In-vitro dissolution-absorption assessment

Optimize drug formulation tests by combining dissolution and absorption measurements in a single assay, ensuring precise bioequivalence assessments and quality control for continuous product performance.

In-vitro dissolution-absorption assessment
Great for making:
In-vitro dissolution-absorption assessment Active pharmaceutical ingredients (API) In-vitro dissolution-absorption assessment Oral liquid formulations In-vitro dissolution-absorption assessment Biopharmaceuticals In-vitro dissolution-absorption assessment Chewable tablets In-vitro dissolution-absorption assessment Vitamins In-vitro dissolution-absorption assessment Gel capsules In-vitro dissolution-absorption assessment Herbal supplements In-vitro dissolution-absorption assessment Extended-release tablets In-vitro dissolution-absorption assessment Protein supplements

Monitors Real-Time Dissolution and Absorption

The MacroFLUX from Pion offers a unique solution for pharmaceutical and biopharmaceutical companies seeking efficient in-vitro dissolution-absorption testing. This system integrates seamlessly into your R&D and laboratory settings, utilizing a fiber-optic UV monitoring approach for real-time monitoring of dissolution and absorption concentrations in both donor and receiver compartments. With capabilities to handle various oral formulations like extended-release tablets and gel capsules, MacroFLUX supports formulation development and life-cycle management by ensuring batch-to-batch bioequivalence and product quality. The filter-supported artificial permeation membrane and Pion Acceptor Sink Buffer TM enable precise drug absorption studies. Easily customizable for different formulations, MacroFLUX assists in developing consistent and bioequivalent drug products, adhering to industry standards for analytical rigor.

Benefits

  • Enhances formulation optimization by providing real-time dissolution and absorption data.
  • Supports regulatory compliance with reliable bioequivalence demonstration.
  • Reduces development time with simultaneous dissolution-absorption studies.
  • Maintains product consistency through precise batch-to-batch comparison.
  • Integrates efficiently into R&D workflows, minimizing operational disruption.

General


Applications
Nutraceuticals,Oral formulations,Biopharmaceuticals,Pharmaceutical tablets
End products
Chewable tablets,Biodegradable polymers,Peptide drug formulations,Vitamin supplements,Gel capsules,Gene therapy formulations,Herbal supplements,Extended-release tablets,Protein supplements,Effervescent tablets
Steps before
Formulation Development,Compound Screening
Steps after
Bioequivalence Testing,Product Quality Assurance,Batch Consistency Analysis
Input ingredients
dissolution buffer,dosage forms,formulations,drug product
Output ingredients
absorption data,dissolution data,bioequivalence data
Market info

Technical Specifications


Donor Compartment Volume
900 mL
Dissolution Buffer Type
Compendial or biorelevant
Receiver Compartment Buffer
pH 7.4 Pion Acceptor Sink Buffer
UV Monitoring
In situ with fiber optic UV probes
Measurement Capability
Real-time dissolution and absorption concentration monitoring

Operating Characteristics


Working mechanism
Simultaneous dissolution-absorption studies
Integrated steps
Dissolution and absorption measurements into a single assay
Batch vs. continuous operation
Batch
Cleanability
CIP / Manual
Energy efficiency
N/A
Automation level
Manual / PLC

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Dissolution Buffer Volume
900 mL
Ph Buffer
pH 7.4
In-vitro Testing
Dissolution and Absorption
Permeation Membrane Type
Filter-supported artificial

Physical Characteristics


Discharge method
Filter-supported artificial permeation membrane

Custom Options


Control panel type
Fiber-optic UV probes positioning
Equipment Groups
Sensors Tablet inspection system
Product Groups
Nutraceuticals Pharmaceuticals Tablets
Processes
Absorption Dissolution Measurement & Control Monitoring Testing