Let's make uncoated tablets
It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.
What uncoated tablets equipment do you need?
Serialization equipment for cases
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Blister inspection system
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High Speed Visual Inspection System for Tablets
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Industrial scale tablet coater
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Tablet coater for laboratory scale
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Tablet counting machine
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Pharmaceutical bottle unscrambler
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Dessicant inserting machine
Desiccant canisters play an important role in the pharmaceutical and nutraceutical industries. T...
High Speed Double-Sided Tablet Press
To achieve as much as double the output of single-sided tablet press, the upper and lo...
High Speed Tablet Press
High speed pharmaceutical tablet presses convert powder to tablets. The operations should be quick an...
High Speed Containment Tablet Press
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High-speed strip packaging machine
Pack your solid pharmaceutical products in four-side sealed foil packs at very high spee...
Side-load case packer
As the final stage in the packaging process, an automated case-packing solution can ensure that your co...
Entry-level blister packaging machine
Blister packaging is a popular packing method in the pharmaceutical industry thanks t...
Industrial blister packaging machine
High-volume, fully-automated blister packaging is the perfect choice for large scale p...
Plate sealing blister machine
Blister packaging is the preferred choice for most large-scale pharmaceutical lines, and a pla...
Automatic blister packaging machine
Automated blister packaging is a popular choice for pharmaceutical production thanks to...
Horizontal cartoner for pharmaceutical applications
Automatic cartoning for cosmetic or pharmaceutical products is a requ...
Automatic filling line for solid doses
For medium-scale production of solid doses such as tablets, capsules, and softgels t...
Benchtop tablet press
For lab work or small-scale production, a purpose-designed tablet press that meets your exact requireme...
Electronic capsule counter
For lab work or small batch production, hand counting of solid doses into dispensing containers i...
Economic tablet press
Successful pharmaceutical manufacturers know that high quality, reliable equipment is essential in orde...
Single rotary tablet press
Creating batches of consistent high quality pharmaceutical grade tablets from your powdered ingre...
Feeder with flexible wall hopper
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Small feeder with flexible wall hopper
In many laboratory applications and production processes, smaller quantities of powd...
Conical mill for drug formulation
The efficient size reduction of granular powders is a key step in many pharmaceutical pro...
Single and double layer tablet press
High performance tablet presses that are capable of producing both single and double-l...
Lab scale single layer tablet press
Automated pressing of tablets saves time and improves quality. In R&D or laboratory...
Granulation line of mixer and fluid bed dryer
A complete granulation line allows for the mixing and granulation of pharmac...
Microencapsulation system for your drug delivery system
Whether you want to improve the stability of nutrients, protect a...
Single layer tablet press
High performance tablet presses for the modern production environment need to be fast, accurate an...
Rotary tablet press
For pharmaceutical tablet producers looking to reduce waste, costs and  increase production volume, a hig...
Fluid bed dryer for production scale
Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for dryi...
Fluid bed dryer for lab scale
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Fluid bed dryer and mixer for lab scale
Designed for pharmaceutical R&D, a lab-scale fluid bed dryer and mixer/granulat...
High-shear mixer
For the efficient mixing of larger batches of pharmaceutical compounds and high-shear mixer provides the opti...
Entry-level high-shear mixer for drug formulation
For pilot and lab-scale pharmaceutical formulations, a high-shear granu...
Premium vacuum conveyor
When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...
Sorption dehumidifier with air-chilled condenser
It is not always possible to duct out the wet air from a dehumidifier ser...
Small portable dehumidifier
Water damaged areas require dehumidification to limit the damage and prepare the area for restor...
Sorption dehumidifier for large temperature differences
Small, humid areas can be difficult to dehumidify in humid ambien...
Sorption dehumidifier for deep drying
Humid ambient conditions such as those in tropical climates make dehumidification mor...
Dehumidifier for difficult wet airflows
Sealed rooms can be challenging to dehumidify with ordinary dehumidifiers. The wet ...
Sorption dehumidifier for overpressured rooms
Small humid spaces, used for processing or storage, often need a simple dehu...
Heat recycling sorption dehumidifier
Facilities that handle large amounts of water can become very humid. High humidity may...
Industrial desiccant dehumidifier
Dehumidification of medium sized manufacturing and processing facilities can be a dauntin...
Large scale desiccant dehumidifier
Moisture sensitive processing and storage facilities need low humidity environments to s...
Customizable dehumidifier
Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fi...
Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent par...
