Vial filling and stoppering for aseptic liquid or lyo products
Ensure optimal aseptic conditions in your production line with reliable vial filling and stoppering technology, enabling precise control during the manufacture of delicate liquid and lyophilized pharmaceuticals.

Fills and Stoppering Vials Aseptically
The STERY-LA and STERY-LC from Marchesini Group are linear vial filling and stoppering machines specifically designed for the meticulous demands of aseptic pharmaceutical production. These machines stand out with a “Vertical Wall Mounting” design, allowing unobstructed front-side access for operations, reducing contamination risks with maintenance performed from the back. Ideal for Small Volume Parenterals (SVP), they expertly handle liquid and lyophilized products, including vaccines, insulin vials, and chemotherapy drugs, ensuring precise filling and stoppering, supported by both Rotary Piston and Peristaltic pump systems.
Capable of processing up to 24,000 vials per hour, the STERY series integrates seamlessly into high-speed production lines. The nitrogen flushing during stoppering significantly lowers oxygen levels, preserving product integrity. Built for integration within aseptic environments like oRABS, cRABS, or Isolators, these machines offer flexible yet robust automation through PLC controls. They are manufactured to meet stringent GMP standards, allowing confidence in compliance. The STERY models also ensure ease of maintenance and cleaning with quick wash-in-place or traditional cleaning options, complemented by a rapid VHP decontamination cycle. This combination of precision, speed, and reliability makes them indispensable in any state-of-the-art production facility.
Benefits
- Enhances production efficiency with high-speed operation up to 24,000 vials per hour.
- Maintains product sterility, reducing contamination through aseptic design and nitrogen flushing.
- Minimizes maintenance-related downtime with easy back-side access and swift cleaning processes.
- Adapts to various aseptic environments, offering seamless integration with oRABS, cRABS, and Isolators.
- Ensures regulatory compliance with GMP standards, delivering reliable quality for pharmaceutical production.
- Applications
- Small volume parenteral (svp),Liquid formulations,Lyophilized (lyo) products,Aseptic products,Biopharmaceuticals,Pharmaceutical products
- End products
- Hormone therapies,Insulin vials,Sterile water for injection,Biologics,Vaccines,Protein-based drugs,Immune globulin products,Antibiotics,Monoclonal antibodies,Antibody solutions,Chemotherapy drugs,Rehydration solutions,Lyophilized antibiotic vials
- Steps before
- Washing,Sterilizing
- Steps after
- Inspection,Labelling,Packing
- Input ingredients
- vials,small volume parenteral (SVP),liquid products,lyophilized (lyo) products,rubber stoppers
- Output ingredients
- filled vials,stoppered vials,aseptic condition products,partially stoppered vials
- Market info
- Marchesini is renowned for manufacturing high-quality packaging machinery for the pharmaceutical and cosmetics industries, offering innovative, customized solutions with advanced automation and technology.
- Filling speed
- up to 24,000 pieces/h
- Vial size
- 2R / 100 ml
- Filling method
- Rotary Piston Pumps / Peristaltic pumps
- Automation
- PLC-controlled
- Nitrogen Flushing
- during stoppering
- Cleaning method
- Wash-in-place
- Working mechanism
- Linear vial filling and stoppering
- Integrated steps
- Filling,rubber stoppering,nitrogen flushing
- CIP/SIP
- Quick and efficient wash-in-place
- Batch vs. continuous operation
- Batch
- Automation level
- PLC-controlled
- Cleaning method
- Wash-in-place or traditional cleaning
- Changeover time
- Quick decontamination cycle by VHP
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Footprint
- Compact and linear
- Vial transport style
- Balcony Style
- Stoppering method
- Full or partial rubber stoppering
- Vertical Wall Mounting
- Made accessible front side
- Mechanical parts on the backside
- Integration
- oRABS,cRABS and Isolator
- Material handling system
- Rotary Piston Pumps and/or Peristaltic pumps
- Control panel type
- HMI/PLC
- Integration possibilities
- oRABS,cRABS,Isolators
- Filling systems
- Rotary Piston Pumps/Peristaltic Pumps
- Stoppering options
- Full/Partial stoppering
- Decontamination method
- VHP cycle