Advanced hydrogenation in continuous flow
Achieve precise, on-demand hydrogenation with advanced safety features, eliminating the need for bulky hydrogen cylinders and providing seamless integration into your existing lab setup.

Generates and Mixes Hydrogen for Chemical Reactions
The H-Cube® Pro from ThalesNano combines electrolytic hydrogen generation with precise reactor control for seamless integration into laboratory-scale chemical synthesis. Using an on-demand electrolysis system, it safely generates up to 60 NmL/min of hydrogen gas, eliminating the need for external hydrogen cylinders and enhancing laboratory safety. The reactor is designed for pharmaceutical, fine chemical, and agrochemical applications, facilitating reactions such as hydrogenation, reduction, and deuteration. It offers scalability from milligram to gram-scale production, making it suitable for R&D and bench-top laboratory operations.
Equipped with user-friendly software, the H-Cube® Pro allows real-time monitoring and parameter adjustment, improving reaction control and efficiency. The system’s versatility is enhanced with additional modules, such as the Phoenix Flow Reactor, enabling operations up to 450°C for more complex synthesis routes. Its design minimizes energy and solvent consumption through efficient reaction parameters and customizable hydrogen flow rates. Suitable for use with a variety of gases beyond hydrogen, when connected to the Gas Module, it widens chemical capabilities significantly.
Constructed from corrosion-resistant materials, the H-Cube® Pro maintains robustness and reliability across a range of chemicals. Its compact design, combined with flexible automation options like integration with an Autosampler system, supports optimization studies and high-throughput screening with minimal manual intervention. With potential custom configuration and ongoing support, ThalesNano’s reactor system enhances productivity in laboratories needing high-precision, continuous flow chemistry solutions.
Benefits
- Enhances laboratory safety by eliminating external hydrogen cylinders.
- Improves reaction precision with adjustable hydrogen flow rates.
- Expands chemical synthesis capabilities through multi-gas compatibility.
- Supports high-throughput research with integration-ready, automated systems.
- Provides robust performance with corrosion-resistant materials for diverse chemical environments.
- Applications
- Academic research,Fine chemicals,Agrochemicals,Flavour and fragrance,Pharmaceuticals
- End products
- Active pharmaceutical ingredients,Academic chemical samples,Fragrance compounds,Pesticide precursors,Synthetic intermediates
- Steps before
- Reactant preparation,Solvent purification,Deionized water preparation
- Steps after
- Product collection,Crystallization,Drying,Filtration (if needed for final product),Packaging
- Input ingredients
- hydrogen gas,solvent,reactants,water,catalyst cartridges,CatCarts
- Output ingredients
- reaction products,reduced compounds,collected vials
- Market info
- Thalesnano is known for manufacturing advanced flow chemistry solutions, particularly in catalyst and hydrogenation technologies. They are recognized for their expertise in continuous processes, enhancing safety and efficiency in chemical synthesis.
- Temperature range
- 10 to 150°C
- Pressure range
- Atmospheric pressure to 100 bar
- Flow rates
- 0.3 – 3 mL/min
- Maximum hydrogen production rate
- 60 NmL/min
- Water reservoir capacity
- 300 mL
- Dimensions
- Height
- Weight
- 23 kg (46.3 lbs)
- Power requirements
- 115-230 VAC,5A/115VAC,2.5A/230VAC,47-63Hz,300W
- HPLC pump power requirements
- 100-240VAC,1.3A,47-63Hz,55W
- Cooling temperature
- Down to 10°C
- Extended heating capability
- Up to 150°C
- Working mechanism
- Continuous flow hydrogenation
- Hydrogenation method
- On-demand hydrogen generation
- Automation level
- User-friendly software with real-time monitoring
- Catalyst handling
- Sealed catalyst cartridges (CatCarts®)
- Temperature control
- Active cooling and heating (10 to 150°C)
- Pressure control
- From atmospheric pressure to 100 bar
- System expansion
- Gas Module,Phoenix Flow Reactor
- Hydrogen flow rate
- 0.3 – 3 mL/min
- Batch vs. continuous operation
- Continuous operation
- Cooling option
- Active cooling system
- Reaction scalability
- Milligrams to grams
- Integrated steps
- Electrolysis of water,mixing valve,reaction zone
- Automation level
- Fully automated with Autosampler system
- CIP/SIP
- Not mentioned
- Corrosion resistance
- High
- Chemical compatibility
- Hydrogen,solvents
- Inertness
- Suitable for variety of reactions
- Thermal stability
- Up to 450°C
- Sealing integrity
- Metal-metal sealed catalyst columns
- Compact footprint
- Height
- Weight
- 23 kg
- Control panel type
- Touch screen included
- HPLC pump dimensions
- Height
- HPLC pump weight
- 2.32 kg
- Control panel type
- User-friendly software interface
- System expansion options
- Gas Module,Phoenix Flow Reactor
- Integration possibilities
- Compatibility with Autosampler system
- Temperature control
- Active cooling system from 10°C and extended heating up to 150°C
- Pressure control
- Adjustable up to 100 bar