Stainless steel bioreactor for small-scale bioprocess production
Optimize your bioprocess development with a modular stainless steel bioreactor designed for seamless scale-up, thorough process control, and efficient integration from pilot to production scale.

Facilitates Bioprocess Scale-Up and Cultivation
The Applikon BioPilot from Getinge is a versatile stainless steel bioreactor designed for biopharmaceutical and vaccine manufacturing. This multi-use pilot plant bioreactor simplifies the transfer from lab scale to production with its modular design and Sterilize-in-Place capability. It’s optimized for cultivating microbial and cell cultures, producing vital therapies like monoclonal antibodies and mRNA vaccines. With working volumes ranging from 20 to 200 liters, the BioPilot excels in scale-up studies, process optimization, and small-scale production. It features PLC automation for precise control and is constructed from pharma-grade 316L stainless steel, ensuring compliance with cGMP standards. The integrated magnetic agitator system and hygienic design minimize contamination risk, while its robust configuration supports both batch and continuous operations.
Benefits
- Accelerates time-to-market by simplifying scale-up from lab to production.
- Minimizes contamination risks with Sterilize-in-Place bioreactor systems.
- Reduces manual intervention through automated PLC controls.
- Ensures regulatory compliance with cGMP standards.
- Enhances flexibility with modular customization for specific process needs.
- Applications
- Microbial cultures,Vaccines,Cell cultures,Medicines,Biopharmaceuticals
- End products
- Insulin,Bacterial vaccines,Monoclonal antibodies,Stem cell therapies,Mrna vaccines,Probiotics,Viral vector vaccines,Therapeutic proteins
- Steps before
- medium preparation,inoculum development,seed train expansion
- Steps after
- sterilization,validation,product refinement
- Input ingredients
- microbial cultures,cell cultures,media,nutrients,gases (N2,Air,O2,CO2),alkali,acid,antifoam agents,sterilizable additions
- Output ingredients
- biopharmaceuticals,vaccines,medicines,small scale production batches
- Market info
- Getinge is known for providing innovative healthcare and life sciences products, specializing in medical technology, infection control, surgical workflows, and critical care solutions. They maintain a strong reputation for quality and technological advancement in these sectors.
- Total volume
- 30-270 liters
- Working volume
- 20-200 liters
- Minimum working volume
- 4-40 liters
- Aspect ratio total volume
- 1.5
- Aspect ratio working volume
- 2.2-2.4
- Drive system
- Magnetically coupled
- Maximum agitator tipspeed
- 3 m/s for microbial,1 m/s for cell cultures
- Impellers
- Rushton and marine
- Gas sparger
- Porous sparger,L-Sparger,Ring-type
- Gas overlay
- Gas overlay line
- Exhaust gas
- Water cooled exhaust gas condenser
- Sampling
- Optional resterilizable sample system
- Draining
- Resterilizable bottom mounted bellows drain
- Additions
- Sterilizable additions,resterilizable ports
- PH Measurement
- 12 mm pH sensor
- PH Control
- Acid pump,CO2 gas,alkali pump
- DO2 Measurement
- 12 mm polarographic DO2 sensor
- DO2 Control
- N2,Air,O2,agitation
- Temperature Measurement
- Pt-100 sensor
- Cultivation control
- Cooling and heating jacket
- Foam Measurement
- Height adjustable conductivity sensor
- Foam Control
- Antifoam pump
- Level Measurement
- Conductivity sensor,loadcells
- Level Control
- Pump for liquid addition or removal
- Automation level
- PLC / SCADA
- Batch vs. continuous operation
- Batch / Perfusion / Continuous
- CIP/SIP
- Sterilize-in-Place
- Cleaning method
- CIP / Sterilize-in-Place
- Automation features
- Pro-Control compatibility
- Biological compatibility
- Pharma-grade 316L stainless steel
- Cleanability
- Surface finish Ra < 0.4 micron
- Corrosive resistance (e.g. acids)
- Pharma-grade 316L stainless steel
- Application
- Microbial and cell culture
- Cultivation Method
- Batch,Fed-Batch,Perfusion,Continuous
- Compact footprint
- Compact design reduces floor space needed
- Tank size
- 30-270 liters
- Shape
- Stainless steel vessel
- Drive system
- Magnetically coupled,bottom or top mounted agitator
- Material
- Pharma-grade 316L stainless steel
- Surface finish
- Ra,lt
- 0.4 micron
- Discharge method
- Resterilizable bottom mounted bellows drain
- Control panel type
- Standardized control systems (e.g.,Pro-Control)
- Gas sparger
- Porous sparger,L-Sparger or Ring-type sparger
- Modular design
- Yes
- Control system
- Compatible with DeltaV™,Siemens,Allen Bradley
- Agitator type
- Magnetically coupled
- Gas sparger type
- Porous,L-Sparger,Ring-type
- Additional packs
- Custom add-on packages available
- Impeller type
- Rushton,Marine
- Surface finish
- Ra,lt
- 0.4 micron