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At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with chemicals or hazardous substances since they can be potentially dangerous to human health.

Packing

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

In the pharmaceutical industry, product serialization is the cornerstone of all legislative requirements for traceability. An automated inline coding and labeling system provides the easiest and most reliable way of addressing serialization needs without adversely impacting on line performance.
<h2>Folding-box serialization units for high flexibility/high speed</h2>
The Amacoder range from Hicof are industry-leading serialization solutions for the pharmaceutical industry, available in two specifications:

Amacoder FLEX - offers the maximum flexibility for packaging sizes. The maximum box depth is 300 mm and the maximum throughput is 75 boxes per minute (depending on box size). This is ideal for batch production and lines with frequent size changeover.

Amacoder SPEED - offers the highest speed at up to 150 boxes per minute for a maximum box depth capped at 200mm. This is perfect for dedicated smaller box lines where maximum throughput is desirable.

The Hicof Amacoder machines are supplied as standard with one inkjet printing unit and one cartridge and one camera on the operator side. Additional printing heads are available as an option. Two labelers enable the application of tamper-evident seals on both sides of the folding box. All box flap configurations are supported, making the Amacoder suitable for use with any existing line.

The Amacoder line has been designed to reduce moving parts and complexity as far as possible, offering an attractive price point as well as reducing the footprint to a minimum. The slower movement of boxes through the Amacoder means a very low rejection rate, offering further cost savings.

The code-reading camera is fully ISO/IEC 15415 compliant, and the complete coding and labeling line offers a comprehensive corporate, easy to operate, GxP compliant database to an integrated solution. The Amacoder IT system allows the processing of all serialization data, supports related business processes and offers optional interfaces to business and governmental partners.

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Serialization coding and labeling equipment

The aggregation of pharmaceutical products for tracking purposes is already compulsory in many countries and is expected to become even more widespread. Regardless of the legislation, logistical demands can also trigger a need for aggregation. For the aggregation of single pharmaceutical items into cases, camera systems and label printers need to be integrated into existing case packers. A modern aggregation unit that can operate as a standalone piece of equipment yet integrate directly with a serialization line provides maximum flexibility and complete traceability into the warehouse.
<h2>Aggregator for shipping cases or pallets with manual loading</h2>
The Amajoiner from Hicof is a semi-automatic aggregator that can be operated as a standalone unit or directly connected to a Hicof Amacoder serialization line, offering maximum flexibility.

The Amajoiner allows the aggregation of folding boxes into shipping cases by using an overhead high-resolution multi-code camera with an adjustable focus for scanning multiple packaging layers. The Amajoiner can work with a wide variety of shipping case sizes up to a maximum of 600mm x 400mm x 400mm. As well as aggregating product boxes into shipping cases, the Amajoiner can also further aggregate cases into pallets.

Hicof has considered operator ergonomics, as well as aggregation technology. The workspace height can be fully adjusted for comfort, including tilt of up to 40 degrees for easy loading, and to allow both seated and standing work positions. The carton is brought to the horizontal position for camera recording then returned to the packing position automatically. Due to a creative mechanical design and the use of cloud technologies the Amajoiner offers a class-leading low initial investment cost.

Fully portable thanks to high-quality castor wheels, the Amajoiner enjoys a compact size of only 1200mm x 1000mm by 2500mm total height. Other key features include a high-end industrial computer, 12MP camera with LED flash, a 200W linear axis for camera focus adjustment, in-built label printer for final shipping case labels, and a hand scanner.

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Stand-alone aggregation station

Pharmaceutical products require complete traceability throughout the production cycle. For smaller scale or batch production, fully automated packing solutions with serialization features can be expensive and inefficient. A semi-automatic model that can be run by a single operator yet delivers fully automatic aggregation features, is a value-for-money solution for smaller-scale pharmaceuticals packing.
<h2>Full-aggregation case packing solution for single-user operation</h2>
The Amapacker from Hicof is a semi-automatic case packer that automatically loads cartons or bundles in one or more layers into pre-formed shipping cases placed in position by an operator. One operator can pack up to 150 boxes per minute while all required aggregation processes are performed by the Amapacker machine in the background.

Made in Switzerland, the Amapacker is constructed of stainless steel and aluminum to an IP-67 rated level of dust and moisture protection. It has been designed to be economical, consuming only a small amount of compressed air in operation.

Aggregation is monitored through the large touchscreen HMI, where the output of the 20MP camera and the outcome of the label reading is displayed. The machine is simple enough to be operated following a minimum of training, with no particular expertise required.

Additional features include a hand scanner and built-in label printer for the production of the final shipping label for filled cartons.

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Semi-automatic case packer

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Making.com is a new online platform that helps makers find production technology quicker by grouping it around the products they make.

Did I take my medicine this morning or not?

Let's be honest. How often have we asked ourselves this question and failed to find an answer simply because… our memory sometimes doesn’t serve us right!

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Coming to the rescue of patients who need to keep track of their chronic medication and adhere to their daily treatment plan is FebriSol, a scratch-card calendar developed by Studio Fundi.

At <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we had the pleasure of meeting Ricky Stoch, the founder of <a href="https://studiofundi.com/" target="_blank" rel="noopener">Studio Fundi</a>, who showed us how simple it is to use FebriSol.

All the patient has to do is scratch off the day’s metallic coating that will reveal the check mark after taking the pill.

Current solutions for daily tracking are inconvenient and expensive.  FebriSol is a low-cost alternative that can help you keep track of your medicine every day.

#Changemaker: Keep track of your medicine every day with FabriSol sticker

Pharmaceutical

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19th century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

What's new in pharmaceutical packaging?



During <a href="https://www.pharmapackeurope.com/en/home.html" target="_blank" rel="noopener">Pharmapack</a>, we met Chantal Younes, Key Account Manager at <a href="https://www.csptechnologies.com/" target="_blank" rel="noopener">Aptar CSP Technology</a>, who introduced us to the world of active packaging.

The pharmaceutical industry is subject to strict regulations, so that's why manufacturers are very meticulous when formulating their products but especially about their packaging, which must keep their products safe. Due to the formulation or active ingredient, pharmaceutical products can present significant stability issues if they come in contact with moisture or oxygen.

This is where Aptar CSP Technology comes in. Aptar CSP Technology has developed several active packaging solutions to protect pharmaceutical products and ensure extended shelf life.

The company has developed a new class of highly engineered polymer compounds that protect drug products, probiotics, and drug delivery systems from impurities, oxygen, and moisture. The polymer can be extruded into a film, injection molded, or blow molded.

#Changemaker: Ready to protect your pharmaceutical products from moisture?

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.

Liquid dosage forms

Find production technology for Multi-layer tablets packing, and connect directly with leading machine manufacturers worldwide

Multi-layer tablets packing

Which multi-layer tablets packing equipment do you need?

Serialization coding and labeling equipment

Stand-alone aggregation station

Semi-automatic case packer

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