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Maker - Product Challenge

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Capsule Dosing Equipment

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

brochure_multigel_powderdosing_system-pdf

Brochure_Multigel_PowderDosing_System.pdf

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

Compact powder doser designed specifically for lab and small-scale production

All-stainless construction for longevity and easy maintenance

Ability to dose into a wide range of sizes of bottles, jars, and containers for flexibility

Full control of dosing parameters via a simple control panel

Compact form factor means it can be installed anywhere, even the smallest labs

Industrial feeders and hoppers are used to provide a consistent, regulated flow of material to the production line for further processing. Feeders and hoppers are generally used in the industry in conjunction with other processing machines like crushers, dryers, conveyors, and mixers. Considerations for choosing a suitable feeding system include the physical state and particle size of the infeed, the output volumetric flow rate required and the type of connection to be made with the processing machinery.

Industrial hoppers

Pharmaceutical

Dosing equipment

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Connect directly with world leading manufacturers of Dosing equipment and find technology to build or improve your production line.

Dosing - Making.com

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Process

R&amp;D

Batch

solid

Powders or granules are common dose types used in many pharmaceutical and nutraceutical products. However, small-scale or lab production volumes make

Semi-automatic powder dosing machine - Making.com

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The marketplace for finding innovative production technology

Making.com

brochure_multigel_suppositoriesmachine-pdf

Brochure_Multigel_SuppositoriesMachine.pdf

Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

Full temperature control of the molten compounds ensuring consistency and quality

Reel-based system for rapid loading and unloading

Wide dosage range available to meet your exact requirements

Full GMP design with FDA-approved materials

Easily combines with S-MND 6000 to complete a suppository production line

Liquid

Continuous

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

liquid

Small-to-medium scale production of suppositories using pre-formed shells can be slow where manual filling is used. An automated filling solution that can

Suppository filling machine - Making.com

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Suitable to fill all capsule sizes

Can be supplied with tamping or dosator system

Change size operation takes less than 10 minutes

  Special dosing discs for minimal powder dosages (starting from 8 mg)

Equipped with both powder and liquids dosing stations

The two halves of a capsule shell are separately filled with your selected material before they are then pressed against one another and closed. Automatic capsule fillers orientate the shells in the precise position, fill them with your specified formula a join the ends. Capsules are then de-dusted and polished by micro brushes before they are ready for packaging.

Capsule fillers

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Packaging

<span style="font-weight: 400">At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with </span><span style="font-weight: 400">chemicals or hazardous substances since they can be potentially dangerous to human health. </span>

Packing

IN-CAP automatic bench top capsule filling machine by Dott.Bonapace is a bench top capsule fully automatic filling machine.

Automatic capsule filling machine for powders, pellets, tablets, mini-tablets, capsule in capsule or liquids. Test the automatic settings of

R&D automatic capsule filler - Making.com

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Hourly output up to 6000 capsules

Equipped with an electronic vibrator

Fully disassemble-able

100% at water tight

R&D semi-automatic capsule filler is suitable to open, fill and close empty hard gelatin capsules already orientated on a 300 holes tray.

Semi-automatic filling machine suitable to open, fill and close empty hard gelatin capsules already orientated on a 300 holes tray, with an hourly output

R&D semi-automatic capsule filler - Making.com

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bakerperkins_confectionery-pdf

BakerPerkins Confectionery

It’s important to get timing and temperature right when making caramel, and this implies being vigilant. For small scale production of caramel, ensure that your heat source distributes heat evenly and monitor the caramelization process closely. This prevents recrystallization and burning the sugar. For medium to large scale caramel production, consider investing in automated caramel making equipment.

&nbsp;

Caramel

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

Chewing gum is usually a polymer that you mix with flavorings – which is something most consumers have no clue about. In a survey in Iceland, 85% of people said they didn't know the product contained plastic. While there are non-plastic options more recently available, the gum base is usually natural latex or a synthetic substitute. To decrease the impacts on the environment, some producers are shifting towards more environmental-friendly options.

Chewing gum

Gummy bears are iconic confectioneries known for their playful shapes and fruity flavors. They have gained immense popularity worldwide due to their versatility and appeal to a wide variety of tastes. In addition to being delicious, gummy bears are also easy to produce, particularly in small quantities. For medium to large-scale production of gummies, there is a multitude of gummy manufacturing equipment to help ensure that you end up with a good product.

Gummy Bears

Sweets, candies, ice lolly, confection, lollypop, and even popsicles - lollipops, the hard candies attached to a short stick, go by different names. While choosing your lollipop equipment now is very different from the time of its creation, back in 1908, the opportunities to differentiate the product in the market are wider.

Lollipops

Nougat is a delicious confection that contains lots of nuts and dried fruits. The word “nougat” itself derives from an old Latin word for nuts. In addition to nuts, the white variety of nougat contains egg whites, honey, and sugar. Similar ingredients make brown nougat variations, except caramelized sugar replaces egg whites as the base ingredient. Depending on your intended scale of production, there are quite a few nougat making equipment you should consider getting.

