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High pressure electric laboratory homogenizer

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Although not all women use makeup every day, almost all of them own at least one makeup product, be it lipstick or face powder. Most makeup products share the same basic ingredients of waxes, oils, and fillers with pigments like iron oxide used for colors and shades. Makeup manufacturing equipment includes pulverizers, mixers, and mechanical press machines to produce cosmetic products in different forms such as powder, liquid, or mousse.

Makeup

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Cannabinoids are natural compounds obtained from the Cannabis sativa plant. Delta-9-tetrahydrocannabinol or THC is a psychotropic substance. Cannabidiol, or CBD, is non-psychotropic and often used for nutraceutical purposes. Cannabinoid equipment extracts THC and CBD from the plant and prepares the substance for formulations that treat pain, nausea, anxiety, and inflammations. Cannabinoids are processed in various forms, including creams, capsules, and oils.

Cannabinoids

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

High-pressure homogenizers are used in bio-pharmacy applications to obtain intracellular components like enzymes and proteins from bacteria, fungi, and animal cells through cell rupture. They are also used in other biotech processes such as the production of nanoparticles for tissue engineering and in the development of new drugs, vaccines, antibiotics, and chemicals. The choice of a high-pressure homogenizer depends on the mixture to be processed, desired particle size distribution, and the type of force to be applied to the particles.

Industrial

When working with high viscosity liquids in industrial processes, achieving thorough dispersion, emulsifying, and homogenization is crucial. Common challenges include maintaining uniformity and preventing particle settlement throughout the process.
<h2>Promotes efficient mixing and uniform particle distribution</h2>
The ME 6100 series by INOXPA is a high shear tank bottom mixer designed for demanding industrial applications like food processing, cosmetics, pharmaceuticals, and fine chemicals. It ensures efficient dispersion, emulsifying, homogenization, and disintegration of solids. The mixer can be used in both open and closed tanks at atmospheric or varying pressures. Its high-speed rotor and precise rotor-stator tolerances create a powerful suction that draws the product to the center of the head, where it is radially thrust and mechanically sheared. This results in particle size reduction to less than 100 microns. The mixer is constructed from high-quality materials, including AISI 316L stainless steel for parts in contact with the product, ensuring durability and ease of cleaning (CIP/SIP). Its design allows for easy maintenance, including stator replacement without disassembling the mixer, and features a sanitary single mechanical seal.

Tank bottom mixer for high viscosity applications

Dispersing systems are used to produce emulsions of two immiscible liquids or dispersions of solid particles in a liquid medium. The mixers generally operate on the rotor/stator principle and apply a high shear force on the suspended particles to break them down. The choice of a dispersion mixer depends on the physical state of the material being dispersed, the continuous or batch nature of the process, desired particle size, and the viscosity of the mixture. Dispersion mixers are widely used in the food industry for the dispersion of solid ingredients in oil or water and in the coatings industry for the dispersion of pigments.

Dispersing

An emulsifier is used to mix two immiscible liquids. Heating or cooling requirements during emulsification, overpressure or vacuum requirements, the need for wall scrapers, design of the mixing head, the viscosity of the liquids, and the desired droplet size are all important considerations when selecting an emulsifying system. Emulsifiers are typically used in the food industry for the production of batters, creams, and sauces, in the pharmaceutical and cosmetics industry for the production of creams and lotions, and in the chemical industry for the production of paint and other emulsions.

Emulsifying

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

liquid

In the dairy and juice processing industries, maintaining product consistency, flavor, and shelf life is crucial. Traditional mixing methods often fall short, resulting in uneven distribution and shorter shelf life, necessitating more effective high-pressure homogenization techniques.
<h2>Enhance product stability and shelf life</h2>
The HST high-pressure homogenizers by HST Maschinenbau are designed for efficient homogenization across various industrial applications. These homogenizers subject pressurized products to turbulent and laminar forces within a narrow ring-shaped gap, breaking up fat globules or agglomerates and ensuring even distribution. This process enhances product stability, color intensity, flavor, consistency, and extends shelf life, which reduces the need for stabilizers. Available in Series HL2-HL6 and the HLI and HLE series, they come in robust designs with capacities ranging from 300 to 80,000 liters per hour. Optional features include aseptic designs for sterile products and energy-saving Multigap valves. Suitable for dairy products, sauces, cosmetics, and chemical emulsions, HST homogenizers meet diverse industrial requirements.

