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steam-in-place-bioreactor-systems-2

Steam-in-place bioreactor systems

Bioreactor Equipment and Systems

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

A bioreactor is an engineered system designed to support, automate and control a biologically active environment. The volume of the reactor, suitability for photosynthesizing organisms, level of scalability and control, and the type of installed sensors are all important considerations when choosing bioreactor equipment. Bioreactors are typically used for biomass such as cell culture, microbial culture, biopharmaceutical, and chemical development processes. They are also used for photosynthesizing commercial organisms such as algae and bacteria and fermentation applications.

Batch

Scaling-up from a laboratory scale to pilot plant and small scale production can be simplified with a consistent bioreactor design and the scalable control solutions. Depending on your desired output, you can choose between a bench scale or pilot plant systems.


<h2>Scale up with consistent bioreactor design</h2>
Getinge Applikon’s concept of modularity (using standard modules to customize the functions of the bioreactor) is extended to the stainless steel pilot plant bioreactors as well. For scaling-up purposes the range of the Bio Bench and Pilot Systems, designed and built to the latest standards on hygienic processing and CGMP and GAMP validation requirements, complements the laboratory-scale bioreactor systems.

Getinge Applikon offers CIP systems ranging from fully manual control to fully automated. The Standardized Steam-in-place bioreactor systems are available with approximately 140-liters volume and custom-built units can be supplied up to 2,000 liters total volume.

liquid

When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot and production scale; a scalable can come to represent a compelling solution to have. The required system has to allow a large number of inputs and outputs, synoptic displays, trending screens, alarms and much more.


<h2>Pilot scale to production bioreactor control system</h2>
Getinge Applikon i-Control is an easy-to-operate Scalable bioreactor controller and utility console. This scalable control solution is used to control processes in bioreactor systems from laboratory scale to pilot plant and production scale. The i-control from Getinge Applikon is a human interface color touch screen device used to control the most important parameters at a laboratory scale scenery.

The seamless scale-ability saves time and money by offering a simple scale-up of a control strategy from research via pilot-plant to production. The simplicity of operation is one of the key features, allowing operation by cell biologists, and configurations to get adapted to changing process demands without the need of an engineer on-site.

Scalable bioreactor controller

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Comprehensive upstream data acquisition and management are essential in the bioprocessing industry. That’s because you can’t be completely sure which historic information you may need in future. SCADA monitoring systems were not designed for laboratory precision. Research work needs more focussed information.


<h2>An Information System for All Stages of Bioreactor Operation</h2>
Lucullus PIMS bioreactor software from Getinge Applikon records the entire process from recipe planning through to automatic reporting and modelling. Phases covered between these points include reactor allocation, experiment design, media preparation, media component traceability, data analysis, and data mining.

This all-embracive approach is time-saving because all information is in a central Oracle database. There’s no need to export and import data between systems. Updating is a thing of the past because you always have the latest version at hand. Moreover, the same software produces accurate spreadsheets and graphs.

Advanced software is necessary to convert data from parallel bioreactor systems into useful information. Data management is key to research and process development in the pharmaceutical industry.

Bioreactor software

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

solid

Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh or membrane, you can have all the benefits from traditional devices without the inherent problems and limitations that come with them.


<h2>Non-clogging retention for high-density perfusion processes</h2>
The Getinge Applikon BioSep Acoustic cell retention system is a unique, cell retention device for high-density perfusion processes. The BioSep, based on the technology of acoustic resonance, is a non-fouling / non-clogging retention system. The BioSep can be applied in both R&amp;D (max. 1 L/day), process development and on production scale (1000 L/day).

Acoustic cell retention system

For accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic fermentations.


<h2>Very accurate characterization of the fermentation quality</h2>
The Anaerobic Fermentation Monitor from Getinge Applikon is a robust and user-friendly laboratory parallel bioreactor that allows for accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic fermentations.

It serves not only as the perfect screening machine for general research on anaerobic yeast fermentations, but also as a powerful, time saving tool for plant design and process optimization. A very accurate characterization of the fermentation quality can be obtained, without the need for highly educated laboratory staff, which is an important, money saving feature.

