Pharmaceutical freeze dryer
Achieve contamination-free, high-quality pharmaceutical powders through an innovative freeze-drying process that ensures sterile conditions while reducing handling time and complexity.
Processes Sterile Bulk Pharmaceuticals into Free-Flowing Powders
The AFD series from Hosokawa Micron represents a breakthrough in lyophilisation technology for pharmaceutical and biotech sectors, offering a contamination-free process for transforming liquids, slurries, or solids into sterile, free-flowing powders. Utilizing dynamic agitation and efficient heat distribution within a vacuum environment, the AFD models—AFD-5, AFD-20, and AFD-100—ensure uniform freezing and sublimation. Ideal for antibiotics, APIs, collagens, and proteins, these freeze dryers operate in batch mode with automation for minimized manual intervention. With sublimation capacities ranging up to 2.2 kg/h, these systems streamline operations by eliminating the need for post-processing steps. CIP and SIP functionalities enhance cleanliness and efficiency, while compliance with GMP standards ensures regulatory adherence. Engineering support from Hosokawa Micron enables process customization in their test facilities for optimized integration into your production line.
Benefits
- Ensures consistent product quality with uniform particle size and enhanced dispersibility.
- Decreases handling time, reducing labor costs by automating the entire lyophilisation process.
- Minimizes contamination risk with enclosed, operator-free drying and integrated CIP/SIP systems.
- Optimizes energy use during drying with efficient heat distribution across the vacuum chamber.
- Compliant with GMP standards, supporting regulatory needs in pharmaceutical manufacturing.
- Applications
- Proteins,Sterile bulk pharmaceuticals,Antibiotics,Collagens,Apis
- End products
- Steps before
- Solution Preparation,Suspension Creation,Paste Formulation,Material Agitation
- Steps after
- Powder Collection,Product Discharge,Contamination Testing
- Input ingredients
- liquid,granular solid,paste,suspension,solution,wet solids
- Output ingredients
- free-flowing powder,sterile bulk pharmaceuticals,fine powder,loose powder,fine,dry particles,open pores
- Market info
- Hosokawa Micron is renowned for specializing in the manufacturing of powder and particle processing technologies, including mixing, drying, and milling equipment. They are respected for their innovative solutions and engineering excellence in industrial engineered-to-order equipment markets.
- Automation
- No operator intervention
- Batch size
- 2.5–100 liters
- Max. sublimation capacity at p = 2 mbar
- 0.3–2.2 kg/h
- Vacuum level
- Deep vacuum
- Jacket surface area
- 0.13–0.98 m²
- Heat distribution
- Effective
- Contamination-free
- Yes
- Sterilization
- SIP capability
- Cleaning
- CIP capability
- Particle size
- Fine and uniform
- Material forms
- Solutions,suspensions,pastes,wet solids
- Working mechanism
- Agitated freeze drying
- Integrated steps
- Freeze,Dry,Discharge
- CIP/SIP capability
- CIP 121°C / SIP 135°C
- Batch vs. continuous operation
- Batch
- Automation level
- PLC-controlled
- Cleaning method
- CIP
- Cleanability
- SIP/CIP capable
- Biological compatibility
- Sterile pharmaceutical powders
- Corrosive resistance (e.g. acids)
- Suitable for toxic materials
- Density/particle size
- Fine,loose powder
- Material Handling
- Liquid / Granular Solid / Paste
- End Product Type
- Sterile Bulk Pharmaceuticals
- Machine footprint
- Varies based on model
- Lyophilisation chamber size
- Indicative values
- Jacket surface area
- 0.13 m²,0.33 m²,0.98 m²
- Max. net product volume (liquid)
- 2.5L,10L,50L
- Discharge method
- Outlet canister collection
- System customization
- Tailor-made design
- Discharge method
- Free-flowing material collection
- Control system
- Automated PLC-based
- Cleaning capability
- CIP/SIP compatible
- Heating and cooling options
- Customized jacket heating
- Vacuum system
- Deep vacuum application
- Processing adaptability
- Handles solutions,suspensions,pastes,and wet solids