Pharmaceutical twin-screw extruder
Optimize your pharmaceutical production with high-speed continuous extrusion that ensures consistent quality and reduced downtime, perfect for producing complex drug delivery systems and controlled-release formulations.

Processes Pharmaceutical Formulations with Precision and Efficiency
The Pharma 24 Twin-Screw Extruder from Thermo Fisher Scientific is engineered to streamline continuous pharmaceutical production for complex drug delivery systems. This twin-screw extruder stands out with its robust design, featuring a segmented screw and barrel system for high precision extrusion and granulation, essential for creating tablets, capsules, and coated formulations. It supports feed rates of up to 70 kg/h for granulation and 20 kg/h for hot melt extrusion, optimizing throughput and efficiency. Integrated PLC control ensures seamless automation and real-time process monitoring, while its PAT compatibility allows enhanced process analytical technologies for quality assurance. Constructed with pharmaceutical-grade steel, it resists corrosion and meets stringent FDA and GMP compliance standards. Maintenance is simplified with a removable liner design and CIP capabilities, reducing downtime and contamination risks. Customizable options, including various dosing feeders and ancillary equipment, offer tailored solutions for specialized applications in R&D and production environments.
Benefits
- Supports continuous production, reducing batch processing inefficiencies and utility costs.
- Enhances product quality through precise control of extrusion parameters and process monitoring.
- Minimizes scale-up risks and streamlines clean room operations with a compact, integrated design.
- Meets regulatory standards, ensuring compliance with GMP and FDA requirements.
- Simplifies maintenance and cleaning, decreasing downtime and ensuring product safety.
- Applications
- Drug delivery systems,Biomedical products,Pharmaceuticals
- End products
- Coated tablets,Biodegradable implants,Pellets,Granules,Controlled-release formulations,Transdermal patches,Tablets,Capsules,Drug-eluting stents
- Steps before
- Mixing,Dosing,Formulation
- Steps after
- Pelletizing,Chilling,Granulation,Product cooling,Collection
- Input ingredients
- pharmaceutical formulations,raw materials,drug compounds,active pharmaceutical ingredients,excipients
- Output ingredients
- granules,pellets,extrudates,flaked products,modified release dosage forms,enhanced solubility products
- Market info
- Thermo Fisher Scientific is renowned for providing innovative scientific instruments, laboratory equipment, and engineered-to-order solutions across various industries, esteemed for their high-quality products and expertise in life sciences, pharmaceuticals, and biotechnology sectors.
- Interface
- Touch screen control panel,Siemens PLC
- Compliance
- 21 CFR part 11
- Power Connections
- 400 V 3PH+N+PE,50/60 Hz
- Power Consumption
- 50 A
- Max. Torque
- 52.5 Nm/Screw
- Barrel Bore Diameter
- 24 mm
- Dimensions (L x W x H)
- 2075 x 875 x 1630 mm
- Feed rate (HME)
- up to 20 kg/h
- Feed rate (TSG)
- up to 70 kg/h
- Screw Design
- High free volume,segmented
- Operation Type
- Continuous
- Automation
- Four user levels with predefined access rights
- Ancillary Options (TSG)
- Volumetric or gravimetric dosing feeders,liquid injection pumps
- Ancillary Options (HME)
- Volumetric or gravimetric dosing feeders,air cooled conveyors,strand and face-cut pelletizers,chill roll/flaker units
- Continuous operation
- Inline Continuous
- Automation level
- PLC / Siemens PLC / SCADA
- Changeover time
- Reduced time
- Cleaning method
- Reliable cleaning / Easy to clean
- Energy efficiency
- Consumes fewer utilities
- Compatibility with PAT
- PAT Compatible
- Feed rate
- 20 kg/h (HME) / 70 kg/h (TSG)
- Abrasion resistance
- High
- Biological compatibility
- Pharmaceutical grade steel
- Cleanability
- Removable barrels and screws
- Corrosive resistance
- Pharmaceutical grade steel
- Density/particle size
- 0.5–2.5 g/cm³
- Machine footprint
- 2075 x 875 x 1630 mm
- Screw Barrel Bore Diameter
- 24 mm
- Control panel type
- Touch screen control panel
- Discharge method
- Open discharge chute with manually operated diverter valve
- Barrel design
- Removable top and bottom liners made from pharma grade steel
- Control panel type
- Touch screen control panel
- Integration possibilities
- Integration with Siemens PLC
- User levels
- Four different user levels with predefined access rights
- Language options
- Standard HMI languages
- Compliance
- 21 CFR part 11 compliance