Pharmaceutical direct compression with linear blending
Streamline your pharmaceutical production with a continuous direct compression line that ensures precise blending and compression, enhancing product quality and consistency for high-value, low-dose medications.
Blends and Compresses Pharmaceutical Powders Continuously
The ConsiGma® Direct Compression with Linear Blending (DC-LB) Lines from GEA offer a highly integrated solution for pharmaceutical manufacturers aiming for precision in blending and compression. This system combines continuous dry blending and tablet compression into a single, efficient process, using linear blenders for seamless production. It supports high-value applications such as low-dose aspirin tablets and specialty oncology drugs, producing up to 150,000 tablets per hour. The Conductor 4.0 software provides full process control and traceability, adapting automatically to changes in bulk density for optimal material yield. With a focus on high blend homogeneity, the system virtually eliminates material hold-ups, enhancing in-line uniformity control. Designed for rigorous pharmaceutical standards, it features cleaning and containment options for handling potent formulations and complies with GMP requirements, offering customizable configurations to meet specific operational needs.
Benefits
- Ensures consistent product quality with real-time blend uniformity control.
- Minimizes material wastage, increasing yield and reducing costs.
- Adapts to variable production scales without compromising precision.
- Streamlines operations with a compact footprint, freeing up factory space.
- Handles potent drugs safely with integrated cleaning and containment features.
- Applications
- New chemical entities,Orphan drugs,Pharmaceutical tablets,High-value products
- End products
- Specialty oncology drugs,Low-dose aspirin tablets,Innovative antiviral compounds,High-potency antihypertensive medication
- Steps before
- Purification,Weighing,Dispensing
- Steps after
- Coating,Packing,Tablet Inspection
- Input ingredients
- powder particles,low dose API,raw materials,excipient blends
- Output ingredients
- tablets,compressed tablets,pharmaceutical dosage forms
- Market info
- GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.
- Production throughput
- 1 to 100 kg/h
- Tablet throughput
- 20,000 to 150,000 tablets/h
- Number of feeders
- Up to 6 loss-in-weight feeders
- Blender type
- Linear blenders
- Software
- Conductor 4.0 software
- Automation
- Seamless control with full reporting
- Batch size flexibility
- Very low to very high API content
- Cleaning method
- Equip with cleaning and containment features
- Compression system
- GEA compression system
- Containment upgrade options
- Available
- Material yield
- High material yield
- Blend uniformity control
- In process control,second-by-second
- Footprint
- Small footprint
- Customizable options
- Number of options to suit customer needs
- Working mechanism
- Continuous Direct Compression
- Integrated steps
- Continuous Dry Blending,Tablet Compression
- CIP/SIP
- Equipped with Cleaning Features
- Batch vs. continuous operation
- Continuous
- Automation level
- Conductor 4.0 Software Control
- Material handling system
- Includes Containment Features
- Changeover time
- Hot Swap Parts for Fast Changeover
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Machine footprint
- Small
- Compact footprint
- Yes
- Control panel type
- Integrated with Conductor 4.0
- Discharge method
- Integrated Continuous System
- System Size
- 1 to 100 kg/h or 20,000 to 150,000 tablets/h
- Feeder Options
- Up to 6 loss-in-weight feeders
- Software Integration
- Conductor 4.0 software
- Cleaning Features
- CIP / Containment upgrade
- Customization Configuration
- Options for two-stage blending or dispersive blending
- Material Handling System
- Including containment features
- PAT Tools
- Available
- Hot Swap Parts
- For fast changeover