitable for standalone or granulation-train configurations. The working volume ranges from 335 to 1,288 liters, depending on the bulk density of the material.

Fluid-bed drying and granulation system

In pharmaceutical manufacturing, ensuring uniform particle size in granulation can be challenging when working with batch processes. Processing efficiency and operational safety are often major concerns, requiring reliable technology to optimize granulation and drying.
<h2>Granulate and dry batches up to 125 liters</h2>
The FBE 125 X•ONE from ACG World is an advanced fluid-bed system designed for top-spray granulation and drying. Developed at the company’s Design Centre in Mülheim, Germany, it offers superior performance and operational safety. With a working volume range from 33 to 168 liters, it is suitable for handling batches up to 125 liters. The system includes a 12-bar pressure-shock-resistant design featuring the MOST™ concept, approved by FSA from Germany and compliant with ATEX (Directive 2014/34/EU). The unique C-flanges prevent explosion pressure transfer beyond the unit, and the X•ONE inflatable seals ensure safety at pressures as low as 4.5 bar. The integrated QASV (Quick Action Stop Valves) contain explosions within 20 milliseconds. Additionally, the X•ONE command process control system provides secure and intuitive monitoring, compliant with GAMP 5 and 21 CFR Part 11 standards. The unit comes with customized charging, discharging, and WIP (wash-in-place) systems for efficient processing and reduced changeover times.

Fluid-bed granulator for top-spray applications

Achieving consistent granulation and drying in the pharmaceutical industry requires equipment that ensures precise control and efficiency. Ensuring that granules have the right moisture content and consistency is essential to producing high-quality pharmaceutical and nutraceutical products.
<h2>Streamlines fluid bed drying and granulation</h2>
The FBE 125 from ACG World is an advanced fluid bed solution designed for pharmaceutical and nutraceutical applications, offering top-spray granulation and wet-mass drying. Capable of handling batches up to 125 liters, it is ideal for efficient processing. The system features a precisely calculated and practically tested vent that ensures operator and system safety during pressure shocks. Additionally, its state-of-the-art filter bag shaking system maximizes filtration area and reduces the use of compressed air, making it both easier to handle and more effective in cleaning. The FBE 125 includes customizable charging, discharging, and WIP (wash-in-place) systems, which can be configured as standalone units or integrated into granulation trains. The 21 CFR part 11-compliant PC control system ensures regulatory compliance and is audit-friendly. This system is suitable for top-spray granulation, wet-mass drying, and hot-melt granulation, providing a comprehensive solution for fluid-bed processing needs.

Advanced fluid bed for pharmaceutical granulation

In pharmaceutical and nutraceutical manufacturing, achieving consistent drying and granulation while ensuring operator safety is a primary challenge. This is particularly true when scaling up processes and conducting design of experiments (DoE) studies, which require versatile and reliable equipment.
<h2>Supports drying, granulation, and coating processes</h2>
The QUEST FB III X•ONE by ACG World is a versatile fluid bed system designed for intermediate-scale applications. It is equipped to handle multiple processes including drying, wet granulation, Wurster coating, top-spray, tangential-spray, and rotor granulation. The system incorporates advanced safety features such as a 12-bar pressure shock-resistant design and unique C-flanged inflatable seals that resist deformation even at low pressures. The twin-filter bag-shaking system effectively removes sticky materials, enhancing filter performance and yield. The integrated X•ONE command process control system complies with ATEX, GAMP 5, and 21 CFR Part 11, offering secure and intuitive control. This equipment is well-suited for both commercial-scale and developmental applications, thanks to its robust design and scalability.

Intermediate-scale fluid bed system for drying and granulation

In laboratory-scale pharmaceutical and nutraceutical production, the need for flexible operation and precise control is paramount. Challenges include managing multiple processes such as granulation and coating with minimal equipment adjustments.
<h2>Combines granulation and coating efficiently</h2>
The ACG World QUEST FB is a compact, portable fluid-bed unit designed for R&D applications. This system features both top-spray and Wurster coating technologies within a single container, making it highly adaptable for various operations. Its configurability allows seamless transition between granulation and coating processes with minor adjustments. The integrated weighing scale connected to a PLC (programmable logic controller) ensures precise spray-rate measurement, while the touchscreen HMI (human-machine interface) provides user-friendly control. The unit is equipped with multiple air distribution plates, enabling customization based on specific product requirements. Ideal for tasks such as top-spray granulation, wet-mass drying, and hot-melt granulation, the QUEST FB enhances process efficiency and flexibility in lab environments.

