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Packing Capsules 

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

brochure_tommy-nielsen_minipharma

Brochure_Tommy Nielsen_MiniPharma

Surgical instruments still involve a significant degree of manual craftsmanship to manufacture. But advances in surgical instruments technology today intertwine with expert handiwork to produce precise tools that make the difference between life and death.

Surgical instruments

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

A missing tooth can wipe a smile off your face. But high-precision engineering is filling the gap with dental implants manufacturing equipment. Advanced technology produces safe implants from biomaterials that fuse with the jawbone.

Dental implants

A pre-filled syringe or PFS is a single-dose disposable syringe that is supplied loaded with the substance to be injected. By using a pre-filled syringe filling machine, you can have excellent dosage accuracy due to the exact filling of medications. During administration, safety from potential contaminants is also ensured as they are directly injected after opening. To further minimize the risk of contamination, pre-filled syringes are often filled and sealed in a sterile environment using stainless steel equipment.

Pre-filled Syringes

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Fast tool change due to the small size of the machine

Optional enhancement of larger filling area

Additional filling aid device for tablets and capsules

Flexibility due to easy and fast tool change 

MOVEsolid

When thinking about blister packaging equipment, pharmaceutical products such as capsules or tablets are the first things that come to mind. Blister packs are used to protect pharmaceutical products from humidity and contamination and to extend their shelf life. However, they are also used for food items or consumer goods such as toys. There are two main methods and packaging solutions on which blister machines are based. Thermoforming heats PVC sheets in batches which are then pressed into blister machines to give them the desired shape. Cold forming doesn’t involve any heat and uses aluminum-based laminate film instead of PVC film.

Blister Packaging Equipment

Pharmaceutical

Industrial Packaging Equipment

At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with chemicals or hazardous substances since they can be potentially dangerous to human health.

Packing

Connect directly with world leading manufacturers of industrial packaging equipment and find technology to build or improve your production line.

Packing - Making.com

Industrial Packaging Equipment - Making.com

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19th century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Process

Continuous

Thermoforming

solid

Product safety is very important when producing tablets, capsules or medical devices and packaging at the end of the production line, needs to abide by

Automatic medical forming and sealing blister machine for packing capsules and tablets - Making.com

https://making-tst.imgix.net/2021/06/MiniPharma-220.jpg

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Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

A dishwasher tablet is an essential detergent. It consists of a pressed mixture of sodium and potassium salts, surfactant, fragrance, and other filler agents, mixed with the help of tablet making machines. The products’ use in America and Europe is high, unlike in the Asian continent, where the price limits its usage. Its global market size will reach $990 million in 2026 from $475.6million in 2019, according to Grand View Research forecasts.

Dishwasher tablets

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

Simple compact design and operation

Reduced downtime, cleaning and maintenance operations

Quick and easy changeover

Clear view of product flow

Error diagnosis and troubleshooting functions

A case is a secondary packaging box that contains a number of identical product items. The items may be arranged in a single layer or stacked in multiple layers separated by trays. A case packer erects the foldable case fills it with product items in the desired configuration and applies the lid before the case is sealed. Case packer selection depends on the configuration of items in the case, the desired level of automation, and the primary packaging of the product item.

Case packers

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Packaging

liquid

The Romaco Promatic PAK 320/100 Case packer si designed for packing cartons and/or bundles into RSC cases and features.

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions like case lifting, forcing case erection, closing the flaps, and

Case packer for cartons and bundles - Making.com

https://making-tst.imgix.net/2014/12/Promatic-PAK.png

romaco-blister-solutions-brochure-pdf

Romaco-blister-solutions-brochure.pdf

Output of up to 400 blisters per minute

Optimal usage of machine capacity

Automatic adjustment of the coding, perforation and die-cutting processes

Die-cutting technology helps reduce waste

Quick format changes and easy adjustment

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applications that require short batches and quick changeover.

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applications that require short batches and quick

Compact blister machine - Making.com

https://making-tst.imgix.net/2014/12/Noack_623.png

romaco-noack-760-datasheet-pdf

Romaco-Noack-760-datasheet.pdf

Output of up to 200 blisters per minute

Number of upgrade options to increase productivity

Quick changeover thanks to innovative servo technology

The Romaco Noack DPN 760 Entry-level blister machine is a compact, solution ideal for start-up operations and offers a number of upgrade options.