Ultra-fine dispersing machine for emulsions and suspensions
Producing the finest micro-emulsions and suspensions require...
High-speed blister machine
If you are looking for a compact machine that produces blisters with an output of up to 700 blist...
Horizontal intermittent motion cartoner
User-friendly cartooning solution with an intermittent motion for a wide range of p...
Horizontal continuous motion cartoner
An automatic cartoning machine designed for both high-speed operations and medium pac...
Pick and place transfer for strips into cartoner
Transfer your strip packs products directly to the cartoner.
Versatile strip packaging machine
Pack diverse products such as diagnostics, pharmaceutical liquids or flat, stable product...
Entry-level blister machine
A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...
Compact blister machine
A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...
Case packer for cartons and bundles
Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...
Stretch bander
A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.
Vertical cartoner
A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...
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Difference between coated and uncoated tablets – When is the coating necessary?
If you’re wondering when coating a tablet is necessary, there’s not just one answer. Uncoated tablets are rougher and don’t really taste good. This makes them harder to swallow especially for children, as they also leave a bad aftertaste in the mouth. So coating is important to mask an unpleasant taste. Another reason may be that the active ingredient the tablet is made of is acid sensitive, so an enteric coating may help resist stomach acidity.
On the other way around, the enteric coating can also help protect the stomach from a more aggressive drug. Apart from that, the coating reduces also tablet friability and it can modify or control drug release. In uncoated tablets, any excipient or added substance is not specifically intended for this purpose.
Problems that can occur during uncoated tablets manufacturing
During uncoated tablet manufacturing, various problems can arise. Capping and lamination are two of these and refer to the separation of the tablet. Capping is the horizontal separation of the upper or lower part of the tablet from its main body; while lamination is the separation of the tablet into several horizontal layers.
Capping and lamination may occur immediately after compression or after several hours or days. To avoid this, it is advisable to test the tablet for friability to see if the problem is present or not.
The main causes can be air entrapment in granules or particles, granules that are too dry, improper tooling, or incorrect setup of the press. Tablet lamination and capping can be prevented by precompression.
If the tablet has excessive binder, sticking can happen. It refers to when tablet materials adhere to the die wall. Picking is used to describing when a portion of material is removed from the tablet surface by a punch due to embossing design. Plating punch faces with chromium can be a solution to produce non-adherent punch faces.
Disintegration time for uncoated tablets
Disintegration is the ability of a tablet to break down into smaller particles to allow the drug to be absorbed by the body. The disintegration test is paramount for tablets that are intended for mouth administration except for chewable tablets.
The disintegration tester consists of a basket that can hold six tablets. The basket is raised and lowered into a beaker that has water as the immersion fluid, unless there is another medium specified, having the temperature at 35 °C to 39 °C.
After running the device for the specified time, if all the tablets are disintegrated completely, they are good to go. If one or two tablets fail the test, it must be repeated on 12 additional tablets. If not less than 16 out of 18 tablets tested are disintegrated, the requirements are met.
Friability test for uncoated tablets
Friability test says to you how much mechanical stress tablet withstand during manufacturing, packaging and transit or when they are handled by consumers. A Friabilator is the laboratory instrument used for friability test. The device consists of a plastic chamber, the rotating drum, where you can place your preweighed tablets. Now you can rotate the drum 100 times and after removing them from the drum, just weight the tablet again.
If they have lost less than 0.5 to 1.0%, they are considered acceptable. Chewable and effervescent tablets have high friability weigh losses, so they have different specification and require special packaging. Basically, with the friability test, you can know the difference in the weight of uncoated tablets before and after the test. In this way, you can evaluate the physical strength of uncoated tablets
Which type of excipients do you have to use in uncoated tablets?
During uncoated tablet manufacturing, you cannot think to start without having your excipients. They play an important role and fulfill different functions – they can improve the taste or modify the disintegration time or the time and place of substance release. Saying that they are everything other than APIs, i.e. active pharmaceutical ingredients. When making uncoated tablets, there are some types of excipients you have to use.
For example, excipients used in orally disintegrating tablets (ODT) are sucrose, mannitol or sorbitol. Since this type of tablet disintegrates very quickly upon contact with saliva, disintegrants such as polyvinylpyrrolidone or sodium starch glycolate play a fundamental role here. In effervescent tablets instead, excipients used are citric acid, sodium citrate, fumaric acid, tartaric acid, with citric acid being one of the most important.
Processing steps involved in uncoated tablets making
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