Manufacturing Active Pharmaceutical Ingredients (API)
API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.
Which active pharmaceutical ingredients (api) equipment do you need?
Ultra-fine dispersing machine for APIs and vaccines
Industrial sieving machine for pharmaceuticals
Fluidized bed system for the granulation and drying of pharmaceuticals
Continuous roller compactor for dry granulation of pharmaceuticals
Container blender for pharmaceuticals
Pharmaceutical tablet coating machine
Single-use containment valves
High containment split butterfly valve
Bellows for pharmaceutical powders
High containment segment ball valve
High containment sampler
Removable GMP compliant connections for tubing
Premium vacuum conveyor
Spiral jet mill
In-line continuous blender
Conical screw mixer
Conical screw vacuum dryer
Pharmaceutical granulator
Spheronizer
Laboratory mill for small batches
Pusher centrifuge
Vertical scraper centrifuges
Vertical peeler centrifuge
Vertical top discharge centrifuge
Mobile pilot plant centrifuge
Isolator centrifuge
Horizontal pharmaceutical scraper centrifuge
Horizontal chemical scraper centrifuge
High-shear impact mixer
Active freeze dryer
Laboratory scale active freeze dryer
Laboratory conical screw vacuum dryer
Powder tester
Vertical paddle dryer
Multipurpose and R&D freeze dryer
GMP laboratory freeze dryer
Purified water systems
Restricted-access barrier systems
Aseptic barrier systems
Transfer system for high-containment environments
Glove tester
Half-suit tester
Downflow booth
Vertical laminar flow cabinet
Horizontal laminar flow benches
Positive pressure isolator
Negative pressure isolator
Checkweigher for sachets and sticks
Checkweigher for stand-up pouches
Mobile pallet turner
Mobile pallet turner for higher stacks
Versatile mobile pallet turner
Mobile pallet changer without turning
Pallet changer
Pallet changer floor level
V-shaped pallet changer
Non-tilting pallet changer
In-line pallet changer
Flexible contained handling of powder transfer bags
Flexible contained powder charging solution
Flexible contained charging for split butterfly valves
Crimping system
Flexible enclosures
Flexible contained drum transfer system
Flexible contained powder discharge into FIBC’s
Flexible contained powder discharge into drums
Filter dryer
Spherical dryer
Centrifugal disc filter
Magnetic agitator
Contained capsule filler
Flexible containment zip
Flexible containment docking solution
Small feeder with flexible wall hopper
Horizontal vacuum dryer with eccentric agitator
Rotary vacuum dryer
Horizontal paddle vacuum dryer
Laboratory-scale vacuum tray drying oven
Hygienic automatic iris valve
Hygienic hand-operated iris valve
Slide gate valve
Roller gate valve
Microencapsulation system for your drug delivery system
High-shear mixer
Conical mill for drug formulation
High capacity capsule filler
Tumbler sieve for classifying and dedusting granular materials
Entry level HFFS Machine for flat sachets
Portable IBC washer
IBC bin washer and dryer
CIP system for bulk tanks
GMP chamber washer
GMP washer
Cleaning and sterilization systems
Vacuum sack lifter
Pharmaceutical container lifter
Mobile drum lifter
Container lifter
Powder transfer vessel
GMP Jib crane
Drum conditioner
Single-use powder handling bag
Metal detector for pharmaceutical powders
API powders storage bottle
Single-use containment valve
High containment closing system
Gravimetric powder microdosing 0.400 - 2 g
Gravimetric powder microdosing 2 - 100 g
Fast gravimetric powder microdosing 50 - 200 g
Hygienic mobile scale
Hygienic floor scale with lifting device
Hygienic floor scale
Fluid bed dryer for pharmaceutical solid dosage form
Industrial high shear mixer granulator for drug formation
Inspection system for tablets chemical composition
Powder transfer system
API containment isolator
Powder micro-dosing system
Accurate multiple dosing system for powders
Filter dryer discharging isolator
High containment micronizing isolator
Sterile Filtration System for GMP-grade products
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Select your active pharmaceutical ingredients (api) process
Tell us about your production challenge
Manufacturing API from a natural, synthetic, or semi-synthetic base
Synthetic APIs are developed from chemical conversions in a lab. Natural APIs, on the other hand, are derived from plants or animals and then purified. Semi-synthetic options stand somewhere in between. They are extracted from natural sources but then biochemically converted into the final Active Pharmaceutical Ingredient API.
The three main groupings of active pharmaceutical ingredients, however, employ similar extraction methods. The intermediaries are extracted from raw materials in a reactor before passing through a series of filtering and centrifuges for isolation and purification. Depending on the finished products, API are milled or freeze-dried before packaging. Distillation is also a key process used in the manufacturing of APIs. The distillation process is used to purify and isolate the desired compound from a complex mixture of chemicals.
Follow GMP standards for your API making equipment
Your API processing equipment must have official certification for reaching production standards.
There are multiple protocols, but Good Manufacturing Practices (GMP) are the global benchmark in pharmaceutical product certification. The World Health Organization (WHO) issues guidelines in this department but other jurisdictions such as China, the EU, and Canada have developed their own GMP.
Classification of API must be clearly displayed on your product label
There are hundreds of active pharmaceutical ingredients used for a wide range of finished pharmaceutical products. Orphenadrine, for example, is the main API found in muscle relaxants, while antivirals are composed of oseltamivir carboxylate. The pharmacological effects of antidepressants are driven by active ingredients such as memantine, amitriptyline, and citalopram. APIs come in various forms such as powders, liquids, tablets and capsules.
The WHO keeps and updates a catalog of all API, ensuring common application and labeling across all pharmaceutical manufacturing markets. The names of these ingredients are non-proprietary and must be displayed under the brand names of packaged pharmaceutical products.
HPAPI manufacturing requires expert containment solutions
The API sector is moving in the direction of highly potent active pharmaceutical ingredients (HPAPI). These special components deliver a stronger drug efficacy than regular API and at a reduced dose. Medicines made from HPAPI minimize side effects and are an important development in the treatment of chronic conditions.
Manufacturing HPAPI, however, raises a series of considerations. Producers must ensure strict handling and cleansing procedures to adhere to occupational exposure limits (OEL) and rigorous quality control to keep their workers safe.