High-shear mixer granulator for small batches
Achieving consistent particle size and mix uniformity in pharmaceutical and nutraceutical production can be challenging. This high-shear mixer granulator ensures precise control and efficiency, crucial for reliable tablet and capsule formulation in R&D and small-scale manufacturing.

Processes and Mixes Powders into Uniform Granules
The HSM 300 X·ONE high-shear mixer granulator by ACG is engineered to streamline the granulation and mixing processes crucial for pharmaceutical and nutraceutical production. Utilizing a unique product bowl geometry and Z-shaped impeller, it achieves uniform mixing by maintaining a roping flow regime, which facilitates faster process stabilization and optimal particle-size distribution. Designed for small production batches, it excels in processing powders into granules for end-products like paracetamol and ibuprofen tablets or omega-3 softgels. Capable of handling a working volume between 90 and 240 liters, the HSM 300 X·ONE integrates seamlessly into granulation trains or can function independently. Equipped with ACG’s X·ONE command process control system, it provides intuitive control and monitoring, compliant with ATEX, GAMP 5, and 21 CFR Part 11 standards. Enhanced safety is guaranteed through the MOST™ operator safety technology, capable of withstanding 12-bar pressure shocks, ensuring operations resume quickly post-event. Efficient cleaning is facilitated by a wash-in-place system, reducing downtime and maintaining high production yield.
Benefits
- Enhances particle uniformity for reliable tablet and capsule performance.
- Minimizes production downtime with quick cleaning via the wash-in-place system.
- Increases safety with 12-bar pressure shock resistance and non-vented design.
- Streamlines small batch processing for flexible, on-demand production schedules.
- Simplifies compliance with ATEX, GAMP 5, and 21 CFR Part 11 standards.
- Applications
- Supplements,Nutraceuticals,Fine chemicals,Pharmaceutical tablets
- End products
- Ibuprofen tablets,Herbal extract tablets,Pharmaceutical tablets: paracetamol tablets,Potassium chloride pellets,Nutraceuticals: omega-3 softgels,Calcium carbonate tablets,Multivitamin capsules,Amoxicillin tablets,Supplements: vitamin d tablets,Protein powder blends,Sodium bicarbonate granules,Fine chemicals: citric acid granules
- Steps before
- Material weighing,Material blending
- Steps after
- Drying,Capsule filling,Tableting,Coating
- Input ingredients
- dry mix,binder
- Output ingredients
- granulated product,uniform particles
- Market info
- ACG World is known for its expertise in manufacturing pharmaceutical and nutraceutical processing and packaging machinery, offering innovative equipment solutions and maintaining a strong reputation for quality and reliability in the global market.
- Working volume
- Min 90 l / Max 240 l
- Batch size
- Small production batches
- Pressure shock resistance
- 12-bar
- Mixing technology
- High-shear mixer granulator
- Control system
- ACG X•ONE command process control system
- Binder distribution
- Z-shaped impeller and multi-blade chopper
- Compliance
- ATEX,GAMP 5,21 CFR Part 11
- Integration capability
- Fully integrated into a granulation train or standalone
- Safety technology
- Maximum Operator Safety Technology (MOST™)
- Cleaning method
- Wash-in-place (WIP)
- Batch vs. continuous operation
- Batch
- Automation level
- PLC / SCADA
- CIP/SIP
- Wash-in-place (WIP)
- Cleaning method
- Wash-in-place (WIP)
- Safety Technology
- Maximum Operator Safety Technology (MOST™)
- Integration capability
- Fully integrable in granulation train or standalone
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Processing Type
- Wet granulation,mixing
- ATEX certification
- Directive 2014/34/EU
- FSA approval
- Germany
- Machine footprint
- Compact design
- Control panel type
- ACG X•ONE command process control system
- Product bowl geometry
- Unique design for uniform mixing
- Impeller type
- Z-shaped with multi-blade chopper
- Discharge method
- Fully contained for safety
- Control panel type
- ACG X•ONE command process control system
- Integration possibilities
- Fully integrable into a granulation train or used as standalone
- Discharge method
- Multiple systems for charging,discharging
- Wash-in-Place (WIP)
- Efficient product handling and easy cleaning