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Maker - Product Challenge

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Capsule Sorting Machines

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

ci-precision-weight-checking-brochure-pdf

CI-Precision-weight-checking-brochure.pdf

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Easily and automatically sort by weight or number within a compact benchtop footprint

Save time with sorting rate of up to 75 units per minute

GMP design with quick and easy cleaning, all contact components stainless steel or PEEK

Highly accurate CI Precision balance

Extreme accuracy up to +/- 0.5mg for even more precision

Option of a hopper for larger batches

Pharmaceutical

Sorting Machines

Sorting is the process of arranging items systematically, using a specified criterion, to categorize and group similar items and identify non-conforming items for removal. The choice of a sorting machine depends on the type of item to sort, the sorting criteria, the number of categories that the items need to be sorted into, sorting speed, and accuracy. Sorting machines can be used in the food processing industry for sorting and categorizing fruits, vegetables, empty bottles, crates, and other items; other examples include sorting of tablets and capsules by weight for quality control in the pharmaceutical industry. As well as sorting waste in the recycling industry. Manual sorting is a laborious task however, with the use of specialized equipment, manufacturers are able to automate their sorting at high speeds.

Sorting

Connect directly with world leading manufacturers of sorting machines and equipment and find technology to build or improve your production line.

Sorting &ndash; Making.com

Sorting Machines and Equipment - Making.com

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

R&amp;D

Batch

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Weighing

solid

The CI Precision SADE SP-B40 is a benchtop checkweigher for tablets and capsules that's easy to use and improves the accuracy and speed of your process.

For laboratory pharmaceutical R&amp;D work or use in clinical trials, a high-accuracy small-scale benchtop weight sorter is the perfect solution. However,

Benchtop weight sorter for tablets &amp; capsules &ndash; Making.com

We open production technology to everyone

Making.com

Reclaims weight-rejected product, reduces wastage

Sorts a variety of doses without downtime for parts change

Suitable for continuous operation at up to 210,000 units per 24 hours

GMP design, all contact components stainless steel or PEEK

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

For medium scale production, you can improve line efficiency and reduce setup costs by opting for a fully flexible weight sorter that can handle a wide

Waste minimization weight sorter for tablets & capsules &ndash; Making.com

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

Sort a variety of doses without downtime for parts change

Suitable for continuous operation at up to 105,000 units per 24 hours

Minimal downtime thanks to quick and easy maintenance

The SADE SP sorters from CI Precision for accurate weight sorting of tablets or capsules can handle a wide range of product shapes and sizes.

Saving costs and improved production efficiencies are possible by opting for a pharmaceutical weight sorter that is fully flexible and able to handle a

Versatile weight sorter for tablets &amp; capsules &ndash; Making.com

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

Made of high quality stainless steel material

  Suitable and adjustable for wide variety of product sizes

New technology counting device programmable logic combined to the fiber optics

Small in size and compact

To claim that a tablet meets quality requirements, you must perform several inspections to ensure its efficacy and patient safety. In addition to the tests described in official compendia such as weight variation test or dissolution test, visual inspection or metal detection are equally important. Metal detection identifies ferrous, non-ferrous, or stainless steel contaminants in tablets while visual inspection can detect defects such as color deviations, bubbles, or cracks.

Tablet inspection system

Packaging

Continuous

Counting

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

The KZ-1 electronic counter by Dott Bonapace guarantees the utmost versatility in counting.

This machine has been designed to offer an ever-precise and reliable count of capsules, tablets and pearls of every size. Semi-automatic electronic

R&D electronic counter for capsules and tablets &ndash; Making.com

R&D electronic counter for capsules and tablets - Making.com

<h3>Mold the shells into shape with capsule manufacturing equipment</h3>
Capsule shells are composed of the body and the cap that closes the dosage. Capsule manufacturing equipment dips a series of steel pins into a drum filled with the base material. The wet molding pins move to the drying chamber to harden as they spin on their axis to ensure even distribution.

Once the shells are formed, they are stripped off the pins. But they are not yet finished for filling. The empty capsules must first be cut to the correct length and joined in a pre-lock position, ready for encapsulation.

Encapsulation technology lines up the capsule bodies on a bed of holders. A stainless steel dosage system pours the formula in the powder tray into the shells. The caps, aligned precisely in their holding section, are ready to be lowered onto the filled capsule bodies. The fins in the body enter the slits of the cap, locking them into position.