High-pressure homogenizers for dairy and juice processing

Continuous

In the dairy and beverage industries, uniform product consistency and extended shelf life are critical. Traditional mixing methods often result in uneven dispersion of fat globules, leading to product separation and reduced stability.
<h2>Achieve uniform texture and long shelf life</h2>
The high-pressure homogenizers by HST Maschinenbau are designed to distribute fat globules or agglomerates evenly, enhancing the stability, color, flavor, and consistency of various liquid products. These homogenizers operate by subjecting pressurised products to turbulent and laminar forces in a narrow ring-shaped gap, breaking up fat globules. This process reduces the need for additional stabilizers and extends product shelf life. The standard HL series offers a capacity range of 5.5 to 250kW, managing flow rates between 300l/h to 35,000l/h, with options for aseptic or ATEX designs. For industries requiring reduced water consumption, the HLI series provides capacities up to 400kW with a flow rate of up to 80,000l/h. Additionally, the economical HLE series targets small capacities with lower costs. Customizable pistons and valves ensure optimal performance for specific product properties, and the integrated aseptic design helps prevent recontamination, making these homogenizers suitable for a wide range of applications, including milk, juices, creams, and sauces.

High-pressure homogenizers for dairy and beverage industries

When producing high-quality dairy and food products, achieving consistent texture, stable emulsions, and long shelf life can be challenging. Traditional methods might fall short in breaking down fat globules or ensuring uniform distribution, leading to quality control issues.
<h2>Enhance stability and consistency in food production</h2>
The high-pressure homogenizers from HST Maschinenbau are specially designed to improve the stability, color intensity, flavor, and consistency of a variety of dairy and food products. These homogenizers operate by subjecting a pressurised product to turbulent and laminar forces in a narrow ring-shaped gap, effectively breaking up fat globules or agglomerates. This results in products with increased shelf life and reduced need for stabilisers. Available in various series such as HL2-HL6, HLI55-90, and HLE3-75, these homogenizers offer robust designs with capacities ranging from 300L/h up to 80,000L/h. Options for aseptic and Atex designs are also available to meet specific industry standards. Machines come equipped with high-efficiency, low-noise valves and customizable pistons, providing optimal performance for various applications in the food, pharmaceutical, and chemicals industries.

High-pressure homogenizers for dairy and food products

In the production of emulsions, cream, and UHT milk, maintaining stability and consistent texture can be challenging. This often requires high-pressure homogenization to efficiently break down fat globules and create uniform mixtures.
<h2>Achieve stable, uniform emulsions under high pressure</h2>
The HST homogenizers from HST Maschinenbau are designed for high-pressure applications to produce stable and uniform emulsions. Utilizing turbulent and laminar forces in a narrow ring-shaped gap, they efficiently break up agglomerates, enhancing product stability, color intensity, flavor, and consistency. Available in various series such as HL, HLI, and HLE, these homogenizers offer capacities ranging from 300 liters per hour up to 80,000 liters per hour. Each model can be optionally configured for aseptic or Atex design, ensuring compliance with stringent hygiene and safety standards. Notable features include noise insulation cladding and reduced water consumption in certain models. Key applications span across the food, pharmaceutical, cosmetics, and chemical industries, processing products like fresh milk, baby food, intravenous emulsions, and lubricants.

Homogenizers for high-pressure applications

In industries like food processing and pharmaceuticals, achieving uniform product consistency and stability is crucial. High-pressure homogenization addresses the challenge of breaking down fat globules and agglomerates to distribute them evenly, enhancing product quality and shelf life.
<h2>Ensures stability and uniform distribution</h2>
The high-pressure homogenizer by HST Maschinenbau is a versatile solution engineered for both the food and pharmaceutical industries. By forcing the pressurized product through a narrow gap, the homogenizer utilizes turbulent and laminar forces to break down fat globules and agglomerates. This process results in significant improvements in product stability, color intensity, flavor, and consistency, reducing the need for stabilizers. The HST homogenizer models range in capacity from 300 liters per hour to 80,000 liters per hour, accommodating various production scales. Available in aseptic designs for sterile products and optional Atex designs for hazardous environments, these homogenizers are built for flexibility. They also feature customizable pistons and valves to suit diverse product characteristics, and are designed for high efficiency with reduced noise and pulsation.

High-pressure homogenizer for food and pharmaceuticals

Pilot

In various industries, achieving uniform particle distribution in liquid mixtures is critical for product stability, consistency, and longevity. High-pressure homogenization is adopted to break down fat globules or agglomerates efficiently, enhancing these attributes in applications such as food, cosmetics, and pharmaceuticals.
<h2>Uniformly distributes particles in liquid mixtures</h2>
The HST homogenizers from HST Maschinenbau are designed to subject pressurized products to turbulent and laminar forces in a narrow ring-shaped gap. This physical energy input effectively breaks up fat globules or agglomerates into uniformly distributed particles, contributing to stability, color intensity, flavor, consistency, and extended shelf life, while reducing the need for stabilizers. These homogenizers are available in various models, including laboratory and pilot plant machines like the HST HLL0 and HST HL1, and production machinery series HL2-HL6, HLI 55-90/HLI8, and HLE 3-75. They offer capacities ranging from 300 liters per hour up to 80,000 liters per hour with power levels from 3kW to 400kW. Options for aseptic and Atex designs, as well as noise insulation cladding, are available. Notably, the HLI series integrates features for reduced water consumption, making it a more sustainable choice. The homogenizing valves and piston versions can be customized based on the product properties to ensure maximum efficiency and lifespan. Additionally, the aseptic design uses superheated steam, condensate, or sterile water as a barrier, preventing product recontamination.

