Continuous granulation and compression line for pharmaceuticals
Optimize your pharmaceutical production with a line that seamlessly integrates granulation, drying, and compression, ensuring high-quality, low-dose tablets while maintaining flexibility and control throughout the process.
Integrates Granulation, Drying, and Compression
The ConsiGma® Granulation and Compression (GC) Lines, offered by GEA, revolutionize pharmaceutical manufacturing by integrating continuous wet granulation, fluid bed drying, and tablet compression into a singular system. Ideal for high-value products like low-dose APIs, orphan drugs, and new chemical entities, these lines cater to the precise needs of pharmaceutical manufacturers. Available in three standard sizes, they efficiently handle throughputs from 5 to 120 kg/h, or 20,000 to 180,000 tablets per hour. Conductor 4.0 software enables seamless process control and comprehensive traceability, ensuring compliance with GMP standards. Materials are managed efficiently with loss-in-weight feeders and twin-screw granulators, while optional configurations offer enhanced dosing, blending, and containment solutions. These lines minimize product loss and eliminate work-in-progress, offering agility with compact design and scalable production capabilities. Cleaning and containment features ensure safe handling of highly potent formulations, supported by customizable options and engineering support to meet diverse processing demands.
Benefits
- Enhances production efficiency by integrating multiple processes into a continuous line.
- Minimizes API waste with precise dosing and controlled granulation.
- Reduces risk of contamination with comprehensive cleaning and containment features.
- Provides flexibility in production scale with adjustable throughput capacities.
- Ensures compliance with pharmaceutical standards through reliable control and traceability.
- Applications
- Low dose api,Pharmaceutical tablets,Coating materials,Orphan drugs,New chemical entities
- End products
- Friable tablet cores,Low-dose pharmaceutical tablets,Novel chemical entity formulations,Orphan drug tablets,Hygroscopic tablet cores
- Steps before
- Formulation premixing,Dosing
- Steps after
- Tablet coating,Packing,Sterilization
- Input ingredients
- low dose API,formulation pre-mix,granulation binder,solvent-free binders
- Output ingredients
- granules,tablet cores,high value products,orphan drugs,new chemical entities
- Market info
- GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.
- Capacity
- 5–120 kg/h or 20,000 to 180,000 tablets/h
- Automation
- Conductor 4.0 software controlled
- Batch size
- Flexible batch size
- Binder distribution
- Controlled granulation binder distribution
- Granule particle size distribution
- Control of granule particle size distribution
- Loss-in-weight feeder
- 1 for formulation pre-mix
- Compression system
- GEA compression system
- Batch vs. continuous operation
- Inline Continuous
- CIP/SIP
- CIP 121°C / SIP 135°C
- Cleaning method
- CIP
- Automation level
- SCADA
- Integrated steps
- Granulation,Drying,Compression
- Control Software
- Conductor 4.0
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Compact footprint
- Small
- Machine sizes
- 3 standard sizes (throughput from 5 to 120 kg/h)
- Integration level
- Continuous wet granulation,drying,and compression
- Configuration
- Modular and customizable
- Control panel type
- Conductor 4.0 software
- Integration possibilities
- Continuous wet granulation,drying and tablet compression
- Cleaning features
- CIP / Containment upgrade
- Material handling system
- Including containment features
- Batch size flexibility
- Customizable throughput capacities
- Module type
- TC coater modules
- Solvent capability
- Solvent capable
- Melt granulation set-up
- Available