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steam-in-place-bioreactor-systems-2

Steam-in-place bioreactor systems

Bioreactor Equipment and Systems

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

A bioreactor is an engineered system designed to support, automate and control a biologically active environment. The volume of the reactor, suitability for photosynthesizing organisms, level of scalability and control, and the type of installed sensors are all important considerations when choosing bioreactor equipment. Bioreactors are typically used for biomass such as cell culture, microbial culture, biopharmaceutical, and chemical development processes. They are also used for photosynthesizing commercial organisms such as algae and bacteria and fermentation applications.

Batch

Industrial

Pilot

Biopharmaceutical research and production require precise control and data acquisition at every stage of the bioprocess. Challenges such as seamless data transfer, technology scalability, and minimizing scale-up risks need reliable solutions.
<h2>Facilitates seamless data transfer and process control</h2>
The Applikon V-Control by Getinge is a scalable DeltaV™ solution optimized for bioreactor systems from discovery to production. This software platform integrates process control, automation, and data management into a single, configurable system. It allows users to optimize their bioprocesses by enabling seamless technology transfer across different development stages and ensuring shorter development lead times. With components such as the DeltaV Discovery for R&D and the DeltaV PK Controller for pilot and production scale, Applikon V-Control supports bioreactors ranging from 250 mL up to production-scale stainless steel or single-use systems. Additionally, features like OPC communication, multiple gas flow options, and DeltaV Batch for automated recipes increase operational efficiency and reduce training requirements. This integration, along with Emerson’s Human Centered Design interface, offers enhanced user experience and flexible scalability for various bioprocessing needs.

Scalable bioprocess control system

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Rinsing

liquid

Entry level

In research and development for cell culture and microbiology, reliable control and scalability are key for reproducible and valid results. Traditional bioreactor systems may fail to deliver consistent data, leading to inefficiencies in process development.
<h2>Enable precise and scalable bioprocess control</h2>
The DASGIP® Parallel Bioreactor System by Eppendorf is a benchtop solution designed to optimize bioprocess performance. With scalable monitoring and control functionality, it addresses the needs of various applications in both cell culture and microbiology. The modular design enables user-defined profiles and numerous automation features, facilitating accelerated and efficient process development. Equipped with DASware software solutions, it supports Design of Experiments (DoE) and comprehensive data management. The system includes advanced features like parallel operation of up to 16 glass or single-use bioreactors, TMFC individual gas mixing, and optical absorbance measurement. It is suitable for stem cell applications, biofuel and biopolymer processes. The system offers dimensions of 140 x 70 x 53 cm and a weight of up to 96 kg, ensuring it fits within typical lab spaces while handling up to 250 sL/h gassing for microbial applications and 50 sL/h for cell culture.

Parallel bioreactor system for cell culture and microbiology

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Processing

When working in R&D or university labs, efficient and scalable bioreactor systems are essential for accurate experimentation and development. The challenge often lies in finding compact and reliable solutions that facilitate both scale-up and scale-down processes without compromising on quality and compliance.
<h2>Supports flexible bioprocesses with modular design</h2>
The NLF by Bioengineering is a bioreactor designed for small production volumes, offering high reliability and space-saving features in a modular unit. Equipped with several automation levels, it is ideal for both low-budget and high-budget production scenarios. The system adheres strictly to FDA and GMP standards, which guarantees compliance for preclinical applications. The design of the NLF makes it optimal for scale-up and scale-down studies, assisted by matched system designs that reflect larger production environments. The bioreactor is constructed with robust, long-lasting components and includes the BioSCADA control software, which ensures precise data collection and analysis. Available in various configurations, from single fermentors to multi-configurations or as part of larger production plants, the NLF meets versatile production needs. With features like automated sterilization (SIP) and cleaning (CIP), and multiple ventilation, stirring, and gas module options, it promises efficient and flexible operation.

Modular bioreactor for low-volume production

Aerators are devices used for mixing air (oxygen transfer) with a liquid such as water or oil to form a homogeneous product. Selecting an industrial aeration system involves choosing a suitable mixing head and considering the desired input and output flows, temperature, level of aeration, properties of the liquid phase, and the degree of automation and pressure control. Aerators are used in the food industry for the production of fat-based center masses and crèmes and in the chemical industry for wastewater treatment. When it comes to water treatment, surface aerators are most commonly used.

Aeration

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

Sterilization

Stirring

Continuous

Industries handling large amounts of organic waste often struggle with inefficient waste management and high disposal costs. Converting organic waste into renewable energy through anaerobic digestion can address these challenges, turning waste into a valuable resource and reducing environmental impact.
<h2>Convert organic waste to renewable energy</h2>
The Organic Waste Biogas Plant by HoSt is a high-efficiency system designed to manage and convert various types of organic waste into biogas. Utilizing advanced digester mixing, heat recovery systems, and in-tank H2S removal, it ensures high and stable biogas production. The plant's automation increases ease of operation, and its patented insulated membrane roofs enhance operational efficiency. Ideal for treating organic waste from food processing industries, industrial and municipal sludge, and slaughterhouse waste, the biogas produced can be upgraded to biomethane, liquid CO2, bio-LNG, and bio-CNG. Additionally, HoSt offers comprehensive service and maintenance plans to guarantee high plant availability.

Organic waste biogas plant

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Recovery

Agricultural businesses looking to enhance sustainability and generate additional revenue must address the challenge of managing large quantities of manure. Traditional manure handling methods often fall short in efficiency, leading to higher operational costs and environmental impact.
<h2>Generate biogas and bio-fertilizer from manure</h2>
The manure biogas plant from HoSt is a versatile solution designed to process various types of manure, including cow, pig, and poultry manure, through anaerobic digestion. This process generates renewable energy in the form of biogas, which can be used on-site or injected into the national grid, creating an additional revenue stream. The plant features advanced digester mixing technologies, a heat recovery system, and patented insulated membrane roofs, ensuring high efficiency and reduced odors. In-tank H2S removal enhances the quality of the produced biogas. The system is highly automated, making it easy to operate. Additionally, the byproduct of the digestion process is a nutrient-rich bio-fertilizer that can enhance soil fertility and reduce the need for chemical fertilizers. HoSt offers tailored solutions ranging from individual components to turnkey biogas systems, catering to the specific needs of the agricultural sector.

