Pharmaceutical twin screw extruders
Optimize the mixing and extrusion of active pharmaceutical ingredients with unmatched precision and flexibility, ensuring enhanced bioavailability and innovative controlled-release formulations for medical applications.
Processes APIs and Solid Dosage Forms
The ZSK Pharma Twin Screw Extruders from Coperion are engineered to enhance the continuous processing of active pharmaceutical ingredients (APIs) and solid dosage forms. Featuring a modular design, these extruders provide flexibility in processing with adjustable barrel and screw configurations, ensuring precise mixing and controlled temperatures to prevent API degradation. Ideal for producing controlled-release tablets, sustained-release capsules, and transdermal drug delivery patches, they are instrumental in pharmaceutical applications requiring high levels of dispersion and encapsulation. The ZSK Pharma Extruders offer specific torque of up to 18 Nm/cm³, accommodating high throughput while maintaining product integrity. Integrated with PLC control systems that comply with CFR Part 11, they facilitate seamless automation and easy scale-up from R&D to full-scale production. Constructed in GMP-compliant stainless steel with FDA-compliant lubricants, these extruders ensure reliability and safety. The self-cleaning twin screws and compact design allow for quick operation, reduced maintenance, and minimal space requirements, supported by Coperion’s extensive engineering expertise and after-sales service network.
Benefits
- Enhances API bioavailability with precise, controlled mixing and dispersion.
- Minimizes product degradation through specific torque, optimizing throughput without excessive temperatures.
- Supports efficient scale-up from laboratory to production, ensuring consistent product quality.
- Reduces maintenance time with self-cleaning screws and quick access components.
- Ensures compliance and safety with GMP design and FDA-compliant materials.
- Applications
- Biodegradable implants,Medical adhesives,Active pharmaceutical ingredients (apis),Transdermal patches,Biopharmaceuticals,Medical implants,Solid dosage forms,Pharmaceuticals
- End products
- Wound closure strips,Biodegradable contraceptive implants,Transdermal drug delivery patches,Solid implants with active ingredients,Stoma care adhesives,Bioavailability-enhanced api dispersions,Controlled-release tablets,Sustained-release capsules
- Steps before
- Automated Batch Dispensing,Vacuum Conveying
- Steps after
- Tablet Coating,Encapsulation,Taste Masking,Degassing,Granulation for Capsule Filling,Pelletizing
- Input ingredients
- pharmaceutical active ingredients,APIs,solvent-free solid dispersions,solids solutions,water for degassing,adhesives for transdermal plasters,medical plastics
- Output ingredients
- enhanced bioavailability APIs,solid dosage forms,controlled/sustained release APIs,de-gassed products,encapsulated APIs,taste masked formulations,granules for capsule filling,extrudates for transdermal plasters,extrudates for medical applications,biodegradable implants,contraceptive rings,wound plasters,butterfly closures
- Market info
- Coperion is known for its expertise in manufacturing industrial compounding and extrusion equipment, bulk materials handling systems, and services for various industries, such as plastics, chemicals, and food processing, with a strong reputation for innovative engineering solutions and customer support.
- Screw diameter
- 18 mm
- Specific torque
- 11.3 Nm/cm³
- Maximum screw speed
- 1,200 min-1
- Maximum motor power
- 10-135 kW
- Throughput rates
- 1-10 kg/h
- Modular design
- Exchangeable screw elements
- Barrel length
- 15 barrels (60 D)
- Torque per shaft
- 38 Nm (for ZSK 18 MEGAlab)
- Flight depth
- 3.2 mm
- Design
- GMP design
- Documentation
- Complete process documentation (V-lifecycle)
- Automation
- PLC control and touch screen
- Batch vs. continuous operation
- Continuous
- Automation level
- PLC / SCADA
- Cleaning method
- CIP
- Changeover time
- Quick-release couplings
- Energy efficiency
- High torque for minimized API degradation
- Corrosive resistance (e.g. acids)
- Stainless steel construction
- Cleanability
- GMP compliant,easy access for cleaning
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Machine footprint
- Compact Design
- Compact design
- Modular Construction
- Screw diameter
- 18 mm
- Screw configuration
- Twin Screw,Co-rotating
- Process section length
- Up to 15 barrels (60 D)
- Barrel design
- Modular,Stainless Steel
- Modular barrel design
- Customized process length (L/D)
- Modular screw design
- Broad selection of screw elements
- Control panel type
- PLC control and touch screen
- Cooling system
- Integrated water cooling system
- Base frame type
- Mobile stainless steel base frame
- Documentation
- Complete process parameter documentation (V-lifecycle)