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API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Which active pharmaceutical ingredients (api) equipment do you need?

Ultra-fine dispersing machine for APIs and vaccines

Multi-staged rotor/stator mixers generate the high shear forces requi...

Industrial sieving machine for pharmaceuticals

One of the physical

Fluidized bed system for the granulation and drying of pharmaceuticals

Pharmaceutical industries employ several process...

Continuous roller compactor for dry granulation of pharmaceuticals

When making tablets, pharmaceutical manufacturers ne...

Container blender for pharmaceuticals

Manufacturing pharmaceutical solids like tablets requires using a proper blender to b...

Pharmaceutical tablet coating machine

Tablet coating requires spraying, mixing, and drying procedures that must be carried ...

Single-use containment valves

From GMP and HSE perspective material transfer is critical for chemical and pharmaceutical for...

High containment split butterfly valve

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. ...
Bellows for pharmaceutical powders

Bellows for pharmaceutical powders

Thermal and mechanical changes can lead to stresses in industrial piping systems. These ...
Ball valve

High containment segment ball valve

Valves fitted in blenders and dryers can have dead spaces that prevent complete process...
high containment sampler

High containment sampler

Drawing a sample for evaluation from a running process is not a simple task, especially when dealing...
removable gmp compliant connections for tubing

Removable GMP compliant connections for tubing

Tubing frameworks can have rough welding joints, corners and sharp angles t...

Premium vacuum conveyor

When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...

Spiral jet mill

Jet mills are frequently used in the pharmaceutical industry and also for the production of fine-grade chemica...

In-line continuous blender

When you consider shifting pharmaceutical mixing processes from batch to continuous, accurate in-...

Conical screw mixer

When you want to mix segregative, free-flowing powders and pastes that require perfect mixing quality and...

Conical screw vacuum dryer

The conical screw vacuum dryer is particularly suitable for the final drying of powders, granules...

Pharmaceutical granulator

Pharmaceutical granulators are often used with active substance mixtures to be processed into gran...

Spheronizer

A spheronizer produces spherical pellets with a smooth surface and a narrow particle size distribution.

Laboratory mill for small batches

The Alpine Picoline is a series of miniature laboratory machines for processing samples d...

Pusher centrifuge

Pusher centrifuges are continuously operating filter centrifuges and can have several basket stages dependi...

Vertical scraper centrifuges

Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the botto...

Vertical peeler centrifuge

A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from ...

Vertical top discharge centrifuge

Discharge solids vertically upward through manual action, optionally using a filter bag o...

Mobile pilot plant centrifuge

The system is perfectly suited for pilot plants as well as small-quantity productions in the f...

Isolator centrifuge

For transferring highly active pharmaceutical ingredients (HAPI) without contamination from the isolator ...

Horizontal pharmaceutical scraper centrifuge

For slurries difficult to discharge, a scraper can improve process reliabilit...

Horizontal chemical scraper centrifuge

For slurries difficult to discharge, a scraper can improve process reliability, effi...

High-shear impact mixer

When you need to mix cohesive powders with liquids or melt binders and require a homogenous end-produ...

Active freeze dryer

Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying ...

Laboratory scale active freeze dryer

The laboratory-scale active freeze-drying is used for dehydrating high-value products ...

Laboratory conical screw vacuum dryer

The laboratory conical screw vacuum dryer is particularly suitable for the final dryi...

Powder tester

When you want to predict powder behavior in future and existing installations, possible measures to be taken or ...

Vertical paddle dryer

Enable vacuum, atmospheric and pressurized processing of a variety of materials such as powders, filter...

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common applic...

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need...

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Transfer system for high-containment environments

A high-performance transfer port system that combines ultimate safety, ...

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

Checkweigher for sachets and sticks

The checkweighers for multiple lanes have a 1.5 times faster response speed and 2 times...

Checkweigher for stand-up pouches

When working with several lines of stand-up pouches, you can benefit from controlling the...

Mobile pallet turner

Turning your pallet may allow for more effective pallet changing than the conventional lifting and grabb...

Mobile pallet turner for higher stacks

When you need to opt a pallet changer that is capable of lifting and turning loads a...

Versatile mobile pallet turner

Here is the versatile mobile pallet turner that completes the typical features of all mobile ...

Mobile pallet changer without turning

If you are looking to change the pallet without turning the load, through a lateral p...

Pallet changer

For turning loads and exchanging them on pallets, here is a stationary pallet changer that will load and unload...