Homogenizer for high-pressure homogenization

In the production of liquid food, pharmaceutical, and chemical products, consistent texture, stability, and shelf life are critical. Achieving these qualities often requires breaking down fat globules and agglomerates into smaller, uniform particles to enhance product quality.
<h2>Enhanced particle size reduction and uniformity</h2>
The homogenizers from HST Maschinenbau are designed to achieve optimal particle size reduction and uniformity in various liquid products. The high-pressure homogenization method subjects a pressurized product to turbulent and laminar forces in a narrow, ring-shaped gap, breaking up fat globules and distributing them evenly. This technique results in improved stability, color intensity, and flavor, and extends shelf life while reducing the need for stabilizers. HST offers various series of homogenizers with diverse capacities and optional features like aseptic design for sterile products and Atex design for explosive environments. For instance, the Series HL2-HL6 ranges from 300 to 35,000 liters per hour, while the HLI series integrates reduced water consumption and noise insulation. These homogenizers are versatile in applications such as food industry products (e.g., milk, sauces, juices), pharmaceutical emulsions, and chemical emulsions. HST provides specialized valves and pistons that can be tailored to specific product requirements to ensure optimal homogenization results.

High-pressure homogenizers for liquid products

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

Size reduction

For industries dealing with fine powdery products, transitioning to a more manageable form is critical. Problems like poor flow properties, dust generation, and inconsistent dosing can hinder efficient processing.
<h2>Transform powders into free-flowing granules</h2>
The compaction and granulation technologies from Hosokawa Alpine are designed for transforming powdery chemical, pharmaceutical, mineral, and metal products into compacted shapes. Utilizing methods such as compaction, dry granulation, high-pressure roller grinding, briquetting, or pelletizing, these technologies improve product characteristics like bulk density, flowability, and dosing accuracy. This results in dust-free granules that streamline subsequent processing steps. Suitable for multiple industries, these technologies reduce common issues associated with fine powders, enhancing overall operational efficiency.

Compactors and granulators for powdery products

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

Granulation

Pelleting equipment transforms powdered, mashed, or grounded material into a denser cylindrical shape. Pellet processing compresses the fine material against a perforated die, where it will be shaped and cut. Although granulating and extrusion also produce pellet-like products, manufacturing pellets is a distinct process.

Pelleting

Powder

solid

In the food industry, maintaining product safety and extending shelf life are critical. Traditional thermal methods can degrade the nutritional and organoleptic properties of foods, presenting a significant challenge for manufacturers.
<h2>Extend shelf life and ensure food safety</h2>
The Hiperbaric 300 is an industrial-scale High Pressure Processing (HPP) system designed to preserve food products through non-thermal pasteurization. With a vessel capacity of 300 liters (79.3 US gallons) and the ability to process approximately 1,350 kg/h (2,976 lbs/h), this system offers significant throughput. Its advanced design features the longest-lasting yoke and vessel in the market, allowing for dependable operation over extended periods. The system operates at pressures up to 600 MPa (87,000 psi) with a hold time of 3 minutes, ensuring effective inactivation of pathogens without compromising food quality. The machine's flexibility is further enhanced by its ability to be configured with intensifiers either on the floor or above the unit, catering to diverse production line layouts. With applications in juices, meat, seafood, and ready-to-eat meals, the Hiperbaric 300 is a versatile addition to any food processing line. Hiperbaric is the manufacturer behind this technology.

High pressure food processing system

The Pasteurization process is the method of subjecting liquids to mild heat at a specific temperature and time, and quickly cooling them down again in order to destroy pathogens in your fermented or semi-fermented products. Thus, increasing the shelf life of the manufactured products. Untreated microorganisms may lead to diseases, spoilage, or unwanted fermentation. Most pasteurization equipment operate in a continuous method using plate heat exchangers to keep a uniform level of high efficiency sterilization.

Pasteurizing

High-volume liquid beverage producers face challenges in maintaining product safety and extending shelf life while optimizing production efficiency. Ensuring minimal processing steps and reducing energy consumption is crucial in meeting these industry demands.
<h2>Streamline and enhance beverage production</h2>
The Hiperbaric 525 and 1050 Bulk systems specialize in high-pressure processing (HPP) of liquid beverages before bottling. These systems feature a revolutionary in-bulk processing approach that fills an inlet tank with liquid, pressurizes it, and subsequently transfers it to an outlet tank via sterilized tubes. With a 525-liter vessel capacity and the ability to process over 4,000 liters/hour, it significantly boosts productivity. The design allows a 90% vessel filling efficiency and reduced energy consumption. This system, created by Hiperbaric, also supports the use of any container type, making it versatile for different packaging needs.