Versatile fluid bed combo for granulation and coating

Weighing

In pharmaceutical and nutraceutical manufacturing, achieving efficient granulation and coating of particles can be challenging without the right technology. Various processes such as drying, particle coating, and spray agglomeration require precise control to ensure high-quality output.
<h2>Dry, granulate, and coat with precision</h2>
The GPCG 1.1 by ACG World is a versatile fluid bed combo designed for a wide range of granulation and coating applications. This equipment supports drying, granulation, particle/pellet coating, dry-powder layering, spray agglomeration, and hot-melt coating. It features both top-spray and Wurster coating technologies. Its mobile plug-and-play design with an optional integrated air-handling unit makes it highly portable and user-friendly for quick application switches. The inclusion of multiple interchangeable air-distribution plates allows users to select and install the most suitable plate for their product. Filter bags with a shaking mechanism ensure faster and more effective cleaning. The hinged filter-housing design reduces height and enhances mobility. Suitable for feasibility and scale-up studies, the GPCG 1.1 has a working volume range from 0.5 liters up to 4 liters.

Fluid bed combo for granulation and coating

In pharmaceuticals and nutraceuticals manufacturing, achieving multiple processing steps such as drying, granulation, and coating in a single operation is essential to enhance process efficiency and reduce downtime. Handling large batch sizes efficiently while ensuring safety and cleanable degrees of freedom pose significant challenges.
<h2>Handle multiple processes in one system</h2>
The FBE 250C from ACG World is a versatile fluid bed combo, designed to significantly enhance your process efficiency with its multi-functional capabilities. Featuring top-spray granulation and Wurster coating technology within a single system, this equipment can carry out drying, top-spray granulation, hot-melt granulation, tangential spray granulation, rotor-based drug layering, and tangential spray processes. Its precisely calculated and tested vent ensures operator and equipment safety by managing pressure shocks. The state-of-the-art twin-chamber filter bag shaking system optimizes fluidization and cleaning while consuming less compressed air. The product container, equipped with multiple air-distribution plates, allows customization based on product requirements. Available in standalone and granulation-train configurations, the system also offers customized charging, discharging, and wash-in-place (WIP) systems for efficient formulation processing and easy maintenance.

Fluid bed combo for top-spray granulation and wurster coating

In the pharmaceutical industry, dealing with varied processes such as drying, granulation, and coating often requires multiple machines, adding complexity and inefficiency to production lines. This creates a need for versatile, robust equipment that can handle multiple processes within a single system.
<h2>Integrated drying, granulation, and coating</h2>
The FBC 1800 X•ONE by ACG World is a versatile fluid bed combo designed to handle drying, top-spray granulation, and Wurster coating for batches up to 1800 liters. The 12-bar pressure shock-resistant system incorporates the MOST™ concept, ensuring supreme operator safety and compliance with ATEX (Directive 2014/34/EU). Unique features such as C-flanges prevent explosion pressure transfer, while QASV ensures containment of explosions within 20 milliseconds. The system also offers customizable charging, discharging, and WIP (wash-in-place) configurations to enhance efficiency and safety during granulation and pellet processing. The exclusive X•ONE command process control system allows intuitive and secure monitoring, compliant with GAMP 5 and 21 CFR Part 11. With components developed in collaboration with Düsen-Schlick GmbH, this solution ensures enhanced productivity and simplified operation and cleaning.

