High-throughput surface plasmon resonance (spr) system

Rapidly achieve high-quality binding kinetics for drug discovery with a cutting-edge system that combines label-free biomolecular interaction analysis capabilities, streamlining the characterization of complex molecular interactions essential for developing therapeutic innovations.

Analyzes Molecular Interactions for Drug Discovery

The Octet® SF3 SPR System from Sartorius is a cutting-edge surface plasmon resonance (SPR) platform that streamlines the analysis of molecular interactions crucial for drug discovery and development in pharmaceutical and biotech environments. Distinguished by its unique OneStep® and NeXtStep™ Gradient Injection technologies, it offers exceptional sensitivity for both small and large molecules, drastically reducing analysis time. This system supports high-throughput operations, capable of processing up to 768 samples in a single assay, thanks to its extended unattended run times and optimized fluidics. Ideal for applications in biopharmaceuticals, vaccines, and antibody fragments, the Octet® SF3 SPR system excels in characterizing complex biomolecular interactions, including high-affinity kinetics and site-specific competition. Engineered for continuous operation and automated integration, it integrates seamlessly into laboratory workflows, delivering precise and reproducible data essential for biomanufacturing and research applications. Its robust design minimizes maintenance while supporting sample recovery, allowing reanalysis across a wide range of conditions.

Benefits

  • Accelerates research timelines by processing up to 768 samples in a single assay.
  • Enhances data accuracy with unique injection technologies for precise kinetic and affinity measurements.
  • Minimizes operational costs with low maintenance and high durability design.
  • Facilitates comprehensive analysis with sample recovery capabilities for reuse.
  • Supports diverse assay conditions with automated in-line buffer degassing and temperature variation options.

General


Applications
Biologics,Drug discovery,Therapeutics,Vaccines,Small molecules,Antibody screening,Biopharmaceuticals,Molecular interactions,Antibody fragments,Protein analysis,Fragment-based drug discovery,Whole cell biologics
End products
Oncolytic viruses,Small molecule drugs,Car-t cell therapies,Fragment antibodies,Peptide drugs,Monoclonal antibodies,Biosimilars,Adeno-associated viruses (aav),Covid-19 vaccines,Engineered protein drugs,Therapeutic antibodies,Mrna vaccines,Influenza vaccines
Steps before
Sample Preparation,Buffer Preparation,Concentration Dilution Series Preparation
Steps after
Data Analysis,Sample Recovery,Thermodynamic and Physiological Measurements
Input ingredients
analyte,buffer,competitor molecule
Output ingredients
binding kinetics data,affinity data,thermodynamic measurements,physiological measurements,kinetic profiles,site-specific competition data
Market info
Sartorius AG is renowned for manufacturing high-precision laboratory and bioprocess equipment. They specialize in filtration, fermentation, and cell cultivation systems, known for their innovation and reliability in the pharmaceutical and biotech industries.

Technical Specifications


Sensitivity
Small and large molecules
Baseline Noise
Low
Drift
Low
Injection Volume
Large
Injection Technology
OneStep® and NeXtStep™
Automation
High-throughput
Sample Capacity
Up to 768 samples per assay
Unattended Run Time
More than 72 hours
Fluidics System
Optimized,low maintenance
Buffer Volume
Up to three one-liter bottles
Buffer Lines
Independently functioning
Sample Recovery
Re-use capability
Temperature Range
Wide range for physiological studies
Syringe Volume
700 µl
Degassing
In-line buffer degassing

Operating Characteristics


High-Throughput Operation
768 samples in a single assay
Automation Level
High-throughput,low maintenance
CIP/SIP
Optimized cleaning protocols
Injection Technology
OneStep® and NeXtStep™ Gradient Injections
Sample Recovery
Predefined Sample Recovery Injection
Fluidics System
Optimized to minimize blockage
Buffer System
Independent buffer lines
Unattended Run Time
More than 72 hours
Temperature Study Range
Wide range for physiological assessments
Injection Volume
Large
Baseline Noise and Drift
Low
Binding Kinetics Data Generation
Fast and accurate

Material Compatibility


Biological compatibility
Yes
Cleanability
High
Corrosive resistance (e.g. acids)
Yes
Density/particle size
0.5–2.5 g/cm³


21 CFR Part 11 Compliance
Yes

Physical Characteristics


Footprint
Compact design
Injection Technology
OneStep®,NeXtStep™ Gradient Injection
Fluidic System
Optimized for minimal blockage
Sensor Chip Selection
Multiple options for accuracy and reproducibility
Sample Capacity
Up to 768 samples per run
Temperature Range
Physiological temperatures
Buffer Capacity
Three-liter total capacity
Control Panel
User-friendly interface

Custom Options


Injection Technology
OneStep® / NeXtStep™
Injection Formats
Single Cycle / Multi-Cycle
Sample Recovery Injection
Predefined Recovery Protocols
Buffer Lines
Independent Function / Dual Running Buffers
Water Line
Dedicated Line for Minimizing Precipitation
Fluidic System
Optimized for Blockage Prevention
Temperature Range
Wide Range Including Physiological Conditions
Syringe Volume
700 µl for Accurate Calculations
Sample Layout
High-Throughput Layout Design