In vitro subcutaneous injection simulator
Developing effective subcutaneous biopharmaceutical formulations can be challenging due to the limitations of traditional animal models. Achieving bio-relevant data earlier in the formulation process can significantly save on costs and time, and provide more reliable results.
Simulate subcutaneous injection conditions
The SCISSOR N3 by Pion is an in vitro model designed to simulate the subcutaneous injection of biopharmaceuticals, enabling researchers to rank order formulations and screen excipients efficiently. This simulator mimics the transition a drug undergoes from formulation to subcutaneous conditions, monitoring potential precipitation events and correlating these events to systemic and lymphatic release dynamics. Compatible with the Rainbow R6 in-situ fiber optic UV-vis spectrometer, it provides real-time data collection. Additionally, an optional fraction collector allows for offline analysis. The SCISSOR N3 uses hyaluronic acid-based extracellular matrices to simulate the human subcutaneous environment for both immediate and sustained-release formulations, making it essential for formulation development.
Benefits
- Obtain bio-relevant data earlier in formulation development
- Reduce reliance on animal models
- Screen excipients and rank order formulations
- Real-time data collection with an optional spectrometer
- Perform offline analysis with an additional fraction collector