Containment blister packaging for highly potent Apis

Ensure operator safety during the blister packaging of highly potent pharmaceuticals, with robust containment measures that meet strict Operational Exposure Band requirements, maintaining product integrity and minimizing cross-contamination risks.

Contains and Packages High-Potency Pharmaceuticals

The SECUREBLIS MINI from ACG is a state-of-the-art containment solution specifically engineered for blister packaging in the pharmaceutical industry. Designed to safely handle highly potent active pharmaceutical ingredients (HPAPIs), it operates under negative pressure environments to minimize operator exposure and ensure compliance with Operational Exposure Band (OEB) 3 standards. The SECUREBLIS MINI is versatile, capable of processing pharmaceutical tablets, hard capsules, and soft gelatine capsules with applications ranging from pain relief to multivitamins.

This machine integrates seamlessly into existing production lines, supporting both thermoforming and cold-forming processes with forming capabilities up to 25 cycles per minute and a maximum forming depth of 12 mm. It features advanced automation, including a wet-in-place (WIP) cleaning system complemented by HEPA filters, which ensures a contaminant-free environment. Its strategic glove ports allow manual interventions without compromising containment, enhancing safety and operational efficiency.

With options to utilize various forming materials, such as PVC and cold-form foil, and lidding materials including child-resistant and tropical foil, the SECUREBLIS MINI offers robust versatility. Its design facilitates fast, safe cleaning and changeovers, reducing downtime and improving throughput. Compliance with GMP and other pharmaceutical standards makes it an ideal solution for companies focusing on regulatory adherence and operator safety.

Benefits

  • Enhances operator safety by maintaining a contained environment, preventing exposure to high-potency compounds.
  • Improves production efficiency with quick changeovers, minimizing downtime.
  • Ensures regulatory compliance with GMP and OEB 3 standards.
  • Reduces cross-contamination risk with effective HEPA filtration and wet-in-place cleaning.
  • Facilitates seamless integration into existing blister packaging lines for versatile operation.

General


Applications
Soft gelatine capsules,Hard capsules,Pharmaceutical tablets
End products
Ibuprofen soft gel capsules,Vitamin d capsules,Anti-inflammatory capsules,Amoxicillin capsules,Probiotic capsules,Acetaminophen soft gels,Calcium supplements,Omega-3 fish oil soft gels,Multivitamin tablets,Pain relief tablets
Steps before
Granulation,Pelletisation,Encapsulation
Steps after
Packing,Cartoning,Vision Inspection
Input ingredients
tablets,hard capsules,soft gelatine capsules,HPAPIs,PVC,PVC/PVdC,Triplex (PVC/PE/PVdC),cold-form foil (Alu),push-through foil,child-resistant foil,peelable (paper),tropical foil,aluminium-based laminates
Output ingredients
blister packaged tablets,blister packaged hard capsules,blister packaged soft gelatine capsules,contained HPAPIs,sealed blister packs
Market info
ACG World is known for manufacturing capsules and capsule filling machines, providing integrated pharmaceutical solutions with a strong reputation for innovation, quality, and comprehensive service offerings in the pharmaceutical manufacturing industry.

Technical Specifications


Forming cycle - Thermoforming
Up to 25 cycles/min
Forming cycle - Cold-forming
Up to 20 cycles/min
Forming depth - Thermoforming
Up to 12 mm
Forming depth - Cold-forming
Up to 9 mm
Maximum forming area
156 mm x 96 mm
Forming materials
PVC,PVC/PVdC,Triplex (PVC/PE/PVdC),cold-form foil (Alu)
Lidding materials
Push-through foil,child-resistant foil,peelable (paper)

Operating Characteristics


Batch vs. continuous operation
Batch
Automation level
Automated with PLC
Changeover time
Quick changeover enabled
Cleaning method
Automated Wet-In-Place (WIP) system
Containment level
Operational Exposure Band (OEB) 3
Cleaning efficiency
High due to strategic nozzle placement
Safety interlocks
Multiple across the machine

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm


Operational Exposure Band (OEB) Compliance
OEB 3

Custom Options


Glove ports location
Diverse positions for manual interventions
Negative pressure operating enclosure
Ensures safety and compliance
Integration with product loading system
Allows safe and contained loading
Wet-in-place (WIP) system
Automated cleaning process
HEPA Filters
Ensures air quality and safety
Safety interlocks
Maintain containment conditions