Lab-scale in-situ sterilizable bioreactor

Ensure precision in your laboratory and pilot projects with this bioreactor, designed for seamless sterilization, mixing, and control, facilitating efficient scale-up from benchtop experiments to full production.

Sterilizes, Mixes, and Controls Bioprocesses

The KLF from Bioengineering AG is an in-situ sterilizable lab and pilot-scale glass bioreactor designed for precision in biopharmaceutical and chemical research applications. What sets this equipment apart is its ability to facilitate seamless batch, fed-batch, and perfusion processes, utilizing BioSCADA software for sophisticated control and data visualization. Capable of processing 1.6 to 2.5 liters, it’s ideal for developing monoclonal antibodies, insulin, and probiotic beverages. The bottom-drive mechanism supports efficient mixing with Rushton and propeller stirrers. Equipped with advanced probes for precise measurement of pH, dissolved oxygen, and temperature, the KLF ensures rigorous process control. With customizable gas and pump modules, it promises flexibility and scalability. Its compact, modular design supports easy scale-up and scale-down, reducing development time and cost. Designed with compliance in mind, it adheres to GMP standards and includes a CIP system for effortless maintenance. The bioreactor’s robust materials and efficient energy use make it a reliable choice for modern labs.

Benefits

  • Enhances process efficiency with precise control, minimizing product variability.
  • Reduces contamination risk through in-situ sterilization, ensuring product safety.
  • Supports scalable bioprocessing, optimizing transition from R&D to production.
  • Simplifies integration with existing systems via adaptable BioSCADA software.
  • Minimizes operational costs with robust construction and energy-efficient design.

General


Applications
Homeopathy,Food and nutritional products,Fine chemicals,Alternative medicine,Cosmetics,Biopharmaceuticals
End products
Perfume essences,Insulin,Active pharmaceutical ingredients (apis),Monoclonal antibodies,Vitamin supplements,Homeopathic tinctures,Herbal extracts,Probiotic beverages
Steps before
Media Preparation,Buffer Preparation,Sample Preparation
Steps after
Data Analysis,Cleaning In Place (CIP),Documentation,Maintenance
Input ingredients
media,buffer,cells,nutrients,gases,antifoam
Output ingredients
biomass,metabolites,exhaust gases,waste products
Market info
Bioengineering is known for its expertise in designing and manufacturing customized bioreactors and fermenters, serving the biotechnology and pharmaceutical industries. They are reputed for high-quality, engineered-to-order solutions and innovative process technologies.

Technical Specifications


Processing capacity
1.6 / 2.0 / 2.5 liters
Vessel Material
Glass or stainless steel
Drive Type
Bottom drive with axial face seal or magnetic clutch
Types of Stirrers
Rushton,propeller,pitched-blade stirrers
Ventilation System
Venting pipe,ring sparger,sinter sparger,bubble-free gassing
Temperature Control
Electrical heating,cooling fingers
Measurement and Control
Speed,temperature,pH,pO2,antifoam/level,redox,OD,weight,exhaust analysis
Gas Modules
Up to 6 individual gassing lines with pulsed valves or mass-flow controllers
Pump Modules
Up to 6 pumps integrated and one external pump
Software Control
BioSCADA
Configuration Control
Up to 6 bioreactors with a single control unit

Operating Characteristics


Sterilization method
Electrical heating
Batch vs. continuous operation
Batch / Fed-batch / Perfusion
Automation level
SCADA
Clean-in-place (CIP) capability
In-situ sterilizable
Space efficiency
Minimal space requirements

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Physical Characteristics


Vessel material
Glass or stainless steel