Bioreactor for cell culture yield optimization

Streamline complex cell culture processes with a bioreactor designed to enhance yield efficiency, offering precise control over agitation, aeration, and mixing for high-purity production of biopharmaceuticals and specialty chemicals.

Cultivates High-Yield Cell Cultures

The Bioreactor – Fermentor System from De Dietrich Process Systems is engineered for cultivating high-purity biopharmaceutical products. With a borosilicate 3.3 glass construction according to EN1595 standards, its design includes a monobloc inner vessel with a surface finish of ≤ Ra 0.02 μm for optimal cleanliness. Capable of precise agitation and aeration, this system is essential for producing monoclonal antibodies, synthetic peptides, and more. Ideal for operations in R&D labs, biotechnology, and specialty chemicals, it integrates seamlessly into existing processes with various control options, including 21 CFR part 11 interface. The equipment is customizable, offering mechanical or magnetically coupled agitation and stainless steel or alloy components, ensuring compatibility and corrosion resistance. It maintains GMP compliance with complete QA/QC plans, and includes CIP systems for efficient cleaning, making it an indispensable tool for high-stakes production environments.

Benefits

  • Enhances production precision, ensuring high-yield cultivation of complex bioactive compounds.
  • Maintains exceptional cleanliness and purity standards critical for pharmaceutical applications.
  • Offers robust customization options, providing compatibility with diverse operational needs.
  • Minimizes contamination risk with easy-to-maintain, clean-in-place (CIP) systems.
  • Ensures regulatory compliance, supporting GMP and FDA guidelines.

General


Applications
D laboratories,Biotechnology,Fine chemicals,Specialty chemicals,R,Biopharmaceuticals,Plant-based ingredients,Pharmaceuticals
End products
Custom oligosaccharides,Enzyme isolates,Biodegradable polymers,Insulin,Bioactive plant extracts,Monoclonal antibodies,Synthetic peptides,Antibiotics,Biopolymers,High-purity amino acids,Specialized pigments,Vaccine components
Steps before
Mixing,Preparation,Formulation
Steps after
Quality Control,Documentation,Sterilization
Input ingredients
cell culture,nutrient media,aeration gas,pH buffer
Output ingredients
biopharmaceutical products,biomass,excreted metabolites
Market info
De Dietrich is renowned for manufacturing high-quality engineered-to-order (ETO) equipment, specializing in chemical process systems, glass-lined reactors, and filtration technologies, with a strong reputation for innovation, reliability, and safety in the chemical and pharmaceutical industries.

Technical Specifications


Borosilicate Glass Type
3.3
Vessel Surface Finish
≤ Ra 0.02 μm
Material
Stainless Steel 316L
Cover Material
Stainless Steel 316 L or Alloy
Ferrite Content
<5%
Electropolish Finish
Ra < 0.5 μm
Agitation Type
Mechanical or Magnetic
Capacity
5 to 20 liters
Control Interface
21 CFR part11 (on request)
Gaskets
EPDM with FDA,USP certificates
Aeration Rate Control
KLa Optimization
PH Control
Available
Temperature Control
Available

Operating Characteristics


Batch vs. continuous operation
Batch
Automation level
Manual / PLC / SCADA
CIP/SIP
CIP 121°C / SIP 135°C
Energy efficiency
0.5–2 kWh/kg moisture
Cleaning method
CIP / Manual


FDA Materials
EPDM gaskets with FDA,USP certificates

Physical Characteristics


Vessel Material
Borosilicate 3.3 Glass
Vessel Size
5–20 liters
Inner Surface Finish
Ra ≤ 0.02 μm
Cover Material
Stainless Steel 316 L,Alloy
Agitation
Mechanical or Magnetic
Footprint
Compact Design
Jacket
With or Without Jacket

Custom Options


Control / Supervision
Entry-level with variable speed control
Control interface
21 CFR part11 Control interface available on request
Inner vessel material
Monobloc inner vessel,≤ Ra 0.02 μm
Cover,Accessories Material
Stainless steel 316 L or Alloy
Ferrite content
<5%
Finish
Electro polished finish Ra < 0.5 μm
Gaskets
EPDM gaskets with FDA,USP certificates
Agitation
Mechanical or magnetic
Design
Customized design (Optimization of the KLa)