The encapsulated ingredients directly impact shell stability. Hygroscopic materials, for example, risk cracking the gelatin capsules. Capsule filling machines must account for the properties of the dosage formula and the materials, thickness, and shelf life of the shells.

Capsule production is either an automatic, semi-automatic or manual process. Manual capsule fillers are still used in smaller production facilities. However, for making large scale pharmaceutical capsules, automation is employed to maximize output and efficiency.

Pair the API with the correct shell before the capsule filling process

<h3>Control the water content in hard gelatin capsules to balance plasticity and containment</h3>
The first hard gelatin capsules were filled with pharmaceutical formulas in powder form. But one of the advantages of encapsulation is that it offers flexibility with a range of dosage solutions, from tablets to beads to micro-capsules.

This versatility means that the gelatin shells have to deliver stability. The gelatin mix must allow <a href="https://making.com/hard-gelatin-capsules" target="_blank" rel="noopener">enough moisture content</a> to create elasticity without altering the properties of the <a href="https://making.com/active-pharmaceutical-ingredients-api" target="_blank" rel="noopener">encapsulated APIs</a>.

Soft gelatin capsules, also known as softgels, are suitable for non-aqueous solutions such as oil. The active pharmaceutical ingredients are dissolved or suspended into an oil-based form.

One of the challenges in <a href="https://making.com/softgel-capsules" target="_blank" rel="noopener">producing softgel capsules</a> is the formation of air bubbles in the gelatin base. This happens when the capsule manufacturing equipment fails to reach the right temperature during the drying stage, and air remains trapped in the mixture. These pockets of unreleased air weaken the structure of the capsule.

Insufficient drying temperature leads to undesirable air pockets in soft gelatin capsules

Hypromellose emerged as the plant-sourced <a href="https://making.com/gelatin-powder" target="_blank" rel="noopener">alternative to gelatin</a>. But <a href="https://making.com/hpmc-capsules" target="_blank" rel="noopener">HPMC capsules</a> are <a href="https://making.com/hpmc-capsules" target="_blank" rel="noopener">less dependent on water content</a>, making them a better solution for hygroscopic ingredients.

However, since Hypromellose has a higher oxygen permeability, the fill ingredients need anti-oxidant additives to compensate. HPMC capsules also require oxygen-resistant packaging, such as aluminum blister configurations.

HPMC capsules are more suitable hygroscopic fillings

<h3>Blister packs offer greater protection for pharmaceutical capsules</h3>
The packing solution depends on the type of capsule. Vitamin or food supplement capsules may be bottled in simple containers. However, a desiccant pouch helps to absorb moisture and maintain a controlled environment.

In the case of pharmaceutical capsules, the ingredients demand safer packaging. Blister packs are more secure and are more convenient for dosage control. Complete <a href="https://making.com/technologies/blister-packing-equipment">blister packaging solutions</a> often include coding and die-cutting systems, but simple entry-level batch machines are also available.

Capsule Making Equipment

Find production technology for filling, forming, and packing capsules and connect directly with leading machine and equipment manufacturers worldwide.

Capsules &ndash; Making.com

Capsule Making Equipment - Making.com

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Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

What's new in pharmaceutical packaging? During Pharmapack, we met Chantal Younes, Key Account Manager at Aptar CSP Technology, who introduced us to the

#Changemaker: Ready to protect your pharmaceutical products from moisture? &ndash; Making.com

#Changemaker: Ready to protect your pharmaceutical products from moisture?

Deborah

Thousands of different capsules are produced every day, so it is inevitable that some of them will come out defect in shape or size, with a colour

How reliable imaging plays an important role in capsule visual inspection &ndash; Making.com

How reliable imaging plays an important role in capsule visual inspection

Irina Lescika

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

We have all come across desiccants at some point in our lives. They come in little white packets or cans in packaged products with the strict instruction,

Keeping pharmaceuticals moisture free &ndash; Making.com

Keeping pharmaceuticals moisture free

We are happy to share our knowledge on making pharmaceuticals and nutraceuticals. Send us a message and we will help you solve your production challenge.