Manure biogas plant for agricultural sector

Blending

The fermentation process stimulates enzymatic activity in organic substrates to transform their chemical composition. Fermentation is aided by storying the biomaterials in anaerobic environments, allowing the microorganisms to decompose their nutrient structures. The process is integral to some of the most popular products throughout time such as wine, beer, cheese, and kimchi. But besides the food sector, fermentation is also an important stage in the industrial manufacturing of chemicals, pharmaceuticals, and biofuels.

Fermentation

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

In the fresh produce industry, ensuring minimal product damage and maintaining sanitary conditions during storage and handling can be challenging. This is particularly crucial during short-term storage of items like potatoes and raw vegetables.
<h2>Streamline storage with gentle handling and flexibility</h2>
The Gentle-Flo Storage and Handling System by Heat and Control is designed to provide a modular and programmable short-term storage solution for fresh produce. Utilizing a shuttling Bin Filling Auger (BFA), the system ensures that products gently descend into storage bins via a lowerator, minimizing damage and the risk of infection. Its open, expandable design prioritizes sanitation, allowing for less time spent on maintenance. The modular configuration means the system can adapt to changing business needs by easily adding extra storage bins. Additionally, the variable speed discharge facilitates synchronization with downstream processes. Ideal for applications involving potatoes, tuber/root vegetables, and raw produce, this system ensures that operations run smoothly and efficiently.

Gentle-flo storage and handling system for fresh produce

Handling

Almost all manufacturers will require industrial storage systems and solutions at some point during their production process. The raw materials that go into your products need dedicated storage solutions to protect them from spoilage and contamination before they enter the manufacturing cycle. Storage usually refers to particular storage space. For example, having enough warehouse storage. Or clearing out a production facility for more floor space.  However, in this case, we are referring to the equipment and solutions that make storage manageable and easier. Such equipment includes solutions such as storage racks, pallet racks and shelving systems. These are just some of many storage options available to manufacturers. Advanced technology facilitates the management of heavy duty and high density tank and silo systems by automating the delivery system and linking it with the rest of the production line.

Storage

solid

In scaling up bioprocessing from lab to production, traditional stainless steel tank bioreactors can slow down the process. Challenges include time-consuming cleaning and sterilization, risk of cross-contamination, and complex setup procedures that increase operator exposure.
<h2>Seamlessly scale your bioprocesses</h2>
The SUPR by Getinge is a single-use bioreactor designed to simplify scaling from laboratory to production level. This system eliminates the need for cleaning and sterilization by utilizing pre-sterilized, gamma-irradiated components. The Click-n-Go bag loading system ensures easy, rapid startup, reducing operator exposure and risk of cross-contamination. The SUPR is available in 50- and 250-liter containers, with a future option for 1000 liters, offering flexible volume capabilities. It combines a height-adjustable impeller with typical Applikon design parameters, such as specific height-to-diameter ratios and a dished bottom, ensuring optimal mixing and compatibility with various bioprocesses. The SUPR is suitable for applications including cell and gene therapies, monoclonal antibodies, vaccines, and diagnostics.

Single-use bioreactor for pilot and production scale

In biopharmaceutical production, managing bioreactor processes precisely is essential to ensure optimal growth conditions for cell cultures. Whether you are scaling up from pilot to full production, precise control systems are crucial to maintain consistency and compliance with regulatory standards.
<h2>Configures bioreactor processes with precision</h2>
The pro-Control by Getinge is designed to offer precise control over bioprocesses in both pilot and production scales. Known for its robust new design, the pro-Control integrates seamlessly with DeltaV DCS, Siemens, and Allen Bradley PLCs, making it adaptable to various factory automation systems. It supports both single-use and stainless steel bioreactors, with volumes ranging from 50 to 5,000 liters. Equipped with the latest in pump, MFC, and sensor technology, the pro-Control ensures precise measurement and control of key bioprocess parameters like pH, DO, and temperature. Compliance with cGMP ensures suitability for high-demand environments.

Controller for pilot and production scale bioreactors

Batching

In research laboratories, managing multiple bioreactors can present challenges in maintaining precise control over experimental conditions. This often results in inefficiencies and delays in research and development processes.
<h2>Configure and control multiple bioreactors simultaneously</h2>
The Livit Flex from Getinge is an advanced bioprocess controller designed for lab-scale bioreactors. It can be configured as a single or dual control system to optimize bench space and streamline workflow in your laboratory. Compatible with both single-use and multi-use bioreactors, the Livit Flex enables seamless integration and efficient data management. It features a user-friendly interface with a 13.3-inch LCD touchscreen and intuitive Livit software platform, which allows easy access and modification of all settings. The Livit Flex supports a variety of sensor options and auxiliary devices like external pumps, ensuring automatic recognition and quick setup. Ideal for microbial and cell culture applications, this controller is designed to reduce operator error and enhance experimental productivity.

Controller for lab-scale bioreactors

In modern biotechnological and pharmaceutical processes, efficiently expanding adherent cells with high productivity while maintaining stability is crucial. Traditional batch processing methods often struggle with scalability and cost-effectiveness, leading to longer development timelines and higher operational costs.
<h2>Expand adherent cells continuously and efficiently</h2>
The Livit ACE by Getinge is a continuous adherent cell expansion platform designed to overcome the inefficiencies of traditional batch processing. This system integrates CellRev's proprietary processing technologies with Getinge's bioprocessing expertise into an automated, scalable, and stable manufacturing solution. Featuring continuous bioprocessing, Livit ACE minimizes manual handling, thereby reducing human error and improving process consistency. Configuration options include the Getinge Livit Flex dual controller, Livit software, and AppliFlex ST single-use bioreactor or Getinge Applikon multi-use bioreactor. The included Carr Biosystems UFMini® enhances cell detachment and collection, ensuring optimal downstream processing. The system is suited for applications such as cell-based vaccines, cell therapies, cellular agriculture, and process intensification by offering superior productivity and reduced capital cost.