Anaerobic Fermentation Monitor

The fermentation process stimulates enzymatic activity in organic substrates to transform their chemical composition. Fermentation is aided by storying the biomaterials in anaerobic environments, allowing the microorganisms to decompose their nutrient structures. The process is integral to some of the most popular products throughout time such as wine, beer, cheese, and kimchi. But besides the food sector, fermentation is also an important stage in the industrial manufacturing of chemicals, pharmaceuticals, and biofuels.

Fermentation

Especially designed for cell culture applications and research applications such as process optimization, screening studies, product optimization, scale up/scale down studies and for educational programs.


<h2>Easy to handle autoclavable glass bioreactor</h2>
Getinge Applikon offers glass autoclavable bioreactors for cell culture applications. The system is built according to the specific demands of a process using an extensive array of standard components. Because of the modularity and flexibility the user can always adapt the system to changed process demands. This results in low initial investment and low running costs. Available in 1, 2, 3, 5, 7, 15 and 20 liter volumes.

Autoclavable glass bioreactor

For cell culture and microbial culture applications.


<h2>Adapt your systems to changed process demands</h2>
The Bio Clave from Getinge Applikon is an autoclavable stainless steel bioreactor which is versatile and easy to use system; offering economical alternatives to steam-in-place bioreactors and fermenters. The Bio Clave range combines the advantages of both, the steam-in place bioreactor (robust design and pressurizable) and the glass autoclavable bioreactors (flexibility and modularity).

Available in 20, 70 and 110 liter volumes. All systems are equipped with a top driven stirrer which can be either a magnetically coupled or a lipsealed stirrer system.

Autoclavable stainless steel bioreactor

SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth applications. A photobioreactor with SSL light is especially suitable for plant growth applications in the laboratory scale and all photosynthesizing commercial organisms such as algae and bacteria.


<h2>Economical set-up for cultivating photosynthesizing organisms</h2>
Using Solid state lamps (SSL), Getinge Applikon has developed a light panel that can be used as add-on modules that are compatible with standard stirred tank and single-use bioreactors from Getinge Applikon. This Photobioreactor for Plant Growth, offers maximum flexibility and economical set-up for the cultivation of photosynthesizing organisms. The volume range covers 3 liters up to 20 liters autoclavable stirred tank bioreactors and 10 up to 50 litters single use bioreactors.

Photobioreactor for plant growth

Success with bioprocesses is all about controlling the environmental conditions controls so you can replicate processes consistently. Good insight and easy adjustment of pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation are crucial for any biopharmaceutical process.


<h2>Easy to use control for lab scale operation</h2>
The ez2-Control from Getinge Applikon is an easy to use control and measurement system for bioreactors and fermentors. The bioreactor control system offers high accuracy, a good insight and easy adjustment of pH, Temperature, dissolved Oxygen, Foam/Level and Agitation, which are crucial for any biopharmaceutical process.

The colour touch screen interface guides the user through the operation.  The adaptive control features allow the user to focus on the process while the controller keeps tight control on the important process parameters.

The new web-interface for ez2-Control with advanced user management option provides a clear overview of the bioprocess parameters. Also it allows back-ups, copies and predefined settings of configurations to be simply shared via USB.

The ez2-Control can be used to control a large variety of reaction environments: From autoclavable bioreactors, steam in place bioreactors, to Appliflex single use bioreactors, milipore Cell Ready single use bioreactors or HyClone SUB bioreactors.

Lab scale Bioreactor controller

When you are working with small bioreactors, starting from 50 ml volumes, you need a good insight and an easy adjustment of pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation.


<h2>Control system for small-scale bioreactors</h2>
MyControl from Getinge Applikon is the most advanced controller available for small-scale bioreactors, compatible with bioreactors ranging from 50 mL to 2,700 mL (working volume), and is easily convertible between microbial and cell culture configurations.

The built-in software interface allows you to access with a web browser via computer, tablet or smartphone, so you can manage your entire laboratory with ease.

