Twin-screw extruder for pharmaceutical applications
Optimize drug formulations by integrating high-containment twin-screw extrusion into your production line, enabling precise granulation and film formation for advanced dosage forms with enhanced solubility and controlled release.
Processes Pharmaceutical Powders and Granules
The ZSE 12 HP-PH twin-screw extruder from Leistritz, offered by AUSTAR, is engineered specifically for the pharmaceutical industry, making it a standout in high-containment production environments. This equipment utilizes a high-torque spline shaft with flexible screw elements to handle processes like hot-melt extrusion and wet granulation efficiently. Adaptable to continuous operations, the extruder ensures stable temperature control and precise mixing, vital for producing solid oral dosage forms, transdermal patches, and other solubility-enhanced drug compounds. Its design supports complex processes with a broad processing window, catering to R&D and large-scale production needs. Available with compliance to GMP and FDA standards, it facilitates seamless integration into existing production lines, enhancing both productivity and safety. The extruder’s maintenance benefits from its easy access for cleaning and optional CIP system, while customization options are available to tailor torque and process capabilities to specific pharmaceutical applications.
Benefits
- Enhances production efficiency with high-torque processing, minimizing operation times.
- Achieves precise temperature control for consistent product quality and formulation stability.
- Expands formulation capabilities through adaptable screw configuration for diverse pharmaceutical processes.
- Facilitates GMP and FDA compliance, ensuring safety and regulatory adherence.
- Minimizes downtime with efficient cleaning and maintenance features, including optional CIP integration.
- Applications
- Wet extrusion products,Wet granulation products,Hot-melt extrusion products,Film dosage forms,Melting granulation products,Implants,Pharmaceuticals
- End products
- Controlled-release capsules,Biodegradable implants,Solubility-enhanced drug compounds,Transdermal patches,Extended-release tablets,Mucoadhesive buccal films,Solid oral dosage forms
- Steps before
- Melting,Purification,Grinding
- Steps after
- Film Coating,Implant Formulation,Dosage Formulation,Sterilization,Packaging
- Input ingredients
- raw pharmaceutical materials,active pharmaceutical ingredients,formulation excipients,solid materials,powders
- Output ingredients
- hot-melt extrudates,granulated products,wet extrudates,film dosage forms,implants
- Market info
- Austar is known for specializing in the design and manufacture of engineered-to-order industrial equipment, particularly in the pharmaceutical and biotechnology sectors, offering solutions that focus on quality, innovation, and meeting specific customer requirements.
- High containment level
- OEB3 to OEB5
- Torque
- High torque
- Outer diameter/Inner diameter ratio
- High ratio
- Process window
- Broad
- Screw unit combination
- Various possibilities
- Temperature control precision
- Stable and accurate
- Temperature control
- Stable and accurate
- Batch vs. continuous operation
- Batch / Inline Continuous
- High containment capability
- OEB3 to OEB5
- Screw unit combination possibilities
- Various
- Integrated steps
- Extrusion,granulation,dosage form
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Emerging fields
- Hot-melt extrusion (HME),melting granulation,wet extrusion,wet granulation
- Dosage form capabilities
- Film dosage,implants
- OEB classification
- OEB3 to OEB5
- Control panel type
- Customizable HMI,PLC integration
- Screw unit combination
- Multiple configurations
- High torque spline shaft
- Customizable for specific operations
- Temperature control
- Precise,stable
- Barrel design
- Unique,customizable
- Process window
- Broad range of customization