
Let's make hyaluronic acid
Hyaluronic acid is a natural lubricant found in all mammals. An effective humectant, its molecules can hold a thousand times their weight in water. However, hyaluronic acid extraction is a complex biotechnological process that requires a specialized manufacturing technique.
What hyaluronic acid equipment do you need?

Small-scale laboratory dispersing machine
Developing and validating new processes requires reliable and highly versatile e...

Vertical paddle dryer
Enable vacuum, atmospheric and pressurized processing of a variety of materials such as powders, filter...

Miniature scale high-shear mixer
When you have a very limited amount of powder available, you can still test your processes ...

Laboratory high shear impact mixer
A Laboratory high shear impact mixer can be used to simulate different processes; from s...

Laboratory conical screw vacuum dryer
The laboratory conical screw vacuum dryer is particularly suitable for the final dryi...

Laboratory scale active freeze dryer
The laboratory-scale active freeze-drying is used for dehydrating high-value products ...

High-shear impact mixer
When you need to mix cohesive powders with liquids or melt binders and require a homogenous end-produ...

Flash drying system
Flash drying refers to the removal of moisture by a stream of hot gas that goes through a stream of small...

In-line continuous blender
When you consider shifting pharmaceutical mixing processes from batch to continuous, accurate in-...

Conical screw vacuum dryer
The conical screw vacuum dryer is particularly suitable for the final drying of powders, granules...

Conical screw mixer
When you want to mix segregative, free-flowing powders and pastes that require perfect mixing quality and...

Colloid mill
For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen. Â ...

High-pressure homogenizer
When processes call for homogenized emulsions with extremely fine particle sizes the traditional t...

Checkweigher for sachets and sticks
The checkweighers for multiple lanes have a 1.5 times faster response speed and 2 times...

Microencapsulation system for your drug delivery system
Whether you want to improve the stability of nutrients, protect a...

GMP homogenizing system
Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accur...

Corundum disk mill
Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mus...

Dispersing machine for emulsions and suspensions
Equipment operating under the rotor/stator principal is often employed wh...

Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent par...

Dispersing machine for very fine emulsions and suspensions
For continuous high performance mixing of solid and liquid ra...

Ultra-fine dispersing machine for emulsions and suspensions
Producing the finest micro-emulsions and suspensions require...

Cone mill machine
When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process n...

Inline batch mixer for solids and liquids
Several issues often arise when your process requires batch-wise mixing of powde...

Continuous homogenizing system
Certain mixing tasks present unique challenges and manufacturers need equipment that is speci...

High accuracy homogenizing system
When extremely high accuracy is required in your recipe or formulation traditional mixing...

Horizontal kneader
For high viscosity products, better results and reduced process times can be achieved with kneading type r...

Vertical kneader
Production of highly viscous products with high solid content often benefits from kneading processes rather t...

Continuous kneader
Effective mixing of highly viscous products with extremely high solids content can be difficult and the re...

Batch dispersing machine
Equipment operating under the rotor/stator principal is often employed when more traditional methods...

Batch dispersing machine for abrasive products
For mixing and dispersing tasks that cannot be completed by conventional st...

Batch dispersing machine for bottom entry into vessels
When your process requires high performance mixing or dispersion b...

Cost-effective homogenizing and emulsifying system
Manufacturers need production mixing equipment that is capable, flexib...

Dust-free continuous homogenizing system
Producers in a wide variety of industries benefit from equipment that can continuo...

Dilution system for two or more liquids in one pass
Onsite dilution of liquid process ingredients has historically been a...

Pilot dispersing machine for testing and scale-up
Innovators in process development need laboratory equipment that helps ...

In-line laboratory dispersing machine
Innovators in a wide variety of industries need laboratory equipment on which process...

Laboratory dispersing machine for low-viscous masses
Laboratory mixers have not always been easy to work with. Â Getting a...

Jet flow agitator for high-viscosity media
Processes including homogenization, dispersing, suspension, emulsification and ...

Agitator for medium viscosity media
Mixing fluids of medium viscosity for many production processes requires an agitator wi...

Agitator for low viscosity media
Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale p...

Checkweigher for stand-up pouches
When working with several lines of stand-up pouches, you can benefit from controlling the...
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Tell us about your production challenge
Defat rooster combs at low temperatures before hyaluronic acid extraction
The rooster comb contains an appreciable amount of hyaluronic acid (HA), making it a primary source for production. Isolated and cleansed, the combs are reduced in size using a grinder before extraction.
The material is suspended in acetone at about 8°C for several hours to break down unwanted chemicals. The procedure is repeated until the combs are dried, resulting in a white, fibrous substance. This is then purified with saline citrate and centrifuged at a high rpm to separate the sediment from the gel-like extract.

Vacuum-dry processed HA to retrieve sodium hyaluronate
The hyaluronic acid extraction process can be refined to produce a highly-concentrated sodium hyaluronate. The derivative is the salts of HA and is used primarily in medical formulations and cosmetic creams.
Manufacturers treat extracted hyaluronic acid with a water-based solvent and pass the substance through a vacuum dryer. The process obtains sodium hyaluronate in the form of a powder that can be then mixed with other materials and chemicals.

Manufacture vegan hyaluronic acid in batch to address stability concerns
Non-animal hyaluronic acid is produced by fermenting a safe strain of bacteria from plants like wheat. Although continuous production prolongs the lifetime of bacterial cultures, the high dilution rate in a chemostat presents a challenge to molecular stability. For this reason, manufacturers typically rely on batch processes.
Plant-based oral dosage types such as HPMC mean that HA supplements can be completely vegan. However, non-animal products are more frequently designed for skincare products.
Target osteoarthritis and other issues with hyaluronic acid supplements
The human body generates hyaluronic acid, but the levels decrease with age. In fact, HA products are primarily designed to treat problems related to osteoarthritis.
However, hyaluronic acid supplements are also thought to prevent various issues, from chronic fatigue syndrome to fibromyalgia. HA is a versatile material distributed in solid, liquid, or semi-solid formats. But nutraceutical preparations are often found as capsules, tablets, or softgels.
Processing steps involved in hyaluronic acid making

Ball mills

Bottle filling equipment

Bottle inspection systems

Filling lines

Freeze dryers

High-shear mixers

Industrial dryers

Industrial emulsifiers

Industrial homogenizers

Industrial inspection equipment

Industrial vacuum mixers

Labeling machines

Mixing equipment

Packaging equipment

Tube filling equipment
