Dissolution-absorption study system for drug formulations
In pharmaceutical development, predicting drug absorption through in vitro studies is crucial. Ensuring that a drug’s solubility and permeability are balanced can significantly impact its bioavailability and efficacy.
Conduct simultaneous dissolution and absorption studies
The BioFLUX™ system by Pion allows for conducting simultaneous dissolution-absorption studies. This system integrates an absorption chamber with a phospholipid-covered membrane, overhead stirrer, and fiber optic (FO) UV probe, which is inserted into the modified cover of a 500 mL USP II dissolution vessel. The dissolution compartment typically contains 200-250 mL of dissolution buffer, while the receiver compartment holds Pion Acceptor Sink Buffer at pH 7.4. The fiber optic UV probes monitor real-time concentration kinetics in both the donor and receiver compartments, providing valuable data on the solubility and permeability interplay of drug formulations. This system is designed to enhance late-stage formulation development and bioequivalence studies.
Benefits
- Real-time monitoring of drug dissolution and absorption
- Enhanced understanding of solubility-permeability interplay
- Adaptable to late-stage formulation development
- Compatible with USP II apparatuses
- Enables biorelevant volume studies (200-250 mL)