Low-volume dissolution-absorption testing system
Optimize your development of oral formulations with a device that enables low-volume, real-time dissolution and absorption testing, streamlining your evaluation of drug solubility and permeability for precise in-vitro analysis.
Performs In-Vitro Dissolution and Absorption Testing
The MicroFLUX system from Pion Inc. is designed for low-volume in-vitro assessment of drug dissolution and absorption processes, streamlining early-stage pharmaceutical formulation. This innovative device features a dual-chamber setup with a biomimetic membrane, enabling simultaneous analysis of dissolution and permeation. Compatible with various aqueous and biorelevant media, it facilitates rapid evaluation by using fiber-optic UV probes for real-time concentration monitoring. The system integrates seamlessly into benchtop operations, offering valuable insights into drug-excipient interactions and supporting biopharmaceutical development with compliance-ready tools. By combining dissolution and absorption into one assay, the MicroFLUX system enhances efficiency and precision for R&D and laboratory environments, particularly for studies on bioequivalence and low-solubility drugs.
Benefits
- Enhances formulation development by providing real-time, simultaneous dissolution and absorption insights.
- Reduces material waste with low-volume sample and media requirements.
- Accelerates research with rapid, in-vitro testing capabilities.
- Improves understanding of drug-excipient interactions, aiding in bioequivalence and solubility studies.
- Integrates efficiently into existing lab setups for seamless operation.
- Applications
- Biopharmaceuticals,Oral formulations,Pharmaceuticals
- End products
- Drug excipient interaction studies,Low-solubility pharmaceuticals,Aripiprazole formulations,Bioequivalence study formulations,Biorelevant drug solutions,Dissolution-permeation assays
- Steps before
- Compound Screening,Oral Formulation Delivery,Physicochemical Characterization
- Steps after
- Bioequivalence Prediction,Flux Measurements Analysis,Excipient Impact Analysis
- Input ingredients
- drug substance,aqueous and biorelevant medias,samples,excipients
- Output ingredients
- dissolution rate,flux parameters,absorption concentration,in vitro dissolution-absorption analysis
- Market info
- Low-volume absorption chamber
- Yes
- Biomimetic gastrointestinal tract permeation membrane
- Yes
- Compatible media
- Aqueous and biorelevant medias
- Real-time concentration monitoring
- Yes
- Integration with Dynamic Dissolution Monitor
- Yes
- UV probe technology
- Fiber-optic
- Dissolution curve modeling tools
- AuPRO software
- Working Mechanism
- In-vitro dissolution-absorption
- Integrated Steps
- Simultaneous dissolution and absorption
- Batch vs. Inline Flow
- Batch
- Automation Level
- Real-time monitoring
- Changeover Time
- N/A
- Cleaning Method
- Manual
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Chamber Type
- Low-volume absorption and donor chambers
- Media Compatibility
- Aqueous and biorelevant medias
- Monitoring Capability
- Real-time concentration
- Integration with Instruments
- Rainbow Dynamic Dissolution Monitor®
- Measurement Type
- UV probes for concentration monitoring
- Low-volume absorption chamber
- Yes
- Donor chamber size
- Low-volume
- Permeation membrane
- Biomimetic gastrointestinal tract
- Compact footprint
- Yes
- Fiber-optic UV probe configuration
- Positioned in donor and receiver compartments
- Control panel type
- HMI touch screen
- Integration possibilities
- Compatible with Rainbow Dynamic Dissolution Monitor®