High pressure processing for bulk liquid beverages

Bottling equipment draws a measured quantity of your drink, food, or formulation from a holding tank and fills it into bottles. These bottles usually need to be checked, capped, labeled, and sealed for distribution. Bottling solutions differ in product metering system, sterilization level, and bottle type and sealing system depending on your production scale and product format and regulations. Bottling systems are utilized in a variety of industries. For example, in the food and beverage industry as well as in cosmetics and pharma.

Bottling

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Processing

Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

Sterilization

Batch

In food processing, challenges include maintaining product quality, optimizing yield, and ensuring microbial safety. Traditional methods often fall short, leading to inefficiencies and inconsistent results. A versatile, pilot-scale system can address these issues effectively.
<h2>Customizable for multiple food applications</h2>
The PEF Pilot Dual from Elea Technology is a modular Pulsed Electric Field (PEF) system designed for both liquid and solid food products. Its core unit can be customized with various external units, enabling the precise treatment of diverse materials such as grapes, meat, and potatoes. This system is ideal for both research and small-scale production, offering easy operation and a compact design for laboratory or on-site use. With capacities ranging from batch modes of up to 10kg to continuous processing of up to 250 l/h, and additional configurations available for larger capacities, it provides a scalable solution for pilot testing and production. The integrated safety features, including a touch screen for control and monitoring, enhance user experience and operational reliability.

Modular pulsed electric field system for food processing

Blending

In large-scale ethanol extraction labs, maintaining extremely cold temperatures is essential for reducing post-extraction processes and ensuring high-quality outcomes. Managing this efficiently without taking up excessive lab space is a common challenge.
<h2>Quickly chills ethanol to -40°c in 20 minutes</h2>
The DC-40 Direct Inline Chiller from Delta Separations is a compact solution designed to quickly lower the temperature of ethanol to -40°C, significantly improving the efficiency of the cold ethanol extraction process. By eliminating the need for bulky ultra-low freezers, the DC-40 saves valuable lab space and minimizes post-processing time. The system includes an ETL Certified condenser, a VFD ethanol pump, and a microprocessor controller for precise temperature management and compatibility with Modbus or Ethernet controllers. This chiller can cool 30 gallons of ethanol from 20°C to -40°C in just 20 minutes, making it a critical component in high-capacity extraction labs.

Inline chillers for ethanol extraction

Industrial cooling equipment varies according to the consistency and temperature conversion demands the material you are handling, but the process typically involves heat exchange treatment as your products are conveyed through a cooling chamber equipped with extraction fans or circulating water. Temperature control is a crucial aspect of your commercial production and cooling systems are applied to a range of industries.

Cooling

Industrial extraction equipment unlocks the valuable compounds hidden away in natural materials. Automated extraction equipment is applied in the pharmaceutical and cosmetic industries to extract active compounds from medicinal plants or herbs. For example, extracting cannabinoids from cannabis plants. But the process is also fundamental to the food industry, recovering various components like aromas, oleoresins, and proteins.  Considerations for selecting suitable extraction technology include the type of plant material to be processed, the extract's heat sensitivity, and the production volume.

Extraction

In the processing of oilseeds, such as soybeans and canola, removal of solvents like hexane is crucial to ensure product safety and quality. These processes demand a solution that provides efficient desolventization and toasting while maintaining low operational costs and minimizing equipment footprint.
<h2>Facilitates solvent removal and toasting efficiently</h2>
The Desolventizer-Toaster (DT) from Crown Iron Works is a vertically oriented cylinder equipped with multiple trays, designed for the desolventization of ethanol, hexane, or other solvent-wet products. Indirect heat transfer using steam, hot water, or oil ensures cost-efficient operation. Direct steam can be introduced for combined heat transfer, enhancing efficiency and reducing equipment size. Suitable for various products including vegetable oilseeds, wood chips, silicas, and algae, it features counter-current desolventization and low horsepower-per-ton requirements. Automatic level controls and robust design elements like heavy-duty steam chests and sweep arms ensure operational smoothness and longevity. Available for both pilot-scale and large-scale production, the DT caters to diverse industrial needs.