In pharmaceutical manufacturing, achieving precise granulation and coating of powders while ensuring operator safety is critical. Challenges include controlling dust, preventing cross-contamination, and ensuring uniform coating of particles.
<h2>Combines drying, granulation, and coating processes</h2>
The FBC 125 X•ONE by ACG World is a versatile fluid bed combo designed for diverse applications such as drying, top-spray granulation, and Wurster coating, capable of handling batches up to 125 liters. This system is equipped with the MOST™ (Maximum Operator Safety Technology) concept, approved by the FSA and compliant with ATEX Directive 2014/34/EU, ensuring supreme safety. The innovative C-flanges prevent explosion pressure transfer beyond the system, while the X•ONE inflatable seals provide safety even at low pressures. The system includes Quick Action Stop Valves (QASV) that contain explosions within 20 milliseconds. Furthermore, the exclusive X•ONE command process control system allows intuitive, secure monitoring and control, complying with GAMP 5 and 21 CFR Part 11 standards. Additionally, the machine features patented nozzles developed in collaboration with Düsen-Schlick GmbH, enhancing productivity and simplifying operation and cleaning.

Fluid bed dryer with granulation and coating

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Apart from soil and water pollution with cholates, chlorine, and metal compounds,  the paper industry is in the world's top 10 largest energy consumers.


<h3>Reduce your paper pulp drying time and energy consumption with superheated steam</h3>
The ExergyPSSD® uses superheated steam as the drying and conveying medium in a fully closed-loop process that operates under pressure. Treated with superheated steam in a low-pressure environment, the wet product is quickly dried off.

The superheated steam serves as a transport gas and drying media and vaporizes the moisture in the product in only 15 seconds. This essentially means that the moisture is efficiently evaporated using steam.  The dried product and superheated steam are separated in a cyclone and the steam is recirculated and reheated. Some of the excess steam is discharged through a pressure control valve to maintain constant pressure in the dryer, which can be recovered and recycled as an energy, heating, or evaporating source used in other processes for example.

The dryer is indirectly heated which means that it is tailored to be integrated with whatever heat source is available- steam, hot water, thermal oil, engine exhaust, electricity, or flue gas to name a few.

The solution by Swedish Exergy is ideal for drying porous particles that tend to trap moisture and has proven to provide substantial benefits in many industries like biomass- and biofuels, paper pulp, sludge, residues from various food industries, and DDGS.

Besides the short process time and energy efficiency, the ExergyPSSD® occupies a small footprint compared with other traditional drying technologies.

Energy saving vertical steam dryer for paper pulp

Traditional drying technologies with low investment cost, such as hot air drying, are high maintenance, energy–intensive, and relatively slow processes.  It may also require additional expensive equipment, like air treatment or firefighting.


<h2>Reduce your feed drying time and energy consumption with superheated steam</h2>
The ExergyPSSD® uses superheated steam as the drying and conveying medium in a fully closed-loop process that operates under pressure. Treated with superheated steam in a low-pressure environment, the wet product is quickly dried off.

The superheated steam serves as a transport gas and drying media and vaporizes the moisture in the product in only 15 seconds. This essentially means that the moisture is efficiently evaporated using steam.  The dried product and superheated steam are separated in a cyclone and the steam is recirculated and reheated. Some of the excess steam is discharged through a pressure control valve to maintain constant pressure in the dryer, which can be recovered and recycled as an energy, heating, or evaporating source used in other processes for example.

The dryer is indirectly heated which means that it is tailored to be integrated with whatever heat source is available- steam, hot water, thermal oil, engine exhaust, electricity, or flue gas to name a few.

The solution by Swedish Exergy is ideal for drying porous particles that tend to trap moisture and has proven to provide substantial benefits in many industries like biomass- and biofuels, paper pulp, sludge, residues from various food industries, and DDGS.

Besides the short process time and energy efficiency, the ExergyPSSD® occupies a small footprint compared with other traditional drying technologies.

Energy efficient steam dryer for feed products

Traditional dryers and heat transfer systems, like belt-, drum- or bed dryers are versatile solutions used in various applications, from sawdust to sludge. One of their main advantages is the low initial investment cost. On the other hand, however, traditional drying technologies, such as hot air drying, are high maintenance, energy–intensive, and relatively slow processes that require a lot of additional expensive equipment, like air treatment or firefighting.


<h3>Reduce drying time and energy consumption with superheated steam drying</h3>
The ExergyPSSD® uses superheated steam as the drying and conveying medium in a fully closed-loop process that operates under pressure. Treated with superheated steam in a low-pressure environment, the wet product is quickly dried off.

