Granulation line for pharmaceutical manufacturing

Enhance your batch production with integrated mixer and fluid-bed technology, offering efficient granulation and drying processes for diverse applications.

Mixes, Granulates, and Dries Pharmaceutical and Food Products

The CCS Granulation Line from DIOSNA is designed to optimize your pharmaceutical and food processing needs. This system seamlessly integrates mixer-granulation and fluid bed processing, allowing for efficient wet granulation followed by precise drying. Capable of producing pharmaceutical tablets, cosmetic cream bases, and nutrient-rich granules, it facilitates everything from yeast-based pre-doughs to specialty chemical granules.

Utilizing a through-the-wall installation, it ensures a strict separation of production and technical areas, promoting operational hygiene and workspace efficiency. With automation in mind, the system is equipped with PC control that complies with 21 CFR Part 11, paired with remote maintenance capabilities to support uninterrupted production.

The CCS Granulation Line is designed to meet stringent safety standards and withstand pressure shocks of up to 12 bar, adhering to ATEX regulations. Its energy-efficient design reduces operational costs while maintaining high throughput, suitable for both pilot and full-scale production. With flexible container sizes and an intuitive interface, it accommodates varied batch sizes effortlessly, ensuring your production line meets evolving demands.

Furthermore, the system supports recipe creation and comprehensive data acquisition, documented with compliant software, enhancing your quality control processes. Available with customizable options, it can be tailored to fit specific application needs, including special solutions for containment in pharmaceutical settings, ensuring your operations are both efficient and compliant with industry standards.

Benefits

  • Streamlines production with seamless integration of granulation and drying processes.
  • Ensures operational safety and compliance with ATEX standards.
  • Enhances efficiency by reducing energy consumption through optimized process controls.
  • Provides flexibility with adaptable container sizing for various batch requirements.
  • Facilitates comprehensive quality control with 21 CFR Part 11-compliant data documentation.

General


Applications
Food,Feed,Dough,Fine chemicals,Pharma solids,Pre-dough,Cosmetics
End products
Bread dough mixes,Pharmaceutical tablets,Nutritional granules,Cosmetic cream bases,Specialty chemical granules,Animal feed pellets,Yeast-based pre-dough
Steps before
Material Container Preparation,Recipe Creation,Mixing
Steps after
Drying,Batch Data Documentation,Quality Control,Spray Granulation
Input ingredients
raw materials,clinical samples
Output ingredients
granulated products,production batches
Market info
Diosna is known for its expertise in manufacturing industrial dough mixing machines and systems, primarily for the bakery and food industries, showcasing a strong reputation for innovation, quality, and reliable engineered-to-order mixing solutions.

Technical Specifications


Automation
PC control,21 CFR Part 11 compliant,with remote maintenance
Pressure-shock resistance
Up to 12 bar
Batch documentation
21 CFR Part 11-compliant software
Batch vs. continuous
Batch

Operating Characteristics


Working mechanism
Mixing,Granulate,Drying - in combination
Integrated steps
Mixer-granulator and fluid bed processor
Batch vs. continuous operation
Batch
Automation level
PC control with remote maintenance
Changeover time
Quick change of material containers
Safety feature
Pressure-shock resistant up to 12 bar,ATEX compliant
Cleaning method
Compliant with GMP standards

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Granulation type
Wet granulation with drying
Spray granulation
Prepared,retrofittable

Custom Options


Control panel type
PC control,21CFR Part 11 compliant
Integration possibilities
Remote maintenance
Container change customization
Quick change of material containers without tools
System operation flexibility
Flexible operation by changing container size and two operating terminals
Installation design
Through-the-wall concept