Single-use bioreactor for cell culture applications
When scaling up cell culture operations for biopharmaceutical production, maintaining sterile conditions and precise control over agitation, temperature, and gas exchange is critical. Traditional bioreactors often struggle to meet these criteria, leading to inefficient processes and potentially compromised products.
Sterile, scalable bioproduction with precise control
The HyPerforma™ 5:1 Single-Use Bioreactor by Thermo Fisher Scientific is designed to ensure optimal cell culture performance while scaling up from pilot studies to commercial production. Utilizing a water-jacketed vessel with an AC motor and integrated load cells, this bioreactor maintains traditional stainless-steel bioreactor principles combined with single-use sterile contact surfaces. The HyPerforma 5:1 S.U.B. features a proprietary mixing system that provides conventional overhead mixing while preserving the sterility and integrity of the bioprocess container (BPC). It supports batch, fed batch, and perfusion cultures, and is compatible with various cell lines, including CHO, Sp2/0 hybridoma, PER.C6, HEK293, Vero, and MDCK. The bioreactor offers precise agitation control, options for analog or digital communication, and compatibility with industry-leading single-use and traditional sensors for pH, DO, and pressure monitoring. Additionally, its minimized footprint and reduced hold-up volumes enhance lab space efficiency. Designed for flexibility, the system can be used as a standalone vessel or integrated into a turnkey system with control platforms from the Finesse™ or Applikon™ families.
Benefits
- Ensures sterile conditions with single-use contact surfaces
- Scalable from pilot studies to commercial production
- Precise control over agitation, temperature, and gas exchange
- Reduces lab space requirements with compact design
- Compatible with industry-standard sensors and control systems