Bench-top syringe & cartridge closing system

Ensure precise and repeatable syringe and cartridge closure with this versatile bench-top system, designed for small-batch operations in pharmaceutical environments, offering flexibility with vacuum and vent-tube insertion methods.

Closes Syringes and Cartridges Precisely

The Container Closing System (CCS) from AST is a benchtop, semi-automatic machine designed to provide precise control over the syringe and cartridge closing process. This system stands out for its use of both vacuum and vent-tube methods, accommodating a range of container sizes with minimal format changes. Ideal for biologics, vaccines, and personalized medicine, the CCS ensures contamination-free sealings, such as those required for monoclonal antibodies and mRNA vaccines.

Operating under aseptic conditions, the system supports small-batch production with its compact footprint, making it suitable for laboratory and cleanroom environments. Key applications include clinical trial materials manufacturing, compounding pharmacies, and processing cell and gene therapies. The electronic control system offers intuitive operation via an HMI touchscreen, allowing operators to create and monitor precise insertion recipes.

Featuring AST’s patented multi-stage vacuum insertion process, the CCS guarantees consistent piston placement, essential for biologic and compounded pharmaceutical products sensitive to oxidation. An optional Electronic Batch Reporting (EBR) system enhances batch documentation, regulatory compliance, and technology transfer. Constructed from pharmaceutical-grade stainless steel, the system also offers compatibility upgrades for isolator use, ensuring compliance with GMP standards.

Benefits

  • Ensures precise and repeatable syringe and cartridge sealing, critical for product integrity in biomedical applications.
  • Reduces operator intervention and potential contamination with semi-automatic operation and easy-to-change format parts.
  • Enhances safety and compliance with aseptic design suitable for cleanroom and isolator environments.
  • Facilitates compliance and process documentation with optional Electronic Batch Reporting (EBR) system.
  • Adapts to various production needs with flexible vacuum and vent-tube insertion processes.

General


Applications
Biologics,Compounded pharmaceuticals,Personalized medicine,Vaccines,Bio-similars,Cell and gene therapy products
End products
Recombinant erythropoietin,Car-t cell therapies,Monoclonal antibodies,Mrna vaccines,Compounded pain relief syringes,Personalized cancer vaccines
Steps before
Manual placement of filled syringe or cartridge,Pre-fill container purging with inert gas
Steps after
Batch documentation,Process analysis,Technology transfer,Regulatory filing,Placement within an isolator,bio-safety cabinet or laminar airflow hood
Input ingredients
pre-filled syringes,cartridges,air,mechanical assist,vent-tube,vacuum
Output ingredients
sealed syringes,sealed cartridges,closed containers,inserted piston,evacuated air
Market info
AST is known for its expertise in designing and manufacturing customized engineered-to-order equipment for industrial applications, renowned for precision engineering, innovation, and reliable solutions tailored to meet unique customer specifications and industry standards.

Technical Specifications


System Dimensions
780mm x 500mm x 740mm [31" x 20" x 29"]
Container Types
Syringes,Cartridges
Syringe Sizes
0.5mL - 50mL
Cartridge Sizes
1mL to 20mL
Available Closing Options
Vacuum,Vent-Tube,,Vent/Vac Combo
HMI
ASTView on a 10" color touchscreen
Materials of Construction
Pharmaceutical grade stainless steel,plastics,and elastomers
Automation
Electronically controlled process
Batch documentation
Electronic Batch Report (EBR) System
Process Flexibility
Vacuum or Vent-Tube insertion
Insertions
Mechanical vent-tube and vacuum piston insertion
Compact Design
Suited for aseptic isolators,biological safety cabinets or laminar airflow hood

Operating Characteristics


Working mechanism
Semi-automatic
Cleanroom compatibility
ISO compliant
Compact design
Yes
Automation level
Electronic control
Process flexibility
Vacuum and Vent-Tube
Tool-less format change
Yes
Batch documentation
Optional EBR system
Changeover time
Quick with format part changes
Cleaning method
cGMP designed

Material Compatibility


Biological compatibility
Aseptic design suitable for biologics
Cleanability
Compatible with cleanrooms,bio-safety cabinets
Corrosive resistance (e.g. acids)
Pharmaceutical grade stainless steel

Product type Characteristics


Aseptic design
Compatible with isolators,safety cabinets

Physical Characteristics


System Dimensions
780mm x 500mm x 740mm [31" x 20" x 29"]
Compact design
Aseptic isolators,biological safety cabinets,laminar airflow hood compatibility
Control panel type
ASTView high-resolution interface on a 10" color touchscreen

Custom Options


Control panel type
HMI ASTView on a 10" color touchscreen
Integration possibilities
Compatibility with isolators,bio-safety cabinets,laminar airflow hoods
Process flexibility
Vacuum or Vent-tube insertion processes with format part changes
Electronic Batch Report (EBR) System
Optional feature for batch documentation
System footprint
Compact design