15l vertical-wheel bioreactor for cell therapy scale-up
Accelerate your cell therapy scale-up with a bioreactor that offers efficient cell culture, sampling, and medium exchange, ensuring seamless transitions from research through clinical trials.

Scales and Optimizes Cell Culture Processes
The PBS-15 Vertical-Wheel Bioreactor from PBS Biotech is designed to advance your cell culture processes by integrating the unique vertical-wheel design for superior mixing and scalability. This bioreactor supports applications in biopharmaceuticals, cell therapy, and regenerative medicine, producing high-quality end products like CAR-T cell therapy and microcarrier-based stem cell cultures. With a maximum working volume of 15 liters, it efficiently scales up from bench-top experiments to clinical production. Equipped with a touchscreen interface, it offers intuitive process control and customization, allowing for seamless medium exchange and sampling via an adjustable height harvest valve. It supports both single-use and reusable sensor configurations, ensuring operational flexibility. The PBS-15’s software allows for remote monitoring and data storage in compliance with 21 CFR Part 11 standards. Designed for easy cleaning and maintenance, it is ideal for pharmaceutical manufacturers, cell therapy developers, and research laboratories looking to optimize their cell culture workflows.
Benefits
- Enhances scalability, accommodating growth from pilot studies to clinical trials.
- Streamlines process management with a user-friendly touchscreen for customization and control.
- Facilitates efficient resource usage with optimized medium exchange and sampling.
- Offers flexibility with compatibility for both single-use and reusable sensors.
- Ensures regulatory compliance with comprehensive data tracking and remote monitoring capabilities.
- Applications
- Clinical trials,Cell therapy,Regenerative medicine,Biopharmaceuticals,Stem cell culture,Exosomes,Tissue engineering,Immunotherapy
- End products
- Msc-derived exosome products,Personalized cell therapies,Car-t cell therapy products,Cell-based vaccines,Engineered tissue constructs,Hipsc aggregates for therapy,Microcarrier-based stem cell cultures
- Steps before
- Cell culture preparation,Media formulation,Bioprocess setup
- Steps after
- Medium exchange,Sampling,Cell harvesting
- Input ingredients
- human cells,anchorage-dependent cells,cell aggregates,microcarriers,culture medium,suspension media
- Output ingredients
- expanded cell cultures,cell aggregates,harvested cells,spent medium
- Market info
- PBS Biotech is known for manufacturing single-use, scalable bioreactor systems designed for cell therapy and biologics production, featuring their innovative Air-Wheel mixing technology for efficient and consistent results.
- Working volume
- 15L
- Sensor compatibility
- Single-use or reusable DO and pH sensors
- Harvest method
- Adjustable height harvest valve
- Software compatibility
- 3.0 (21 CFR Part 11 cGMP Upgrade)
- Automation level
- Touchscreen interface for process customization and control
- Mobility
- Floored with wheels for movement
- Working Volume
- 15L
- Scale-up capability
- From PBS-Mini and PBS-3
- Touchscreen Interface
- Intuitive process customization,control,and reporting
- Sensor Configurations
- Single-use or reusable DO and pH sensors
- Harvest Valve
- Adjustable Height Harvest Valve (AHHV)
- Remote Monitoring
- Available for 3L and larger bioreactors
- Data Storage
- 21 CFR Part 11 cGMP compliant
- Cell culture process
- Scale-up
- Machine footprint
- Recommended for floor placement
- Tank shape and size
- Vertical-Wheel design,15L working volume
- Adjustable Height Harvest Valve (AHHV)
- Adjustable for rapid medium exchange,sampling,and harvesting
- Discharge method
- Bottom discharge via AHHV
- Control panel type
- Touchscreen interface
- Integration possibilities
- Single-use or reusable sensors
- Discharge method
- Adjustable Height Harvest Valve (AHHV)
- Remote process monitoring
- Yes,via secure connection