The superheated steam serves as a transport gas and drying media and vaporizes the moisture in the product in only 15 seconds. This essentially means that the moisture is efficiently evaporated using steam.  The dried product and superheated steam are separated in a cyclone and the steam is recirculated and reheated. Some of the excess steam is discharged through a pressure control valve to maintain constant pressure in the dryer, which can be recovered and recycled as an energy, heating, or evaporating source used in other processes for example.

The dryer is indirectly heated which means that it is tailored to be integrated with whatever heat source is available- steam, hot water, thermal oil, engine exhaust, electricity, or flue gas to name a few.

The solution by Swedish Exergy is ideal for drying porous particles that tend to trap moisture and has proven to provide substantial benefits in many industries like biomass- and biofuels, paper pulp, sludge, residues from various food industries, and DDGS.

Besides the short process time and energy efficiency, the ExergyPSSD® occupies a small footprint compared with other traditional drying technologies.

Exergy pressurized superheated steam dryer

Processed grains absorb moisture throughout the production line. Lowering that water content is essential for quality and shelf life, but achieving this can be challenging with delicate materials such as flaked oats.


<h2>Use gentle systems to regulate the moisture content of oats</h2>
Schule developed a fluidized bed drier/cooler for fragile processed grains. This technology cools the steamed flakes, dries off excess moisture, and is made of food-grade stainless steel. The gentle techniques preserve the integrity of the kernels to ensure a quality end product.

The system is designed for the food industry and is suitable for other applications, including cereals and legumes.

Fluidized bed drier/cooler for grains

It is rather difficult to successfully produce a pharmaceutical solid dosage forms with the desired properties such as size, morphology, hardness and friability. You need a solution that can transform fine heterogeneous powders into homogeneous blend of granules with bigger size and higher density in a short time and with repeatability. Wet granulation is carried out to convert fine and cohesive active ingredient and excipients, into more uniform, free-flowing granules that are optimised for downstream processing.
<h2>Achieve uniform particle size distribution for wet granulation</h2>
The High Shear Mixer Granulator from Romaco Tecpharm is configured to optimize the wet granulation process. It is used to turn a fine-powder heterogeneous mixture into a uniform granulation, with increased particle size and higher density.

The equipment offers you proper flow and compactness while having a shorter operational time. It can handle capacities ranging from 25 L to 1,400 L.The bottom impeller and the side chopper enables the intensive mixing in a short period of time. In addition, the equipment uses a synchronized system to avoid extrusion effect.

The high-shear granulator for drug formation processes the solid material down to the desired particle size, and the mixture is then pumped to the fluid bed dryer where the moisture is removed, leaving behind the granular product. During the process of wet granulation, the constituents of the oral solid dosage form blend are combined, along with agglutinative solution, to form granules with a homogenous composition.

Industrial high shear mixer granulator for drug formation

Fluid bed drying is a pharmaceutical process carried out to reduce the humidity and achieve the required moisture content in the granules or powders. It also applies binders or granulation liquid to facilitate the agglomeration of wet mass before further processing. When drying pharmaceutical granules, it is essential to avoid over-drying as this could result in significant wearing down, leading to product loss. To prevent losses and poor product quality, you need a fluid bed dryer to handle continuous operation.
<h2>An efficient, robust solution to dry pharmaceutical compounds</h2>
The Fluidized Bed Dryer from Romaco Tecpharm uses the drying process to reduce the moisture content in the granules. It can be configured as a dryer, granulator, and coater. It can thus dry wet granulate, top drive granulation, and bottom spray coating. It has a capacity from 30 L to 1,540 L, with other dimensions being available on request.

The fluid bed dryer for pharmaceutical solid dosage form is constructed with an in-wall design concept. It is equipped with a side-valve for automatic loading from the high shear mixer granulator. For the drying process, hot air is passed through a vacuum generated inside the machine. The wet solids rise from the bottom and are suspended in a current of air, remaining in a fluid state. The heat transfer and the low moisture content of the air in direct contact with the wet granule allow the evaporation of the water or solvents, reducing their humidity.

The equipment has a top spray that helps in carrying out the granulation. Next, the movement of the powder in a fluidized state is combined with the spraying of a binder solution. This combination allows increasing the particle sizing, generating a granulate. Finally, the coating process is carried out by combining the spraying of the coating suspension on the micro granules in a fluid bed movement.

