Pharmaceutical spray dryer
Unlock the potential of spray drying to enhance bioavailability, achieve controlled release, and create fine powders for inhalation with ease, meeting stringent pharmaceutical standards.
Spray Dries and Atomizes Pharmaceutical Liquids
The PHARMA-SD® Spray Dryer from GEA provides a robust solution for pharmaceutical and biotech manufacturers requiring precise, cGMP-compliant spray drying capabilities. Utilizing a high-performance atomization system, it effectively converts pharmaceutical liquids into fine powders, crucial for APIs, inhalation products, and controlled-release formulations. With a range accommodating lab to industrial scales, the PHARMA-SD® supports processing across various production capacities, including a nominal drying gas rate of up to 4,000 kg/hr. The equipment incorporates HEPA filtration and operates under positive pressure, ensuring product integrity and safety, with optional high-containment designs for handling potent compounds safely. Its energy-efficient operation, facilitated by variable-speed motor control, ensures cost-effective performance. Constructed with AISI316 stainless steel and FDA-compliant gasket materials, it offers excellent corrosion resistance. Integration with upstream and downstream operations, including Clean-In-Place systems and automated process controls, is seamless, enhancing operational efficiency. GEA also supports customization to meet specific process requirements, exemplifying engineering excellence with flexible configuration options.
Benefits
- Ensures high product quality and safety with cGMP compliance and HEPA filtration systems.
- Enhances process efficiency with customizable configurations tailored to specific production needs.
- Safely handles high-potency compounds with containment levels below 10 µg/m³ OEL.
- Minimizes energy use through optimized variable-speed motor control.
- Facilitates easy integration and maintenance with CIP systems and straightforward control interfaces.
- Applications
- Vitamins,Supplements,Fine chemicals,Pharmaceutical tablets,Nutraceuticals,Pharmaceutical powder,Biopharmaceuticals
- End products
- Inhalation powders,Taste-masked formulations,Active pharmaceutical ingredients (apis),Controlled release tablets,Probiotics,Vaccine powders,Vitamin c powders,Protein supplements,High-potency drugs,Antibiotic powders
- Steps before
- Formulation Preparation,Emulsification,Grinding,Mixing,Purification
- Steps after
- Controlled Release Testing,Bioavailability Testing,Packaging,Coating,Tablet Pressing
- Input ingredients
- pharmaceutical product,atomization gas,process gas
- Output ingredients
- fine powders,precise powders for inhalation,bio-available compounds,controlled release powders,taste masked products,potent compound powders
- Market info
- GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.
- Nominal Drying Gas Rate
- 4,000 kg/hr
- Containment Level
- Below 10 µg/m³ (OEL)
- Material
- AISI316 (EN 1.4401/1.4436)
- Atomization Gas Filtration
- HEPA Filter
- Exhaust Gas Filtration
- Bag Filter and Police HEPA Filter
- Pressure Operating Mode
- Slight Positive Pressure
- Calibration
- Manufacturers’ Calibration Certificates
- Venturi and Differential Pressure
- Calibrated Differential Pressure Measurement
- Working mechanism
- Spray drying
- Automation level
- PLC / SCADA
- Batch vs. continuous operation
- Batch / Inline Continuous
- CIP/SIP
- Clean-In-Place (CIP)
- Cleaning method
- CIP / Manual
- Integration capability
- Up- and down-stream operations
- Containment level
- Below 10 µg/m3(OEL)
- Design Flexibility
- Customizable modules for specific requirements
- Risk assessment cooperation
- Client collaboration for optimal solutions
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- FDA Materials
- FDA 21 CFR part 177
- Machine size/Footprint
- Lab size to large-scale
- Tank and cone shape
- Standardized modules
- Spray dryer nominal drying gas rate
- Up to 4,000 kg/hr
- Control System Integration
- Customizable PLC/SCADA
- Containment Level Customization
- High-containment Design
- Cleaning System Options
- CIP/SIP Integration
- Configuration Customization
- Modules for Specific Requirements
- Size Options
- Lab to Large-scale Production Units
- HEPA Filter Customization
- Customizable Filter Assemblies
- Process Set-up Changes
- Minor Modifications Possible