Bench top bioreactor for microbial and cell cultures
Optimize your bioprocessing workflow with this versatile bench top solution, designed to seamlessly integrate into your R&D and production environments, allowing for precise control over microbial and cell culture conditions.
Cultivates and Processes Microbial and Cell Cultures
The Applikon BioBench from Getinge is a versatile stainless steel bench-scale bioreactor designed for precision in biopharmaceutical applications. Ideal for microbial and cell cultures, this equipment mimics commercial-scale processes in a compact form, maintaining essential geometric ratios. It supports operations like cultivation, sampling, draining, sterilization, heating, cooling, and mixing. With capacities ranging from 15 to 30 liters, it caters to scale-up studies and small-scale production of monoclonal antibodies, vaccines, and recombinant proteins. Its Sterilizable-in-Place feature minimizes contamination risks, while the open frame construction ensures easy maintenance. The bioreactor is built with durable 316L stainless steel, offering resistance to biofilms and ensuring compliance with cGMP standards. Customization options and engineering support are available to meet specific process demands.
Benefits
- Enhances scalability with consistent scale-down geometric ratios, facilitating seamless transition from lab to production.
- Minimizes contamination risk through Sterilizable-in-Place technology and magnetic coupled agitator systems.
- Ensures effortless compliance with cGMP standards, simplifying validation processes.
- Reduces operational downtime with easy access and maintenance via an open-frame design.
- Supports versatile process options like batch, fed-batch, and perfusion, adapting to various production needs.
- Applications
- Microbial cultures,Vaccines,Cell cultures,Medicines,Small scale production,Biopharmaceuticals,Pharmaceutical production
- End products
- Small molecule drugs,Cell culture-based influenza vaccines,Human growth hormones,Insulin,Monoclonal antibodies,Covid-19 vaccines,Probiotic supplements,T-cell therapies,Recombinant proteins,Hepatitis b vaccines
- Steps before
- Medium optimization,Seed train preparation,Process optimization
- Steps after
- Sterilization,Cleaning,Validation
- Input ingredients
- microbial cultures,cell cultures,sterilizable additions,pH sensor input,DO2 sensor input,antifoam agent,liquids for level control,gases (N2,Air,O2,CO2)
- Output ingredients
- exhaust gas,sterilized drained contents,analyzed culture samples,processed microbial and cell culture,foam control output,temperature regulated output
- Market info
- Getinge is known for providing innovative healthcare and life sciences products, specializing in medical technology, infection control, surgical workflows, and critical care solutions. They maintain a strong reputation for quality and technological advancement in these sectors.
- Total volume
- 15-30 liters
- Working volume
- 12-27 liters
- Minimum working volume
- 2-3 liters
- Aspect ratio total volume
- 2.2-2.0
- Aspect ratio working volume
- 1.7-2.4
- Drive system
- Magnetically coupled,top mounted agitator
- Maximum agitator tipspeed
- 5 m/s for microbial cultures,1 m/s for cell cultures
- Impellers
- Rushton and marine,0.3 - 0.5 vessel diameter
- Gas sparger
- Porous sparger or L-Sparger
- Exhaust gas condenser
- Water cooled with internal spiral and/or jacketed
- Temperature control
- Cooling and heating jacket via bioreactor wall
- Foam control
- Height adjustable conductivity based foam sensor
- Level control
- Height adjustable conductivity based level sensor
- Material
- Pharma-grade 316L stainless steel
- Surface finish
- Ra < 0.4 micron
- Modular design
- Customizable for microbial and cell cultures
- Automation level
- Manual / PLC / SCADA
- CIP/SIP
- Sterilize-in-place (SIP)
- Cleaning method
- Pharma-grade 316L stainless steel surface finish
- Batch vs. continuous operation
- Batch,Fed-Batch,Perfusion,Continuous
- Biological compatibility
- Yes
- Cleanability
- 316L stainless steel,Ra < 0.4 micron
- Corrosive resistance (e.g. acids)
- Yes
- Compact footprint
- Yes
- Tank shape and size
- 15,20,30 liters
- Aspect ratio
- 2.2 total,1.7 working
- Material
- 316L stainless steel
- Surface finish
- Ra < 0.4 micron
- Control panel type
- Magnetically coupled,top mounted agitator
- Discharge method
- Bottom mounted bellows drain
- Sterilization
- Sterilize-in-Place
- Modularity
- Standard modules for customization
- Control system
- PLC-controlled for process demands
- Impeller types
- Rushton and marine impellers
- Gas sparger types
- Porous or L-Sparger
- Drive system
- Magnetically coupled agitator
- Sampling system
- Optional resterilizable sample system
- Addition ports
- Sterilizable and resterilizable ports
- Gas overlay
- Gas overlay line with exhaust gas condenser
- Temperature control
- Cooling and heating jacket
- Foam control
- Conductivity based foam sensor
- Level control
- Conductivity based level sensor