Low-volume dissolution-absorption testing system
In pharmaceutical development, accurately predicting in-vivo drug behavior during early stages can be challenging due to the intricate relationship between solubility, permeability, and dissolution rate. A system capable of assessing these parameters with minimal sample and media requirements is essential.
Simultaneously assess dissolution and absorption
The MicroFLUX by Pion is an advanced system designed for in-vitro assessment of dissolution-absorption processes in low-volume environments. The device features a low-volume absorption chamber separated from a low-volume donor chamber by a biomimetic gastrointestinal permeation membrane. It supports rapid evaluation of sample performance under various conditions, making it a valuable tool for early-stage ranking of in-vivo outcomes. The MicroFLUX is compatible with a range of aqueous and biorelevant media, and integrates fiber-optic UV probes from the Rainbow Dynamic Dissolution Monitor®, allowing real-time concentration monitoring in both chambers. Additionally, the AuPRO software provides modeling tools to calculate dissolution rate and flux parameters, streamlining data processing.
Benefits
- Low media and sample requirements for efficient testing
- Real-time dissolution and absorption monitoring
- Rapid assessment of drug performance under various conditions
- Accurate ranking of in-vivo outcomes
- Streamlined data processing with integrated software tools