A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade available. Easy to upgrade compact blistering solution The

Entry-level blister machine - Making.com

https://making-tst.imgix.net/2014/12/Noack_760.png

brochure_tommy-nielsen_universal-compressed

Brochure_Tommy Nielsen_Universal -compressed

No preformed blisters needed 

A two-in-one solution for forming and sealing

Same production capacity as with preformed blisters

Batch

As a manufacturer of medical device, the packaging is a critical factor in preventing the product from damage. Conducting forming and sealing of blisters

Semi-automatic forming and sealing blister machine - Making.com

https://making-tst.imgix.net/2021/06/Universal.jpg

romaco-cartoning-solutions-brochure-pdf

Romaco-cartoning-solutions-brochure.pdf

Auxiliary devices such as product security systems are easily accommodated

Up to 100 cartons per minute in fully automatic mode

  Venturi vacuum unit reduces the noise level to a minimum

  Automatic product feeding by the continuous motion pick & place unit

Cartoning involves erecting a folded carton, filling it with the product, closing the flaps, or applying a lid and sealing with glue or adhesive tape. Choosing a cartoning solution involves, considering the type of primary packaging, the production volume, the size and count of the product in a carton, and the desired level of automation.

Cartoning

The BIPAK vertical cartoner built by Romaco Promatic is reliable, flexible and versatile cartooning solution.

A cartoning solution that can be operated in either continuous or intermittent mode depending on the cartoning application and with max speed around 100

Vertical cartoner - Making.com

https://making-tst.imgix.net/2014/12/Promatic-vertical-cartoner-semi-automatic.jpg

romaco-promatic-sm2000-datasheet-pdf

Romaco-Promatic-SM2000-datasheet.pdf

GMP compliant

Quick, tool less format changes (in less than five minutes thanks to the digital position indicators)

Automatic quick-release system speeds up film changes

Short times for retooling, cleaning and maintenance

  It's capable of packing at a speed of 40 to 50 packs per minute

The Romaco Promatic SM2000 Stretch bander is designed to meet the challenging demands of the pharmaceutical industry.

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute. Stretch film packaging solution to tightly wrap and seal your

Stretch bander - Making.com

https://making-tst.imgix.net/2014/12/Promatic-Stretch-Bander.png

romaco-promatic-pc-datasheet-pdf

Romaco-Promatic-PC-datasheet.pdf

Easy access reduces retooling and cleaning times to a minimum

Patented positive carton pick-up and of carton quality

Output of up to 400 cartons /min

High flexibility for customization

Low vibration and noise levels thanks to servo motors and belt drives

The Romaco Promatic Horizontal continuous motion cartoners are designed to satisfy the most demanding applications.

An automatic cartoning machine designed for both high-speed operations and medium packaging speeds with an output of approximately 400 cartons/min.

Horizontal continuous motion cartoner - Making.com

https://making-tst.imgix.net/2014/12/Promatic-PC-4000.png

romaco-promatic-p91-datasheet-pdf

Romaco-Promatic-P91-datasheet.pdf

GMP compliant design

Easy-access reduces retooling and cleaning times to a minimum

Servo-controlled carton pick-up with positive opening system protects the materials

The Romaco Promatic P 91 Horizontal intermittent motion cartoners are designed to achieve maximum production performance.

User-friendly cartooning solution with an intermittent motion for a wide range of products. User-friendly cartoner for a wide range of products The Romaco

Horizontal intermittent motion cartoner - Making.com

https://making-tst.imgix.net/2014/12/Promatic-P-91.png

High packaging capacity

Low lifecycle costs

Output of up to 300 to 700 blisters/min

Short cleaning times

  Automatic station control system

If you are looking for a compact machine that produces blisters with an output of up to 700 blisters per minute and has a servo and auto-control features,

High-speed blister machine - Making.com

https://making-tst.imgix.net/2014/12/Noack-900-series.png

Max Output up to 6000 capsules per hour

  Compatible with both KAP-150 and KAP-300

The two halves of a capsule shell are separately filled with your selected material before they are then pressed against one another and closed. Automatic capsule fillers orientate the shells in the precise position, fill them with your specified formula a join the ends. Capsules are then de-dusted and polished by micro brushes before they are ready for packaging.

Capsule fillers

R&amp;D

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

The RK-15 Capsule Filler by Dott. Bonapace capsule inserter is an orientator which processes 150 capsules per cycle.

A semi-automatic orienter for capsules with an output speed up to 6000 capsules. Orientate your capsules so that they are ready for filling The RK-15

R&D capsule orientater - Making.com

https://making-tst.imgix.net/2014/12/RK-15.png

Packing Capsules

Which packing capsules technology do you need?

Automatic medical forming and sealing blister machine for packing capsules and tablets

Case packer for cartons and bundles

Compact blister machine

Entry-level blister machine

Semi-automatic forming and sealing blister machine

Vertical cartoner

Stretch bander

Horizontal continuous motion cartoner

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