Pharmaceutical bottom-drive high shear granulator
Achieve optimal granule uniformity and precise control over moisture levels in high-speed pharmaceutical production with a versatile bottom-drive high shear granulator, designed to streamline mixing, granulation, and drying processes in both batch and continuous operations.
Processes and Granulates Pharmaceutical Powders and Compounds
The PMA Bottom-Drive High Shear Granulator from GEA is a versatile piece of equipment crucial for pharmaceutical production, renowned for its modular design and adaptability. This granulator excels in efficient mixing and granulation of powders and active pharmaceutical ingredients using high shear forces. It is ideal for producing diverse pharmaceutical end-products, including extended-release tablets and spherical pellets. Capable of processing volumes from 1 to 1800 liters, it supports both batch and continuous operations. Integration into existing lines is seamless with its PLC-controlled automation for precision and repeatability, while energy efficiency is enhanced by its optimized motor control. The construction materials, including stainless steel options, ensure compatibility with corrosive substances. It meets rigorous GMP standards, featuring advanced CIP systems for swift maintenance. Customization options and engineering support allow for tailored solutions, making it suitable for evolving pharmaceutical demands.
Benefits
- Enhances production efficiency with rapid processing of pharmaceutical compounds.
- Reduces contamination risks through fully contained, CIP-enabled design.
- Complies with GMP standards, ensuring regulatory adherence in pharmaceutical production.
- Provides flexibility with modular design for easy adaptation to changing process needs.
- Minimizes operational costs with energy-efficient motor systems.
- Applications
- Pharmaceutical tablets,Pellets,Granules,Active pharmaceutical ingredients (apis),Powders,Pharmaceutical compounds
- End products
- Ibuprofen tablets,Paracetamol granules,Spherical pellets,Fast-melt granules,Enteric-coated pellets,Extended-release tablets,Effervescent tablets,Solid drug formulations,Microcrystalline cellulose
- Steps before
- Powder dispensing,Pre-blending,Material feeding,Binder solution preparation
- Steps after
- Fluid bed drying,Product sampling,Sizing mill operation,Coating
- Input ingredients
- dry powders,aqueous granulations,solvent granulations,active compounds,excipients,granulation liquid,binder liquid
- Output ingredients
- granules,spherical granules,pellets,homogeneous blend
- Market info
- GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.
- Capacity
- 1–1800 L
- Batch size
- 60-1350 kg
- Operating Range
- 60-115 L to 720-1350 L
- Automation
- Fully automated/manual
- Binder distribution
- Rotary atomizer spray system
- Mixing technology
- High shear mixing
- End-point detection
- Latest techniques
- Chopper options
- Multi-bladed,U-shaped
- Impeller type
- Standard PMA,M8 impeller
- Discharge method
- Through-the-wall mill
- Cleaning method
- CIP/WIP
- Batch vs. continuous operation
- Batch
- Automation level
- Fully automated / Manual
- Process containment
- Integrated
- Cleaning Method
- CIP / WIP
- Changeover time
- Rapid (due to modular upgrades and easy inspection)
- Energy efficiency
- High (integrated process control systems)
- Level of Integration
- Can be part of complete systems including drying and containment
- Integrated Steps
- Mixing,granulating,pelletizing
- End-point Control
- Automated with trending for optimization
- Safety Standards
- Explosion proof,pressure shock resistant
- Loading
- Gravity / Vacuum
- Discharge Method
- Through-the-wall Mill
- Binder Solution Addition
- Spray nozzle with mechanical or peristaltic pump
- Cleanability
- CIP / WIP options
- Density/particle size
- Varied granulation capabilities
- Agglomeration Risk
- High/Low
- EC Type Approval
- Pressure Shock Resistant Systems
- Machine footprint
- Small footprint
- Operating range
- 60-115 liters to 720-1350 liters
- Modular options
- Blending,High Shear Granulating,Melt or Wet Pelletizing
- Discharge method
- Through-the-wall Hinged Mounting
- Tank shape
- Conical bowl
- Control system
- PLC-based / manual
- Process module integration
- Blending / Granulating / Pelletizing
- Modular upgrades
- Available for future requirements
- Installation type
- Standalone / Through-the-wall
- Impeller design
- Standard / M8 swept-back
- Chopper options
- Standard / Multi-bladed
- Cleaning integration
- CIP / WIP
- Loading method
- Gravity / Vacuum
- Binder addition method
- Pump / Pressure Pot
- Probe integration
- Lighthouse Probe Technology®