Let's make hard gelatin capsules
The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.
Which hard gelatin capsules equipment do you need?
R&D semi-automatic capsule filler
R&D hard gelatin capsule sealing machine
Semi-automatic capsule filler
Entry-level blister machine
R&D automatic capsule filler
R&D capsule orientater
R&D electronic counter for capsules and tablets
High-sensitivity metal detection system
Checkweigher for capsules
Easy to validate capsule filler
High-yield capsule filler
Automatic capsule filler
Contained capsule filler
Automatic laboratory capsule filler
Automatic capsule filler for liquid solutions
Laboratory capsule filler for liquid solutions
Industrial capsule checkweigher
Versatile weight sorter for tablets & capsules
Entry level capsule filler
Scale up capsule filler
High capacity capsule filler
High capacity weight sorter for tablets & capsules
Serialization coding and labeling equipment
Stand-alone aggregation station
Automatic filling line for solid doses
Electronic capsule counter
Semi-automatic case packer
Metal detector for tablets and capsules
Metal detector for bottles
Tablet counting machine
Pharmaceutical bottle unscrambler
Dessicant inserting machine
Lifter and De-duster for Tablets
High Speed Visual Inspection System for Tablets
High speed bottle filler with inspection
Effective Visual Inspection System for Capsules
Contained Visual Inspection System
Cold forming aluminum blister machine for capsules
Blister inspection system
Flat carton serialization station
Pharmaceutical data management software
Serialization and aggregation inspection system
Entry-level X-ray inspection system
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Dosing accuracy is key to manufacturing hard gelatin capsules
The bright colors that hard-gel capsules are synonymous with come from dyes and edible colorings. However, the main ingredients of the shell are gelatin and plasticizers, which combine at a typical ratio of 1:0.4 using precise dosage technology.
Compared with softgel capsules, the hard gelatin alternatives require fewer components to produce. But your standard formula will also include sugars, an opacifier, and preservatives.
Hygroscopic ingredients weaken the hard-shell structure
The flexibility of hard-gel caps and their relatively long shelf-life make them an ideal solution for the delivery of various drugs. Two-piece capsules can hold a range of powder formulations, tablets, and semisolid solutions.
But hygroscopic agents may lead to cracks in the shell over time, making the production of hard gelatin capsules unsuitable for materials such as silicon dioxide and magnesium carbonate.
Production of hard gelatin capsules is largely impacted by the water content
The mixture to manufacture hard gelatin capsules consists of 14% to 16% demineralized water. Achieving this delicate proportion is key to ensuring that your shells have the proper elasticity to hold their structure and protect the filling.
Too little water will result in brittle capsules, while too much of it risks destabilizing the drug content inside.
Plant-based gelatin alternatives follow the same manufacturing process
Gelatin has been the industry standard in manufacturing hard capsules for nearly a century. But currents drifting away from animal-based ingredients are spurring research into vegetarian alternatives. Substitute materials like starches and carrageenan can be handled with minor modifications to existing technology.
HPMC capsules have emerged as a prime contender to produce plant-based encapsulation formulas. An edible natural polymer, HPMC is made from plant-extracted cellulose. Unlike gelatin, which is non-allergenic foodstuff, HPMC is considered an additive (E460).