In-vitro dissolution-absorption assessment
Optimize drug formulation tests by combining dissolution and absorption measurements in a single assay, ensuring precise bioequivalence assessments and quality control for continuous product performance.
Monitors Real-Time Dissolution and Absorption
The MacroFLUX from Pion offers a unique solution for pharmaceutical and biopharmaceutical companies seeking efficient in-vitro dissolution-absorption testing. This system integrates seamlessly into your R&D and laboratory settings, utilizing a fiber-optic UV monitoring approach for real-time monitoring of dissolution and absorption concentrations in both donor and receiver compartments. With capabilities to handle various oral formulations like extended-release tablets and gel capsules, MacroFLUX supports formulation development and life-cycle management by ensuring batch-to-batch bioequivalence and product quality. The filter-supported artificial permeation membrane and Pion Acceptor Sink Buffer TM enable precise drug absorption studies. Easily customizable for different formulations, MacroFLUX assists in developing consistent and bioequivalent drug products, adhering to industry standards for analytical rigor.
Benefits
- Enhances formulation optimization by providing real-time dissolution and absorption data.
- Supports regulatory compliance with reliable bioequivalence demonstration.
- Reduces development time with simultaneous dissolution-absorption studies.
- Maintains product consistency through precise batch-to-batch comparison.
- Integrates efficiently into R&D workflows, minimizing operational disruption.
- Applications
- Nutraceuticals,Oral formulations,Biopharmaceuticals,Pharmaceutical tablets
- End products
- Chewable tablets,Biodegradable polymers,Peptide drug formulations,Vitamin supplements,Gel capsules,Gene therapy formulations,Herbal supplements,Extended-release tablets,Protein supplements,Effervescent tablets
- Steps before
- Formulation Development,Compound Screening
- Steps after
- Bioequivalence Testing,Product Quality Assurance,Batch Consistency Analysis
- Input ingredients
- dissolution buffer,dosage forms,formulations,drug product
- Output ingredients
- absorption data,dissolution data,bioequivalence data
- Market info
- Donor Compartment Volume
- 900 mL
- Dissolution Buffer Type
- Compendial or biorelevant
- Receiver Compartment Buffer
- pH 7.4 Pion Acceptor Sink Buffer
- UV Monitoring
- In situ with fiber optic UV probes
- Measurement Capability
- Real-time dissolution and absorption concentration monitoring
- Working mechanism
- Simultaneous dissolution-absorption studies
- Integrated steps
- Dissolution and absorption measurements into a single assay
- Batch vs. continuous operation
- Batch
- Cleanability
- CIP / Manual
- Energy efficiency
- N/A
- Automation level
- Manual / PLC
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Dissolution Buffer Volume
- 900 mL
- Ph Buffer
- pH 7.4
- In-vitro Testing
- Dissolution and Absorption
- Permeation Membrane Type
- Filter-supported artificial
- Discharge method
- Filter-supported artificial permeation membrane
- Control panel type
- Fiber-optic UV probes positioning