Sterilizable filter dryer for pharmaceutical applications
Ensure full sterility and efficient moisture removal in critical pharmaceutical processes with this advanced filter dryer, optimizing purity and compliance from filtration to discharge.

Processes and Sterilizes Slurry into Dry Cake
The COMBER Pressofiltro® Series PF 50 – PF 6000 is a versatile sterilizable agitated Nutsche filter dryer from HEINKEL’s esteemed product line, designed to maintain sterility throughout the filtration, washing, drying, and discharge processes. This equipment excels in applications requiring stringent sterility and cleanliness, such as manufacturing active pharmaceutical ingredients, specialty chemicals, and powdered food additives.
With a filtration area ranging from 0.13 to 6 m², and a slurry volume capacity of 55 to 6,000 liters, the COMBER Pressofiltro® is engineered for both batch and pilot operations. Its PLC-controlled system ensures seamless integration and automation, while compliance with cGMP and FDA guidelines guarantees product safety and quality.
Utilizing a steam sterilizable design, it ensures thorough sterilization, reaching all contact points without air entrapment, and incorporates CIP and SIP systems for automatic, efficient cleaning and disinfecting. Fabricated with materials like stainless steel, Hastelloy, and titanium, it offers excellent corrosion resistance. Moreover, it features an aseptic design with externally interchangeable dry running double mechanical seals.
The versatile COMBER Pressofiltro® comes equipped with options for dust filters, sampling valves, and vacuum systems, supporting tailored engineering to meet specific production needs.
Benefits
- Ensures sterile production with integrated CIP and SIP systems, minimizing contamination risks.
- Supports high-purity output by maintaining compliance with cGMP and FDA standards.
- Enhances chemical compatibility with durable material options like stainless steel and Hastelloy.
- Reduces maintenance time through steam sterilizable design and externally interchangeable seals.
- Offers customizable configurations to meet diverse operational and production needs.
- Applications
- Chemicals,Surface coating,Fine chemicals,Metal recycling,Food products,Pharmaceuticals
- End products
- High-purity chemical precursors,Powdered food additives,Flavor enhancers,Active pharmaceutical ingredients,Specialty chemicals,Surface coating powders,Nutraceutical supplements,Recycled metal powders
- Steps before
- Slurry feeding,Inerting
- Steps after
- Discharge,Sterilization,Packing
- Input ingredients
- slurry,liquid mixtures
- Output ingredients
- dry product,filtered material
- Market info
- Heinkel (Comber) is renowned for manufacturing industrial engineered-to-order equipment, specializing in filtration, centrifugal, and mixing solutions. They are recognized for their precision engineering, quality, and ability to tailor solutions for pharmaceutical and chemical industries.
- Filter area
- 0.13 to 6 m²
- Slurry volume
- 55 – 6,000 liters
- Design temperature
- -10 to 150°C (14 to 302°F)
- Design pressure
- -1 to +4 barg (FV to 60 psig)
- Heated areas
- All product wetted components,including agitator
- Automation
- PLC-controlled
- Cycle temperature
- 121–135°C
- CIP/SIP
- CIP 121°C / SIP 135°C
- Material wetted components
- Stainless steels,Nickel based alloys such as Hastelloy C 22 or Alloy 59,Titanium
- Sealing materials
- PTFE gaskets,O-Rings in FFKM or FEP encapsulated
- Automation level
- PLC-controlled
- Batch vs. continuous operation
- Batch
- CIP/SIP
- CIP with Cleaning-In-Place,SIP with Sterilization-In-Place
- Cleaning method
- Automatic CIP/SIP
- Energy efficiency
- 0.5–2 kWh/kg
- Product wetted materials
- Stainless steels,Nickel based alloys such as Hastelloy C 22 or Alloy 59,Titanium
- Sealing materials
- PTFE gaskets,O-Rings in FFKM or FEP encapsulated
- Filling purpose
- Nutsche Filtration
- Machine footprint
- Depends on model (e.g.,PF 50 - PF 6000)
- Filter area
- 0.13 to 6 m²
- Slurry volume
- 55 – 6,000 liters
- Discharge method
- Automatic / Manual
- Tank shape
- Nutsche type
- Heating areas
- All product wetted components,including agitator
- Design temperature
- -10 to 150°C (14 to 302°F)
- Design pressure
- -1 to +4 barg (FV to 60 psig)
- Control panel type
- PLC,HMI with touch screen
- Integration possibilities
- Interface for DCS