Adherent cell expansion platform

Managing microbial and cell cultures in a lab environment often requires precise control over conditions while also conserving space and resources. In such environments, achieving scalable results with minimal media usage is crucial.
<h2>Facilitate small-scale bioprocessing</h2>
The Applikon MiniBio by Getinge is a compact, multi-use glass autoclavable bioreactor designed for small-scale operations in research laboratories. It allows for precise control of microbial and cell cultures while conserving bench space and reducing media costs. Its small volume is ideal for screening studies, media optimization, and process optimization. The bioreactor features a direct drive system with lipseals, choice of Rushton or Marine impellers, and electrically cooled exhaust gas condenser. It also includes configurable Luer fittings for multiple additions, sensors, and fittings. Available in three sizes—250 mL, 500 mL, and 1000 mL—the MiniBio is suitable for batch, fed-batch, perfusion, and continuous cultivation processes.

Small size multi-use glass autoclavable bioreactor

Industrial sampling equipment are systems that allow manufacturers to test (in other words to take a sample of) the products they are manufacturing. This process is generally implemented as a means of quality control but it can also be used as a mean to ensure that production processes adhere to certain regulatory standards. Quality control in your manufacturing process starts with precision sampling techniques. Automated systems deliver consistent samples at a pre-set rate for accurate testing and probing. Sampling technology uses a calibration system involving a series of sensors to extract the material at high levels of reliability.

Sampling

Managing high-density cell cultures over prolonged periods requires maintaining cell viability and efficient separation of cell debris without causing damage to the cells or risking blockages.
<h2>Separate cells and remove debris automatically</h2>
The Applikon BioSep, provided by Getinge, is a unique cell retention device critical to continuous bioprocesses. It employs high frequency resonant ultrasonic waves to separate viable cells from cell debris, which are automatically removed. The system's high separation efficiency, up to 99%, ensures minimal damage to cells. Designed for scalability, it supports a range of perfusion rates from 0.1 L/day to 1000 L/day across differing bioreactor sizes, making it adaptable for various stages from process optimization to production. The BioSep can be installed directly onto the bioreactor head plate and is proven under cGMP conditions, with available models delivering standard documentation and services required for such environments.

Cell retention device for high-density perfusion processes

To produce life-saving vaccines and medicines, highly optimized bioreactors are essential. These systems need to support large-scale production while adhering to strict regulatory requirements and ensuring quality control throughout the manufacturing process.
<h2>Customizable bioreactors for large-scale production</h2>
The Applikon BioProduction from Getinge is a stainless steel bioreactor specifically designed for cGMP production. This system allows for complete customization to suit various bioprocessing needs, from microbial to cell cultures, with volumes ranging up to 5000 liters. It includes options for magnetic coupling to minimize contamination risk and offers a variety of agitator options to optimize mixing. The bioreactor is constructed from pharma-grade 316L stainless steel, ensuring a smooth surface finish (Ra < 0.4 micron) that simplifies cleaning and eliminates biofilm formation. Its automation capabilities include extensive control options for pH, DO2, temperature, and foam levels, making it well-suited for batch, fed-batch, perfusion, or continuous cultivation processes. The system also supports full traceability and cleanability, complying with stringent GMP and GAMP standards. Ideal for industries involved in producing vaccines and other biopharmaceutical products.

Stainless steel bioreactor for cgmp production

Cultivation

Scaling up from lab-scale bioreactors to small-scale production requires a solution that ensures consistent and efficient transfer of processes. Without such technology, delays in production can result from challenges in customization and validation.
<h2>Streamline upstream bioprocessing</h2>
The Applikon BioPilot from Getinge is a pilot plant stainless steel bioreactor designed for upstream bioprocessing. This bioreactor is modular, using standard modules to facilitate customization for both microbial and cell cultures. It features a Sterilize-in-Place (SIP) system and a compact design that saves floor space. The bioreactor is constructed from pharma-grade 316L stainless steel with a surface finish of Ra < 0.4 micron, ensuring ease of cleaning and reducing contamination risks. The Applikon BioPilot's magnetically coupled agitator and consistent component scaling from lab-scale simplify validation and minimize human error. It complies with cGMP and GAMP standards, further easing the process of validation. This bioreactor is ideal for various applications, including scale-up studies and process optimization. The available volume capacities range from 30 liters to 270 liters, with options for microbial or cell culture operations.

Stainless steel bioreactor for small-scale bioprocess production

In a research laboratory setting, managing multiple components for bioprocessing can be time-consuming and error-prone. Efficient and standardized solutions are needed to streamline cell culturing processes and ensure reproducibility across experiments.
<h2>Facilitates efficient and reproducible bioprocessing</h2>
The Applikon BioBundle by Getinge is a complete bioreactor system designed for ease of use and sophisticated control. The system arrives with all necessary components, including silicone tubing and sample bottles, making it ready for immediate use. Its intelligent and powerful process controller ensures accurate management of bioprocess parameters and actuators through both digital and analog outputs. The system's advanced autotuning adaptive control minimizes the need for manual PID controller settings, improving process accuracy. Additionally, the compact design integrates essential accessories into a single console, optimizing lab space. This solution supports various applications including cell cultures, microbial cultures, batch, fed-batch, and continuous bioprocessing.

Turnkey bioreactor system for cell culture

Industrial feeding systems allows you to control the flow of solid bulk materials throughout the manufacturing line. After loading your material onto the vibrating hopper, a screw at the base drives it out in uniform doses to the next stage of processing. New feeding technologies are designed to deal with challenges of powders clumping together in the hopper (bridging and ratholing) that interrupt the outflow. Common feeder systems include centrifugal feeders, vibratory feeders as well as elevator, linear and pneumatic feeders.

