Single-use bioreactor for protein expression
In bioprocessing and biotechnology, scaling up cell culture processes for protein expression often poses challenges related to mixing, sterility, and scalability. Ensuring optimal conditions for cell growth while maintaining flexibility across different production scales is essential for efficient protein production.
Optimize cell cultures with scalable bioreactor solutions
The HyPerforma™ 5:1 Single-Use Bioreactor is a jacketed system by Thermo Fisher Scientific designed to ensure optimal cell culture performance for protein expression. This bioreactor employs traditional stainless-steel bioreactor principles but with single-use sterile contact surfaces, ensuring high sterility and minimal contamination risks. With a proprietary mixing system that facilitates conventional overhead mixing while maintaining the integrity of the bioreactor’s BioProcess Container (BPC), it supports effective venting, sparging, and temperature sensing. Available in sizes ranging from 50 liters to 2,000 liters, it offers consistent scalability from pilot studies to commercial production. The bioreactor includes an AC motor for precise agitation control and analog load cells for accurate weight measurement. It also supports various monitoring options for pH, dissolved oxygen, and pressure, using either industry-leading single-use or traditional sensors. Customization is facilitated by the largest qualified standard component library. For those requiring turnkey systems, it can integrate seamlessly with controls from Finesse™ or Applikon™.
Benefits
- Ensures sterility with single-use contact surfaces
- Consistent scalability from 50 L to 2,000 L
- Precise agitation control with AC motor
- Customizable with largest component library
- Supports various sensor monitoring options