Pharmaceutical twin-screw extruder

Optimize your pharmaceutical production with high-speed continuous extrusion that ensures consistent quality and reduced downtime, perfect for producing complex drug delivery systems and controlled-release formulations.

Processes Pharmaceutical Formulations with Precision and Efficiency

The Pharma 24 Twin-Screw Extruder from Thermo Fisher Scientific is engineered to streamline continuous pharmaceutical production for complex drug delivery systems. This twin-screw extruder stands out with its robust design, featuring a segmented screw and barrel system for high precision extrusion and granulation, essential for creating tablets, capsules, and coated formulations. It supports feed rates of up to 70 kg/h for granulation and 20 kg/h for hot melt extrusion, optimizing throughput and efficiency. Integrated PLC control ensures seamless automation and real-time process monitoring, while its PAT compatibility allows enhanced process analytical technologies for quality assurance. Constructed with pharmaceutical-grade steel, it resists corrosion and meets stringent FDA and GMP compliance standards. Maintenance is simplified with a removable liner design and CIP capabilities, reducing downtime and contamination risks. Customizable options, including various dosing feeders and ancillary equipment, offer tailored solutions for specialized applications in R&D and production environments.

Benefits

  • Supports continuous production, reducing batch processing inefficiencies and utility costs.
  • Enhances product quality through precise control of extrusion parameters and process monitoring.
  • Minimizes scale-up risks and streamlines clean room operations with a compact, integrated design.
  • Meets regulatory standards, ensuring compliance with GMP and FDA requirements.
  • Simplifies maintenance and cleaning, decreasing downtime and ensuring product safety.

General


Applications
Drug delivery systems,Biomedical products,Pharmaceuticals
End products
Coated tablets,Biodegradable implants,Pellets,Granules,Controlled-release formulations,Transdermal patches,Tablets,Capsules,Drug-eluting stents
Steps before
Mixing,Dosing,Formulation
Steps after
Pelletizing,Chilling,Granulation,Product cooling,Collection
Input ingredients
pharmaceutical formulations,raw materials,drug compounds,active pharmaceutical ingredients,excipients
Output ingredients
granules,pellets,extrudates,flaked products,modified release dosage forms,enhanced solubility products
Market info
Thermo Fisher Scientific is renowned for providing innovative scientific instruments, laboratory equipment, and engineered-to-order solutions across various industries, esteemed for their high-quality products and expertise in life sciences, pharmaceuticals, and biotechnology sectors.

Technical Specifications


Interface
Touch screen control panel,Siemens PLC
Compliance
21 CFR part 11
Power Connections
400 V 3PH+N+PE,50/60 Hz
Power Consumption
50 A
Max. Torque
52.5 Nm/Screw
Barrel Bore Diameter
24 mm
Dimensions (L x W x H)
2075 x 875 x 1630 mm
Feed rate (HME)
up to 20 kg/h
Feed rate (TSG)
up to 70 kg/h
Screw Design
High free volume,segmented
Operation Type
Continuous
Automation
Four user levels with predefined access rights
Ancillary Options (TSG)
Volumetric or gravimetric dosing feeders,liquid injection pumps
Ancillary Options (HME)
Volumetric or gravimetric dosing feeders,air cooled conveyors,strand and face-cut pelletizers,chill roll/flaker units

Operating Characteristics


Continuous operation
Inline Continuous
Automation level
PLC / Siemens PLC / SCADA
Changeover time
Reduced time
Cleaning method
Reliable cleaning / Easy to clean
Energy efficiency
Consumes fewer utilities
Compatibility with PAT
PAT Compatible
Feed rate
20 kg/h (HME) / 70 kg/h (TSG)

Material Compatibility


Abrasion resistance
High
Biological compatibility
Pharmaceutical grade steel
Cleanability
Removable barrels and screws
Corrosive resistance
Pharmaceutical grade steel
Density/particle size
0.5–2.5 g/cm³

Physical Characteristics


Machine footprint
2075 x 875 x 1630 mm
Screw Barrel Bore Diameter
24 mm
Control panel type
Touch screen control panel
Discharge method
Open discharge chute with manually operated diverter valve
Barrel design
Removable top and bottom liners made from pharma grade steel

Custom Options


Control panel type
Touch screen control panel
Integration possibilities
Integration with Siemens PLC
User levels
Four different user levels with predefined access rights
Language options
Standard HMI languages
Compliance
21 CFR part 11 compliance