IndustryExpertPharma

<span style="font-weight: 400;">Soft gelatin (or softgel) capsules have become a popular mode of oral liquid dosing for the pharmaceutical and food supplements industries. Their obvious benefits include the lack of any taste, their tamper-proof enclosure, and the ease with which they can be swallowed compared to tablets and capsules. For full-scale manufacturing, a high quality, reliable, accurate and fast softgel filling solution is required. A machine range that offers a variety of throughput and speed options allows tailoring to your exact production requirements.</span>
<h2>Full-scale, high quality softgel encapsulators for a range of production volumes</h2>
<span style="font-weight: 400;">The SGM407, SGM610i, and SGM612i softgel encapsulators from Technophar offer industry-leading quality and reliability for the full-scale production of oval or oblong filled softgel capsules. With maximum output capacities ranging from 172,800 capsules per hour up to a class-leading 506,880 per hour, the SGM range has the ability to meet your exact production needs.</span>

<span style="font-weight: 400;">All SGM models feature the same top-quality systems and components and feature superb build-quality for operational reliability and longevity. The SGM range has avoided the need to use less reliable mechanical gearing, and has adopted servo motors and electronic gearing in all critical components to decrease downtime associated with preventative maintenance and breakdown.</span>

<span style="font-weight: 400;">The SGM softgel filling range are all built on solid aluminium frames, and offer a range of stainless steel outer covers to your requirements, including GMP/FDA specification if required. The all-stainless cladding ensures that SGM filling machine are easy to clean and sanitise and are totally corrosion-resistant for a long lifespan.</span>

<span style="font-weight: 400;">The SGM407 features a separate Programmable Logic Controller (PLC) and electrical cabinet, while the other models are fully integrated. All feature a touchscreen user interface which gives quick access to, and full control over, all the production parameters. </span><span style="font-weight: 400;">Each machine can produce oval or oblong capsules, and you can select the best option to fit your production throughput requirements.</span>

Automatic soft gelatin capsule machines

A recent important change in the industry is the trend toward providing liquid doses contained in hard capsules.  The right equipment is need to develop processes to fill hard capsules with the wide variety of liquids used by today's pharmaceutical producers.  Laboratory equipment that is capable of handling waxes and lipids, automatically sealing the capsules, and maintaining a tightly controlled process suitable for scaling to production levels will give pharmaceutical innovators an edge of the competition.


<h2>Fill and seal hard capsules with any pharmaceutical liquid</h2>
Fluidocap 1000 is a semi-automatic machine for filling hard pharmaceutical capsules with liquid an sealing them.  It is provided by ACGE-Associated Capsules a world leader in pharmaceutical machinery manufacturing.  Traditionally liquid doses have been provided in soft gel-cap form and have presented drug makers with the common problems of high cost, wastage, cross contamination, migration of the drug into the capsule, and low bioavailability.

The Fluidocap range of machines address these issues by allowing the filling and sealing of hard capsules with liquid compounds rather that relying on soft gelcaps.  The hard capsules can be filled with a wide range of formulations including lipid-based products, high viscosity pastes, and wax type products.  They are sealed with a gelatin band.  The Fluidocap 1000 capsule filler for liquid is designed for laboratory use and can produce up to 1000 capsules per hour but can easily be scaled up to commercial level production.

Laboratory capsule filler for liquid solutions

The global fish oil market is expected to reach USD 5.42 Billion by 2026. Fish oil is mainly used for aquaculture feed, animal &amp; pet feed,

The rising tide of fish oil supplements &ndash; Making.com

The rising tide of fish oil supplements

Did I take my medicine this morning or not? Let's be honest. How often have we asked ourselves this question and failed to find an answer simply because…

#Changemaker: Keep track of your medicine every day with FabriSol sticker &ndash; Making.com

#Changemaker: Keep track of your medicine every day with FabriSol sticker

Do you know how long it takes a tree to grow? To answer this question precisely, you have to consider various factors such as climate or the tree species,

#Changemaker: Turning grass into pharmaceutical packaging &ndash; Making.com

#Changemaker: Turning grass into pharmaceutical packaging

Find production technology for Capsule Sorting Machines, and connect directly with leading machine manufacturers worldwide.

Capsule Sorting Machines

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Benchtop weight sorter for tablets & capsules

Waste minimization weight sorter for tablets & capsules

Versatile weight sorter for tablets & capsules

R&D electronic counter for capsules and tablets

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Which capsule sorting machines equipment do you need?

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