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Maker - Product Challenge

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Capsule Dosing Equipment

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

brochure_multigel_powderdosing_system-pdf

Brochure_Multigel_PowderDosing_System.pdf

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

Compact powder doser designed specifically for lab and small-scale production

All-stainless construction for longevity and easy maintenance

Ability to dose into a wide range of sizes of bottles, jars, and containers for flexibility

Full control of dosing parameters via a simple control panel

Compact form factor means it can be installed anywhere, even the smallest labs

Industrial feeders and hoppers are used to provide a consistent, regulated flow of material to the production line for further processing. Feeders and hoppers are generally used in the industry in conjunction with other processing machines like crushers, dryers, conveyors, and mixers. Considerations for choosing a suitable feeding system include the physical state and particle size of the infeed, the output volumetric flow rate required and the type of connection to be made with the processing machinery.

Industrial hoppers

Pharmaceutical

Dosing equipment

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Connect directly with world leading manufacturers of Dosing equipment and find technology to build or improve your production line.

Dosing - Making.com

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Process

R&amp;D

Batch

solid

Powders or granules are common dose types used in many pharmaceutical and nutraceutical products. However, small-scale or lab production volumes make

Semi-automatic powder dosing machine - Making.com

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The marketplace for finding innovative production technology

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images.html

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

Syringes

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

High precision dosing from 0.5 mg

Automatic transport and dosing processes

Integrated checkweighing system

User-friendly 10-inch touch panel

Versatile application for various containers

A pouch is a small bag made from a single layer or a multi-layered laminate of paper, foil, and plastic films. The choice of pouch packaging equipment depends on the type of pouch, physical form of the product to be packaged, desired dimensions or volume of the pouch, and whether pouch forming is required or pre-formed pouches will be used. Specialized equipment may be required for the inclusion of a dispensing spout in the pouch or to make the pouch retortable.

Pouch packing equipment

A tablet press consists of two essential tools, namely dies and punches. It compresses powder or granules into a desired solid substance of uniform size and weight. After filling the dies with powder or granules, upper and lower punches are pressed together within the die hole to form tablets. Then the upper punches come back to their original position while the lower punches help the ejection of the tablet from the dies.

Tablet presses

Packaging Formats

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Entry level

Blending

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

In pharmaceutical development and galenics, precise dosing of small quantities of powder is essential. Ensuring accuracy while minimizing waste can be a

Semi-automatic powder dosing system - Making.com

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Configurable up to OEB 5 classification for high safety

Integrated 100% gross weight control for precise dosing

Reliable cleaning system (WIP) for reduced maintenance

360° accessibility due to separate control cabinet

Supports a wide range of filling units and capsule sizes

The two halves of a capsule shell are separately filled with your selected material before they are then pressed against one another and closed. Automatic capsule fillers orientate the shells in the precise position, fill them with your specified formula a join the ends. Capsules are then de-dusted and polished by micro brushes before they are ready for packaging.

Capsule fillers

Industrial

Weighing

In pharmaceutical manufacturing, handling highly active substances demands stringent safety protocols for both operators and products. Issues such as

High-containment capsule dosing and filling system - Making.com

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Fast determination of product attributes

Precise design of format parts

Binding definition of processes and their parameters

Cost-effective production of sample capsules

Reproducible and comparable trials

Micro dosing systems

Manual

In pharmaceutical development, accurately dosing minimal quantities of powder is crucial. Determining product attributes and processes with precision

Powder dosing for lab and galenics - Making.com

https://making-tst.imgix.net/2024/09/Harro_Hoefliger_4765_Image.png

Customizable for various dosing methods

Automatic product transport between stations

Suitable for small to production scale dosing

Handles a range of dosing volumes and particle sizes

Supports multiple packaging formats

Assembly platforms combine different parts into one final product. Components are inspected for quality and joined or affixed together into the goods. Assembly lines automate the process to ensure consistent quality and integrate into other technologies, such as packaging equipment. But a primary consideration for assembly solutions is their capacity to scale manufacturing processes. Assembly platforms must be adaptable to your long-term volume requirements.

Assembling

The process of forming allows you to shape your products homogeneously. Forming machines are fed the manufactured material in bulk and cut it down to specification, so the process takes place between formulation of the mass and the packaging of the final item.

A special class of this equipment – Form, Fill, and Seal Machines (FFS) – creates bags and pouches from flat material such as plastic sheets, fills them with your designated product, and seals them.