Efficient desolventization and toasting solution for oilseeds

Rinsing

Producing shortenings and margarine involves transporting and processing emulsions at high pressures to achieve the desired consistency and quality. The challenges include maintaining consistent flow rates and pressure levels, and ensuring a hygienic environment to prevent contamination.
<h2>Efficiently transport and process emulsions</h2>
The high pressure product pumps from CHEMTECH are designed specifically for managing shortening and margarine emulsions. These pumps handle flow rates ranging from 100 to 20,000 kg/hour at pressures up to 200 bar. They are skid-mounted and come equipped with pulsation dampers, pressure transmitters, and integral pressure relief valves. The sanitary design includes stainless steel and ceramic contact parts to maintain product purity. These features ensure consistent operation and compliance with hygiene standards, making them ideal for the food industry.

High pressure pumps for margarine production

Conveyor systems are used for moving materials from one location to another. Considerations for choosing a suitable industrial conveying system include the nature of the product, its physical state, the desired conveying rate, and sensitivity of the product to heat and mechanical shock. Conveying equipment is used in the food, pharmaceutical, chemical, biomass, and mineral industries to move materials around a warehouse as well as to transport bulk powders, granules, and grains for processing and filling. These types of systems are usually automated and there is a wide variety of solutions to choose when it comes to the type of conveyor. Types include screw, gravity, chain, roller and belt conveyors.

Conveying

In industries like dairy, food and beverage, chemical, cosmetic, and pharmaceutical, achieving uniform particle size distribution in liquid products is crucial. High-pressure homogenizers are essential to ensure product consistency, stability, and quality, especially when dealing with viscous or abrasive materials.
<h2>Achieve uniform particle distribution at high pressure</h2>
The HA32-SM, part of Bertoli's Raffaello Series, is an industrial homogenizer specifically designed for high-pressure applications up to 1500 bar at a capacity of 800 liters per hour. It features a three-plunger system and integral carbide plungers to handle abrasive and viscous products efficiently. The unit includes poppet valves for improved performance and a transmission system with low maintenance costs. Its design boasts easy-access panels and hygienic construction as per MOCA standards. Additionally, it operates silently and has low water consumption, making it a reliable choice for continuous industrial operations. The HA32-SM is ideal for various sectors, including food and beverage, chemical and nano dispersion, cosmetics, pharmaceutical, and biotech industries.

Industrial homogenizers for high-pressure applications

Manufacturing sectors such as food and beverage, pharmaceuticals, and cosmetics frequently require a method to efficiently homogenize their products. These processes often demand high pressure to ensure product consistency, particle size reduction, and stability.
<h2>Efficiently homogenizes under high-pressure conditions</h2>
The Michelangelo Series HA30 by Bertoli, part of the Interpump Group, is a robust industrial homogenizer designed for high-pressure applications. With a power capacity of 9.2 kW, it can operate at pressures up to 1,500 bars, delivering up to 1,900 liters per hour at 150 bars. The HA30 features a hygienic design compliant with MOCA standards and ensures extended maintenance intervals. Its three-plunger system with a 50 mm stroke guarantees consistent performance. The unit also integrates easy-open panels for straightforward maintenance, reducing downtime and operational costs. Its low-maintenance transmission system and silent operation make it suitable for environments where noise reduction and reliability are critical. Industries such as food and beverage, chemical and nano dispersion, cosmetics, and pharmaceuticals can significantly benefit from its efficient homogenization capabilities.

Industrial homogenizer for high pressure applications

In the production of dairy and food products, maintaining consistent texture and quality is critical. Homogenization is an essential technique to achieve uniform particle size distribution and improved product stability.
<h2>Achieve consistent texture and improved stability</h2>
The Leonardo Series - HA52 by Bertoli, part of the Interpump Group, is a high-pressure homogenizer used for various industrial applications, including dairy, food and beverage, chemical and nano dispersion, cosmetic, and pharma and biotech industries. It is equipped with a power range of 200/250 kW and can operate at pressures up to 1500 bar with a maximum capacity of 37,600 liters per hour. The HA52 features a hygienic design and an extended maintenance schedule compliant with MOCA regulations. The self-alignment plunger system and poppet valves are engineered to handle viscous and abrasive products efficiently. Additionally, the device operates without pulsation dampers and offers an easily maintainable liquid end. Options include a closed cabinet for soundproofing and easy open panels for convenient access.

High-pressure homogenizer for dairy and food production

When working with pharmaceutical or biotech samples, achieving consistent particle size reduction and mixture uniformity is essential. Precision and reliability are key factors in ensuring effective homogenization of small batches, especially when dealing with abrasive or viscous products.
<h2>Ensures precision and reliability in small batch homogenization</h2>
The Quark from Bertoli, a brand under Interpump Group, is a laboratory homogenizer designed for high-pressure applications. Its single plunger design ensures reliable scaling from test to production, making it ideal for R&D settings. With a power capacity of 0.75 kW and capable of delivering up to 3 l/h at 2,000 bar, the Quark addresses the needs of small-volume and high-pressure homogenization. The unit is equipped to handle minimum sample volumes as low as 10 ml, and its construction makes it suitable for abrasive and viscous products. Featuring welding flanges DIN 11851 for product inlet and outlet, it ensures seamless integration into existing processes. Weighing 50 kg, it is also available in ATEX configuration for use in explosive atmospheres. Additionally, the Quark can be fed with syringes, increasing its versatility in the laboratory.

