Vial filling and stoppering for aseptic liquid or lyo products

Ensure optimal aseptic conditions in your production line with reliable vial filling and stoppering technology, enabling precise control during the manufacture of delicate liquid and lyophilized pharmaceuticals.

Fills and Stoppering Vials Aseptically

The STERY-LA and STERY-LC from Marchesini Group are linear vial filling and stoppering machines specifically designed for the meticulous demands of aseptic pharmaceutical production. These machines stand out with a “Vertical Wall Mounting” design, allowing unobstructed front-side access for operations, reducing contamination risks with maintenance performed from the back. Ideal for Small Volume Parenterals (SVP), they expertly handle liquid and lyophilized products, including vaccines, insulin vials, and chemotherapy drugs, ensuring precise filling and stoppering, supported by both Rotary Piston and Peristaltic pump systems.

Capable of processing up to 24,000 vials per hour, the STERY series integrates seamlessly into high-speed production lines. The nitrogen flushing during stoppering significantly lowers oxygen levels, preserving product integrity. Built for integration within aseptic environments like oRABS, cRABS, or Isolators, these machines offer flexible yet robust automation through PLC controls. They are manufactured to meet stringent GMP standards, allowing confidence in compliance. The STERY models also ensure ease of maintenance and cleaning with quick wash-in-place or traditional cleaning options, complemented by a rapid VHP decontamination cycle. This combination of precision, speed, and reliability makes them indispensable in any state-of-the-art production facility.

Benefits

  • Enhances production efficiency with high-speed operation up to 24,000 vials per hour.
  • Maintains product sterility, reducing contamination through aseptic design and nitrogen flushing.
  • Minimizes maintenance-related downtime with easy back-side access and swift cleaning processes.
  • Adapts to various aseptic environments, offering seamless integration with oRABS, cRABS, and Isolators.
  • Ensures regulatory compliance with GMP standards, delivering reliable quality for pharmaceutical production.

General


Applications
Small volume parenteral (svp),Liquid formulations,Lyophilized (lyo) products,Aseptic products,Biopharmaceuticals,Pharmaceutical products
End products
Hormone therapies,Insulin vials,Sterile water for injection,Biologics,Vaccines,Protein-based drugs,Immune globulin products,Antibiotics,Monoclonal antibodies,Antibody solutions,Chemotherapy drugs,Rehydration solutions,Lyophilized antibiotic vials
Steps before
Washing,Sterilizing
Steps after
Inspection,Labelling,Packing
Input ingredients
vials,small volume parenteral (SVP),liquid products,lyophilized (lyo) products,rubber stoppers
Output ingredients
filled vials,stoppered vials,aseptic condition products,partially stoppered vials
Market info
Marchesini is renowned for manufacturing high-quality packaging machinery for the pharmaceutical and cosmetics industries, offering innovative, customized solutions with advanced automation and technology.

Technical Specifications


Filling speed
up to 24,000 pieces/h
Vial size
2R / 100 ml
Filling method
Rotary Piston Pumps / Peristaltic pumps
Automation
PLC-controlled
Nitrogen Flushing
during stoppering
Cleaning method
Wash-in-place

Operating Characteristics


Working mechanism
Linear vial filling and stoppering
Integrated steps
Filling,rubber stoppering,nitrogen flushing
CIP/SIP
Quick and efficient wash-in-place
Batch vs. continuous operation
Batch
Automation level
PLC-controlled
Cleaning method
Wash-in-place or traditional cleaning
Changeover time
Quick decontamination cycle by VHP

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Physical Characteristics


Footprint
Compact and linear
Vial transport style
Balcony Style
Stoppering method
Full or partial rubber stoppering
Vertical Wall Mounting
Made accessible front side
Mechanical parts on the backside
Integration
oRABS,cRABS and Isolator
Material handling system
Rotary Piston Pumps and/or Peristaltic pumps

Custom Options


Control panel type
HMI/PLC
Integration possibilities
oRABS,cRABS,Isolators
Filling systems
Rotary Piston Pumps/Peristaltic Pumps
Stoppering options
Full/Partial stoppering
Decontamination method
VHP cycle