Bioreactor for cell culture yield optimization
Streamline complex cell culture processes with a bioreactor designed to enhance yield efficiency, offering precise control over agitation, aeration, and mixing for high-purity production of biopharmaceuticals and specialty chemicals.

Cultivates High-Yield Cell Cultures
The Bioreactor – Fermentor System from De Dietrich Process Systems is engineered for cultivating high-purity biopharmaceutical products. With a borosilicate 3.3 glass construction according to EN1595 standards, its design includes a monobloc inner vessel with a surface finish of ≤ Ra 0.02 μm for optimal cleanliness. Capable of precise agitation and aeration, this system is essential for producing monoclonal antibodies, synthetic peptides, and more. Ideal for operations in R&D labs, biotechnology, and specialty chemicals, it integrates seamlessly into existing processes with various control options, including 21 CFR part 11 interface. The equipment is customizable, offering mechanical or magnetically coupled agitation and stainless steel or alloy components, ensuring compatibility and corrosion resistance. It maintains GMP compliance with complete QA/QC plans, and includes CIP systems for efficient cleaning, making it an indispensable tool for high-stakes production environments.
Benefits
- Enhances production precision, ensuring high-yield cultivation of complex bioactive compounds.
- Maintains exceptional cleanliness and purity standards critical for pharmaceutical applications.
- Offers robust customization options, providing compatibility with diverse operational needs.
- Minimizes contamination risk with easy-to-maintain, clean-in-place (CIP) systems.
- Ensures regulatory compliance, supporting GMP and FDA guidelines.
- Applications
- D laboratories,Biotechnology,Fine chemicals,Specialty chemicals,R,Biopharmaceuticals,Plant-based ingredients,Pharmaceuticals
- End products
- Custom oligosaccharides,Enzyme isolates,Biodegradable polymers,Insulin,Bioactive plant extracts,Monoclonal antibodies,Synthetic peptides,Antibiotics,Biopolymers,High-purity amino acids,Specialized pigments,Vaccine components
- Steps before
- Mixing,Preparation,Formulation
- Steps after
- Quality Control,Documentation,Sterilization
- Input ingredients
- cell culture,nutrient media,aeration gas,pH buffer
- Output ingredients
- biopharmaceutical products,biomass,excreted metabolites
- Market info
- De Dietrich is renowned for manufacturing high-quality engineered-to-order (ETO) equipment, specializing in chemical process systems, glass-lined reactors, and filtration technologies, with a strong reputation for innovation, reliability, and safety in the chemical and pharmaceutical industries.
- Borosilicate Glass Type
- 3.3
- Vessel Surface Finish
- ≤ Ra 0.02 μm
- Material
- Stainless Steel 316L
- Cover Material
- Stainless Steel 316 L or Alloy
- Ferrite Content
- <5%
- Electropolish Finish
- Ra < 0.5 μm
- Agitation Type
- Mechanical or Magnetic
- Capacity
- 5 to 20 liters
- Control Interface
- 21 CFR part11 (on request)
- Gaskets
- EPDM with FDA,USP certificates
- Aeration Rate Control
- KLa Optimization
- PH Control
- Available
- Temperature Control
- Available
- Batch vs. continuous operation
- Batch
- Automation level
- Manual / PLC / SCADA
- CIP/SIP
- CIP 121°C / SIP 135°C
- Energy efficiency
- 0.5–2 kWh/kg moisture
- Cleaning method
- CIP / Manual
- FDA Materials
- EPDM gaskets with FDA,USP certificates
- Vessel Material
- Borosilicate 3.3 Glass
- Vessel Size
- 5–20 liters
- Inner Surface Finish
- Ra ≤ 0.02 μm
- Cover Material
- Stainless Steel 316 L,Alloy
- Agitation
- Mechanical or Magnetic
- Footprint
- Compact Design
- Jacket
- With or Without Jacket
- Control / Supervision
- Entry-level with variable speed control
- Control interface
- 21 CFR part11 Control interface available on request
- Inner vessel material
- Monobloc inner vessel,≤ Ra 0.02 μm
- Cover,Accessories Material
- Stainless steel 316 L or Alloy
- Ferrite content
- <5%
- Finish
- Electro polished finish Ra < 0.5 μm
- Gaskets
- EPDM gaskets with FDA,USP certificates
- Agitation
- Mechanical or magnetic
- Design
- Customized design (Optimization of the KLa)