Feeding

In the field of bioprocessing, developing and scaling up microbial and cell cultures often requires precise, scalable, and contamination-free systems. Ensuring reliable and reproducible results while maintaining process control is crucial for vaccine and medicine production.
<h2>Customizable for varied bioprocessing needs</h2>
The Applikon BioBench by Getinge is a modular bioreactor specifically designed for bench-top bioprocessing applications. Its stainless steel construction and Sterilize-in-Place capability eliminate the risk of contamination from external factors. The system retains geometric ratios consistent with commercial-scale bioreactors, allowing for accurate scale-up studies. It includes multiple configuration options such as porous spargers, water-cooled exhaust gas condensers, and various impeller types, making it highly adaptable to specific process requirements. Suitable for both microbial and cell cultures, the bioreactor offers a compact design that saves floor space and meets cGMP and GAMP compliance requirements, simplifying validation processes.

Bench top bioreactor for microbial and cell cultures

In laboratories focused on bioprocessing, the challenge of minimizing cross-contamination while increasing throughput is paramount. Researchers often struggle with time-consuming preparation and the risk of contamination during their experiments.
<h2>Optimized bioreactor setup and performance</h2>
The Applikon AppliFlex ST by Getinge is a single-use bioreactor designed for lab-scale cultivations, offering a unique combination of easy setup and high customization through 3D printing technology for head plate configuration. This bioreactor eliminates the risk of cross-contamination with its pre-sterilized components, reducing operator handling. Available in 500 mL, 3 L, and 15 L sizes, it mimics the high standards of traditional glass bioreactors while allowing for quick design adjustments to fit specific bioprocessing needs. The AppliFlex ST is suitable for various applications such as cell line development, process development, and scale-up studies for batch, fed-batch, and perfusion processes, as well as cell and gene applications.

Single-use lab-scale bioreactor for upstream bioprocessing

When working with microbial applications like bacterial, yeast, or fungal cultures, maintaining high cell density and ensuring effective mass transfer are vital. Traditional bioreactors often require extensive cleaning and sterilization, posing significant work interruptions and potential contamination risks.
<h2>Optimized for small-scale microbial fermentation</h2>
The BioBLU® f Single-Use Bioreactors by Eppendorf are rigid-walled stirred tank bioreactors designed specifically for robust microbial applications. These bioreactors mimic traditional bioreactors in their design, making them compatible with established laboratory processes. The BioBLU® f series covers a working volume range from 65 mL to 3.75 L, supporting high cell density fermentation. This series incorporates multiple Rushton-type impellers for efficient mixing and mass transfer. The interior baffles enhance mixing and provide effective heat removal, vital for high-density fermentation. The bioreactors come preassembled with spargers, gas filters for inlet and exhaust, and are sensor-ready for pH, dissolved oxygen (DO), and temperature probes. Various head plate ports allow for flexibility in additional fittings. BioBLU 0.3f and 1f models are delivered sterile, irradiated by >15 kGy (β) or >25 kGy (X-ray). The BioBLU 3f model can be sterilized using an autoclave, offering further flexibility. Suitable for integration with Eppendorf bench-scale bioprocess controllers and select third-party controllers, BioBLU® f bioreactors minimize the risks of contamination and downtime typically associated with traditional glass bioreactors.

Single-use bioreactors for microbial fermentation

Scaling up mammalian and insect cell cultures in a consistent and contamination-free environment can be challenging, especially when dealing with high-volume requirements and diverse cell types such as suspension, anchorage-dependent, and stem cells.
<h2>Support scalable cell cultivation processes</h2>
The BioBLU® c Single-Use Bioreactors from Eppendorf are rigid-walled stirred-tank bioreactors designed to facilitate the scalable cultivation of human and animal cells. These bioreactors offer a 400-fold cell expansion with a working volume range from 100 mL to 40 L, making them adaptable to various volume requirements. Different versions have been developed to meet the specific needs of suspension cells, anchorage-dependent cells, and stem cells. All BioBLU c bioreactor sizes are equipped with pitched-blade impellers for optimal mixing and mass transfer. The BioBLU 0.3sc, in particular, features an 8-blade impeller optimized for reduced cell settling and low-shear mixing, ideal for stem cell applications. BioBLU bioreactors are compatible with both Eppendorf's small and bench-scale bioprocess controllers as well as selected third-party systems. With non-invasive sensor technology for pH, DO, and temperature, these bioreactors drastically reduce contamination risk. Additional features include a sealed magnetic drive for maintaining sterility and exhaust treatment options.

Single-use bioreactors for mammalian and insect cell cultivation

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

In process development for cell culture and microbial applications, conserving valuable materials and achieving precise control over experimental conditions are critical challenges. This is particularly relevant in scenarios involving small working volumes and the need for parallel processing capabilities.
<h2>Efficiently develop cell culture and microbial processes</h2>
The DASbox Mini Bioreactor from Eppendorf is an industry-standard autoclavable glass bioreactor designed for use in cell culture and microbial process development. With working volumes of 60–250 mL, it is ideal for conserving resources while ensuring scalability and reproducibility. The bioreactor features a stainless steel head plate equipped with standard sensors for precise measurement and control of temperature, pH, dissolved oxygen (DO), and level. It also comes with a powerful direct overhead drive, configured with either a marine impeller for cell cultures or two Rushton-type impellers for microbial applications. Additionally, the liquid-free exhaust condenser offers automatic slide-in activation and slide-out deactivation for easy handling.