It is pre-configured and ready to use. Adding additional control loops, sensors, actuators, or external I/O is also fast and easy, so you will receive a system that meets your exact process specifications! Moreover, it is modular, so you can change your configuration options in the future as your experimental objectives.

One control system can control: 250 ml up to 1000 ml MiniBio bioreactors, 1L up to 3 liter Autoclavable bioreactors, 3 liter Cellready single use bioreactors.

Small-scale bioreactor controller

The vast majority of all biotechnological processes are aerobic, where a microorganism or cell responds to the liquid phase oxygen concentration in regulating its overall metabolism. Knowing the exact oxygen content in the working atmosphere is critical for your process.


<h2>DO2 Sensor optimized for bioprocesses</h2>
The Dissolved Oxygen sensor is a measuring device that informs about the dissolved oxygen in biotechnology processes, which is a basis for process optimization and control.

The AppliSens Low-Drift DO2 sensor from Getinge Applikon is specifically designed for long-term, stable, and accurate measurements in bioprocesses, such as fermentation and cell culture applications. Designed to withstand repeated sterilizations without failure.

The DO2 sensor has a titanium membrane module to minimize the measurement drift, and the available autoclave polarization module allows you to reduce start-up time for your cultures.

Dissolved Oxygen sensor

During the initial stages of scale-up, researchers often have limited data available with which they must decide on what to do next. High throughput, informative and predictive tools are necessary to cope with the number of cultures that must be done early on.


<h2>Cultivation in microtiter plates</h2>
The Micro-Flask system by Getinge Applikon, is a simple and powerful set of tools for improving the quality of experiments performed in micro-titer plates. Using a unique "sandwich cover" plate closure, it is possible to eliminate well-to-well variability in flasks, dramatically improve gas transfer in cultures, and achieve outstanding results from high-throughput experimentation.

The Micro bioreactor ensures that every microtiter plate is exposed to identical culture conditions. In addition to preventing cross-contamination during vigorous shaking, the sandwich covers also provide uniform diffusion paths for each well, virtually eliminating well-to-well variability.

Micro-Flask

When a screening study takes place, optimizing media process and working with microbial and cell cultures is quite common. Working with small volumes reduces media costs, which in consequence maximizes bench space and such factor would normally be considered a premium benefit.


<h2>Considerably small, real bioreactors</h2>
The MiniBio from Getinge Applikon is a range of bioreactors (250 ml, 500 ml and 1000 ml total volume) is a true scale down of the laboratory scale bioreactors in the 1 to 15-liter range. The Mini bioreactors systems have the same flexibility as the laboratory scale bioreactors, which means that the MiniBio systems can be customized to fit the demands of any process.

Mini bioreactors

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New technologies are emerging that warrant accurate measurement and improve durability even in high-temperature steam-sterilization processes.


<h2>Acidity sensor optimized for bioprocesses</h2>
The pH sensor from Getinge Applikon is constructed using FDA approved materials, like the non-toxic solid gel electrolyte. Furthermore this sensor has an internal pressure, which reduces cross contamination. The pH sensor is designed to withstand repeated sterilization cycles without failure.

pH Sensor

Utilized when applying low-frequency and high-intensity acoustic energy to agitate microbial cultures.


<h2>Enhances oxygenation and bulk mixing for bacterial and fungi cultures</h2>
The Resonance Acoustic Mixer, from Getinge Applikon is a highly-efficient orbital-shaker replacement that dramatically enhances oxygenation and bulk mixing for bacterial and fungi cultures. Combined with the patented Oxy-Pump® stopper, oxygen transfer rates up to 6-fold higher than orbital-shaken cultures can be achieved. The Resonance Acoustic Mixer is an indispensable product for any cutting-edge biological laboratory.

Resonance Acoustic Mixer

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, containing fewer parts compared with conventional bioreactors, so the initial purchasing and maintenance costs in the R+D process are reduced.


<h2>Rocking Single-Use Bioreactors from 10 up to 50 liter volume</h2>
The Single-use bioreactor Appliflex, from Getinge Applikon is a flexible bag bioreactor ideal for cell culture, specially the growth of animal cells like CHO cells, Hybridoma cell lines and insect cells like Sf-9, Sf-21 cells, also excellent working for the seeding of pre-seeding for larger cell cultivation systems.

