In vitro subcutaneous injection simulator
Optimize drug formulation screening and selection with an innovative solution that simulates subcutaneous injection environments, reducing reliance on animal models and expediting development with bio-relevant insights.
Simulates Subcutaneous Injections for Formulation Testing
The SCISSOR N3 from Pion is an in vitro subcutaneous injection simulator designed for biopharmaceutical and pharmaceutical R&D. This tool accurately mimics the physiological conditions experienced by injectables, allowing you to assess drug release dynamics and optimize formulations without relying on animal models. Ideal for screening excipients and rank ordering formulations, it yields bio-relevant insights for injectable drugs, including adalimumab and insulin formulations. Compatible with optional fraction collectors and the Rainbow R6 UV-vis spectrometer, the SCISSOR N3 enables real-time, in situ data collection. It supports liquid formulations in controlled, bench-top environments, providing critical data for long-acting injectables and innovative drug delivery solutions.
Benefits
- Enhances formulation development by simulating real subcutaneous conditions for accurate predictive analysis.
- Saves time and costs by reducing the need for animal model testing in drug release studies.
- Empowers informed decision-making with real-time, in situ data collection capabilities.
- Facilitates excipient screening and formulation optimization, accelerating the candidate selection process.
- Customizable conditions for versatile application across various injectable products, from insulin analogs to monoclonal antibody therapies.
- Applications
- Injectable formulations,Biopharmaceuticals,Long-acting injectables
- End products
- Rituximab injectables,Erythropoietin (epo) injectables,Insulin formulations,Long-acting insulin analogs,Adalimumab injections,Depot medroxyprogesterone acetate injections,Monoclonal antibody therapies,Glatiramer acetate syringes,Naltrexone depot injections
- Steps before
- Formulation Development,Excipient Screening,Rank Ordering Formulations
- Steps after
- Bio-relevant Data Collection,Offline Analysis,Lymphatic and Systemic Release Analysis
- Input ingredients
- subcutaneous injectable formulations,biopharmaceuticals,excipients,drug samples
- Output ingredients
- release dynamics data,bio-relevant information,formulation performance evaluation,excipient screening results,stability data,precipitation events monitoring
- Market info
- Automation
- Real-time measurement with in-situ fiber optic UV-vis spectrometer
- Sample Collection
- Optional external fraction collector for offline analysis
- Compatibility
- Compatible with ECMA and ECM-XRA matrices
- Operational Use
- Simulates human subcutaneous space for 24-hour to week-long assays
- Working mechanism
- In vitro simulation of subcutaneous injection
- Integrated steps
- Formulation comparison and excipient screening
- Automation level
- Real-time in-situ measurements coupled with fiber optic UV-vis spectrometer
- Bio-relevance
- Mimics the human subcutaneous space
- Batch vs. inline operation
- Batch
- Precipitation monitoring
- Real-time correlation with lymphatic and systemic release
- Sample Collection
- In-situ and offline analysis
- Injection site modeling
- Subcutaneous
- Model Type
- In vitro injection site simulator
- Footprint
- Compact design for lab environments
- Optional Accessories
- Compatible with Rainbow R6in-situ fiber optic UV-vis spectrometer and external fraction collector
- Extracellular Matrix Types
- ECMA and ECM-XRA
- Control panel type
- Digital/Manual
- Integration possibilities
- In-situ spectrometer
- Optional Add-ons
- Fraction collector