Integrated small-scale granulation and drying system
In pharmaceutical research and development, handling potent active ingredients requires precise granulation and drying processes to maintain product integrity and regulatory compliance. Ensuring safe and efficient processing of batch sizes, particularly in small-scale operations, presents unique challenges.
Granulate and dry with modular integration
The PharmaConnect® PLUS by GEA is a state-of-the-art system designed for small-scale granulation and drying applications. It leverages a modular design, enabling batch processing from as little as 5 kg up to 60 kg, making it suitable for 1:10 scale-up procedures. The system integrates seamlessly with GEA’s FlexStream 500 and FlexStream 1000 fluidized bed processors, ensuring cohesive operation across different processes. Key features include the BUCK® containment valve technologies and the disposable Hicoflex® system, which are capable of delivering Occupational Exposure Band (OEB) 4 containment levels. This capability ensures the safe handling of potent active pharmaceutical ingredients (APIs). The high shear granulator discharges through an integrated wet mill, with granules conveyed directly into the fluid bed processor. Post-drying, GEA’s lean phase conveying technology facilitates the rapid and contained transfer of the product, maintaining integrity and quality.
Benefits
- Process batches as small as 5 kg up to 60 kg
- Ensures OEB 4 containment for potent APIs
- Seamless integration with FlexStream fluidized bed processors
- Modular design enables diverse process modules
- Efficient product transfer with lean phase conveying technology