Nougat

Gummies make everything more colorful. The squishy droplets make a tasty and practical carrier of special ingredients such as CBD oil. Chewing the gum increases the bioavailability of the substance as opposed to vaping. But before the cannabidiol can take effect, it must first be processed through a line of CBD gummy equipment.

CBD gummies

Chewy, sweet, and nutritious. Vitamin gummies were a couple’s attempt to get their child to take their essential micronutrients. The idea quickly caught on, and manufacturing vitamin gummies soon grew into a whole new industry.

Vitamin gummies

Continuous dissolvers for all confectionery syrup types, including those containing dairy fats

Designed for hygienic operation and with robust construction

Energy efficient dissolving for reduced operating costs

Available in a range of outputs up to 2000kg per hour to suit all production scales

Food

To make candy, all you need to do is create a syrup by dissolving sugar and boiling it to your desired consistency. For medium to large scale candy production, candy making equipment fully automates the whole process and takes care of other production regulations and standards (such as hygiene and proper homogenization). Planning on getting one? There’s a wide range of choices to pick from.

Candy

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

During the Middle Ages, sugar sweets were a delicacy only for the rich due to the high cost of sugar. Thankfully, the discovery that sugar could be extracted from sugar beets made sweets affordable for everyone. The sweet category is broad, covering chocolates, chewing gums, sugar candies, and candied/glazed products with sugar. To make these confections, sugar manufacturing equipment needs to cover different steps within the production line such as sugar dissolution, syrup cooking and cooling.

Sweets

<span style="font-weight: 400">The heating process is a step of raising the temperature of food, pharma, cosmetics, and many other types of products. You may employ different heating solutions for this process, depending on the type of product you intend to manufacture. Selecting the appropriate heater machine for your product is quite important since various products require different ranges of temperatures and different ways of heat transfer using exchangers. Industrial heating equipment varies in two ways - the type of material it can process and the reaction you want to achieve.</span>

Heating

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Many high quality confectionery products require a dissolved syrup as their starting point. Key aspects to high quality syrup are retention time and

Dissolver of confectionery syrups - Making.com

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The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Scale-up machine that boosts line efficiency and fills 126,000 units per hour

Innovative powertrain design increases component life and reduces downtime for maintenance

Automatic jam removal with no disassembly required

AWC systems automatically rejects incorrect weight as well as faulty capsules

Fully 21 CFR part 11 compliant graphical control and recording system

In the pharmaceutical world, encapsulation refers to various techniques to enclose and protect the drug ingredients by forming the capsule shell. Encapsulation equipment changes depending on whether the manufacturer needs to produce a soft or hard gel capsule. For instance, encapsulation systems and machines for softgels control the entire process from start to finish because their shells are filled at the same time they are produced. On the other hand, the filling of hard gel capsules comes by separating the body from the cap, and after the filling operations, the two parts are sealed together again, forming the shell.

Encapsulation

For higher production volumes of pharmaceutical capsules, speed, accuracy and reliability of production machinery is vital. For medium volume production

Scale up capsule filler - Making.com

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<h3>Mold the shells into shape with capsule manufacturing equipment</h3>
Capsule shells are composed of the body and the cap that closes the dosage. Capsule manufacturing equipment dips a series of steel pins into a drum filled with the base material. The wet molding pins move to the drying chamber to harden as they spin on their axis to ensure even distribution.

Once the shells are formed, they are stripped off the pins. But they are not yet finished for filling. The empty capsules must first be cut to the correct length and joined in a pre-lock position, ready for encapsulation.

Encapsulation technology lines up the capsule bodies on a bed of holders. A stainless steel dosage system pours the formula in the powder tray into the shells. The caps, aligned precisely in their holding section, are ready to be lowered onto the filled capsule bodies. The fins in the body enter the slits of the cap, locking them into position.

The encapsulated ingredients directly impact shell stability. Hygroscopic materials, for example, risk cracking the gelatin capsules. Capsule filling machines must account for the properties of the dosage formula and the materials, thickness, and shelf life of the shells.

Capsule production is either an automatic, semi-automatic or manual process. Manual capsule fillers are still used in smaller production facilities. However, for making large scale pharmaceutical capsules, automation is employed to maximize output and efficiency.

Pair the API with the correct shell before the capsule filling process

<h3>Control the water content in hard gelatin capsules to balance plasticity and containment</h3>
The first hard gelatin capsules were filled with pharmaceutical formulas in powder form. But one of the advantages of encapsulation is that it offers flexibility with a range of dosage solutions, from tablets to beads to micro-capsules.

This versatility means that the gelatin shells have to deliver stability. The gelatin mix must allow <a href="https://making.com/hard-gelatin-capsules" target="_blank" rel="noopener">enough moisture content</a> to create elasticity without altering the properties of the <a href="https://making.com/active-pharmaceutical-ingredients-api" target="_blank" rel="noopener">encapsulated APIs</a>.

