Autoclavable and in-situ sterilizable lab-scale fermentors
For researchers seeking precise control in bioprocessing, these lab-scale fermentors offer advanced scalability and seamless integration with existing systems, ensuring consistent and sterile environments for diverse applications.
Facilitates Scalable Fermentation and Bioprocessing
The LP and P bioreactor series from Bioengineering is a scalable solution for diverse fermentation and bioprocessing needs, offering both lab-scale and pilot operations. Known for its adaptability, this bioreactor series is particularly suited for R&D applications in the biopharmaceutical, food, and cosmetics industries.
Utilizing a double-shelled stainless steel vessel and bottom drive system, the bioreactors ensure efficient heat transfer and minimal downtimes. Integrated with Bioengineering’s proprietary BioSCADA system, the equipment allows precise monitoring and control of critical parameters such as temperature, pH, and oxygen levels, while supporting programmable logic control (PLC) for automation.
With capacities ranging from 28 to 650 liters, these bioreactors are ideal for producing monoclonal antibodies, yogurt cultures, and craft beers. The design includes in-situ sterilization and autoclaving capabilities, minimizing contamination risks and meeting stringent cGMP requirements. Options for customization are available, including rotor filters for perfusion systems and various gassing configurations to cater to specific production processes.
The LP and P series support rapid cleaning via its advanced CIP systems, and the modular design allows easy integration into existing production lines, while offering the flexibility to upscale for future growth. Compliance with global standards ensures the series’ reliability and safety in demanding production environments.
Benefits
- Enhances scalability from lab to pilot production, supporting seamless growth.
- Lowers contamination risk with integrated in-situ sterilization capabilities.
- Improves process precision and efficiency through BioSCADA-based monitoring and control.
- Reduces operational costs with energy-efficient design and automated systems.
- Ensures compliance with global cGMP standards for safe and reliable production.
- Applications
- Homeopathy,Food and nutritional products,Metallurgy,Fine chemicals,Beverage,Alternative medicine,Performance materials,Cosmetics,Biopharmaceuticals,Chemical,Petrochemical,Mining
- End products
- Monoclonal antibodies,Vitamin supplements,High-performance plastics,Propylene,Homeopathic remedies,Processed gold ore,Herbal tinctures,Extracted lithium,Ethylene,Facial serums,Craft beers,Yogurt cultures
- Steps before
- Media preparation,Buffer preparation,Solution mixing
- Steps after
- Sterilization,Data documentation,Packing
- Input ingredients
- bacteria,yeasts,animal cells,plant cells,heat-instable media,oxygen for bacteria,shear-sensitive cells
- Output ingredients
- fermented products,biocultures,upscaled bioreactive solutions,clinical production batches,small-batch production outputs
- Market info
- Bioengineering is known for its expertise in designing and manufacturing customized bioreactors and fermenters, serving the biotechnology and pharmaceutical industries. They are reputed for high-quality, engineered-to-order solutions and innovative process technologies.
- Processing capacity
- 28 / 33 / 50 / 65 / 100 / 130 / 200 / 300 / 500 / 650 liters
- Vessel
- Stainless steel,double shell,double floor
- Drive
- Bottom drive with belt,double axial face seal,magnetic drive,top drive
- Stirrers
- Rushton,propeller stirrers,pitched-blade stirrers,Vibromixer
- Gassing
- Auto-sterile filters,separate filters or double filters. Ring sparger,sinter sparger,surface gassing,bubble-free gassing. Up to 8 gassing lines with pulsed valves or mass-flow controllers.
- Temperature circuit and sterilization
- Steam heating / Cooling water. Automated sterilization,empty sterilization.
- Dosing / Transfer
- Manual dosing,SteriCaps,transfer concepts,full valve automation. Up to 6 pump module selectable.
- Measurement and control technology
- Speed,temperature,pH,pO2,antifoam/level,redox,OD,weight,exhaust-gas analysis. Several interfaces and regulators available for external devices/equipment.
- BioSCADA
- Process monitoring,data management,documentation,batch reports,profiles,cascades,sequencer program. Intuitive operation,no programming skills required.
- Batch vs. continuous operation
- Batch / Inline Continuous
- Automation level
- Manual / PLC / SCADA
- CIP/SIP
- CIP 121°C / SIP 135°C
- Cleaning method
- CIP / Manual
- Biological compatibility
- Suitable for bacteria,yeasts,animal and plant cells
- Cleanability
- Components available for CIP and SIP
- Corrosive resistance (e.g. acids)
- Stainless steel construction
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Container size
- 28 / 33 / 50 / 65 / 100 / 130 / 200 / 300 / 500 / 650 liters
- Options for cell culture
- Rotor filter for perfusion,bubble-free gassing for shear-sensitive cells,empty sterilization for heat-instable media,cell-free sampling system
- Options for bacteria fermentation
- Stirrer systems for bacteria with high oxygen requirement,weight regulation for continuous cultivation,Hi-containment sampling system
- HMI Type
- Intuitive
- Integration Possibilities
- BioSCADA,PLC
- Control Panel Type
- Local regulators,BioSCADA or PLC
- Vessel Size
- 28 to 650 liters
- Stirrer Type
- Rushton,propeller,pitched-blade,Vibromixer
- Drive Type
- Bottom drive,top drive,magnetic drive
- Gassing System
- Auto-sterile filters,ring sparger,bubble-free gassing
- Dosing/Transfer Options
- Manual dosing,SteriCaps,valve automation
- Sampling System
- Hi-containment,cell-free
- Sterilization Options
- Automated,empty sterilization
- Control System
- BioSCADA