Multi-parallel bioreactors for cell line selection and process development

Enhance your biopharmaceutical production with scalable multi-parallel bioreactors, enabling rapid cell line selection and process optimization, while minimizing time and resources in your development workflow.

Facilitates Clone Screening and Process Optimization

The Ambr® series from Sartorius offers state-of-the-art multi-parallel bioreactor systems like the Ambr® 15 Cell Culture and Ambr® 250 variants, which are engineered to enhance biopharmaceutical production processes. These systems excel in rapid clone screening and process optimization through automated liquid handling and data integration, making them invaluable for biopharmaceutical, cell and gene therapy, and monoclonal antibody production. Designed to handle small-scale, high-throughput operations effectively, these bioreactors support a range of cell cultures, including mammalian and microbial, with customizable vessel configurations. The single-use design optimizes cleaning and maintenance, while built-in data analytics tools facilitate process scaling and integration into existing production workflows. Compliant with industry standards, these systems are suitable for environments demanding stringent process control and efficiency.

Benefits

  • Enhances process efficiency by allowing simultaneous evaluation of multiple cell lines or clones.
  • Reduces setup and turnaround times with single-use, pre-assembled bioreactor vessels.
  • Improves scalability potential with integrated data analytics tools for seamless process transfer.
  • Lowers operational costs through automated sampling and data management.
  • Ensures compliance with biopharmaceutical production standards for reliable process control.

General


Applications
Biologics,Vaccines,Monoclonal antibodies,Biosimilars,Regenerative medicine,Biopharmaceuticals,Cell and gene therapy
End products
Biontech bnt162 vaccine,Moderna mrna-1273 vaccine,Bluebird bio car-t cell therapy,Novartis kymriah®,Crispr therapeutic gene-edited therapies,Shanghai fosun pharmaceutical biosimilars,Regeneron pharmaceuticals monoclonal antibodies
Steps before
Clone selection,Media preparation,Inoculation,Calibration,Initial setup
Steps after
Process optimization,Data analysis,Scale-up,Quality control,Sampling
Input ingredients
cell lines,clones,microbial strains,media,feeds,inoculation densities,cell culture media composition
Output ingredients
process data,pH measurement,cell viability,viable cell density,metabolite levels,spectroscopic analysis results,product titer,glycosylation levels,critical quality attribute (CQA) information
Market info
Sartorius AG is renowned for manufacturing high-precision laboratory and bioprocess equipment. They specialize in filtration, fermentation, and cell cultivation systems, known for their innovation and reliability in the pharmaceutical and biotech industries.

Technical Specifications


Vessel working volume
10 – 15 mL
Vessel working volume
100 – 250 mL
No. of parallel cultivations
24 – 48
No. of parallel cultivations
2 – 8
No. of parallel cultivations
12 – 24
No. of parallel cultivations
12 – 24
Cell culture types
Insect and mammalian
Culture type
Microbial
Automation
Automated liquid handling
Baffled vessel versions
Available for mammalian and microbial cultures
Unbaffled vessel versions
Available for cell and gene therapy
Operation space
2m of bench space
Filtration method
Integrated filtration with irradiated and pre-assembled consumables
Analyzers compatibility
Bioprocess analyzer technologies
Measurement parameters
pH,cell viability,viable cell density,metabolite levels,spectroscopic analysis
Sample data transfer
Automated transfer of bioreactor sample data
Data management
Simplified workflow reduces errors
Perfusion process
Scalable perfusion processes
Software integration
MODDE® Design of Experiments

Operating Characteristics


Automation level
Manual / PLC / SCADA
CIP/SIP
CIP 121°C / SIP 135°C
Cleaning method
CIP / Manual
Batch vs. continuous operation
Batch / Inline Continuous
Energy efficiency
0.5–2 kWh/kg moisture

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Physical Characteristics


Machine footprint
2m of bench space for 8 bioreactors
Vessel working volume
10–15 mL,100–250 mL
No. of parallel cultivations
24 – 48,2 – 8,12 – 24
Vessel configuration
Baffled for mammalian and microbial,unbaffled for cell and gene therapy
Single-use bioreactors
Yes
Automation
High-throughput automated operation

Custom Options


Control panel type
Touchscreen / HMI
Integration possibilities
PLC / SCADA Integration
Automation options
Manual / Semi-automatic / Fully automatic
Scalability
10–250 mL mini bioreactors
Vessel configuration
Baffled / Unbaffled
Number of parallel cultivations
2–48
Liquid handling automation
High-throughput automated
Software integration
MODDE® / Umetrics®
Data connectivity
Integrated analyzers / Data-connected analyzers