Soft gelatin capsules, also known as softgels, are suitable for non-aqueous solutions such as oil. The active pharmaceutical ingredients are dissolved or suspended into an oil-based form.

One of the challenges in <a href="https://making.com/softgel-capsules" target="_blank" rel="noopener">producing softgel capsules</a> is the formation of air bubbles in the gelatin base. This happens when the capsule manufacturing equipment fails to reach the right temperature during the drying stage, and air remains trapped in the mixture. These pockets of unreleased air weaken the structure of the capsule.

Insufficient drying temperature leads to undesirable air pockets in soft gelatin capsules

Hypromellose emerged as the plant-sourced <a href="https://making.com/gelatin-powder" target="_blank" rel="noopener">alternative to gelatin</a>. But <a href="https://making.com/hpmc-capsules" target="_blank" rel="noopener">HPMC capsules</a> are <a href="https://making.com/hpmc-capsules" target="_blank" rel="noopener">less dependent on water content</a>, making them a better solution for hygroscopic ingredients.

However, since Hypromellose has a higher oxygen permeability, the fill ingredients need anti-oxidant additives to compensate. HPMC capsules also require oxygen-resistant packaging, such as aluminum blister configurations.

HPMC capsules are more suitable hygroscopic fillings

<h3>Blister packs offer greater protection for pharmaceutical capsules</h3>
The packing solution depends on the type of capsule. Vitamin or food supplement capsules may be bottled in simple containers. However, a desiccant pouch helps to absorb moisture and maintain a controlled environment.

In the case of pharmaceutical capsules, the ingredients demand safer packaging. Blister packs are more secure and are more convenient for dosage control. Complete <a href="https://making.com/technologies/blister-packing-equipment">blister packaging solutions</a> often include coding and die-cutting systems, but simple entry-level batch machines are also available.

Capsule Making Equipment

Find production technology for filling, forming, and packing capsules and connect directly with leading machine and equipment manufacturers worldwide.

Capsules - Making.com

Capsule Making Equipment - Making.com

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Producing the finest micro-emulsions and suspensions requires a mixing machine that generates extremely high shear.  Multi-staged rotor/stator dispersing machines work well for this purpose because of the high shear forces applied to the mixture at each rotor/stator stage.  A rotor /stator dispersing machine that also incorporates extremely fast rotation and resultant tip speeds for even greater shearing action will lead to the creation of super-fine emulsions and ensure the success of your process.
<h2>Top-of-the-line rotor/stator dispersion with utlra high shear for nano-scale particle emulsions and suspensions</h2>
The DISPAX-REACTOR® DRS from IKA is an inline ultra high shear dispersing machine used to achieve the finest micro-emulsions and suspensions. Extremely high shear rates (up to 190.000 1/s) combined with a fine generator geometry enable crushing of droplets and solids particles down to the nanoscale. The resulting product has long-term stability which reduces the need for emulsifying agents and thickeners. Because of the extremely high energy density, other dispersing aids can be reduced or possibly eliminated.

The DRS is usually equipped with a two-stage rotor-stator system (generators). The high tip speed of 40 m/s (10.000 fpm) often negates the need for a third stage. The ultra-fine dispersing machine, designed with the same high quality features as the ULTRA-TURRAX® UTL and the DISPAX-REACTOR® DR, is especially well suited for challenging pharmaceutical applications.  The units are designed for easy and reliable scalability and sizes are available with flow rates from 70 to 40.000 liters per hour.

Ultra-fine dispersing machine for emulsions and suspensions

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

To serve the industry across diverse production scales, IKA replicated Magic Lab’s success on a larger scale, ensuring consistent milling outcomes

In the pharmaceutical industry, change often moves at a snail’s pace due to stringent regulations, but it does happen. Traditionally, API manufacturers

Wet milling: The revolution in the API production - Making.com

Wet milling: The revolution in the API production

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Deborah

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

What's new in pharmaceutical packaging? During Pharmapack, we met Chantal Younes, Key Account Manager at Aptar CSP Technology, who introduced us to the

#Changemaker: Ready to protect your pharmaceutical products from moisture? - Making.com

#Changemaker: Ready to protect your pharmaceutical products from moisture?

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Thousands of different capsules are produced every day, so it is inevitable that some of them will come out defect in shape or size, with a colour

How reliable imaging plays an important role in capsule visual inspection - Making.com

How reliable imaging plays an important role in capsule visual inspection

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Irina Lescika

We have all come across desiccants at some point in our lives. They come in little white packets or cans in packaged products with the strict instruction,

Capsule Dosing Equipment

Which capsule dosing technology do you need?

Semi-automatic powder dosing machine

Suppository filling machine

R&D automatic capsule filler

R&D semi-automatic capsule filler

Dissolver of confectionery syrups

Scale up capsule filler

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