Cell retention device for high-density perfusion processes

Effortlessly manage high-density cell cultures with advanced ultrasonic separation, optimizing continuous bioprocesses by facilitating efficient cell retention and seamless media exchange.

Facilitates Continuous Cell Separation and Retention

The Applikon BioSep from Getinge is an ultrasonic cell retention device designed for continuous, high-density perfusion processes in biopharmaceutical applications. Utilizing high-frequency resonant ultrasonic waves, it efficiently separates cells and automatically removes cell debris, reducing fouling and ensuring long-term operation. Ideal for producing monoclonal antibodies, recombinant proteins, and gene therapy products, the BioSep supports capacities from 1 L/day to 1000 L/day, with up to 99% separation efficiency depending on cell concentration and flow. The system integrates seamlessly with any bioreactor, offering flexible operation modes including continuous and semicontinuous strategies. Proven under cGMP conditions, it meets strict compliance standards and offers robust documentation to support regulated environments. The inclusion of a Clean-in-Place (CIP) system simplifies maintenance, while customizable configurations are available to suit specific production needs.

Benefits

  • Maximizes cell yield with efficient separation, enhancing productivity.
  • Minimizes maintenance downtime with non-fouling ultrasonic technology.
  • Supports regulatory compliance in pharmaceutical production with cGMP-approved documentation.
  • Reduces operational costs through automated cell debris removal.
  • Ensures scalability from development to production, accommodating diverse batch sizes.

General


Applications
Bioprocess technology,Biopharmaceuticals,Continuous bioprocessing,Cell cultures
End products
Biologics,Cell therapy products,Gene therapy products,Viral vectors,Vaccines,Monoclonal antibodies,Enzymes,Recombinant proteins
Steps before
Bioreactor Preparation,Media Preparation
Steps after
Cell Concentration,Washing,Downstream Processing
Input ingredients
fresh media,viable cells,cell concentration
Output ingredients
spent media,cell debris,separated cells,cell/particle concentration
Market info
Getinge is known for providing innovative healthcare and life sciences products, specializing in medical technology, infection control, surgical workflows, and critical care solutions. They maintain a strong reputation for quality and technological advancement in these sectors.

Technical Specifications


Maximum perfusion rate
1 L/day to 1000 L/day
Minimum perfusion rate
0.1 L/day to 100 L/day
Separation efficiency
Up to 99%
Minimum cell concentration
2 x 10^5 cells/ml
Bioreactor connection
6 mm OD tube,12 mm OD tube
Medium inlet
3 mm hosebarb to 0.5" TC
Return line to bioreactor
3 mm hosebarb to 0.5" TC
Perfusion outlet
3 mm hosebarb to 0.5" TC
Weight
0.1 kg to 70 kg
Resonator volume
0.7 ml to 1450 ml
BioSep Controller Power
15 Watt to 1500 Watt
BioSep Controller Dimensions
305x130x130 mm to 450x300x450 mm
BioSep Controller Weight
3.5 kg to 17.6 kg

Operating Characteristics


Working mechanism
High frequency resonant ultrasonic waves
Batch vs. continuous operation
Continuous perfusion
Automation level
Automatic removal of cell debris
Cleaning method
No fouling or blocking,suitable for long term operation
Setup flexibility
Direct mounting onto bioreactor head plate
Scalability
Full scalability between different sizes (1 L/day to 1000 L/day)
Operation mode
Continuous and semi-continuous operation
Separation efficiency
Up to 99%

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Bioreactor compatibility
Any brand

Physical Characteristics


Machine footprint
Varies with model
Control panel type
Mounted with my-Control
Resonator volume
0.7 ml (1L model) - 1450 ml (1000L model)
Weight
0.1 kg (1L model) - 70 kg (1000L model)
Maximum perfusion rate
1 L/day - 1000 L/day
Minimum perfusion rate
0.1 L/day - 100 L/day
Bioreactor connection
6 mm OD tube - Mounted separately
Medium inlet
3 mm hosebarb - 0.5” TC
Return line to bioreactor
3 mm hosebarb - 0.5” TC
Perfusion outlet
3 mm hosebarb - 0.5” TC

Custom Options


Perfusion options
1 L/day,10 L/day,50 L/day,200 L/day,1000 L/day
Mounting options
Bioreactor head plate or separate mounting
Compatibility
Compatible with any brand of bioreactor
Operation modes
Standard,semicontinuous,cell recirculation strategies
Resonator volume options
0.7 ml,7 ml,50 ml,290 ml,1450 ml
Cell concentration range
Minimum 2 x 105 cells/ml (depending on cell size)