Laboratory homogenizer for pharmaceutical and biotech applications

In industries such as pharmaceuticals, cosmetics, and food processing, achieving consistent and high-quality emulsions and dispersions in high viscosity products presents a challenge. Reliable control over particle size and distribution is crucial for product stability and performance.
<h2>Ensure consistent emulsion and dispersion quality</h2>
The HRB Homogenizer from Bachiller allows for both internal and external recirculation during the homogenization process. It incorporates an adjustable gap system ranging from 0.1 mm to 1.5 mm, which can handle shear rates up to 250,000 s-1. This ensures the production of fine emulsions and dispersions with particle sizes from 10 μm to 1 μm. The HRB is designed to introduce raw materials directly into the high turbulence zone, bypassing the limitations of conventional suction methods. It can process high viscosity products, making it suitable for applications in the cosmetics, pharmaceutical, and food industries. The built-in CIP system simplifies cleaning and maintenance.

Homogenizer for high viscosity emulsion and dispersion

Producing high-quality cosmetic or pharmaceutical creams often requires precise control over mixing and homogenization processes to ensure consistency and eliminate air bubbles.
<h2>Efficient mixing and homogenizing under vacuum</h2>
The Axomatic Axomix 400 - 1000 is an undervacuum homogenizer designed to optimize the mixing and homogenization of cosmetic and pharmaceutical creams. With contra-rotating slow mixing enabled by teflon scrapers and a high-speed homogenizing turbine (up to 3,000 rpm), the unit ensures thorough blending without introducing air bubbles. The control panel provides clear visibility over all operational parameters. The hydraulic lifting of the cover and vessel tilting facilitates the discharge of the finished product. Optional features include check weighters, a cleaning system with spray balls, and production data printing capabilities. Suitable for applications requiring precision and efficiency, with a central bottom valve for vacuum raw material suction and finished product discharge.

Undervacuum homogenizer for cosmetic and pharmaceutical creams

In industries where precise mixing and homogenization of ingredients is essential, traditional methods often fall short in maintaining product consistency and quality. Especially in sectors like pharmaceuticals and cosmetics, achieving a high degree of uniformity is crucial to meet regulatory standards and customer expectations.
<h2>Ensure uniform mixing and efficient homogenization</h2>
The Axomix 25-50 by Axomatic, part of the Marchesini Group, is an under vacuum homogenizer designed for consistent and efficient mixing of complex formulations. Contra-rotating slow mixing with Teflon scrapers and a high-speed homogenizing turbine (up to 3,000 rpm) ensure thorough processing. This equipment features a mechanical lifting cover and tilting vessel for easy discharge of finished products. The system's ability to suck raw materials under vacuum and discharge the finished product through central bottom valves adds to its efficiency. Optional features include check weighters, a cleaning system by spray balls, production data printing, and steam heating. The control panel T&S color kind displays all key operating data to enhance user oversight. The equipment includes a vacuum pump with a power of 0.75 kW and heating elements rated at 6 kW. Key industries that benefit from this technology include pharmaceuticals, cosmetics, and food processing.

Industrial under vacuum homogenizer

In the food and beverage industry, achieving efficient and sustainable extraction of plant-based proteins is a significant challenge. Traditional methods often fall short in meeting the demands for purity and yield, while also being energy-intensive and environmentally taxing.
<h2>Extract plant-based proteins efficiently</h2>
The plant-based protein extraction solution by ALPMA Alpenland Maschinenbau GmbH is designed to efficiently extract high-quality proteins from various plant sources. Utilizing advanced process technology, it ensures optimal protein yield and purity. The system is compatible with a range of raw materials including starch plants, oil plants, and fermented proteins. It operates with reduced energy consumption and minimal environmental impact, making it a sustainable choice for manufacturers. The technology is particularly useful for producing vegan cheese, yogurt, and milk alternatives, catering to the growing demand for plant-based foods. ALPMA's expertise in dairy and protein process technology guarantees a reliable and efficient extraction process. Key features include easy integration into existing production lines, high throughput rates, and robust construction for long-term use in industrial environments.

Plant-based protein extraction technology

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

In industries such as food, cosmetics, chemicals, and pharmaceuticals, achieving a uniform emulsion with fine droplet structures is crucial. Traditional methods often face challenges with shear-sensitive goods and viscosity, requiring a versatile and efficient process.
<h2>Produce and homogenize fine emulsions efficiently</h2>
The Hydro Grind® Processing system from AK Systems offers a self-developed homogenizing unit that facilitates the seamless introduction of solids into liquids, achieving a fine droplet structure akin to high-pressure homogenization. The system merges multiple process steps into one unit, ensuring shear-sensitive goods are gently mixed into highly viscous emulsions. A key feature is the direct dosing of solids into the dispersing turbine area, preventing lump formation and ensuring a homogeneous mix. This patented technology is adaptable across various industries, producing storage-stable emulsions. The dynamically controlled shear forces provide flexibility, enhancing product quality without the need for multiple system changes.

