Dissolution-absorption study system for drug formulations
Optimize drug formulations with precise in-situ dissolved substance monitoring and absorption analysis, ensuring compliance and enhancing bioavailability predictions for new pharmaceutical products.
Monitors Real-Time Dissolution and Absorption Kinetics
The BioFLUX™ system from Pion is an innovative in-situ fiber optic UV dissolution-absorption system designed for the pharmaceutical and biotechnology sectors. It seamlessly integrates with USP II dissolution apparatuses, facilitating simultaneous and real-time analysis of solubility, permeability, and dissolution kinetics. This system is particularly valuable in R&D environments for pharmaceutical manufacturers, allowing for precise testing of immediate-release tablets, extended-release capsules, and more. Its configuration includes an absorption chamber integrated with a lipophilic membrane, offering insights into the interplay between solubility and permeability. Equipped with Rainbow Dynamic Dissolution Monitor® for enhanced data accuracy, it operates in biorelevant volumes, ideal for late-stage formulation development and bioequivalence studies. Its PLC-controlled setup ensures efficient workflow integration, while the fiber optic UV probes enable direct monitoring in both donor and receiver compartments, thus reducing experimental time and improving data reliability.
Benefits
- Enhances formulation decisions with insights into solubility and permeability interactions.
- Streamlines drug development by monitoring kinetics in real-time, reducing experimental time.
- Performs studies at biorelevant volumes, improving the relevance of experimental results.
- Integrates easily into existing workflows, minimizing operational disruptions.
- Supports bioequivalence studies with detailed in vitro analysis.
- Applications
- Drug formulations,Medical supplements,Nutraceuticals,Biopharmaceuticals,Pharmaceuticals
- End products
- Liquid emulsions,Extended-release capsules,Nanoparticle suspensions,Oral disintegrating tablets,Soft gelatin capsules,Immediate-release tablets
- Steps before
- Formulation Development,Sample Preparation,Compound Mixing
- Steps after
- Bioequivalence Studies,Data Analysis,Quality Control Testing
- Input ingredients
- drugs final dosages,dissolution buffer,Pion Acceptor Sink Buffer at pH 7.4,biorelevant dissolution buffer,compendial dissolution buffer
- Output ingredients
- absorption potential data,permeability-solubility interplay information,real-time concentration kinetics
- Market info
- Absorption Chamber
- Integrated with lipophilic membrane
- Overhead Stirrer
- Yes
- Fiber Optic UV Probe
- In situ
- Vessel Size
- 500 mL (miniaturized)
- Receiver Chamber pH
- 7.4
- Dissolution Buffer Volume
- 200–250 mL
- Concentration Monitoring
- Real-time
- System Compatibility
- USP II apparatus
- Monitoring Instrument
- Rainbow Dynamic Dissolution Monitor®
- Volumes for Studies
- Biorelevant (200-250 mL)
- Working mechanism
- In-situ UV monitoring
- Integrated steps
- Dissolution-absorption study
- Batch vs. continuous operation
- Batch
- Automation level
- Manual / Instrument connected
- Cleaning method
- Manual
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Container type
- Miniaturized 500 mL vessel
- Vessel Size
- 500 mL
- Vessel Type
- USP II dissolution apparatus
- Probe Type
- Fiber Optic UV Probe
- Membrane Type
- Lipophilic Membrane