High-shear mixer granulator for small batches

Achieving consistent particle size and mix uniformity in pharmaceutical and nutraceutical production can be challenging. This high-shear mixer granulator ensures precise control and efficiency, crucial for reliable tablet and capsule formulation in R&D and small-scale manufacturing.

Processes and Mixes Powders into Uniform Granules

The HSM 300 X·ONE high-shear mixer granulator by ACG is engineered to streamline the granulation and mixing processes crucial for pharmaceutical and nutraceutical production. Utilizing a unique product bowl geometry and Z-shaped impeller, it achieves uniform mixing by maintaining a roping flow regime, which facilitates faster process stabilization and optimal particle-size distribution. Designed for small production batches, it excels in processing powders into granules for end-products like paracetamol and ibuprofen tablets or omega-3 softgels. Capable of handling a working volume between 90 and 240 liters, the HSM 300 X·ONE integrates seamlessly into granulation trains or can function independently. Equipped with ACG’s X·ONE command process control system, it provides intuitive control and monitoring, compliant with ATEX, GAMP 5, and 21 CFR Part 11 standards. Enhanced safety is guaranteed through the MOST™ operator safety technology, capable of withstanding 12-bar pressure shocks, ensuring operations resume quickly post-event. Efficient cleaning is facilitated by a wash-in-place system, reducing downtime and maintaining high production yield.

Benefits

  • Enhances particle uniformity for reliable tablet and capsule performance.
  • Minimizes production downtime with quick cleaning via the wash-in-place system.
  • Increases safety with 12-bar pressure shock resistance and non-vented design.
  • Streamlines small batch processing for flexible, on-demand production schedules.
  • Simplifies compliance with ATEX, GAMP 5, and 21 CFR Part 11 standards.

General


Applications
Supplements,Nutraceuticals,Fine chemicals,Pharmaceutical tablets
End products
Ibuprofen tablets,Herbal extract tablets,Pharmaceutical tablets: paracetamol tablets,Potassium chloride pellets,Nutraceuticals: omega-3 softgels,Calcium carbonate tablets,Multivitamin capsules,Amoxicillin tablets,Supplements: vitamin d tablets,Protein powder blends,Sodium bicarbonate granules,Fine chemicals: citric acid granules
Steps before
Material weighing,Material blending
Steps after
Drying,Capsule filling,Tableting,Coating
Input ingredients
dry mix,binder
Output ingredients
granulated product,uniform particles
Market info
ACG World is known for its expertise in manufacturing pharmaceutical and nutraceutical processing and packaging machinery, offering innovative equipment solutions and maintaining a strong reputation for quality and reliability in the global market.

Technical Specifications


Working volume
Min 90 l / Max 240 l
Batch size
Small production batches
Pressure shock resistance
12-bar
Mixing technology
High-shear mixer granulator
Control system
ACG X•ONE command process control system
Binder distribution
Z-shaped impeller and multi-blade chopper
Compliance
ATEX,GAMP 5,21 CFR Part 11
Integration capability
Fully integrated into a granulation train or standalone
Safety technology
Maximum Operator Safety Technology (MOST™)
Cleaning method
Wash-in-place (WIP)

Operating Characteristics


Batch vs. continuous operation
Batch
Automation level
PLC / SCADA
CIP/SIP
Wash-in-place (WIP)
Cleaning method
Wash-in-place (WIP)
Safety Technology
Maximum Operator Safety Technology (MOST™)
Integration capability
Fully integrable in granulation train or standalone

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Processing Type
Wet granulation,mixing


ATEX certification
Directive 2014/34/EU
FSA approval
Germany

Physical Characteristics


Machine footprint
Compact design
Control panel type
ACG X•ONE command process control system
Product bowl geometry
Unique design for uniform mixing
Impeller type
Z-shaped with multi-blade chopper
Discharge method
Fully contained for safety

Custom Options


Control panel type
ACG X•ONE command process control system
Integration possibilities
Fully integrable into a granulation train or used as standalone
Discharge method
Multiple systems for charging,discharging
Wash-in-Place (WIP)
Efficient product handling and easy cleaning