Fluid bed dryer for pharmaceutical solid dosage form

<span style="font-weight: 400;">A complete granulation line allows for the mixing and granulation of pharmaceutical compounds for the production of tablets. By linking fully compatible milling, mixing and fluid bed machinery with vacuum conveying it provides a turnkey solution for preparation of powder doses ready for pressing into tablets.</span>
<h2>Complete solution for preparation of granular pharmaceutical compounds for tablets</h2>
<span style="font-weight: 400;">Sejong Pharmatech’s Granulation Line is the most cost-effective way to achieve a turn-key granulation solution for the manufacture of pharmaceutical compounds for tablet preparation.</span>

<span style="font-weight: 400;">The granulation line consists of the Sejong CM series production scale conical mill, the Sejong M series production-scale speed mixer, the Sejong D series production scale fluid bed dryer and an optional vacuum conveyor system for the creation of a completely closed line environment.</span>

<span style="font-weight: 400;">Designed for total compatibility, these devices work together seamlessly to provide the perfect input for tablet pressing machines. When buying as a line package, significant cost savings can be made compared to sourcing individual machines.</span>

<span style="font-weight: 400;">The optional vacuum conveyor removes the need for manual handling between processes, and ensure a clean and safe transfer of powders between process stages.</span>

<span style="font-weight: 400;">All the Sejong machinery is manufactured with ergonomics and ease of use in mind, and the touch screen HMI’s are fully 21CFR part 11 compliant.</span>

Granulation line of mixer and fluid bed dryer

<span style="font-weight: 400;">Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for drying compounds to achieve the required moisture content, as well as applying coatings or binders before further processing prior to the tablet formulation. For production-scale processes, a fluid bed dryer needs to be robust, easy to operate and flexible enough to handle continuous operation.</span>
<h2>Dry pharmaceutical compounds with increased control and reduced maintenance time</h2>
<span style="font-weight: 400;">The Sejong D Series is a production scale fluid bed dryer for use in the pharmaceutical industry, or in any scenario where powder fluid processes are required.</span>

<span style="font-weight: 400;">The D Series has been designed to offer a robust production unit with the highest levels of safety and operator ease of use. All valves, seals, flanges and weld points have been designed to be 12 bar pressure resistant. The ergonomic user interface uses graphical representations to allow a single operator to manage all aspects of the machine setup, running and discharge. Recipe systems allows full automation of the whole drying process, without user intervention.</span>

<span style="font-weight: 400;">The D Series filter system uses pulse blowback air to clear dust from the filters. This allows for a highly consistent fluid flow and can reduce the production time. For ease of maintenance, the in-built winch is computer-controlled to allow for quick and accurate filter maintenance.</span>

<span style="font-weight: 400;">For cleaning, the D series adopts a Clean in Place system using 3 low-flow rotary nozzles which are placed directly inside the body of the machine and powered by a high-pressure pump. This allows maximum cleaning performance with low water flow and minimal downtime.</span>

Fluid bed dryer for production scale

<span style="font-weight: 400;">Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compounds to achieve the required moisture content, as well as applying coatings or binders before further processing prior to tablet formulation. For R&amp;D work a fluid bed dryer with economical batch sizes is required, but it must also be able to scale up successfully for satisfactory full-scale production.</span>
<h2>Flexible lab-scale fluid bed dryer/granulator with advanced features</h2>
<span style="font-weight: 400;">The Sejong Pharmatech D5L is a compact small-scale fluid bed dryer/granulator with features specifically designed for lab work and small batch processing in volumes from 1 to 5 litres.</span>

<span style="font-weight: 400;">The D5L features both top and bottom spray arms for maximum flexibility, with fully adjustable height control for both. This allows the machine to be used for drying, granulating and coating.  The product container is ergonomic to use and makes adding and discharging compounds quick and simple, and the capacity is fully controllable based on the required production volume. The container also features a built-in sampler, to allow physical inspection of the progress of the cycle as it runs - perfect for R&amp;D situations.</span>

