Let's make hard gelatin capsules
Find innovative production technology for making hard gelatin capsules and connect directly with world-leading specialists.
The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.
Which hard gelatin capsules equipment do you need?
Semi-automatic capsule filler
Hard gelatin capsules are a popular format for delivering a wide variety of pharmaceutical dose…
R&D hard gelatin capsule sealing machine
When encapsulating products at temperatures up to + 80°C, these tend to solidify at…
R&D semi-automatic capsule filler
Semi-automatic filling machine suitable to open, fill and close empty hard gelatin capsule…
Entry-level X-ray inspection system
Without compromising on performance, if you need an entry level x-ray inspection system …
Serialization and aggregation inspection system
Including serialization and aggregation inspection systems to packaging lin…
Pharmaceutical data management software
A typical pharmaceutical production handles numerous work flow activities like manag…
Flat carton serialization station
The packaging lines in the pharmaceutical industry handle several flat cartons. Manual pac…
Blister inspection system
The pharma and healthcare industries widely use blister thermoforming machines to package a variety…
Cold forming aluminum blister machine for capsules
Aluminum blisters are mainly used for packaging products that are sensi…
Contained Visual Inspection System
In the medicine industry, it is important to ensure there are no defects in tablets or ca…
Effective Visual Inspection System for Capsules
The attribute of capsule packing is a critical parameter that controls the …
High speed bottle filler with inspection
Medicines in tablet, capsule, or soft gel forms undergo various processes before re…
High Speed Visual Inspection System for Tablets
In order to ensure quality and standard specifications of tablets, capsules…
Lifter and De-duster for Tablets
The use of several different tools for lifting, de-dusting, and polishing in the pharmaceuti…
Dessicant inserting machine
Desiccant canisters play an important role in the pharmaceutical and nutraceutical industries. Th…
Pharmaceutical bottle unscrambler
Pharmaceutical packaging industry requires the ability to quickly manage the process yet a…
Tablet counting machine
Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and co…
Metal detector for bottles
For metal contamination detection in finished products that are bottled, traditional solutions req…
Metal detector for tablets and capsules
Identification of metallic contaminants is a vital part of pharmaceutical quality co…
Semi-automatic case packer
Pharmaceutical products require complete traceability throughout the production cycle. For smaller…
Electronic capsule counter
For lab work or small batch production, hand counting of solid doses into dispensing containers is…
Automatic filling line for solid doses
For medium-scale production of solid doses such as tablets, capsules, and softgels th…
Stand-alone aggregation station
The aggregation of pharmaceutical products for tracking purposes is already compulsory in man…
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Serialization coding and labeling equipment
In the pharmaceutical industry, product serialization is the cornerstone of all…
High capacity weight sorter for tablets & capsules
By employing a weight sorter that is fully flexible and able to han…
Capsule checkweigher
The production of pharmaceutical capsules requires that individual doses are checked for accuracy. In a p…
High capacity capsule filler
In the highest volume pharmaceutical production environments, capsule filling needs to be extrem…
Scale up capsule filler
For higher production volumes of pharmaceutical capsules, speed, accuracy and reliability of productio…
Entry level capsule filler
For the production of pharmaceutical doses in capsule form complete accuracy of fill is paramount.…
Versatile weight sorter for tablets & capsules
Saving costs and improved production efficiencies are possible by optin…
Industrial capsule checkweigher
Pharmaceutical manufacturing demands the highest quality standards and completely consistent …
Laboratory capsule filler for liquid solutions
A recent important change in the industry is the trend toward providing liqu…
Automatic capsule filler for liquid solutions
Use of liquid filled hard capsules is increasingly popular with today's pharm…
Automatic laboratory capsule filler
Innovators in the highly regulated and highly dynamic pharmaceutical market place need e…
Contained capsule filler
For pharmaceutical formulations that are highly active specialized capsule filling equipment is often…
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Contact usDosing accuracy is key to manufacturing hard gelatin capsules
The bright colors that hard-gel capsules are synonymous with come from dyes and edible colorings. However, the main ingredients of the shell are gelatin and plasticizers, which combine at a typical ratio of 1:0.4 using precise dosage technology.
Compared with softgel capsules, the hard gelatin alternatives require fewer components to produce. But your standard formula will also include sugars, an opacifier, and preservatives.
Hygroscopic ingredients weaken the hard-shell structure
The flexibility of hard-gel caps and their relatively long shelf-life make them an ideal solution for the delivery of various drugs. Two-piece capsules can hold a range of powder formulations, tablets, and semisolid solutions.
But hygroscopic agents may lead to cracks in the shell over time, making the production of hard gelatin capsules unsuitable for materials such as silicon dioxide and magnesium carbonate.
Production of hard gelatin capsules is largely impacted by the water content
The mixture to manufacture hard gelatin capsules consists of 14% to 16% demineralized water. Achieving this delicate proportion is key to ensuring that your shells have the proper elasticity to hold their structure and protect the filling.
Too little water will result in brittle capsules, while too much of it risks destabilizing the drug content inside.
Plant-based gelatin alternatives follow the same manufacturing process
Gelatin has been the industry standard in manufacturing hard capsules for nearly a century. But currents drifting away from animal-based ingredients are spurring research into vegetarian alternatives. Substitute materials like starches and carrageenan can be handled with minor modifications to existing technology.
HPMC capsules have emerged as a prime contender to produce plant-based encapsulation formulas. An edible natural polymer, HPMC is made from plant-extracted cellulose. Unlike gelatin, which is non-allergenic foodstuff, HPMC is considered an additive (E460).