Offering reliable measurement and control in rocking Single-Use Bioreactors from 10 up to 50-liter volume. The bag and sensors (pH, dissolved oxygen, T) are designed for single-use, in compliance with CE guidelines.

The control system (pH, DO, T, rpm) is formed by the standard Getinge Applikon ez-Control, which guarantees real-time measurement of pH, DO, T and rocking speed.

Single-use bioreactor Appliflex

A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture of cells, instead of a glass culture vessel, containing fewer parts compared with conventional bioreactors, this way the initial purchasing and maintenance costs are reduced.


<h2>3 liter single-use stirred tank bioreactor</h2>
The Single-use bioreactor CellReady 3L, from Getinge Applikon is a stirred tank bioreactor platform that works by eliminating the cleaning process, it is disposable, autoclave and assembles your traditional glass bioreactors, saving you downtime days, which sometimes represent quite a setback at the initial scale-up stage, due to the limited data available.

This Single-use bioreactor CellReady 3L, allows you to focus on experimentation and data analysis, getting you to faster conclusions.

The control system is formed by the standard Getinge Applikon ez-Controller, configured for a cell culture application, it measures and controls pH, temperature and dissolved oxygen (DO).

Single-use bioreactor CellReady 3L

A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead of a glass culture vessel, containing fewer parts compared with conventional bioreactors, so the initial purchasing and maintenance costs are reduced.


<h2>Bioreactor vessel with single-use contact surfaces for mixing</h2>
Getinge Applikon is an authorized integrator for the HyClone S.U.B. bioreactors. The Hyclone is a fully functional and unique tank bioreactor mixing system which provides overhead mixing while maintaining sterility and integrity. A re-usable outer support container also provides a mixer motor, heating/cooling, control unit for integration with an external control system and a mobile skid.

This bioreactor operating system enables to set-up and the application of your processes in a reduced time-to-market, going from R+D to production in the shortest time.

The main features of this unique equipment are scalability, for both larger and smaller volume systems for research and process development; alternative Sparging, the product is also supplied with an open pipe and (optional) micro porous “frit”.

Single-use Non-invasive Sensors, like the ez-Control is capable of measuring both classical sensors for pH and Dissolved Oxygen as well as Fluorophore type sensors.

The combination of ez-Control and HyClone S.U.B. offers the advantages of Single-Use Processing.

Single use bioreactor Hyclone

When undertaking a screening study, process development or optimisation study, you can speed up your project by growing and controlling multiple small cultures simultaneously. If time and reproducibility are critical for your project, you may consider investing in technology that will help you increase your efficiency in time and costs.


<h2>Independently control up to 24 bioreactors with one system</h2>
The Micro-matrix from Getinge Applikon is an high throughput fermentation and cell culture device which allows easy operation of 24 bioreactors in parallel. The micro-Matrix comes on a simple microtiter plate footprint, allowing independent control and measurements of the following:
<ul>
 	<li>pH,</li>
 	<li>temperature,</li>
 	<li>dissolved oxygen control, individually controlled by up to 4 separate gas additions, and</li>
 	<li>individual liquid additions.</li>
</ul>
The bioreactors are a true scale down of small scale bioreactors, giving all the functionality of their larger counterparts in a space-saving format. The accompanying software allows for simple comparisons of experimental cultures, and advanced controls such as time- and event-based control actions. The volume per bioreactor is 10ml (recommended working volume is 5ml).

&nbsp;

24 fully controlled bioreactors in a microtiter format

Continuous

Single use, micro-bioreactors could be a good solution for replication processes, especially when they eliminate cross contamination and time-consuming cleaning. Moreover, they are small and portable for use in the field. However, it’s important to ensure the design is consistent if using multiple instruments for comparative work.


<h2>A Tailor-Made 3D Printed Alternative Micro-Bioreactor</h2>
AppliFlex ST disposable reactors from Getinge Applikon are customizable to individual requirements. Moreover, the company 3D prints its tailor-made single-use bioreactors, meaning it can accurately create a perfect clone at any time after completing the first order.