Mini bioreactor for cell culture and microbial process development

In modern bioengineering, precise control over cell culture conditions is paramount. Microbial growth and mammalian cell cultivation require systems that offer flexibility, reliable scalability, and robust monitoring to ensure optimal results.
<h2>Enables versatile and scalable cell culture processes</h2>
The BioFlo® 320 by Eppendorf is an advanced bioreactor designed to meet the diverse needs of cell culture and microbiology research. This bioreactor system supports a range of vessel types, including autoclavable borosilicate glass and stainless-steel dished-bottom vessels for rapid heat transfer, as well as water-jacketed vessels for gentle temperature control. Available in volumes from 0.6 L to 10.5 L, it offers interchangeable direct and magnetic drive options. Users can select from multiple impellers, such as Rushton, pitched-blade, marine, and specialized packed-bed impellers, to suit various applications including stem cell culture, vaccine production, and biopolymer development. Integrated sensors and software ensure precise monitoring and automation, ideal for batch, fed-batch, and continuous processing. Eppendorf provides validation packages for processes requiring GMP compliance.

Bioreactor for mammalian and microbial cell cultivation

In the production of biopharmaceuticals, vaccines, and other microbial products, controlling the fermentation process is critical. Achieving precise environmental conditions ensures optimal growth of microbial cells, which is essential in these high-stakes industries.
<h2>Optimize microbial fermentation with precise control</h2>
The stainless steel fermenter from Endulus Krom is specifically designed for microbial fermentation processes, including biopharmaceutical and vaccine production. Its advanced process analytical technology provides precise control over parameters such as temperature, pH, and dissolved oxygen. This leads to consistent and repeatable results, ensuring the highest quality output. The fermenter is built with high-grade materials ensuring maximum durability and reliability. Its integrated system optimizes the fermentation process, making it highly efficient and cost-effective. With strict quality assurance protocols, every unit adheres to the highest production standards.

Fermenter for microbial fermentation processes

In bio-pharmaceutical production or research and development, ensuring high cell culture yields is crucial. You might face challenges like maintaining sterility, optimizing growth conditions, and ensuring consistent agitation and aeration in your cell culture processes.
<h2>Enhance cell culture with precise control</h2>
The Bioreactor by De Dietrich Process Systems is designed to maximize cell culture yields. Ranging from 5 to 20 liters, it features a monobloc inner vessel with borosilicate 3.3 glass construction, meeting EN1595 standards. The vessel is available with or without a jacket, ensuring a consistent internal surface roughness of ≤ Ra 0.02 μm for optimal cleaning. To minimize agitation restrictions, the system uses mechanical or magnetic agitation. The cover and accessories are constructed from stainless steel 316 L or alloy with a ferrite content of less than 5%, finished with an electro-polished surface Ra < 0.5 μm. EPDM gaskets that meet FDA and USP certificates maintain the integrity of the assembly. Control options include entry-level variable speed control and, upon request, a 21 CFR part11 control interface that monitors pH, RedOx, temperature, aeration (KLa), and stirring speed. Industries that benefit include R&D and bio-pharmaceutical sectors.

Bioreactor for cell culture yield optimization

Agitation

In cocoa processing plants, microbial contamination poses a serious risk to both product quality and consumer safety. Controlling microbial levels is essential to meeting food safety standards and maintaining the desired flavor profile of the cocoa beans.
<h2>Reduce microbial contamination in cocoa beans</h2>
The Debac Debacterizing System by Bühler is designed to effectively reduce microbial contamination in cocoa beans using steam sterilization. Operating in small batch sizes with high temperatures and steam pressure up to 5 bar, it ensures thorough debacterization. The system removes pathogens such as salmonella and thermophilic vegetative germs, resulting in germ counts that meet market standards. The system's innovative use of cocoa bean shells during the process maintains the flavor and moisture content of the beans. Capable of achieving a throughput of up to 4 tons per hour, the Debac system improves productivity while ensuring flavor protection and high-quality results.

Debacterizing system for cocoa beans

When producing high-quality beverages like beer or cider, maintaining the sterility and propagation of yeast is essential. Without careful propagation and optimal conditions, yeast performance can suffer, impacting the consistency and flavor of the final product.
<h2>Propagate, store, and pitch yeast under sterile conditions</h2>
The Yeast Plant by Bucher Unipektin is designed for the vital propagation, storage, and pitching of yeast in beverage production. It offers a flexible design that caters to various yeast strains, ensuring the highest hygienic standards. The system includes features such as gentle homogenizing and optimized aeration to maintain yeast vitality. It also encompasses yeast harvest, treatment, and storage, as well as precise pitching, autolysis, and disposal. This comprehensive approach ensures that yeast remains effective and consistent, enhancing the quality of beverages produced. The system’s design focuses on reducing contamination risks while allowing easy adjustments to meet specific production requirements.

Industrial yeast propagation system

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

Scaling up microbiological synthesis processes from the laboratory to small-scale production requires precise and reliable equipment. This is vital for applications in pharmaceutical production, veterinary chemicals, and biotechnology research centers.
<h2>Facilitates efficient scale-up and small-scale production</h2>
The BRS pilot fermentors and bioreactors by Brs Biotechnology Equipment serve as a crucial link between laboratory-scale experiments and larger production scales. These units, with volumes ranging from 5 to 80 liters, are designed for small-scale pilot production of agricultural and veterinary chemicals, pharmaceutical production, and diverse biotech processes. Their platform-mounted, open-frame modular construction allows easy access for maintenance and operations. Central connections for steam, water, and air minimize start-up time and effort. Advanced models feature automatic air flow metering, optical density sensors, and remote control systems via SCADA. The fermentors support a wide range of processes involving enzymes, bacteria, fungi, algae, and various cell cultures. Compliant with GMP and FDA standards, they are optimized for medium and process optimization in research settings.