<span style="font-weight: 400;">The D5L features a full colour touchscreen with easy-to-read schematics for control and diagnostics, allowing the operator to monitor all parts of the cycle. All control software is fully 21CFR part 11 compliant.</span>

<span style="font-weight: 400;">The exhaust features a dust collection system with easy-to-change cartridge filter system, and the unit features a powerful 4.8kW electric coil heat exchanger for precise temperature control.</span>

Fluid bed dryer for lab scale

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

<span style="font-weight: 400;">Designed for pharmaceutical R&amp;D, a lab-scale fluid bed dryer and mixer/granulator combination provides a value-for-money solution that allows for economical yet scalable production of oral solid dosage compounds.</span>
<h2>Flexible R&amp;D fluid bed system for economical production of pharmaceutical powder doses</h2>
<span style="font-weight: 400;">Available in a range of batch sizes, the Sejong Pharmatech D5Lm drying and mixing machine has been designed for the economical preparation of lab-scale quantities of dry compounds.</span>

<span style="font-weight: 400;">With options for 1l, 3l and 5l capacity, the D5Lm can be specified to meet your exact requirements. Touchscreen controls with full schematic status indication provide easy visibility of the machine status and simple operation. The control system is fully 21CFR part 11 compliant.</span>

<span style="font-weight: 400;">With lower power consumption that two separate units, and only one air supply required, the D5Lm combined dryer/mixer unit is an economical lab or small batch production system.</span>

Fluid bed dryer and mixer for lab scale

Fluid bed dryers

Brewers' grain, also known as brewers' spent grain or BSG, is the residue of malt and beer production. This brewing by-product is sometimes wasted causing an important environmental impact, nevertheless, with the circular economy in mind, brewers' grain processing can turn waste into value mainly for the feed and food industry, tackling some of the sustainable development goals (SDGs).

Brewers grain

Croutons

Elderberry falls squarely in the category of superfoods. Every part of the plant (flowers, berries, and bark) is loaded with vitamins, antioxidants, bioflavonoids, and other compounds. However, cyanide in the plant could be lethal if consumed raw, making elderberry extraction processing complex.

Elderberry extract

Tissue paper can be traced back to tree fibres. But turning hardwood into soft sheets involves a string of manufacturing processes. Specialized facial tissue making machines adopt industry techniques such as drying and packaging to produce convenient boxes of silky paper.

Facial Tissues

The fishmeal powder market forecast shows that its global market value will reach USD 10.3 billion by 2025. Expanding since 2019, at an annual growth rate of 6.5%. Fishmeal powder production has strong business potential with the increase of applications in animal feed, pet food, and fortified foods.

Fishmeal powder

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Kaolin, also called china clay, is made from natural rock composed of aluminosilicate clay or kaolinite. Kaolin has wide applications in different industries. Moreover, their classification depends on their industrial use, which includes film formation, fiber extension, polymer extension and chemical composition. Choose a kaolin processing machine to help you make kaolin for beauty products, paper filler, coating, ceramics and even medicine.

Kaolin

Laundry detergents are currently on the rise due to increasing urbanization and the need for automation. The global market will reach $98,139.7 million by 2030 from $61,711.0 in 2020, influencing the demand for laundry detergent equipment. Unlike in Western countries, powdered detergents are more popular in Asia and China because they’re cheaper.

Laundry detergent

Basically, to make milk powder, you need to remove the water content from the liquid milk and turn it into powder. How to do it? After pasteurizing and homogenizing the milk, milk’s water content is removed through filtration, evaporation, and drying. You have then to cool and sieve it before filling the containers. Here's how you get milk powder.

Milk powder

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

Poultry feed

Powder detergent is one of the most widespread washing solutions used in the laundry of fabrics. Since they contain no water, powder detergents are lighter than liquid detergent or pods, which results in cheaper transport and, thus, a more affordable choice for the end consumer. Although manufacturers can formulate their powder detergents differently, the detergent powder production process relies on a combination of builders, surfactants, and enzymes.

Powder detergent

It took the scientific community almost 70 years to agree on the name ‘protein’ and discard the popular alternative, proteid. But protein powder processing still needed another five decades to be commercialized in the 1950s. Once extraction and purification could be industrialized, protein powder soon became a basic staple supplement.

Protein powder

Roasted nuts

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.