Emulsion processing system for homogenizing solids into liquids

From food to pharma, homogenization is an essential step in the production process that provides uniformity to the product by improving its physical properties. If not homogenized, the fluid product might degenerate over time, leading to the formation of sediments and phase separation. This will lead to the loss of desirable product properties like uniformity, viscosity, consistency and reduced shelf life. 
<h2>Reducing product particle size using cavitation provides fluid stability</h2>
High Pressure Industrial Homogenizer from HOMMAK facilitates permanent homogenization of heterogeneous fluid products like milk, fruit juices, creams, ointments and more. The homogenization effect is achieved by reducing the product particle size through cavitation, shear force, impact velocity and turbulence effect under pressure, thereby preventing phase separation in the product.

The homogenizer consists of two main elements – the compression block and the homogenization unit. As the name suggests, the compression block compresses the ingredients under high pressure. The homogenization unit micronizes the decomposed particles to the specified size per the product.

The equipment's design and manufacturing considerations like capacity, pressure, material selection and valve design are tailored to its specific industrial application.

Pilot plant homogeniser

<span style="font-weight: 400;">For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot/small scale pharmaceutical production is the ideal choice. Full control over all process elements and 100% scalability coupled with cost-effective electric operation offers substantial cost-savings over alternative options.</span>
<h2>Cost-effective unit suited for both laboratory and pilot use</h2>
<span style="font-weight: 400;">The Mini DeBEE from BEE International is hydraulically driven homogenizer that is suitable for both laboratory use and in pilot plants or in small-scale production. Offering the highest process intensity available in its class, it will disrupt the toughest cells with the highest yield, or obtain the smallest particle size.  </span>

<span style="font-weight: 400;">With proprietary modular homogenising cell, the Mini DeBEE offers completely independent control of pressure, flow, cavitation, impact, shear and process duration. The minimal sample size of only 10ml makes it an excellent choice for R&amp;D and lab work. Because it guarantees 100% scalability, it can easily be transferred to pilot operations, or the machine itself can also be used for small-scale and batch production, offering continuous flow of up to 15 litres per hour.</span>

<span style="font-weight: 400;">PLC control with digital interface means simple operation and monitoring, with user-adjustable operating pressure from 2,000 to 45,000 PSI. Coupled with a wide range of options, this makes the Mini DeBEE suitable for application in the pharmaceutical, biotech, chemicals, cosmetics and food industries.</span>

Pilot high pressure homogenizer

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

<span style="font-weight: 400;">For any industrial pharmaceutical process that relies on high pressure homogenization it’s vital that the equipment used is robust enough to cope with the demands of continuous operation. More than this, modern production demands high levels of process control and automation, as well as seamless integration with plant controls and providing results that satisfy the highest regulatory demands.</span>
<h2>Homogenizer offering the highest level of automation, compliance and capacity</h2>
<span style="font-weight: 400;">The DeBEE 4000 series from BEE International is the company’s top-of-line homogenizing solution for high performance situations. Designed from the ground up to achieve the best results as efficiently as possible, the DeBEE 4000 uses DeBEE’s proprietary homogenization technology for unequalled results, coupled with a hydraulically driven vertical intensifier pumps with a slow stroke rate to provide higher pressure and higher process intensity, all with lower maintenance costs.</span>

<span style="font-weight: 400;">Featuring a PLC with bespoke HMI software and full-colour touch screen, the DeBEE 4000 offers easy access to several features including security modes and authorisations, integrations with plant controls using network data gathering, and dynamic visual schematics for at-a-glance system status and component parameters.</span>

<span style="font-weight: 400;">The DeBEE 4000 features a fully sanitary design making it ideal for pharmaceutical and biotech production, as well as use in the chemical industries.</span>

High pressure industrial homogenizer

<span style="font-weight: 400;">Biotech and pharmaceutical development programs often require a mixing method that achieves both particle size reduction and complete cell lysis. When piloting production systems, it’s vital that you have complete control over the pressure to accommodate all cell types, and that the results of testing are completely scalable to full production.</span>
<h2>High-pressure homogenizer offering all configurations</h2>
<span style="font-weight: 400;">The DeBEE 2000 from BEE International is a complete pilot solution for high pressure homogenization in a highly compact format. Offering user-adjustable pressure control from 5,000 to 45,000 psi, the unit is suitable for a wide range of pharmaceutical and biotechnology applications and its modular design means lower costs of maintenance and repair.</span>

