15l vertical-wheel bioreactor for cell therapy scale-up

Accelerate your cell therapy scale-up with a bioreactor that offers efficient cell culture, sampling, and medium exchange, ensuring seamless transitions from research through clinical trials.

Scales and Optimizes Cell Culture Processes

The PBS-15 Vertical-Wheel Bioreactor from PBS Biotech is designed to advance your cell culture processes by integrating the unique vertical-wheel design for superior mixing and scalability. This bioreactor supports applications in biopharmaceuticals, cell therapy, and regenerative medicine, producing high-quality end products like CAR-T cell therapy and microcarrier-based stem cell cultures. With a maximum working volume of 15 liters, it efficiently scales up from bench-top experiments to clinical production. Equipped with a touchscreen interface, it offers intuitive process control and customization, allowing for seamless medium exchange and sampling via an adjustable height harvest valve. It supports both single-use and reusable sensor configurations, ensuring operational flexibility. The PBS-15’s software allows for remote monitoring and data storage in compliance with 21 CFR Part 11 standards. Designed for easy cleaning and maintenance, it is ideal for pharmaceutical manufacturers, cell therapy developers, and research laboratories looking to optimize their cell culture workflows.

Benefits

  • Enhances scalability, accommodating growth from pilot studies to clinical trials.
  • Streamlines process management with a user-friendly touchscreen for customization and control.
  • Facilitates efficient resource usage with optimized medium exchange and sampling.
  • Offers flexibility with compatibility for both single-use and reusable sensors.
  • Ensures regulatory compliance with comprehensive data tracking and remote monitoring capabilities.

General


Applications
Clinical trials,Cell therapy,Regenerative medicine,Biopharmaceuticals,Stem cell culture,Exosomes,Tissue engineering,Immunotherapy
End products
Msc-derived exosome products,Personalized cell therapies,Car-t cell therapy products,Cell-based vaccines,Engineered tissue constructs,Hipsc aggregates for therapy,Microcarrier-based stem cell cultures
Steps before
Cell culture preparation,Media formulation,Bioprocess setup
Steps after
Medium exchange,Sampling,Cell harvesting
Input ingredients
human cells,anchorage-dependent cells,cell aggregates,microcarriers,culture medium,suspension media
Output ingredients
expanded cell cultures,cell aggregates,harvested cells,spent medium
Market info
PBS Biotech is known for manufacturing single-use, scalable bioreactor systems designed for cell therapy and biologics production, featuring their innovative Air-Wheel mixing technology for efficient and consistent results.

Technical Specifications


Working volume
15L
Sensor compatibility
Single-use or reusable DO and pH sensors
Harvest method
Adjustable height harvest valve
Software compatibility
3.0 (21 CFR Part 11 cGMP Upgrade)
Automation level
Touchscreen interface for process customization and control
Mobility
Floored with wheels for movement

Operating Characteristics


Working Volume
15L
Scale-up capability
From PBS-Mini and PBS-3
Touchscreen Interface
Intuitive process customization,control,and reporting
Sensor Configurations
Single-use or reusable DO and pH sensors
Harvest Valve
Adjustable Height Harvest Valve (AHHV)
Remote Monitoring
Available for 3L and larger bioreactors
Data Storage
21 CFR Part 11 cGMP compliant

Product type Characteristics


Cell culture process
Scale-up

Physical Characteristics


Machine footprint
Recommended for floor placement
Tank shape and size
Vertical-Wheel design,15L working volume
Adjustable Height Harvest Valve (AHHV)
Adjustable for rapid medium exchange,sampling,and harvesting
Discharge method
Bottom discharge via AHHV

Custom Options


Control panel type
Touchscreen interface
Integration possibilities
Single-use or reusable sensors
Discharge method
Adjustable Height Harvest Valve (AHHV)
Remote process monitoring
Yes,via secure connection