Forming

Sealing

In laboratory settings, precise and flexible dosing of powders is crucial, especially during development stages. Ensuring accurate dosage for products

Powder dosing machine for laboratory applications - Making.com

https://making-tst.imgix.net/2024/09/Harro_Hoefliger_4762_Image.png

Optimum dosing system for each product

Safe processing of highly effective and toxic products with powder containment

Quick change between dosing processes for maximum productivity

User-friendly and easy to maintain

Scalable to production standard with standardized processes

Chemical tablet formulas allow granules to break away under the conditions you would have designed them for. Powder presses distribute particles from the stock material evenly onto molds and subject the it to pressure to produce a dense block. Powder tablets often include a precise mixture of products and presses combine the correct dosage to form multi-layered slabs ready for packaging.

Powder presses

Volumetric dosing systems

In the pharmaceutical industry, precise dosing of powders is critical during the development of new formulations and for producing small batches for

Powder dosing system for development and small batches - Making.com

https://making-tst.imgix.net/2024/09/Harro_Hoefliger_4761_Image.png

ima_5464_brochure-pdf

IMA_5464_brochure.pdf

High production speed up to 200,000 capsules/hour

Multi-product dosing for diverse formulations

100% weight control ensures dosage accuracy

Advanced sensors minimize waste and enhance quality

Easy access for straightforward cleaning and maintenance

Sensors

Continuous

liquid

In pharmaceutical production, precise and flexible capsule filling is crucial for maintaining product quality and meeting industry regulations.

Capsule filler for multi-product dosing - Making.com

https://making-tst.imgix.net/2024/09/IMA_5464_Image.png

ima_5491_brochure-pdf

IMA_5491_brochure.pdf

Hard Candy

Handles diverse product types and container shapes

Supports various closure styles

Ergonomic design for easy maintenance and format changeovers

High production speeds for medium- to high-demand lines

Modular design allows easy integration of additional systems

Food

To make candy, all you need to do is create a syrup by dissolving sugar and boiling it to your desired consistency. For medium to large scale candy production, candy making equipment fully automates the whole process and takes care of other production regulations and standards (such as hygiene and proper homogenization). Planning on getting one? There’s a wide range of choices to pick from.

Candy

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

A fresh salad with a walnut oil dressing or a peanut butter sandwich? A bag of roasted cashews or a pack of almond cookies? The common thread among these tasty treats is nut processing equipment. Not all nut ingredients are indeed nuts, botanically speaking. But the machinery that transforms shelled fruits, legumes, and drupes into fried snacks or a paste is similar. As for the food products, there is a nut recipe for every mood and occasion.

Nuts

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Packaging

Counting

In the confectionery industry, handling various product types and shapes while ensuring consistent dosing and filling in diverse formats is a complex

Vertical dosing and filling solution for confectionery packaging - Making.com

https://making-tst.imgix.net/2024/09/IMA_5491_Image.png

ima_5512_brochure-pdf

IMA_5512_brochure.pdf

Precise micro-dosing for accurate product assessments

Compatibility with all capsule sizes and dosage forms

Scalable to larger production lines

Portable and requires only compressed air

Minimal user requirements for easy operation

In pharmaceutical research and development, precise micro-dosing and solid product filling are essential for ensuring accurate dosage and process

Table-top capsule filler for micro-dosing - Making.com

https://making-tst.imgix.net/2024/09/IMA_5512_Image.png

brochure_multigel_suppositoriesmachine-pdf

Brochure_Multigel_SuppositoriesMachine.pdf

Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

Full temperature control of the molten compounds ensuring consistency and quality

Reel-based system for rapid loading and unloading

Wide dosage range available to meet your exact requirements

Full GMP design with FDA-approved materials

Easily combines with S-MND 6000 to complete a suppository production line

Liquid

Small-to-medium scale production of suppositories using pre-formed shells can be slow where manual filling is used. An automated filling solution that can

Suppository filling machine - Making.com

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API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Ensures operator safety with high containment standards

Accurate and precise filling for various HPAPI formulations

Efficient cleaning with integrated wet-in-place system

Supports high-speed production up to 40,000 capsules per hour

Compatible with ancillary equipment for enhanced quality control

Barrier isolator systems create a physical and an aerodynamic barrier between the operator and the work process. The product or process inside the isolator can only be manipulated through the use of gloves or a robotic arm. Choosing an isolation system involves considering the safety regulations (for example; operator protection or cGMP standards), positive or negative pressure specifications, and monitoring and control requirements. Barrier and isolator systems are used in the pharmaceutical industry for sterile processes such as injectable drug filling and cytotoxic drug compounding. Barrier systems and isolators are integrated into full production lines and the most important thing is to control and monitor airflow.

Containment isolators

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Capsule Dosing Equipment

Which capsule dosing technology do you need?

Semi-automatic powder dosing machine

Semi-automatic powder dosing system

High-containment capsule dosing and filling system

Powder dosing for lab and galenics

Powder dosing machine for laboratory applications

Powder dosing system for development and small batches

Capsule filler for multi-product dosing

Vertical dosing and filling solution for confectionery packaging

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