<span style="font-weight: 400;">This pilot unit also offers a wide range of options to suit all process and budget requirements, including Dual Feed, Dual Jet, control of cavitation, shear and impact and secondary additive feed for particle synthesis.</span>

<span style="font-weight: 400;">PLC control and HMI touch screen provide simple monitoring, and the unit is designed to be easily cleaned (Clean in Place) and portable.</span>

High pressure pilot homogenizer

When processes call for homogenized emulsions with extremely fine particle sizes the traditional toothed ring dispensers are not always sufficient.  For extremely high levels of disintegration required to produce true micro-emulsions, extreme pressure cycling is more successfully used.
<h2>Homogenization with pressure shock to achieve extremely small particle sizes</h2>
The HPH High Pressure Homogenizer from IKA uses one or more piston pumps to apply pressure up to 2000 bar to the liquid medium to be homogenized.  The fluid is then fed through a homogenizing valve which very quickly reduces the pressure to the atmosphere.  This abrupt change in pressure in the moving fluid causes cavitation, a high degree of turbulent flow, and internal shearing forces in the fluid all of which serve to break up and distribute larger particles forming a very fine emulsion.  The pressure applied on the uphill side of the homogenizing valve is infinitely adjustable as is the flow rate through the valve, so the process can be easily adapted to achieve a wide range of outcomes and to accommodate fluids with different flow characteristics.  All parts that contact the product flow are stainless steel and autoclavable and the entire unit is designed for robustness and long service life.

High-pressure homogenizer

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  These machines use pressure shock to create very even distributions of extremely small particles.  They are; however, limited in their available flow rates and their ability to handle tough agglomerations of solids.  For these applications where a high pressure homogenizer cannot handle the raw materials or provide enough throughput, a colloid mill is often the better choice.
<h2>Extremely high quality dispersions of consistently sized particles with a very high throughput</h2>
The IKA MK 2000 is a high-performance inline colloid mill capable of performing wet and fine milling of tough and grainy raw materials. The MK 2000 is especially suitable for the production of colloidal solutions or extremely fine emulsions and suspensions. Excellent dispersing performance allows the IKA Colloid Mill MK 2000 to be used for continuous processes, providing a narrow distribution range of ground particles in a single pass. For challenging milling tasks the colloid mill can be installed into a recirculation loop with a working vessel by means of tube connections.

The conical geometry of the milling tools enables an axial displacement of the stator for an infinite adjustment of the milling gap. This allows influencing the dispersing effect, particularly regarding tasks with variable raw materials.

As neither the rotor nor the stator is slotted throughout, the probability of particles passing through the generator untreated is negligibly small. These collective features enable the IKA Colloid Mill MK to achieve the finest particle size reduction, thereby contending with a high pressure homogenizer by attaining similar dispersing results at higher flow rates.

The machines are designed for easy and reliable scalability and sizes are available with flow rates from 200 to 80,000 liters per hour.

Colloid mill

High pressure homogenizers

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

To make glue, you usually starting from gelatin, which is animal collagen. Glues help in the production of furniture, automobiles, clothing, paper, wood, art and craft, to name a few applications. The production of different glues depends on their industrial use. Different manufacturing processes and glue making equipment make it easier to create the many variations of this useful product.

Glue

Basically, to make milk powder, you need to remove the water content from the liquid milk and turn it into powder. How to do it? After pasteurizing and homogenizing the milk, milk’s water content is removed through filtration, evaporation, and drying. You have then to cool and sieve it before filling the containers. Here's how you get milk powder.

Milk powder

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

Stock cubes, also known as bouillon cubes or broth cubes, have been used in cooking for centuries. Think that, the first written version of a stock cube comes from Anne Blencowe’s recipe book from 1694. Made of dehydrated vegetables or meat stock, the bouillon cube production line consists of mixers, homogenizers, cube forming machines and packaging machines.

Stock cubes

Sunscreen is an emulsion which can be either oil-in-water or water-in-oil. To create it, you must prepare an oil phase and a water phase separately, then mix and heat them. Homogenization is a key process to guarantee that the product will have the right consistency. When manufacturing sunscreen, give special attention to protection against UV filters.

Sunscreen

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

After pasteurizing and homogenizing the raw milk, you need to ferment the milk with starter culture until solid curds and liquid whey is formed. Then, the liquid whey goes through a filtration and drying process to turn it into powder. Before sending it to packaging, flavorings are usually added.

Whey protein

Neige de lait in French or neve di latte in Italian, as referred to in very old texts and both meaning milk snow, has been used in recipes since the 15th century. Withstanding the test of time, whipped cream is still one of the most beloved dessert toppings. What starts with milk ends as a silky delicacy with the help of whipped cream equipment and specified manufacturing processes.

Whipped cream

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