These bioreactors can be stirred, and the user can choose the type and number of impellers, liquid and gas additions, and sparger gas diffusers to create a bioreactor that suits their purpose. They could even design their own impeller and Getinge Applikon will create it.

The AppliFlex ST design caters for both cell culture at 500 millilitre / 3 litre volumes, and 500 millilitre microbial applications. The customisable design allows the user to specify their bioreactor, and therefore optimise the output. The fully removable top plate provides easy access to the product.

Single use bioreactor

Sufficient oxygen is critical to the success of processes like cell culture and fermentation, in order to support cell growth. Measuring oxygen online provides concurrent control and can signal alarms and automatically trigger remedial action. Polarographic sensors using special electrodes need polarization at least for several hours.


<h2>Optical Technology for Determining Oxygen Concentration Levels</h2>
Getinge Applikon’s Lumisens Sensors avoid these project delays because they use optical technology that is ready right away. This method takes accurate measurements even at low oxygen concentration levels, where polarographic sensors may be less accurate.

Lumisens optical sensors for the Getinge Applikon bioreactor range are suitable for 250mm to 3,000mm total volumes. Bespoke technology separates the glass sensor from the electronics, promoting long sensor life despite repeated sterilizations. Strong magnets accurately position the components together,

These optical sensors measure the phase shift between excitation and emission, which directly relates to partial oxygen pressure. This assures precision, reliability, low cross-sensitivity, and fast response to red light excitation.

Optical Dissolved Oxygen Sensors

An autoclavable bioreactor establishes special conditions for a variety of applications, for example yeast and microbial cultivation. These conditions may include particular high and low pressures, and temperatures without which a particular chemical reaction or biological event cannot occur.


<h2>A Bundled Reactor for Yeast, Microbial and Mammalian Cell Cultivations</h2>
An EZ2 control bundle from Getinge Applikon is a complete bioreactor system containing everything needed to facilitate bioprocesses. The equipment is easy to set up, does not require special tools or skills, and is easy to learn to operate. Software for data acquisition is included.

Typical projects could include yeast and microbial culture, and also mammalian cultivation including suspension and anchorage-dependent cells. Continuous perfusion cultures are also a possibility, because everything down to silicon tubing, sample bottles and even spare parts are in the kit.

Getinge Applikon touched on all the details when designing its EZ2 system. The quiet agitation motor will hardly be noticed in a busy laboratory, while the sophisticated controller is simple to use thanks to an integrated touch screen. A USB port enables software updates without needing a service engineer.

The EZ2 bundled reactor range includes 2, 3, 5, 7, 15, and 20 litre total volume sizes for cell or microbial cultures.

Complete bioreactor system

Bioreactor systems

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

What does a $300,000 burger taste like? Meat. The first lab-grown burger took two years and 20,000 strands of muscle tissue to produce. But with rapid advances in cultivated meat processing technology, non-animal meat alternative products can now take a lot shorter to prepare. And cost much less.

Cultivated meat

Glycerine is a water-soluble liquid mix of alcohol and sugar. It is a by-product of the oil and fats industry that offers added value to various industries. There are three ways to process it: transesterification, saponification, and fat splitting (hydrolysis). In 2020 these 3 forms of glycerine production reached around 4 million metric tons, with a global market of $1.68 billion.

Glycerine

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Everything tastes like porridge, the saying goes. That may be an exaggeration, but in theory, reaction flavors could make everything taste the same. Thankfully, flavorists and chemists in the flavor industry are more inventive than that, and colorful process flavors treat our taste buds to a broad palette of sensations, flavors and aromas.

Reaction flavors

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Ancient civilizations were using yeast as it naturally occurred in bread-making and brewing. But yeast processing equipment wasn't developed and fully commercialized until the end of the 18th century. Today, this industrialized micro-organism is critical in producing biofuels and other products beyond food and drinks.

Yeast

Connect directly with world leading manufacturers of Bioreactor Equipment and systems and find technology to build or improve your production line.