Pilot fermentors for biotech processes

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

Scaling up biotechnological, pharmaceutical, or food production processes requires effective fermentation systems. Challenges include managing large-capacity cultivation of microorganisms or cells while maintaining control over process parameters to ensure product consistency and quality.
<h2>Facilitate efficient large-scale fermentation</h2>
The industrial fermentors and bioreactors offered by BRS Biotech are designed for both pilot and full-scale industrial applications. Featuring volumes ranging from 100 liters to 60,000 liters, these stainless steel units are built to GMP and FDA standards. The open frame construction and platform-mounted design ensure easy maintenance and operation. Central connections for steam, water, and air streamline the startup process. These systems are versatile, supporting the cultivation of bacteria, yeast, fungi, and animal cells, with specific bioreactors available for solid-phase fermentation and photobioreactors. Key features include advanced control functions for temperature, agitation speed, pH, and DO, with options for mass flow control, various sensor integrations, and remote control via SCADA systems. Suppliers can benefit from the specialized capabilities of these units, such as precise environmental control and scalability, offered by BRS Biotech.

Industrial fermentors for large-scale bioprocessing

Maintenance

When conducting fermentation research, ensuring the sterility of the cultivable environment is crucial. Researchers face challenges in maintaining consistent temperature, pH, and oxygen levels for optimal microbial or cell growth.
<h2>Optimize microbial growth in sterile conditions</h2>
The BRS Biotechnology Equipment autoclavable lab fermentors and bioreactors are designed for research applications and fermentation process optimization. These fermentors, available in volumes ranging from 1 to 10 liters, feature table-mounted design for ease of maintenance and operation. Connections for water and air are accessible, reducing setup time. Measurement and control tools are housed in a separate cabinet for easy access and customization. They are suitable for both batch and continuous cultivation of bacteria, fungi, yeasts, and cells, and for small-scale production of proteins and monoclonal antibodies. Made from 316L steel and borosilicate glass, these fermentors ensure durability and resistance to contamination. Control functions include temperature, agitation speed, pH, and dissolved oxygen monitoring, with advanced options for multi-channel feeding and exhaust analysis.

Autoclavable glass fermentor for biotech research

In research and development, producing high-quality microbial cultures requires systems that offer precise environmental control. Challenges include maintaining optimal oxygen levels, temperature precision, and ensuring bio-safety standards.
<h2>Customizable fermentors for precise microbial cultivation</h2>
The lab-scale fermentors by Bioengineering are designed for microbial cultivation with a focus on R&D and university applications. These fermentors are available in both autoclavable and in-situ sterilizable configurations, ranging from benchtop to pilot scale. They leverage the advanced BioSCADA software, the same used in large production plants, for seamless scale-up. Key features include customized vessel geometry (h:d = 3:1), optimized oxygen supply strategies, and integrated dosage vessels for acids, bases, and anti-foams. The systems ensure short heating and cooling periods to maintain media quality and process efficiency. Suitable for a diverse range of microorganisms such as bacteria, archaea, yeast, and extremophiles, these fermentors cater to various process requirements from anaerobic conditions to high oxygen demand and GMP production.

Lab-scale fermentors for microbial cultivation

Industrial cooling equipment varies according to the consistency and temperature conversion demands the material you are handling, but the process typically involves heat exchange treatment as your products are conveyed through a cooling chamber equipped with extraction fans or circulating water. Temperature control is a crucial aspect of your commercial production and cooling systems are applied to a range of industries.

Cooling

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

<span style="font-weight: 400">The heating process is a step of raising the temperature of food, pharma, cosmetics, and many other types of products. You may employ different heating solutions for this process, depending on the type of product you intend to manufacture. Selecting the appropriate heater machine for your product is quite important since various products require different ranges of temperatures and different ways of heat transfer using exchangers. Industrial heating equipment varies in two ways - the type of material it can process and the reaction you want to achieve.</span>

Heating

In biopharmaceutical manufacturing, ensuring all system components are free from contamination is critical to product safety and quality. A typical challenge is cleaning complex equipment configurations, including vessels, piping, and ancillary lines, without disassembly.
<h2>Automated cleaning of bioreactor components</h2>
The CIP systems by Bioengineering offer tailored and automated cleaning solutions for bioreactor components, ensuring thorough contamination removal. These systems can be either rigidly installed for large plants or mobile for smaller bioreactors, providing flexible operation. They employ advanced features such as programmable cleaning steps, circulation pumps, and heat exchangers for optimal performance. Integrated PLCs automate and document the cleaning process, adjusting steps dynamically for consistent cleanliness. The systems utilize a combination of mechanical components (e.g., spray balls, CIP lances) and chemical agents (e.g., NaOH, acids) tailored to specific needs. Additionally, they are designed to be economical and environmentally friendly by recycling cleaning solutions when cross-contamination is not an issue.

Cleaning in place systems for bioreactors

Industrial cleaning equipment is used to wash or disinfect machinery and the production/warehouse area. It may also be used to sterilize the product, equipment, tools, floor or work surfaces and to purify or clean the product by removing impurities. Choosing a suitable cleaning system depends on the type of product or equipment to be cleaned, the sensitivity of the product to heat, pressure, and chemicals, and the level of sterility desired.

Cleaning

Industrial disinfection equipment use antimicrobial agents to destroy microorganisms found on machines, floors, walls, and other surfaces. In industry, disinfection of machinery and the production area is important to prevent product contamination which may lead to spoilage and health hazards for workers and the consumer. The choice of industrial cleaning equipment depends on the level of disinfection needed, the sanitizing agent, the size of the area or objects to be treated, and the suitable method of treatment such as sterilization, pasteurization, exposure to ultraviolet light, or chemical fogging.

Disinfection

In cell culture applications, ensuring optimal growth conditions for cells is critical. Challenges often include dealing with shear-sensitive cells, heat-instable media, and limited clean-room space. Addressing these issues requires advanced bioreactor solutions tailored to specific cell culture requirements.
<h2>Cultivate various cell cultures with precision</h2>
The bioreactors from Bioengineering AG are designed to address the specific needs of diverse cell culture processes. With capacities ranging from 30 to 25,000 liters, they offer solutions for mammalian, plant, insect cells, and virus cultivation on cells. Featuring systems for both suspended cells and adherent cells on micro-carriers, Bioengineering's bioreactors ensure precise control of environmental conditions. Special components and designs, such as gas-mixing stations, surface gassing, and bubble-free gassing, cater to shear-sensitive cells and ensure effective aeration. The perfusion systems, offering continuous production with internal or external spin filters, further enhance their efficiency. These bioreactors also integrate auxiliary vessels for metering solutions, reducing clean-room costs, and come equipped with super skids for faster installation and qualification times.