Pallet changer floor level

For transferring goods from wooden pallets to plastic pallets, or vice-versa, this Pallet changer...

V-shaped pallet changer

If you are looking for a sturdy pallet changing solution, a stationary V-shaped pallet changer can be...

Non-tilting pallet changer

Stable vertical lifting of the load from the pallet to enable EPAL or industrial pallet exchange.

In-line pallet changer

When you need to transfer load from one pallet to another without tilting or turning, then selecting t...

Flexible contained handling of powder transfer bags

Filling of transportation bags and discharging them into mix tanks or...

Flexible contained powder charging solution

Filling of transportation bags and discharging them into mix tanks or reactor ...

Flexible contained charging for split butterfly valves

Poly bottles with split butterfly valves are often used to transfe...

Crimping system

Flexible disposable containment systems in the form of specially designed plastic bags are an excellent choice...

Flexible enclosures

Maintaining the purity of products as well as avoiding worker exposure to potentially harmful substances ...

Flexible contained drum transfer system

Transferring powders from drums to process equipment such as reactors or mills can ...

Flexible contained powder discharge into FIBC’s

Flexible intermediate bulk containers known as FIBC’s are commonly used ...

Flexible contained powder discharge into drums

Powdered products are handled every day in the pharmaceutical and bioproces...

Filter dryer

The pharmaceutical and bioprocess industries need filtration processes of particularly high quality to ensure the...

Spherical dryer

Drying vessels that are simple, reliable, and easy to maintain increases product quality and process efficienc...

Centrifugal disc filter

The pharmaceutical and bioprocess industries need filtration processes of particularly high quality t...

Magnetic agitator

Reliable mixing and agitation are essential to any quality production process that involves a fluid. This n...

Contained capsule filler

For pharmaceutical formulations that are highly active specialized capsule filling equipment is ofte...

Flexible containment zip

Transfer of sensitive and toxic bulk goods across process units requires specialist handling to prev...

Flexible containment docking solution

When sampling or transferring hazardous substances and sensitive bulk goods, a dust-t...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Horizontal vacuum dryer with eccentric agitator

Conventional dryers are inefficient and can lead to significant mechanical...

Rotary vacuum dryer

Powdered products tend to agglomerate during vacuum drying. This adds an additional step to the productio...

Horizontal paddle vacuum dryer

Agitated vacuum dryers can be difficult to clean which makes them unsuitable for multi-produc...

Laboratory-scale vacuum tray drying oven

Vacuum drying is used to remove moisture from sensitive materials. Drying small ba...

Hygienic automatic iris valve

In automated systems where controlled discharge of powders and bulk solids is required with a ...

Hygienic hand-operated iris valve

Hand-operated valves are required for the walls of clean rooms for glanding around cables...

Slide gate valve

In the powder and bulk handling industries, in-line shut off valves are required to provide uninterrupted smo...

Roller gate valve

In large scale operations, modular and configurable valves are required to isolate and control dry powders,...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

High-shear mixer

For the efficient mixing of larger batches of pharmaceutical compounds and hi...

Conical mill for drug formulation

The efficient size reduction of granular powders is a key...

High capacity capsule filler

In the highest volume pharmaceutical production environments, c...

Tumbler sieve for classifying and dedusting granular materials

For the classification of delicate granular material, scr...

Entry level HFFS Machine for flat sachets

Traditional horizontal form fill and seal sachet machines for lower volume lines...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but tradit...

GMP chamber washer

The thorough cleaning of small product contact parts has always been chall...

GMP washer

In order to guarantee zero cross-contamination between production batches, the prop...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutica...

Vacuum sack lifter

In the production of pharmaceuticals and other high-hygiene environments, manual handling of inputs or int...

Pharmaceutical container lifter

Moving larger or heavier containers from height is out of the scope for standard handling eq...

Mobile drum lifter

The production of pharmaceuticals and other hygienic products often requires the handling of large and bul...

Container lifter

Container handling in the pharmaceutical industry brings its own set of unique challenges. Traditional barrel...

Powder transfer vessel

Intermediate bulk storage of pharmaceutical product requires specialist containers. For increased effi...

GMP Jib crane

Vacuum manual handling systems are the ideal way of quickly and safely moving small to medium sized loads in all...

Drum conditioner

Many pharmaceutical production processes involve the use of products that have naturally hardened within thei...

Single-use powder handling bag

Containers for handling pharmaceutical and biopharmaceutical powders may be disposable, to av...

