In-vitro dissolution-absorption assessment
In pharmaceutical development, accurately evaluating the dissolution and absorption processes of drug formulations is crucial. This step is necessary to ensure bioequivalence and optimize product performance. Achieving this involves combining dissolution and absorption measurements within a single assay to streamline the process.
Simultaneously monitor dissolution and absorption
The MacroFLUX by Pion is a sophisticated platform designed for in-vitro assessment of dissolution-absorption processes from full dosage forms. This system combines dissolution and absorption measurements into a single assay, using a filter-supported artificial permeation membrane that creates two separate compartments: the dissolution compartment and the receiver compartment. The dissolution compartment typically contains 900 mL of compendial or biorelevant dissolution buffer, while the receiver compartment holds pH 7.4 Pion Acceptor Sink Buffer. The system features fiber-optic UV probes positioned in both compartments, connected to the Rainbow Dynamic Dissolution Monitor® instrument, allowing real-time concentration monitoring of both dissolution and absorption processes. The MacroFLUX is instrumental during formulation development, life-cycle management, and ensuring product quality and consistency.
Benefits
- Combines dissolution and absorption assays
- Real-time concentration monitoring
- Facilitates bioequivalence studies
- Aids in formulation optimization
- Ensures consistent product quality