Bioreactors for cell culture processes

When working on R&D projects or university applications, precise control over fermentation processes is essential for reliable and reproducible results. This includes maintaining specific environmental conditions and scaling up experiments effectively without compromising data integrity or process efficiency.
<h2>Enable precise control and efficient scaling.</h2>
The RALF fermenter from Bioengineering is a versatile lab-scale fermenter designed to support batch, fed-batch, or perfusion processes. It features autoclavable glass vessels with sizes ranging from 1.3 to 4.5 liters, and a direct top drive system for enhanced stirring options such as Rushton, propeller, or pitched-blade stirrers. Temperature control is managed using heating pads and cooling fingers or through a heated circuit integrated into the vessel walls. BioSCADA software ensures customizable, flexible control compliant with 21 CFR Part 11. This fermenter is ideal for scaling up studies due to its consistent system design and minimal space requirements. Bioengineering's RALF is perfect for applications in biopharma, food, beverage, and cosmetics industries, ensuring robust and reproducible results.

Lab-scale fermenters for research and development

In laboratory settings, producing reliable and repeatable results necessitates precise control over microbial and cell cultures. The challenge lies in minimizing contamination risks while maintaining the integrity and sterility of the cultures under study.
<h2>Facilitates precise control and sterility</h2>
The autoclavable and in-situ sterilizable lab-scale fermentors and bioreactors from Bioengineering are designed to ensure maximum sterility and control in laboratory and pilot-scale applications. These systems, ranging from benchtop to pilot scale, utilize the advanced BioSCADA software, which provides control comparable to full-scale production plants. The bioreactors are constructed with stainless steel, featuring a double shell and double floor for optimal temperature control and efficient sterilization. The belt drive system reduces vessel height, offering convenient access for all operations. Options are available for both cell culture and bacteria fermentation, including stirrer systems and gassing technologies tailored to specific requirements. Processing capacities range from 28 to 650 liters, allowing scalability from research and development to small-batch production. Complete GMP documentation ensures regulatory compliance.

Autoclavable and in-situ sterilizable lab-scale fermentors

In R&D and university laboratories, precise control over fermentation and bioprocessing is crucial. Researchers often face challenges such as ensuring uniform conditions and scalability from benchtop to pilot scale, all while maintaining a sterile environment.
<h2>Facilitates scalable fermentations with in-situ sterilization</h2>
The KLF Bioreactor, manufactured by Bioengineering AG, offers a unique, in-situ sterilizable bench-top bioreactor made of glass. This bioreactor is distinguished by its ease of operation, requiring no tools for conversion and offering substantial flexibility with numerous extension possibilities. The system is optimized for batch, fed-batch, or perfusion processes and is equipped with accurate process control via high-grade probes. The KLF employs BioSCADA, a sophisticated control and visualization software, ensuring data collection and compliance with 21 CFR Part 11. The design allows for minimal space requirements and can support up to six bioreactors controlled by a single unit, making it ideal for both scale-up and scale-down testing. Technical features include multiple configurations for processing capacities (1.6, 2.0, and 2.5 liters), robust components, and compatibility with various stirring, ventilation, and measurement systems. The system's versatility and reliable construction make it well-suited for biopharma, food, beverage, and cosmetic industries.

Lab-scale in-situ sterilizable bioreactor

In biopharmaceutical manufacturing, the integration of various systems for upstream and downstream processes such as cell culture and purification is crucial to maintain efficiency and product quality. Customizable solutions that cater to specific process needs are often required to meet stringent regulatory standards and production goals.
<h2>Integrate stainless steel and single-use systems</h2>
The Hybrid Bioprocess System from Austar offers a comprehensive solution incorporating both stainless steel and single-use systems for upstream and downstream bioprocessing. Designed to handle tasks such as media preparation, buffer preparation, cell culture, separation, purification, and aseptic transfer, this system ensures flexibility and customization according to client needs. By combining the technical benefits and cost advantages of stainless steel with single-use systems, it provides high-quality, low-cost solutions. The system includes hardware, consumables, automatic control, and validation services. Additionally, it supports the entire process from feasibility evaluation to project management services, making it a versatile option for biopharma operations.

Hybrid bioprocess system for cell culture and purification

Transfer

In biopharmaceutical production, ensuring seamless upstream and downstream processes is critical for the efficient and regulated production of protein and antibody drugs. Access to integrated systems reduces risk and improves process control, crucial for maintaining quality standards in drug manufacturing.
<h2>Optimize biopharmaceutical production processes</h2>
The bioprocess system offered by Austar is designed to provide comprehensive solutions for both upstream and downstream processing in the biopharmaceutical industry. This system integrates various essential functions, including media preparation, fermentation through bioreactors, chromatographic separation, and product clarification and harvesting. Austar's system is adaptable for use with recombinant protein drugs, antibody drugs, vaccines, and blood products. The system supports both stainless steel and single-use configurations, ensuring flexibility based on production needs. With compliance to industry standards like ISO9001 and ASME-BPE, Austar ensures reliable and high-quality production practices. Clients benefit from Austar's expertise not only in hardware but also in engineering consultation, facilitating efficient, scalable production from research and development through to commercial scale.

Bioprocess system for protein and antibody drugs

Clarifying

In pharmaceutical production, scaling up from laboratory research to commercial production involves specific equipment for microbial culture fermentation. This process requires strict regulatory compliance and the ability to handle various bacteria strains under controlled conditions.
<h2>Scale up microbial culture fermentation efficiently</h2>
The Biological Fermentation Tank by Austar addresses these needs with its comprehensive range, offering volumes from 5 to 30 kiloliters. This allows for smooth transitions from pilot-scale projects to commercial production. The tanks are designed in accordance with GMP regulations and ASME-BPE requirements, meeting pressure vessel standards worldwide, including ASME-U, GB150, and PED. The specialized, user-friendly, and modular design supports high oxygen-consuming bacteria such as E. coli and Pichia pastoris. This makes it suitable for the production of biological drugs like recombinant proteins (e.g., insulin) and vaccines (e.g., HPV, pneumococcal vaccine).