Metal detector for pharmaceutical powders

Powdered and granulated pharmaceuticals require careful screening against metal ...

API powders storage bottle

Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions ...

Single-use containment valve

Safe transfer of liquids and hazardous powders into systems can be a challenge in pharma, bioph...

High containment closing system

Pharma and biopharma laboratories need fast effective solutions for tightly sealing bags for...

Gravimetric powder microdosing 0.400 - 2 g

If you need to process high value food, pharmaceuticals or chemicals, there is ...

Gravimetric powder microdosing 2 - 100 g

Powders and granules are commonly dosed for the manufacturing of pharmaceuticals, ...

Fast gravimetric powder microdosing 50 - 200 g

Micro-dosing powders of high-value food or chemical products can be challen...

Hygienic mobile scale

Having a reliable and accurate weighing and measuring solution is absolutely essential, especially in t...

Hygienic floor scale with lifting device

The food and pharmaceutical industries require maintaining high levels of sanitati...

Hygienic floor scale

The food and pharmaceutical industries require maintaining high levels of sanitations as well as logisti...

Fluid bed dryer for pharmaceutical solid dosage form

Fluid bed drying is a pharmaceutical process carried out to reduce t...

Industrial high shear mixer granulator for drug formation

It is rather difficult to successfully produce a pharmaceutica...

Inspection system for tablets chemical composition

The packaging of pharmaceuticals and oral solid products such as table...

Powder transfer system

Loading powder from a container source to vessels, tanks, or mixers that are under pressure may be haz...

API containment isolator

Contamination is a major concern in powder handling, not least when processing pharmaceutical produc...

Powder micro-dosing system

Pharmaceutical powders in metered doses demand maximum filling precision. This is particularly ch...

Accurate multiple dosing system for powders

Dosing multiple powders in a batch process is time inefficient, especially whe...

Filter dryer discharging isolator

Contained discharging is critical to the quality of filtration and drying processes. But ...
micronizing isolator

High containment micronizing isolator

Powder processing for chemical compounds demands product-specific micronizing solutio...

Sterile Filtration System for GMP-grade products

Processing equipment used in industries regulated by GMP must ensure full...
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Stories about Active pharmaceutical ingredients (API)

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Manufacturing API from a natural, synthetic, or semi-synthetic base

Synthetic APIs are developed from chemical conversions in a lab. Natural APIs, on the other hand, are derived from plants or animals and then purified. Semi-synthetic options stand somewhere in between. They are extracted from natural sources but then biochemically converted into the final Active Pharmaceutical Ingredient API.

The three main groupings of active pharmaceutical ingredients, however, employ similar extraction methods. The intermediaries are extracted from raw materials in a reactor before passing through a series of filtering and centrifuges for isolation and purification. Depending on the finished products, API are milled or freeze-dried before packaging. Distillation is also a key process used in the manufacturing of APIs. The distillation process is used to purify and isolate the desired compound from a complex mixture of chemicals.

 

Follow GMP standards for your API making equipment

Your API processing equipment must have official certification for reaching production standards.

There are multiple protocols, but Good Manufacturing Practices (GMP) are the global benchmark in pharmaceutical product certification. The World Health Organization (WHO) issues guidelines in this department but other jurisdictions such as China, the EU, and Canada have developed their own GMP.

Classification of API must be clearly displayed on your product label

There are hundreds of active pharmaceutical ingredients used for a wide range of finished pharmaceutical products. Orphenadrine, for example, is the main API found in muscle relaxants, while antivirals are composed of oseltamivir carboxylate. The pharmacological effects of antidepressants are driven by active ingredients such as memantine, amitriptyline, and citalopram. APIs come in various forms such as powders, liquids, tablets and capsules.

The WHO keeps and updates a catalog of all API, ensuring common application and labeling across all pharmaceutical manufacturing markets. The names of these ingredients are non-proprietary and must be displayed under the brand names of packaged pharmaceutical products.

HPAPI manufacturing requires expert containment solutions

The API sector is moving in the direction of highly potent active pharmaceutical ingredients (HPAPI). These special components deliver a stronger drug efficacy than regular API and at a reduced dose. Medicines made from HPAPI minimize side effects and are an important development in the treatment of chronic conditions.

Manufacturing HPAPI, however, raises a series of considerations. Producers must ensure strict handling and cleansing procedures to adhere to occupational exposure limits (OEL) and rigorous quality control to keep their workers safe.

Processing steps involved in active-pharmaceutical-ingredients-api making

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