Advanced hydrogenation in continuous flow

Achieve precise, on-demand hydrogenation with advanced safety features, eliminating the need for bulky hydrogen cylinders and providing seamless integration into your existing lab setup.

Generates and Mixes Hydrogen for Chemical Reactions

The H-Cube® Pro from ThalesNano combines electrolytic hydrogen generation with precise reactor control for seamless integration into laboratory-scale chemical synthesis. Using an on-demand electrolysis system, it safely generates up to 60 NmL/min of hydrogen gas, eliminating the need for external hydrogen cylinders and enhancing laboratory safety. The reactor is designed for pharmaceutical, fine chemical, and agrochemical applications, facilitating reactions such as hydrogenation, reduction, and deuteration. It offers scalability from milligram to gram-scale production, making it suitable for R&D and bench-top laboratory operations.

Equipped with user-friendly software, the H-Cube® Pro allows real-time monitoring and parameter adjustment, improving reaction control and efficiency. The system’s versatility is enhanced with additional modules, such as the Phoenix Flow Reactor, enabling operations up to 450°C for more complex synthesis routes. Its design minimizes energy and solvent consumption through efficient reaction parameters and customizable hydrogen flow rates. Suitable for use with a variety of gases beyond hydrogen, when connected to the Gas Module, it widens chemical capabilities significantly.

Constructed from corrosion-resistant materials, the H-Cube® Pro maintains robustness and reliability across a range of chemicals. Its compact design, combined with flexible automation options like integration with an Autosampler system, supports optimization studies and high-throughput screening with minimal manual intervention. With potential custom configuration and ongoing support, ThalesNano’s reactor system enhances productivity in laboratories needing high-precision, continuous flow chemistry solutions.

Benefits

  • Enhances laboratory safety by eliminating external hydrogen cylinders.
  • Improves reaction precision with adjustable hydrogen flow rates.
  • Expands chemical synthesis capabilities through multi-gas compatibility.
  • Supports high-throughput research with integration-ready, automated systems.
  • Provides robust performance with corrosion-resistant materials for diverse chemical environments.

General


Applications
Academic research,Fine chemicals,Agrochemicals,Flavour and fragrance,Pharmaceuticals
End products
Active pharmaceutical ingredients,Academic chemical samples,Fragrance compounds,Pesticide precursors,Synthetic intermediates
Steps before
Reactant preparation,Solvent purification,Deionized water preparation
Steps after
Product collection,Crystallization,Drying,Filtration (if needed for final product),Packaging
Input ingredients
hydrogen gas,solvent,reactants,water,catalyst cartridges,CatCarts
Output ingredients
reaction products,reduced compounds,collected vials
Market info
Thalesnano is known for manufacturing advanced flow chemistry solutions, particularly in catalyst and hydrogenation technologies. They are recognized for their expertise in continuous processes, enhancing safety and efficiency in chemical synthesis.

Technical Specifications


Temperature range
10 to 150°C
Pressure range
Atmospheric pressure to 100 bar
Flow rates
0.3 – 3 mL/min
Maximum hydrogen production rate
60 NmL/min
Water reservoir capacity
300 mL
Dimensions
Height
Weight
23 kg (46.3 lbs)
Power requirements
115-230 VAC,5A/115VAC,2.5A/230VAC,47-63Hz,300W
HPLC pump power requirements
100-240VAC,1.3A,47-63Hz,55W
Cooling temperature
Down to 10°C
Extended heating capability
Up to 150°C

Operating Characteristics


Working mechanism
Continuous flow hydrogenation
Hydrogenation method
On-demand hydrogen generation
Automation level
User-friendly software with real-time monitoring
Catalyst handling
Sealed catalyst cartridges (CatCarts®)
Temperature control
Active cooling and heating (10 to 150°C)
Pressure control
From atmospheric pressure to 100 bar
System expansion
Gas Module,Phoenix Flow Reactor
Hydrogen flow rate
0.3 – 3 mL/min
Batch vs. continuous operation
Continuous operation
Cooling option
Active cooling system
Reaction scalability
Milligrams to grams
Integrated steps
Electrolysis of water,mixing valve,reaction zone
Automation level
Fully automated with Autosampler system
CIP/SIP
Not mentioned

Material Compatibility


Corrosion resistance
High
Chemical compatibility
Hydrogen,solvents
Inertness
Suitable for variety of reactions
Thermal stability
Up to 450°C
Sealing integrity
Metal-metal sealed catalyst columns

Physical Characteristics


Compact footprint
Height
Weight
23 kg
Control panel type
Touch screen included
HPLC pump dimensions
Height
HPLC pump weight
2.32 kg

Custom Options


Control panel type
User-friendly software interface
System expansion options
Gas Module,Phoenix Flow Reactor
Integration possibilities
Compatibility with Autosampler system
Temperature control
Active cooling system from 10°C and extended heating up to 150°C
Pressure control
Adjustable up to 100 bar