Biological fermentation tank for pharmaceutical production

In the pharmaceutical industry, cultivating mammalian cells for vaccines, mono-antibody drugs, or recombinant proteins requires precise control over the cell culture environment. Ensuring consistent conditions for sterility, temperature, and nutrient supply is critical for achieving high-quality results in both pilot and commercial-scale production.
<h2>Enables precise control for mammalian cell cultures</h2>
The bioreactor offered by Austar is a highly modular system designed specifically for mammalian cell culture applications. This bioreactor meets strict GMP regulations and follows ASME-BPE requirements, ensuring compliance and quality. The system includes a tank unit, stirring unit, jacket temperature control unit, and advanced automatic control systems. It supports various culture methods, such as cell suspension and micro-carrier cultures, making it adaptable to different production needs. Featuring clear, S88-standard programming, it records, stores, manages, and analyzes culture data effectively, complying with GAMP5. Audit tracking conforms to CFR 21 PART11, making it suitable for industries needing stringent regulatory adherence, such as vaccine and monoclonal antibody production.

Bioreactor for mammalian cell culture

When conducting synthetic reactions in a controlled environment, maintaining precise temperature and vacuum conditions is essential. Researchers face challenges in achieving uniform material mixing and consistent reaction parameters.
<h2>Facilitates controlled synthetic reactions</h2>
The Ai R-series single glass reactor system by Across International is designed specifically for synthetic reaction processes, allowing for precise temperature and vacuum control. The system features adjustable stirring speeds and a constant pressure feeding funnel to ensure uniform material addition. It includes a built-in condenser for material recovery at a controlled rate. The reactor utilizes solvent-resistant PTFE on all sealing components, enhancing durability. Hand-made from food grade high borosilicate glass, the reactor is corrosion-resistant and operates across a wide temperature range, from -120°C to 200°C. The single jacketed design supports both 2L and 5L vessel options for customizable use. Additional features include a large condenser cooling surface, a reinforced PTFE stirrer, and digital speed and temperature displays for easy monitoring.

2l single jacketed glass reactor system

The process of forming allows you to shape your products homogeneously. Forming machines are fed the manufactured material in bulk and cut it down to specification, so the process takes place between formulation of the mass and the packaging of the final item.

A special class of this equipment – Form, Fill, and Seal Machines (FFS) – creates bags and pouches from flat material such as plastic sheets, fills them with your designated product, and seals them.

Forming

In laboratory settings, precise control of reaction conditions is crucial for the synthesis of various compounds. Researchers and engineers often face challenges in maintaining consistent temperature, pressure, and mixing during complex reactions.
<h2>Control temperature and pressure for synthetics</h2>
The Ai 20L Single or Dual Jacketed Glass Reactor Systems With Air Motor from Across International is designed to facilitate synthetic reactions under controlled temperature and vacuum environments. The system features adjustable stirring speeds and a constant pressure feeding funnel for uniform material addition. The built-in condenser enables material recovery at a controlled rate. The reactor is constructed from food-grade high borosilicate glass, making it resistant to heat, cold, and corrosion. Equipped with a solvent-resistant PTFE stirring rod and stainless steel frame, this reactor provides durability and stability. It operates within a wide temperature range, from -110 °F to 400 °F, and offers high efficiency with features such as a large condenser cooling surface and an optional double-jacketed model for superior vacuum control. The unit's air motor allows use in C1D1 environments without requiring expensive EX retrofits.

20l jacketed glass reactor

In chemical synthesis, precise temperature control and efficient material recovery are crucial for successful reactions. Challenges often include maintaining consistent pressure and ensuring uniform material addition.
<h2>Supports controlled temperature and vacuum conditions.</h2>
The AI 10L Single/Dual Jacketed Glass Reactor System by Across International is designed for versatile synthetic reactions in a controlled vacuum and temperature environment. Featuring adjustable stirring speeds, the system also includes a constant pressure feeding funnel for uniform material addition. Its built-in condenser allows for material recovery at a controlled rate. The dual jacketed model enhances control by allowing vacuum drawing from the outer jacket. The high-quality borosilicate glass construction ensures durability and resistance to heat, cold, and corrosion. The reactor operates within a wide temperature range from -110°F to 400°F and includes an optional ETL certification to meet UL and CSA standards.

10l glass reactor system for synthetic reactions

Bioreactor systems

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

What does a $300,000 burger taste like? Meat. The first lab-grown burger took two years and 20,000 strands of muscle tissue to produce. But with rapid advances in cultivated meat processing technology, non-animal meat alternative products can now take a lot shorter to prepare. And cost much less.

Cultivated meat

Glycerine is a water-soluble liquid mix of alcohol and sugar. It is a by-product of the oil and fats industry that offers added value to various industries. There are three ways to process it: transesterification, saponification, and fat splitting (hydrolysis). In 2020 these 3 forms of glycerine production reached around 4 million metric tons, with a global market of $1.68 billion.

Glycerine

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Everything tastes like porridge, the saying goes. That may be an exaggeration, but in theory, reaction flavors could make everything taste the same. Thankfully, flavorists and chemists in the flavor industry are more inventive than that, and colorful process flavors treat our taste buds to a broad palette of sensations, flavors and aromas.

Reaction flavors

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Ancient civilizations were using yeast as it naturally occurred in bread-making and brewing. But yeast processing equipment wasn't developed and fully commercialized until the end of the 18th century. Today, this industrialized micro-organism is critical in producing biofuels and other products beyond food and drinks.

Yeast

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