Single-use bioreactors for mammalian cell culture
Enhance agility and cut costs with scalable, single-use bioreactors ideal for streamlining the transition from lab-scale cell cultures to full-scale biomanufacturing, ensuring consistent and efficient production cycles.
Facilitates Scalable Biopharmaceutical Production
The Ambr® 15 and Ambr® 250 series from Sartorius are single-use bioreactor systems designed for streamlined biopharmaceutical production. These systems uniquely enhance scalability and adaptability in processes such as monoclonal antibody and mRNA-based vaccine manufacturing. Utilizing a modular design, they allow for seamless integration into batch or continuous operations, supported by advanced process automation and monitoring capabilities. The Ambr® systems accommodate varying scales from pilot to commercial production, ensuring flexibility without compromising on precision control over cell culture conditions. With their disposable bag technology, they eliminate the need for cleaning and sterilization, reducing turn-around times and increasing operational efficiency. Known for superior performance in high cell-density and sensitive cell lines, the systems feature Flexsafe® film, contributing to consistent growth and viability. The equipment is engineered for compliance with GMP standards, while offering customization options to meet specific production requirements, supported by Sartorius’ extensive engineering and technical support network.
Benefits
- Reduces operational costs by eliminating cleaning and sterilization requirements.
- Enhances production flexibility with modular, scalable configurations.
- Shortens turn-around time between batches, boosting overall facility output.
- Supports compliance with GMP standards for biopharmaceutical manufacturing.
- Ensures consistent cell growth and viability with Flexsafe® film technology.
- Applications
- Vaccines,Nutraceuticals,Monoclonal antibodies,Mrna production,Biosimilars,Regenerative medicine,Biopharmaceuticals,Blood and plasma,Cell and gene therapy
- End products
- Blood plasma derivatives,Immune support nutraceuticals,Covid-19 vaccines,Regenerative medicine therapies,Mrna-based vaccines,Gene therapy treatments,Biologic biosimilars,Monoclonal antibody drugs
- Steps before
- Process Development,Seed Train,Inoculum Preparation,Cell Line Development,Media Preparation
- Steps after
- Culture Harvesting,Downstream Processing,Filtration,Purification,Sterility Testing
- Input ingredients
- mammalian cells,microcarrier-based materials,cell culture media,gassing elements,feed lines,sensor inputs
- Output ingredients
- cultured cells,biopharmaceutical products,waste bags,process data
- Market info
- Sartorius AG is renowned for manufacturing high-precision laboratory and bioprocess equipment. They specialize in filtration, fermentation, and cell cultivation systems, known for their innovation and reliability in the pharmaceutical and biotech industries.
- Working volume
- 15 mL to 2000 L
- Scale-up capability
- Ambr® to Biostat STR®
- Material
- Plastic bag
- Temperature control
- Integrated in bag holder
- Automation
- Process Analytical Technologies (PAT) enabled
- Gas exchange method
- Sensors and feed lines
- Robustness
- Flexsafe® film ensures structural support
- Ease of use
- Single-use,disposable culture bags
- Turn-around time
- Reduced due to single-use design
- Oxygen demand compatibility
- Limited for extremely high demand processes
- Process conditions
- Less suited for extreme temperature/acidity
- Bag holder features
- Structural support and heating capabilities
- Batch vs. continuous operation
- Batch
- Automation level
- Manual / PLC
- CIP/SIP
- CIP 121°C / SIP 135°C
- Cleaning method
- CIP / Manual
- Energy efficiency
- 0.5–2 kWh/kg moisture
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Cell culture type
- Mammalian/High cell-density/Microcarrier-based
- Culture Vessel Type
- Plastic Bag
- Working Volume Range
- 15 mL to 2000 L
- Bag Holder Support
- Yes
- Modular Design
- Yes
- Discharge Method
- Disposable Bag
- Gassing and Stirring Elements
- Integrated in Bag
- Feed Lines and Sensor Ports
- Integrated in Bag
- Structural Support and Heating Capabilities
- Bag Holder
- Control panel type
- Touchscreen / PLC
- Integration possibilities
- SCADA / DCS
- Modular design
- Yes
- Bag type
- Single-use sterilized plastic
- Sensors,ports
- Single-use / Integrated
- Stirring and gassing elements
- Customizable