Stainless steel bioreactor for small-scale bioprocess production

Optimize your bioprocess development with a modular stainless steel bioreactor designed for seamless scale-up, thorough process control, and efficient integration from pilot to production scale.

Facilitates Bioprocess Scale-Up and Cultivation

The Applikon BioPilot from Getinge is a versatile stainless steel bioreactor designed for biopharmaceutical and vaccine manufacturing. This multi-use pilot plant bioreactor simplifies the transfer from lab scale to production with its modular design and Sterilize-in-Place capability. It’s optimized for cultivating microbial and cell cultures, producing vital therapies like monoclonal antibodies and mRNA vaccines. With working volumes ranging from 20 to 200 liters, the BioPilot excels in scale-up studies, process optimization, and small-scale production. It features PLC automation for precise control and is constructed from pharma-grade 316L stainless steel, ensuring compliance with cGMP standards. The integrated magnetic agitator system and hygienic design minimize contamination risk, while its robust configuration supports both batch and continuous operations.

Benefits

  • Accelerates time-to-market by simplifying scale-up from lab to production.
  • Minimizes contamination risks with Sterilize-in-Place bioreactor systems.
  • Reduces manual intervention through automated PLC controls.
  • Ensures regulatory compliance with cGMP standards.
  • Enhances flexibility with modular customization for specific process needs.

General


Applications
Microbial cultures,Vaccines,Cell cultures,Medicines,Biopharmaceuticals
End products
Insulin,Bacterial vaccines,Monoclonal antibodies,Stem cell therapies,Mrna vaccines,Probiotics,Viral vector vaccines,Therapeutic proteins
Steps before
medium preparation,inoculum development,seed train expansion
Steps after
sterilization,validation,product refinement
Input ingredients
microbial cultures,cell cultures,media,nutrients,gases (N2,Air,O2,CO2),alkali,acid,antifoam agents,sterilizable additions
Output ingredients
biopharmaceuticals,vaccines,medicines,small scale production batches
Market info
Getinge is known for providing innovative healthcare and life sciences products, specializing in medical technology, infection control, surgical workflows, and critical care solutions. They maintain a strong reputation for quality and technological advancement in these sectors.

Technical Specifications


Total volume
30-270 liters
Working volume
20-200 liters
Minimum working volume
4-40 liters
Aspect ratio total volume
1.5
Aspect ratio working volume
2.2-2.4
Drive system
Magnetically coupled
Maximum agitator tipspeed
3 m/s for microbial,1 m/s for cell cultures
Impellers
Rushton and marine
Gas sparger
Porous sparger,L-Sparger,Ring-type
Gas overlay
Gas overlay line
Exhaust gas
Water cooled exhaust gas condenser
Sampling
Optional resterilizable sample system
Draining
Resterilizable bottom mounted bellows drain
Additions
Sterilizable additions,resterilizable ports
PH Measurement
12 mm pH sensor
PH Control
Acid pump,CO2 gas,alkali pump
DO2 Measurement
12 mm polarographic DO2 sensor
DO2 Control
N2,Air,O2,agitation
Temperature Measurement
Pt-100 sensor
Cultivation control
Cooling and heating jacket
Foam Measurement
Height adjustable conductivity sensor
Foam Control
Antifoam pump
Level Measurement
Conductivity sensor,loadcells
Level Control
Pump for liquid addition or removal

Operating Characteristics


Automation level
PLC / SCADA
Batch vs. continuous operation
Batch / Perfusion / Continuous
CIP/SIP
Sterilize-in-Place
Cleaning method
CIP / Sterilize-in-Place
Automation features
Pro-Control compatibility

Material Compatibility


Biological compatibility
Pharma-grade 316L stainless steel
Cleanability
Surface finish Ra < 0.4 micron
Corrosive resistance (e.g. acids)
Pharma-grade 316L stainless steel

Product type Characteristics


Application
Microbial and cell culture
Cultivation Method
Batch,Fed-Batch,Perfusion,Continuous

Physical Characteristics


Compact footprint
Compact design reduces floor space needed
Tank size
30-270 liters
Shape
Stainless steel vessel
Drive system
Magnetically coupled,bottom or top mounted agitator
Material
Pharma-grade 316L stainless steel
Surface finish
Ra,lt
0.4 micron
Discharge method
Resterilizable bottom mounted bellows drain
Control panel type
Standardized control systems (e.g.,Pro-Control)
Gas sparger
Porous sparger,L-Sparger or Ring-type sparger

Custom Options


Modular design
Yes
Control system
Compatible with DeltaV™,Siemens,Allen Bradley
Agitator type
Magnetically coupled
Gas sparger type
Porous,L-Sparger,Ring-type
Additional packs
Custom add-on packages available
Impeller type
Rushton,Marine
Surface finish
Ra,lt
0.4 micron