Single-use bioreactor for cell culture applications
Achieve optimal cell growth and product yield with a single-use bioreactor designed to streamline scaling from pilot studies to commercial production.

Facilitates Mixing, Sparging, and CO2 Stripping
The HyPerforma™ 5:1 Single-Use Bioreactor from Thermo Scientific is designed for biopharmaceutical manufacturers seeking reliable scalability. It utilizes a water-jacketed system with an AC motor for precise control, enabling effective mixing and sparging essential for high-quality protein expression and viral vector manufacturing. With sizes ranging from 50 to 2000 liters, the HyPerforma™ S.U.B. ensures consistent scalability across pilot-scale to commercial production. Its unique mixing system maintains sterility and minimizes foam damage, enhancing productivity by reducing the need for multiple vessels. Integrating seamlessly with Finesse™ or Applikon™ control systems, it supports diverse bioproduction environments using software platforms like Delta V™, Allen-Bradley™, or Siemens™. The single-use design includes load cells for precise monitoring and compatibility with industry-standard sensors for pH, DO, and pressure, meeting GMP and FDA standards. Its minimized footprint and load cells as standard features optimize operational efficiency, while optional component customization provides flexibility to meet specific process requirements.
Benefits
- Enhances productivity by enabling efficient scale-up from pilot to commercial production.
- Minimizes operational costs with its compact design and reduced vessel count.
- Ensures consistent product quality through precise control of mixing and sparging processes.
- Facilitates seamless integration with leading control systems for improved process management.
- Complies with GMP standards, supporting regulatory requirements in biopharmaceutical production.
- Applications
- Cell culture,Viral vector manufacturing,Cell therapy,Biopharmaceuticals,Gene therapy,Protein expression,Vaccine production
- End products
- Cho-derived proteins,Crispr-modified cells,Lentivirus vectors,Monoclonal antibodies,Covid-19 vaccines,Adenovirus vectors,Car t-cells
- Steps before
- Cell inoculation,Media preparation,Sterilization preparation
- Steps after
- Harvesting,Purification,Filtration,Downstream processing
- Input ingredients
- cell culture media,microcarriers,suspension cells,gas (for sparging)
- Output ingredients
- protein products,cultured cells,cellular biomass
- Market info
- Thermo Fisher Scientific is renowned for providing innovative scientific instruments, laboratory equipment, and engineered-to-order solutions across various industries, esteemed for their high-quality products and expertise in life sciences, pharmaceuticals, and biotechnology sectors.
- Unit Size
- 50,100,250,500,1000,2000 L
- Mixing System
- Proprietary overhead mixing
- Motor Type
- AC Motor
- Turn-Down Ratio
- 5
- Sparger Technology
- Patented cross-flow sparger
- Automation
- Precise agitation control
- Load Cells
- Standard feature,analog or digital communication
- Sensing Options
- Single-use and traditional sensors for pH,DO,pressure
- Application
- Batch,fed batch,perfusion,suspension,microcarrier cultures
- Control System
- Standalone or turnkey system with Finesse™/Applikon™
- Software Platforms
- PC,Delta V™,Allen-Bradley™,Siemens™
- Material
- Stainless Steel
- Mixing system
- Conventional overhead mixing
- Sterility and integrity management
- Single-use sterile contact surfaces
- Automation level
- Manual / PLC / SCADA
- CIP/SIP
- Manual / Thermo Fisher systems
- Cleaning method
- SIP / Manual
- Batch vs. continuous operation
- Batch
- Gas introduction method
- Patented cross-flow sparger technology
- Mass transfer efficiency
- Efficient CO2 stripping
- Biological compatibility
- Yes
- Abrasion resistance
- High
- Corrosive resistance (e.g. acids)
- Yes
- Cleanability
- Easy
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Machine footprint
- Minimized vessel footprint
- Discharge method
- Batch,fed batch,and perfusion cultures
- Tank shape and size
- 50,100,250,500,1000,and 2000 L sizes
- Compact footprint
- Yes
- Control panel type
- PC,Delta V™,Allen-Bradley™,or Siemens™ software platforms
- Optional features
- Cable management tree,Industry-leading single-use and traditional sensors,Stand-alone or complete system
- Material
- Stainless Steel
- Mixing system
- Unique proprietary mixing system with overhead mixing
- Control panel type
- Finesse™ or Applikon™ control systems
- Integration possibilities
- PC,Delta V™,Allen-Bradley™,Siemens™ software platforms
- Motor type
- AC or DC motors
- Cable management
- Optional cable management tree
- Sensor compatibility
- Single-use and traditional sensors for pH,DO,pressure