Let's make uncoated tablets
Find innovative production technology for making uncoated tablets and connect directly with world-leading specialists.
It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.
Which uncoated tablets technology do you need?
Continuous roller compactor for dry granulation of pharmaceuticals
When making tablets, pharmaceutical manufacturers nee…
Container blender for pharmaceuticals
Manufacturing pharmaceutical solids like tablets requires using a proper blender to bl…
Blister inspection system
The pharma and healthcare industries widely use blister thermoforming machines to package a variety…
Agitator bead mill for API
To achieve precisely defined API properties and safe and reproducible production, rigorous impleme…
Continuous wet granulator and dryer for R&D
Pharmaceutical laboratories need compact equipment to handle and produce small …
Dry granulator for pharmaceutical powders
In pharmaceutical industries, where large-volume production is the norm, compacto…
Entry-level X-ray inspection system
Without compromising on performance, if you need an entry level x-ray inspection system …
Serialization equipment for cases
Serialization is a multi-stage process that includes printing, inspection, and labeling. B…
Serialization and aggregation inspection system
Including serialization and aggregation inspection systems to packaging lin…
Contained Visual Inspection System
In the medicine industry, it is important to ensure there are no defects in tablets or ca…
High Speed Visual Inspection System for Tablets
In order to ensure quality and standard specifications of tablets, capsules…
Granulation line for pharmaceutical solid dosage forms
Granulation is a common technique in production of pharmaceutical s…
Dessicant inserting machine
Desiccant canisters play an important role in the pharmaceutical and nutraceutical industries. Th…
Pharmaceutical bottle unscrambler
Pharmaceutical packaging industry requires the ability to quickly manage the process yet a…
Tablet counting machine
Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and co…
Metal detector for bottles
For metal contamination detection in finished products that are bottled, traditional solutions req…
Wash-in-Place metal detector for tablets
Where hygiene and decontamination are vital, traditional pharmaceutical metal detec…
Dust-tight metal detector for tablets
For FDA-compliant production of tablets, the elimination of airborne dust containing a…
High Speed Containment Tablet Press
High speed containment presses make pharmaceutical tablets in closed environments with g…
High Speed Double-Sided Tablet Press
To achieve as much as double the output of single-sided tablet press, the upper and low…
High Speed Tablet Press
High speed pharmaceutical tablet presses convert powder to tablets. The operations should be quick and…
Semi-automatic case packer
Pharmaceutical products require complete traceability throughout the production cycle. For smaller…
Benchtop tablet press
For lab work or small-scale production, a purpose-designed tablet press that meets your exact requiremen…
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Horizontal cartoner for pharmaceutical applications
Automatic cartoning for cosmetic or pharmaceutical products is a requi…
Automatic blister packaging machine
Automated blister packaging is a popular choice for pharmaceutical production thanks to …
Stand-alone aggregation station
The aggregation of pharmaceutical products for tracking purposes is already compulsory in man…
Serialization coding and labeling equipment
In the pharmaceutical industry, product serialization is the cornerstone of all…
Side-load case packer
As the final stage in the packaging process, an automated case-packing solution can ensure that your com…
Plate sealing blister machine
Blister packaging is the preferred choice for most large-scale pharmaceutical lines, and a plat…
Industrial blister packaging machine
High-volume, fully-automated blister packaging is the perfect choice for large scale ph…
Entry-level blister packaging machine
Blister packaging is a popular packing method in the pharmaceutical industry thanks to…
Tablet auto coater for lab scale
Many pharmaceutical doses in tablet form require a coating before they are ready for use. Th…
Automatic tablet coater for lab scale
The ability to coat tablets in an even and controlled way is an important stage in the…
Single layer tablet press
High performance tablet presses for the modern production environment need to be fast, accurate and…
Single and double layer tablet press
High performance tablet presses that are capable of producing both single and double-la…
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Contact usDifference between coated and uncoated tablets – When is the coating necessary?
If you’re wondering when coating a tablet is necessary, there’s not just one answer. Uncoated tablets are rougher and don’t really taste good. This makes them harder to swallow especially for children, as they also leave a bad aftertaste in the mouth. So coating is important to mask an unpleasant taste. Another reason may be that the active ingredient the tablet is made of is acid sensitive, so an enteric coating may help resist stomach acidity.
On the other way around, the enteric coating can also help protect the stomach from a more aggressive drug. Apart from that, the coating reduces also tablet friability and it can modify or control drug release. In uncoated tablets, any excipient or added substance is not specifically intended for this purpose.
Problems that can occur during uncoated tablets manufacturing
During uncoated tablet manufacturing, various problems can arise. Capping and lamination are two of these and refer to the separation of the tablet. Capping is the horizontal separation of the upper or lower part of the tablet from its main body; while lamination is the separation of the tablet into several horizontal layers.
Capping and lamination may occur immediately after compression or after several hours or days. To avoid this, it is advisable to test the tablet for friability to see if the problem is present or not.
The main causes can be air entrapment in granules or particles, granules that are too dry, improper tooling, or incorrect setup of the press. Tablet lamination and capping can be prevented by precompression.
If the tablet has excessive binder, sticking can happen. It refers to when tablet materials adhere to the die wall. Picking is used to describing when a portion of material is removed from the tablet surface by a punch due to embossing design. Plating punch faces with chromium can be a solution to produce non-adherent punch faces.
Disintegration time for uncoated tablets
Disintegration is the ability of a tablet to break down into smaller particles to allow the drug to be absorbed by the body. The disintegration test is paramount for tablets that are intended for mouth administration except for chewable tablets.
The disintegration tester consists of a basket that can hold six tablets. The basket is raised and lowered into a beaker that has water as the immersion fluid, unless there is another medium specified, having the temperature at 35 °C to 39 °C.
After running the device for the specified time, if all the tablets are disintegrated completely, they are good to go. If one or two tablets fail the test, it must be repeated on 12 additional tablets. If not less than 16 out of 18 tablets tested are disintegrated, the requirements are met.
Friability test for uncoated tablets
Friability test says to you how much mechanical stress tablet withstand during manufacturing, packaging and transit or when they are handled by consumers. A Friabilator is the laboratory instrument used for friability test. The device consists of a plastic chamber, the rotating drum, where you can place your preweighed tablets. Now you can rotate the drum 100 times and after removing them from the drum, just weight the tablet again.
If they have lost less than 0.5 to 1.0%, they are considered acceptable. Chewable and effervescent tablets have high friability weigh losses, so they have different specification and require special packaging. Basically, with the friability test, you can know the difference in the weight of uncoated tablets before and after the test. In this way, you can evaluate the physical strength of uncoated tablets
Which type of excipients do you have to use in uncoated tablets?
During uncoated tablet manufacturing, you cannot think to start without having your excipients. They play an important role and fulfill different functions – they can improve the taste or modify the disintegration time or the time and place of substance release. Saying that they are everything other than APIs, i.e. active pharmaceutical ingredients. When making uncoated tablets, there are some types of excipients you have to use.
For example, excipients used in orally disintegrating tablets (ODT) are sucrose, mannitol or sorbitol. Since this type of tablet disintegrates very quickly upon contact with saliva, disintegrants such as polyvinylpyrrolidone or sodium starch glycolate play a fundamental role here. In effervescent tablets instead, excipients used are citric acid, sodium citrate, fumaric acid, tartaric acid, with citric acid being one of the most important.
